IRAKf_c-2

Species: S.moellendorffii
Alias: IRAKf_c-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_c-2.AA Protein None 927 None Fasta, JSON
IRAKf_c-2.NA RNA None 2784 None Fasta, JSON
IRAKf_c-2.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of IRAKf_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_c-2.AA LRRNT_2 46-86 41 1.6e-14 50.11 Pfam 1-46 (46) Show / Hide
Range on Protein: 46-86
Range on HMM: 1-46/46
Sequence Identity: 41% (19 aa)

WNDDVLGLLVFKAGLQD-PR--GSLASWSEAD--SSPCNWTGIRCG
 |||.. || ||..|.| ..  |.|.||.  .  |..|.|||. | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD

LRR_1 IRAKf_c-2.AA LRR_1 115-138 40 0.034737 11.92 Pfam 1-26 (26) Show / Hide
Range on Protein: 115-138
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLKTLSLSA-N--NLSGNVVPELFRML
.|..|.||  |  ||.|.. |. |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_c-2.AA LRR_TYP 113-137 34 0.106902 7.81 SMART 1-24 (24) Show / Hide
Range on Protein: 113-137
Range on HMM: 1-24/24
Sequence Identity: 34% (9 aa)

LERLKTLSLSANNLSGNVVP-ELFRM
|  |..|.|| |.|    .| ..|. 
LPNLRELDLSNNQL--THLPPGAFQG

LRR_1 IRAKf_c-2.AA LRR_1 91-113 22 75.613317 0.08 Pfam 1-26 (26) Show / Hide
Range on Protein: 91-113
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RVESVSLDG-L--ALSGTIGRG-LLKL
. .. .|.|     |.|.|  . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 159-182 25 1.310059 6.33 Pfam 1-26 (26) Show / Hide
Range on Protein: 159-182
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SIRYVDLSD-N--AFTGALARDFFGGG
.... |||. |   .|| .  . | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 184-206 37 0.008655 14.06 Pfam 1-26 (26) Show / Hide
Range on Protein: 184-206
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLRYLSLSK-N--RLTGQLSPS-LAAN
 |..|.||  |  .|||...|| . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 258-280 44 0.00025 19.52 Pfam 1-26 (26) Show / Hide
Range on Protein: 258-280
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLRSLNLAG-N--NLTGVVPQS-LLQL
.|..|.| | |  |||| .| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 234-256 44 0.000544 18.32 Pfam 1-26 (26) Show / Hide
Range on Protein: 234-256
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALQELDFSW-N--GFQGSIPPS-LATL
 ||.||.|  |   ..|.|||| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_c-2.AA LRR_TYP 256-279 37 0.012143 15.55 SMART 1-24 (24) Show / Hide
Range on Protein: 256-279
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LSSLRSLNLAGNNLTGVVPQSLLQ
|..||.|.| .|.|| . |. .  
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP IRAKf_c-2.AA LRR_TYP 280-304 44 0.036746 11.61 SMART 1-24 (24) Show / Hide
Range on Protein: 280-304
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LLRLSSLDLSSNHLGGKIPFGLFSS
|  | .||||.|.|   .| |.|..
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_c-2.AA LRR_1 305-326 29 0.04276 11.6 Pfam 1-26 (26) Show / Hide
Range on Protein: 305-326
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLQFLNLSR-N--EFLGDFPI--WPPC
.|| |.||. |   . |..|      .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 282-304 37 0.077714 10.68 Pfam 1-26 (26) Show / Hide
Range on Protein: 282-304
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLSSLDLSS-N--HLGGKIPFG-LFSS
.| .||||. |  .| |.|| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_c-2.AA LRR_TYP 232-255 36 0.930168 0.11 SMART 1-24 (24) Show / Hide
Range on Protein: 232-255
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LRALQELDFSWNGFQGSIPPSL-AT
|..|.||| |.| .  ..|| . . 
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_c-2.AA LRR_1 209-232 22 1.219747 6.44 Pfam 1-26 (26) Show / Hide
Range on Protein: 209-232
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

GLVTLRIAE-N--GFSGDLPDWIGKSL
 | .| .   |   ..|..|...  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 328-350 29 0.00731 14.32 Pfam 1-26 (26) Show / Hide
Range on Protein: 328-350
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALQVVDISG-N--RIFGEVPSR-IAQC
 ||. |.|| |  .. |..|.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 376-398 44 0.000409 18.76 Pfam 1-26 (26) Show / Hide
Range on Protein: 376-398
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLMFLDLSH-N--QLQGGIPST-FTNM
.|  ||||. |  .|.| ||.  | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 352-374 37 0.051957 11.3 Pfam 1-26 (26) Show / Hide
Range on Protein: 352-374
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQHLNVGW-N--VLSGGIPGQ-ISQL
.||||...  |   |.| ||   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 400-422 29 0.07426 10.75 Pfam 1-26 (26) Show / Hide
Range on Protein: 400-422
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLTVLKLAK-N--LLVGNIPKA-ISKC
.|..| |   |   |.|.||.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_c-2.AA LRR_TYP 374-397 45 0.10964 7.72 SMART 1-24 (24) Show / Hide
Range on Protein: 374-397
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LQRLMFLDLSHNQLQGGIPSTFTN
|  |  ||||.|||.   | .| .
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP IRAKf_c-2.AA LRR_TYP 398-422 24 0.439355 2.78 SMART 1-24 (24) Show / Hide
Range on Protein: 398-422
Range on HMM: 1-24/24
Sequence Identity: 24% (6 aa)

MSSLTVLKLAKNLLVGNIPKAISKC
...|..| |  | |   .|  .  .
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_c-2.AA LRR_1 424-446 40 0.000125 20.59 Pfam 1-26 (26) Show / Hide
Range on Protein: 424-446
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLVELDLSS-N--RLSGSIPGA-LSRL
.| .||||. |  .|.|.||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 448-470 48 0.000577 18.23 Pfam 1-26 (26) Show / Hide
Range on Protein: 448-470
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

FLQSLDLAW-N--NLTGPIPKE-LVKL
 ||.|||   |  |||| ||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_c-2.AA LRR_1 472-495 40 0.040595 11.68 Pfam 1-26 (26) Show / Hide
Range on Protein: 472-495
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLSSLDVSH-N--HLDGPIPKGGVFNL
.| .||.|. |  .| | ||..   ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_c-2.AA LRR_TYP 470-495 38 0.188585 5.79 SMART 1-24 (24) Show / Hide
Range on Protein: 470-495
Range on HMM: 1-24/24
Sequence Identity: 38% (10 aa)

LESLSSLDVSHNHLDGPIPKGGVFNL
| .| .|| |.|.|   .|  |.|. 
LPNLRELDLSNNQL-THLP-PGAFQG

Kinase IRAKf_c-2.AA TKL 640-906 21 8.1e-55 188.44 In-house 1-364 (364) Show / Hide
Range on Protein: 640-906
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

IGRGGFGVVYRAAISD---------GRTFAVKKLVTAGLVKSQL-------------------------EFEKEVQ-QLGKIEHPNLVALQGYYWTSRM-
||.||||.||..             |.. ||||. .    .. .                         .||.|.  .. .. |||.| . ||   ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGTAMGLSHLHHSC-----QPQVIHYDLKSNNILLGVDNR------------
              ......|.|||...||          |. |...|...| |...|| .       |..|| ||||.|||.  ...            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PLISDYGLANLLPVL-----------------DRYAISSKFQGALGYMAPEFASQS---------------SKVTEKCDVYGFGIILLELVTGRRPVE
  . |.|.||.  .                    ..   ...  | ...||||   ..               .. .|||||| |||.| |..|..|| .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YMEEDVVIL---CDYVRALLNEGRGMSC------VEPSLEASPEDEVLP-VIKLGLICSSPLPSNRPSMAEVVQIL
 |.......     ..     ..|.   .      ..     .|.. ..| ..||   | .. |..|||. |....|
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAKf_c-2.AA IRAK 635-839 37 9.6e-47 161.61 In-house 2-224 (317) Show / Hide
Range on Protein: 635-839
Range on HMM: 2-224/317
Sequence Identity: 37% (83 aa)

NKEQEIGRGGFGVVYRAAISDGR-TFAVKKL---VTAGLVKSQLEFEK---EVQQLGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGE
.|.  || ||||.|||. ..    ..|||||   .     ..  .|     |.... .. |||.|.| ||   .    |.|.. |||||  ||. ..   
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

PP--LSWSERFKIAQGTAMGLSHLHHSCQPQ--VIHYDLKSNNILLGVDNRPLISDYGLANLL---PVLDRYAI----SSKFQGALGYMAPEFAS-QSSK
||  |||  |..|..||| |. .| |. .|   .|| | || ||||  .  | |.| ||.      ... .  .     |...| . ||.|||    . .
PPKPLSWHQRCSICWGTACGIQFL-HQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTEKCDVYGFGIILLELVTGRRPV
 | | ||| ||| |||..||.|.|
LTKKTDVYSFGIVLLEVLTGCRAV

Kinase IRAKf_c-2.AA LRRK 634-840 26 1.3e-32 112.67 In-house 1-284 (351) Show / Hide
Range on Protein: 634-840
Range on HMM: 1-284/351
Sequence Identity: 26% (75 aa)

LNKEQEIGRGGFG-VVYRAAISD---------------------------GRTFAVKKLVT---------------------------------AGLVKS
| .|..||||||| .||||   .                           . . |.||. .                                 ... ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QLEFEKEVQQLGKIEHPNLVALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGE-----PPLSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNI
  || .||  . . .|||.| | |.    ..  .. ...|.|.||..||..   .     . .||. . |||   | |. .| ||. | .|| |||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LLGVDNRPL------------ISDYGLANLLPVLDRYAISSKFQGALGYMAPEFASQS--SKVTEKCDVYGFGIILLELVTGR-RPVE
||   . .             |.|.|.  .    ..... ... |  |.||||       .  ||| |.| ||.|| ||.|.. .| .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase IRAKf_c-2.AA MLK 634-838 24 2.6e-31 105.93 In-house 1-235 (291) Show / Hide
Range on Protein: 634-838
Range on HMM: 1-235/291
Sequence Identity: 24% (59 aa)

LNKEQEIGRGGFGVVYRAAISDGR----TFAVKKLVTAG--LVKS---QLEFEKEVQQLGKIEHPN--LVALQGYYWTSRM-Q--LLIYDFVPNGSLYSR
.. .. || |.||.|...     .    . |||.  .     ...   | .||.|. .| .. |||      | |.  ..  .  ...  ....||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHERT-------FGEP---PLSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGV------DNRPLISDYGLANLLPVLDRYAI---SSKFQG
||...        ...     . .  ...|   | |.. ||   ....||.|||| |||.        .    |.| |..      | . .     ...|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS-----RDWHQMCTNMMSNAG

ALGYMAPEFA--SQSSKVTEKCDVYGFGIILLELVTGRRP
 . .||||    ....|..|||||. .|..| |..|.. |
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase IRAKf_c-2.AA TKL-Unique 638-838 28 4.5e-31 106.91 In-house 3-233 (290) Show / Hide
Range on Protein: 638-838
Range on HMM: 3-233/290
Sequence Identity: 28% (67 aa)

QEIGRGGFGVVYRAAISDGRTFAVKKLVT-AGLVKSQLE-FEKEVQQLGKIE-HPNLVALQGYYW----TSRMQLLIYDFVPNGSLYSRLH---------
  ||.||.|.||. ..  |   |.|..   ... .. .. ||.||  . |.. |||.| . ||      .     .. ...| ||||. ||         
NKIGEGGYGQVYK-GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

ERTFGEPPLSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVD-----NRPLISDYGLANLLPVLDRYAIS-------SKFQGALGYMAPEF
..     .|... | |.|.  | |. .|||.  | .|| |||| |.|.  .     ..  |.| ||. ..   ..  ..       . ..| . .|||| 
NNNC---KLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

ASQS-SKVTEKCDVYGFGIILLELVTGRR------P
 ... .. .||.||| |||.| |..|. .      |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP

Kinase IRAKf_c-2.AA Pkinase 634-836 24 1.3e-30 109.38 Pfam 1-209 (293) Show / Hide
Range on Protein: 634-836
Range on HMM: 1-209/293
Sequence Identity: 24% (53 aa)

LNKEQEIGRGGFGVVYRA-AISDGRTFAVKKLVTAGLVKSQLEFEK---EVQQLGKIEHPNLVALQGYYWTSRMQLLIYDFVPNG----SLYSRLH--ER
. ... ||.|.||.||..  ...|...|||..   .  .....      |.| . .. ||| | | ... ...   .. .....|    .|.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TFGEPPL--SWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRP----LISDYGLANLLPVLDRYAISSKFQGALGYMAPEFASQSSKVT
.    ..  |. |  ...  .. || ..|      .|| |||. |||.  .. .     |.| ||| ..  . ..   . | | ..|||||    ... .
G----CFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

EKCDVYGFGIILLELVTGR
 |.|....|.|| |...||
PKVDMWSCGCILYEMLCGR

Kinase IRAKf_c-2.AA S_TKc 634-909 21 2.4e-28 101.44 SMART 1-231 (231) Show / Hide
Range on Protein: 634-909
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

LNKEQEIGRGGFGVVYRAAISD-GRTFAVKKLVTAGLVKSQLEFEKEVQQLGKIEHPNLVALQGYYWTSRMQLLIYDFVPN--GSLYSRLHERTFGEPP-
  . ..||.|.||.||..   . || .|.|..           ...|.| | |  |||.| | ... .     .. .....  |.|......|  . .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGALGYMAPEFASQSSKVTE-KCDVYGFGI
 ..  .  .... .. .| ..|   . ..|| |||  ||||    .  |.| ||| .|         . | | . |||||      . .  |||.. .|.
PFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

ILLELVTGRRPVEYMEEDVVILCDYVRALLNEGRGMSCVEPSLEASPEDEVLPVIKLGLICSSPLPSNRPSMAEVVQ------ILELV
|| |...|. | .    ..  . . ..                         ... .   |    |..||.  |. |      . . .
ILYEMLCGYPPFP----QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAKf_c-2.AA TK 634-906 13 2.9e-25 80.98 In-house 1-486 (486) Show / Hide
Range on Protein: 634-906
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)

LNKEQEIGRGGFG---VVYRAAISDGR--------------------------TFAVKKLV--TAGLVKSQLE--------------FEKEVQQLG--KI
.  ....|.| ||   .||..   ...                          . ||| |   .|   . ...              .  | ...   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHPNLVALQG-------------YYWTSRMQLLIYDFVPNGS----LYSRLH--ERTFGEPP--------------------------------------
.|||.| | |             .   ..  ...  ..|.|.    | . |.   ..| ...                                      
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LSWSERFKIAQGTAMGLSHLHHS----CQPQVIHYDLKSNNILLGVDNR-----------PLISDYGL
                                |.  ..  ...  | |...||        ....| ||   |.|.| .|.             |.|.||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

AN-----LLPVLDR--YAISSKFQGALG-------------------------YMAPEFASQSS--------KVTEKCDVYGFGIILLELVT-G-RRPVE
.      |   ...  .  ... .|. .                         .||||              | |.| ||. ||. . |..| |   . .
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

YMEEDVVIL---CDYVRALLNE------------GRGMSCVEP---------SLEASPEDEVLPVIKL-GLICSSPLPSNRPSMAEVVQIL
.|  . |.    .. |  .| .            |..| .  |            . |. .  ... .  . | .. |. ||....... |
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAKf_c-2.AA STE 634-838 20 1.1e-23 80.62 In-house 1-267 (359) Show / Hide
Range on Protein: 634-838
Range on HMM: 1-267/359
Sequence Identity: 20% (57 aa)

LNKEQEIGRGGFGVVYRAAISD----------------GRTFAVKKLVTAGL----------------VKSQLEFEKEVQQLGKIE--HPNLVALQGYYW
. . ..||.|.||.||.|.  .                |. .|.|..                      . . ...||.. . |    ||| |   |.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSR-------MQLLIYDFVPNGSLYSRLHER-TFGEP---------PLSWSERFKIAQGTAMG-LSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYG
             ..  ....||| . ....   |.|         ... |.  .|.. .  | |..||      .|| |.|. ||||       ..| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAN-LLPVLD------------RYA-ISSKFQGALGYMAPEFASQ-----SSKVTEKCDVYGFGIILLELVTGRRP
..  | . ..              .  .  | |   .||||  .|     ... ..|||.. .|. ..|..||. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

Kinase IRAKf_c-2.AA Ciliate-E2 634-838 17 2.9e-23 76.7 In-house 1-295 (365) Show / Hide
Range on Protein: 634-838
Range on HMM: 1-295/365
Sequence Identity: 17% (52 aa)

LNKEQEIGRGGFGVVYRA-AISDGRTF------------------AVKKLVTAGLVKSQLEFE-KEVQQLGKIE----------------HPNLVALQGY
 .. . ||.|.||.||..  ..... |                  ..|.     . |.|.|.  .| ... .|.                |||.. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YW--TSRMQLLIYDFVPNGSLYSRLHER---TFGEPP----LSWSERFKIAQGTA---------------MGLSHLHHSCQPQVIHYDLKSNNILLGVDN
.   .     |. ...  |.|.... ..    . |..    ... |. .| .  .                .| .||      .|| |.| .|||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

RPLISDYGLA-NLLPVLDRYAISSKFQG-----------------------------ALGYMAPEFASQSSK--------VTEKCDVYGFGIILLELVTG
 . |.| ||. .. .  ... .  . ..                              .||||||  .  .          ..|||.. .|.|| |...|
-IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

RRP
..|
KPP

Kinase IRAKf_c-2.AA HH498 705-838 26 1.4e-22 68.04 In-house 79-225 (284) Show / Hide
Range on Protein: 705-838
Range on HMM: 79-225/284
Sequence Identity: 26% (39 aa)

LLIYDFVPNGSLYSRL--------------HERTFGEPPLSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLD
... ... ||||.|.|              |.    .  ..   .  |.   | |   || | ....|| || | |||.  | .  . |.|    .  ..
AIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMH

RYAISSKFQGALGYMAPEFASQSSKVTEKCDVYGFGIILLELVTGRRP
   . .   | | .||||  ||. | ..| ||....... |. |.. |
DDNMTKQP-GNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVP

Kinase IRAKf_c-2.AA Dicty4 634-838 33 1.1e-21 69.19 In-house 1-216 (277) Show / Hide
Range on Protein: 634-838
Range on HMM: 1-216/277
Sequence Identity: 33% (74 aa)

LNKEQEIGRGGFGVVYRAAISDGRTFAVKKL--VTAGLVKSQL-EFEKEVQQLGKIEHPNLVALQGYYW----TSRMQLLIYDFVPNGSLYSRLHE---R
.|.||.||.|.|| ||. ..  |   |||||     ..  . | || |||  ..|| |||.. . |.      ..   .    ..| |.||| ||     
INIEQRIGKGSFGEVYK-GTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

TFGEPPLSWSERFK---IAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLAN-LLPVLDRYAISSKFQGALGYMAPEFASQSSKVTEK
   . .|.|. . .   .|  .| |. .| |.| | .|| |||| |.|   ..|  ..| ||.    .. |  .  .   |  ..||||   ..   .||
QQQSIKLDWPLIKRAMRMAFDAARGMNWL-HCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-MHQPYNEK

CDVYGFGIILLELVTGRRP
 ||| |||.| |..|.  |
ADVYSFGIVLWEILTRQEP

Kinase IRAKf_c-2.AA TyrKc 634-906 23 3.1e-19 71.15 SMART 1-280 (280) Show / Hide
Range on Protein: 634-906
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

LNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAGLVKSQLEFEKEVQQLGKI--EHPNLVALQGYYWTS-------RMQLLIYDFVPNGSLYSRL--HE
. .....|.| ||.||..  .  .. |||.|        . .| .| . . |.  .|||.|.| |.  ..          ...  ..|.|.| ..|  |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RTFGEPPLSWSERFKIAQGTAMGLSHLHHSCQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVL-------DRYAI----SSKFQGALGYMAPEFAS
..     |....  ...   | | ..||.    ..|| ||   |.|.| ...  ||| ||.  .          | |      ..|.   .  ||||   
PK-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

QSSKVTEKCDVYGFGIILLELVT-GRRPVEYMEEDVVILCDYVRALLNEGRGMSCVEP-----SLEASPEDEVLPVIKLGLICSSPLPSNRPSMAEVVQI
. .| |.| ||. ||. . |. | |  | . |..  ..  . |.... .|. | . .      .      ||.  ..|    |    |..||...|....
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQ---CWHEDPEDRPTFSEIHEC

L
.
F

Kinase IRAKf_c-2.AA Pkinase_Tyr 634-750 22 1.9e-16 56.29 Pfam 1-128 (270) Show / Hide
Range on Protein: 634-750
Range on HMM: 1-128/270
Sequence Identity: 22% (29 aa)

LNKEQEIGRGGFGVVYRAAIS-----DGRTFAVKKLVTAGLVKSQ---LEFEKEVQQLGKI-EHPNLVALQGYYW-TSRM--QLLIYDFVPNGSLYSRLH
. . ...|.| ||.||..        .. . |||.|   |  ..|    .| .|.. . ..  |||.| | |     ..    ...  ..|.|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ERTFGEPPLSWSERFKIAQGTAMGLSHLH
..  ...||. ..  ....  |.|...|.
KHREDKQPLTMKDLLQMCWQIAKGMEYLE

Kinase IRAKf_c-2.AA Dicty4 893-908 44 1.5e-05 14.63 In-house 260-277 (277) Show / Hide
Range on Protein: 893-908
Range on HMM: 260-277/277
Sequence Identity: 44% (8 aa)

PSNRPSMAEVVQI--LEL
|..|||..|..|.  || 
PQHRPSFEEIIQRRILEH

Kinase IRAKf_c-2.AA MLK 887-906 40 0.000179 11.58 In-house 272-291 (291) Show / Hide
Range on Protein: 887-906
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

ICSSPLPSNRPSMAEVVQIL
.| .. |..|||....||.|
QCWNQDPHKRPSFRQIVQHL

Kinase IRAKf_c-2.AA HH498 887-906 45 0.0002 9.5 In-house 265-284 (284) Show / Hide
Range on Protein: 887-906
Range on HMM: 265-284/284
Sequence Identity: 45% (9 aa)

ICSSPLPSNRPSMAEVVQIL
.| .| |.|||. ...| ||
MCWHPCPENRPDFDQIVTIL

Kinase IRAKf_c-2.AA LRRK 893-908 31 0.010157 5.43 In-house 336-351 (351) Show / Hide
Range on Protein: 893-908
Range on HMM: 336-351/351
Sequence Identity: 31% (5 aa)

PSNRPSMAEVVQILEL
| .||.. ..|..|. 
PKKRPHFSQIVKRLSQ

Kinase IRAKf_c-2.AA Pkinase_Tyr 893-906 35 0.140542 5.97 Pfam 257-270 (270) Show / Hide
Range on Protein: 893-906
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PSNRPSMAEVVQIL
|..||...|....|
PEDRPTFSEIHEQL

Kinase IRAKf_c-2.AA TKL-Unique 888-906 42 0.172585 1.24 In-house 272-290 (290) Show / Hide
Range on Protein: 888-906
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CSSPLPSNRPSMAEVVQIL
|  . ||.|||  |..  |
CWHHDPSQRPSFDEIIHRL

Kinase IRAKf_c-2.AA IRAK 895-906 50 0.188499 1.11 In-house 306-317 (317) Show / Hide
Range on Protein: 895-906
Range on HMM: 306-317/317
Sequence Identity: 50% (6 aa)

NRPSMAEVVQIL
.|..||.|.| |
RRCDMAWVMQQL

Kinase IRAKf_c-2.AA Pkinase_Tyr 805-838 40 1.18025 2.84 Pfam 181-214 (270) Show / Hide
Range on Protein: 805-838
Range on HMM: 181-214/270
Sequence Identity: 40% (14 aa)

MAPEFASQSSKVTEKCDVYGFGIILLELVT-GRRP
||||  . .   |.| ||. ||. . |..| |. |
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQP