Gene IRAKf_n-2 (S.moellendorffii)

IRAKf_n-2

Species: S.moellendorffii
Alias: IRAKf_n-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_n-2.AA Protein None 1054 None Fasta, JSON
IRAKf_n-2.NA RNA None 3165 None Fasta, JSON
IRAKf_n-2.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAKf_n-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_n-2.AA LRRNT_2 21-60 43 4.1e-13 45.49 Pfam 1-46 (46) Show / Hide 
Range on Protein: 21-60
Range on HMM: 1-46/46
Sequence Identity: 43% (20 aa)

LSGDGIALLAVKKALD---P-SDALSGWNAGS--VDPCLWAGVSCA
.. || |||| |..|.   | ...|| ||. |  .|.| | ||.| 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKf_n-2.AA LRR_1 91-113 33 0.007123 14.36 Pfam 1-26 (26) Show / Hide 
Range on Protein: 91-113
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLQVLSLQE-N--SFSGGIPAE-LGAL
.||.|.|.  |  ...| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 115-137 40 0.007077 14.37 Pfam 1-26 (26) Show / Hide 
Range on Protein: 115-137
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLEVLDLEG-N--LLDGPIPPA-IASC
.|..||| | |   | | |||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 139-161 37 0.006016 14.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 139-161
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLVHISLGR-N--KLSGGIPAS-LGGL
.| |..|.. |  .|.| || | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 163-185 35 0.002888 15.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 163-185
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

RLRHLSLTS-N--QLS-SVIPPG-LQGL
.|.||.| . |  .|. . |||. . .|
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 188-210 33 0.007502 14.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 188-210
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLEYLDLGS-N--FFIRGIPPW-LGNC
.|..|||.. |   . . |||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 212-234 37 0.003721 15.36 Pfam 1-26 (26) Show / Hide 
Range on Protein: 212-234
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLQVLVLES-N--YLQGFIPSE-LGRL
.||.| | . |   |.| ||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 236-258 37 0.008768 14.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 236-258
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

MLQVLDVSM-N--RLTGQVPAA-LGDC
 ||.||.|  |  .|||..|   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 332-354 29 0.000428 18.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 332-354
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLRSLNLAG-N--SFTGDFPQG-LGKC
.|..|.| | |  ..||..| . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 356-378 32 0.469574 7.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 356-378
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

SLTYLDLSL-N--RLE-AQLPPQ-LPTS
.|..||||  |  .|.   .||  .   
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 379-403 17 16.266004 2.45 Pfam 1-26 (26) Show / Hide 
Range on Protein: 379-403
Range on HMM: 1-26/26
Sequence Identity: 17% (5 aa)

CMIVFNVSR-N--SLSGDVLPRRSIECN
   . ..|. |  .|.|. .| ...   
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 463-486 33 2.475458 5.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 463-486
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

PVYELLMSE-N--RLAGNIPSSFFAFC
   .| .|  |  .| |.||.| |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 495-513 18 5.466047 4.13 Pfam 6-26 (26) Show / Hide 
Range on Protein: 495-513
Range on HMM: 6-26/26
Sequence Identity: 18% (4 aa)

NLSD-N--QISGELSGQDIGGC
.||. |  ...|...   . ..
DLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 515-537 17 14.757216 2.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 515-537
Range on HMM: 1-26/26
Sequence Identity: 17% (5 aa)

SLVQFSASN-N--LIE-EALPKE-LGTL
.|   . |. |   .. . .|.. .  |
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 539-561 44 0.00027 19.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 539-561
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLSLLDLSR-N--RLSGSIPGE-LGEL
||  ||||. |  .|.|.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 563-585 29 0.174997 9.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 563-585
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

MLTSLFLAN-N--SLVGDIPEK-LGQA
 |..| | . |  .|.|.||.  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 587-609 51 0.000559 18.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 587-609
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLSLLDLSG-N--TLNGTIPSS-LANL
.|  ||||| |   | |.||.| . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 611-633 29 0.01455 13.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 611-633
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLEYLLLNN-N--DFSGTIPPV-LSDI
.|..| |.. |   ..|.|||  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_n-2.AA LRR_1 635-659 25 1.540967 6.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 635-659
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLVAVNLAF-N--NFSGSVPSSGSWVGM
.|   .|   |  |..|..|.| .  ..
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase IRAKf_n-2.AA TKL 778-1043 21 1.7e-56 194.05 In-house 1-364 (364) Show / Hide 
Range on Protein: 778-1043
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

IGNGGFGATYKAEMMP---------GLVVAVKRLSIGRFQGV---------------------------QQFDTEIRTLGRIQHSNLVKLIGYHASEGE-
|| ||||  ||.. .          | .||||....   .                             ...  ||. . |..| |.|...||  ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MFLIYNYFPRGNLESFIHNRSRGEISWAVVHRIAMGIAEALAYLHDEC-----QPRVLHRDIKPSNILLDNNLT--------------
            ..... | |.|.|....|        | . .|.|..|| ...||| .       | ..|||.|..|||.|.|.|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AFLADFGLARLL------GASETH------------ATTDVAGTFGYVAPEYAM----------------TCRVSDKADVYSYGVVLLELLSGKKALDPA
. ..||||.| .       ...|.            .|  . ||... |||  .                    | |.||||.|.|| |.|....     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----P

FSDYGHGFTIVG----WACLLIGQGRAHEVFIVELWE-----MGPEAFLLETLKLAVMCTVDSLTVRPTMRQVVDRL
..||..   |..    .   .... . .   | . |.     . .. .. .  ||. .|     . ||.. ....||
YYDYPYMPMIFQDPFEEMFMMVCDKG-LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKf_n-2.AA IRAK 772-973 32 2.9e-44 153.36 In-house 1-226 (317) Show / Hide 
Range on Protein: 772-973
Range on HMM: 1-226/317
Sequence Identity: 32% (74 aa)

FSVDYLIGNGGFGATYKAEMMPGLV--VAVKRL----SIGRFQGVQQFDT---EIRTLGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRS-
|..| .|| ||||  |....  ..   .|||.|    ..   .  |.|..   |.... |..| |.| | || . ...  |.| | | | ||   . .  
FHKDNRIGEGGFGCVYRGQWK-NTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

RGE---ISWAVVHRIAMGIAEALAYLHDECQPR--VLHRDIKPSNILLDNNLTAFLADFGLARLL---G--ASETH---ATTDVAGTFGYVAPEYAM--T
 .     ||   . |. |.| .. .||.  .|   . |.|||..||||| ..|. ..||||.|     .   . |     |  | ||  | .||.    .
QCPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

CRVSDKADVYSYGVVLLELLSGK-KALD
 . . | |||| |.||||.|.|   ..|
GQLTKKTDVYSFGIVLLEVLTGCRAVYD
Kinase IRAKf_n-2.AA TKL-Unique 774-969 28 8.3e-44 151.86 In-house 1-225 (290) Show / Hide 
Range on Protein: 774-969
Range on HMM: 1-225/290
Sequence Identity: 28% (64 aa)

VDYLIGNGGFGATYKAEMMPGLVVAVKRLSI---GRFQGVQQFDTEIRTLGRIQ-HSNLVKLIGYHA----SEGEMFLIYNYFPRGNLESFIH-------
.  .|| ||.|. ||. . .|  ||.|....    ... .| |  |.... ... | |.|...|| .    ....|...  |.|.|.| . .|       
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-NRSRGEISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNN-----LTAFLADFGLARLLGASETHATT--------DVAGTFGYVAPEYA
 |..  ....... ..|  || .. ||| .  | ..|||.|.||.|.|||     . . ..||||....  . .  ..        .. |.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MT--CRVSDKADVYSYGVVLLELLSGK
.   |  | |.||||.|.|| |....|
RMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAKf_n-2.AA MLK 772-969 25 1.8e-42 145.14 In-house 1-233 (291) Show / Hide 
Range on Protein: 772-969
Range on HMM: 1-233/291
Sequence Identity: 25% (60 aa)

FSVDYLIGNGGFGATYKAEMMPGL----VVAVKRLSIGRFQGVQQ-------FDTEIRTLGRIQHSN----LVKLIGYHASEGE-MFLIYNYFPRGNLES
. .   ||.|.||. .|...   .    .|||||  .  |  ...       |..|.| | ...| |     ... |  ....   ...  | . | | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FIHN-RSRGE-----------ISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDN------NLTAFLADFGLARLLGASETHATTDVAGTFG
..|. || ..           .. ... ..|. .|....||| . .. . |||.|..|||.|.      ..|.  .|||..| .  ..    .. |||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YVAPEY---AMTCRVSDKADVYSYGVVLLELLSGK
. |||    .   ..| |.||.|.|||| |.|...
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKf_n-2.AA Pkinase 772-969 27 1e-39 141.51 Pfam 1-209 (293) Show / Hide 
Range on Protein: 772-969
Range on HMM: 1-209/293
Sequence Identity: 27% (60 aa)

FSVDYLIGNGGFGATYKAEMMPG-LVVAVKRLSIGRFQGVQQFDT-----EIRTLGRIQHSNLVKLIGYHASEGEMFLIYNYFPRG----NLESFIHNRS
. .   || |.||  ||.       .||||...    .  ..  |     ||. . |..| | |.|...  ..... ..  | . |     | ..|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGEI--SWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTA----FLADFGLARLLGASETHATTDVAGTFGYVAPEYAM-TCRVSDKAD
.| .  |. .. ...  |...|.|.|..   ...|||.||.|||.||| .      ..|||||...     . .|...|| .|.|||  .     . |.|
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGVVLLELLSGK
..|.|..| |.|.|.
MWSCGCILYEMLCGR
Kinase IRAKf_n-2.AA LRRK 772-973 22 3.5e-35 121.89 In-house 1-284 (351) Show / Hide 
Range on Protein: 772-973
Range on HMM: 1-284/351
Sequence Identity: 22% (65 aa)

FSVDYLIGNGGFG-ATYKAEMMP---------------------------GLVVAVKRLSIGR-------------------------------------
.    .|| ||||   |.|...                            .  ||.| . ...                                     
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQGVQQFDTEIRTLGRIQHSNLVKLIGYHASEGEMFLIYNYFPRGNLESFIHNRSRGE-------ISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKP
|.  ..   |.  . . .|.|.|.|.|.  .   . ..  | | |.| .|.||... .       ||| ....||. ||....|||. . | ..||| |.
FREFRH---EVWIMSHLNHPNIVSLKGF--CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKS

SNILL---D---------NNLTAFLADFGLARLLGASETHA-TTDVAGTFGYVAPEYAM---TCRVSDKADVYSYGVVLLELLSGK-KALD
 ||||   .         .. .| .||||. |.  .. ... . .. |..|..|||      .   ..|.|.||.|..| |||...  . |
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAKf_n-2.AA S_TKc 772-1024 25 5.4e-33 116.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 772-1024
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

FSVDYLIGNGGFGATYKAEMMP-GLVVAVKRLSIGRFQGVQQFDTEIRTLGRIQHSNLVKLIGYHASEGEMFLIYNYFPR--GNLESFIHNRSRGE----
. .  .|| |.||  ||.     | .||.|...       ...  ||. | . .| |.|||...  . ......  | .   |.| ..|..| |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHATTDVAGTFGYVAPEYAMTCRVSD-KADVYSYGVVLL
..  .. ...  |..||.|.|.  . ...|||.||.|||||.  .  ..||||||.|        | . ||  |.|||       .  |.|..| |..| 
FPE-HARFYMYQICCALEYCHS--H-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLSGKKALDPAFSDYGHGFTIVGWACLLIGQGRAHEVFIVELWEMGPE--AFLLETLK-------LAVM
|.|.|.   .    ..   | ..|         .    ||  .... ||      | |.          .
EMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKf_n-2.AA Dicty4-Unclassified 772-968 33 1.5e-31 105.34 In-house 1-204 (263) Show / Hide 
Range on Protein: 772-968
Range on HMM: 1-204/263
Sequence Identity: 33% (70 aa)

FSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSIGRFQGV----QQFDTEIRTLGRIQHSNLVKLIGYHASE----GEMFLIYNYFPRGNLESFIH---NR
  .|  || | |   .|     |  |||| .  ..|.      | |  |.  || ||| ||||. ||          |  .    ..|||   ||     
IQIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

SRGEISWAV--VHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHATTDVAGTFGYVAPEYAMTCRVSDKADVYSY
    |.     . ..|. ||  ...||      . ||||| ||||.| .  .  ||||..|    . .   | .|||    .||  |      |.|||||
QQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELLSG
...| ||. |
AMMLYELATG
Kinase IRAKf_n-2.AA Dicty4 772-966 31 1.1e-30 99.67 In-house 1-211 (277) Show / Hide 
Range on Protein: 772-966
Range on HMM: 1-211/277
Sequence Identity: 31% (67 aa)

FSVDYLIGNGGFGATYKAEMMPGLVVAVKRL---SIG-RFQGVQQFDTEIRTLGRIQHSNLVKLIGYHA----SEGEMFLIYNYFPRGNLESFIHN----
  .. .|| |.||  ||.    |  |||| |    .. .    . |  |.  .. |.| |.... |.        |.|     | |.|||.| .|.    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RSRGEISWAVVHR---IAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT--TDVAGTFGYVAPEYAMTCRVSDKA
  .. ...|  . |   .|  .|  ...|| .| |...|||.|..|.| | |...  .||||...    |.| .  . ..|| ...|||  |  .   ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGVVLLELL
||||.| || |.|
DVYSFGIVLWEIL
Kinase IRAKf_n-2.AA RIPK 778-971 25 4.7e-29 96.14 In-house 1-227 (290) Show / Hide 
Range on Protein: 778-971
Range on HMM: 1-227/290
Sequence Identity: 25% (59 aa)

IGNGGFGATYKAEMMPGLVVAVKRLSIGRF-------QGVQQFDTEIRTLGRIQHSNLVKLIGYHASE-----GE-MFLIYNYFPRGNLESFIHNRSR--
.| ||||  .||      ....|  . .         | ...   |   . ...... |.. |    |     .. . .   | . |.|. | | ...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-GEISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHA----------TTDVA--GTFGYVAPEYAM---T
   . | .  |.   |...  |||.  .| ..||| ||.|||.|||. . .||||||  .. |. |           ..     ||  | .||       
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

CR---VSDKADVYSYGVVLLELLSGKKA
 .   |. | ||||...|. |.|..|..
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAKf_n-2.AA TK 772-967 14 3.4e-28 90.99 In-house 1-389 (486) Show / Hide 
Range on Protein: 772-967
Range on HMM: 1-389/486
Sequence Identity: 14% (55 aa)

FSVDYLIGNGGFG---ATYKAEMMPGL--------------------------VVAVKRLSIG-RFQGVQQFD----------------TEIRTLG--RI
  .   .| | ||     ||.|. ..                            |||| |  |   .  ..||                 |.  .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHSNLVKLIG-------------YHASEGEMFLIYNYFPRGN----LESFIHNRSRG-------------------------------------------
.| |.|.|.|             .   .. . ..  | | |.    | .. ......                                           
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-----------EISWAVVHR-------------------IAMGIAEALAYLHDE----CQPRVLHRDIKPSNILLDNNLT-----------AFLADFG--
           ... .  ..                   ... ||....|||.       ... |||.   |.|...|..           . .||||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLLGASETHATTDVAGTFG-------------------------YVAPEYAM---------TCRVSDKADVYSYGVVLLELLS
      ||| .. ..   ...  || .                         . |||  .         . . . | ||.|.||.. |...
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKf_n-2.AA STE 772-969 23 4.6e-28 96.23 In-house 1-265 (359) Show / Hide 
Range on Protein: 772-969
Range on HMM: 1-265/359
Sequence Identity: 23% (64 aa)

FSVDYLIGNGGFGATYKAEMM----------------PGLVVAVKRLSIGRFQG-----------------VQQFDTEIRTLGRIQ--HSNLVKLIGYHA
.     ||.|.|| .|||  .                 | ..|.|.... . .                  .||.  ||... . .  | | || .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SEG-------EMFLIYNYFPRGNLESFIH-NRSRGE-----------ISWAVVHRIAMGIAEA-LAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFG
 ||       | ...  | . | |...|. . ..|.           ..  .. .|.  | .. |.|||.     . ||||||.||||     . |.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLLGAS-------------ETHA--TTDVAGTFGYVAPEYAM--TCR----VSDKADVYSYGVVLLELLSGK
..  |  |             || .  .. ..||  . |||  .  ..      . |.|..| | ...|.. ||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKf_n-2.AA Pkinase_Tyr 772-967 23 1.1e-22 77.42 Pfam 1-209 (270) Show / Hide 
Range on Protein: 772-967
Range on HMM: 1-209/270
Sequence Identity: 23% (49 aa)

FSVDYLIGNGGFGATYKAEMM-----PGLVVAVKRLSIGRFQG---VQQFDTEIRTLGRI-QHSNLVKLIGYHA-SEGE--MFLIYNYFPRGNLESFIHN
 . .  .| | ||  ||...      ... |||| |  |  .     . |  |....  . .| |.|.|.|     ..   ....  | | |.| .. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--SRGEISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLL-GASET-HATTDVAGTFGYVAPEYAMTCRVSDKADV
.  ... ..      ... ||....||..       |||.   |.|...|...  .||||||..   ..  .....        |||  .... . | ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSYGVVLLELLS
.|.||.. |...
WSFGVLMWEIFT
Kinase IRAKf_n-2.AA TyrKc 772-1043 19 1.5e-17 61.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 772-1043
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSIGRFQGVQQFDTEIRTLGRI--QHSNLVKLIGYHASE-------GEMFLIYNYFPRGNLESFIHNRSR
 . .  .|.| ||  ||...   . |||| |  .    .. |  |.| . ..  .| |.|.|.|.  ..       . ....  | | |.| ...... .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GEISWAVVHRIAMGIAEALAYLHDECQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGAS--------ETHATT--DVA--GTFGYVAPEYAMTCRVS
  ....  . ..  ||.  .|||.    .. |||.   |.|...|.|.  .||||.| ..            ....  .          |||  .... .
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

DKADVYSYGVVLLELLSGKKALDPAFSDYGH-GFTIVGWACLLIGQGRAHEVFIVELWEMGPEA--------FLLETLKLAVMCTVDSLTVRPTMRQVVD
 | ||.|.||.. |...         . |    .         .   ...|        . |.            |  ..  .|       |||......
TKSDVWSFGVCMWEIFTY------GQQPYPGMIQQ-------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

RL
..
CF
Kinase IRAKf_n-2.AA IRAK 1000-1043 25 0.004449 6.95 In-house 274-317 (317) Show / Hide 
Range on Protein: 1000-1043
Range on HMM: 274-317/317
Sequence Identity: 25% (11 aa)

EVFIVELWEMGPEAFLLETLKLAVMCTVDSLTVRPTMRQVVDRL
| || .. .. |... .| . .|. |.   .  |..|..|. .|
EKFIDHRMPPCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKf_n-2.AA TK 1033-1043 45 0.01518 3.49 In-house 476-486 (486) Show / Hide 
Range on Protein: 1033-1043
Range on HMM: 476-486/486
Sequence Identity: 45% (5 aa)

RPTMRQVVDRL
|||..|....|
RPTFSQLHEQL
Kinase IRAKf_n-2.AA Dicty4-Unclassified 1020-1043 37 0.030076 3.46 In-house 240-263 (263) Show / Hide 
Range on Protein: 1020-1043
Range on HMM: 240-263/263
Sequence Identity: 37% (9 aa)

KLAVMCTVDSLTVRPTMRQVVDRL
|| . |  ..   |||| |....|
KLIKWCWHNDPNKRPTMNQIIQYL
Kinase IRAKf_n-2.AA Dicty4 1031-1045 29 0.077937 2.1 In-house 261-277 (277) Show / Hide 
Range on Protein: 1031-1045
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

TVRPTMRQVVDR--LRH
..||.. ... |  | |
QHRPSFEEIIQRRILEH
Kinase IRAKf_n-2.AA LRRK 1033-1045 46 0.092356 1.99 In-house 339-351 (351) Show / Hide 
Range on Protein: 1033-1045
Range on HMM: 339-351/351
Sequence Identity: 46% (6 aa)

RPTMRQVVDRLRH
||.. |.|.||  
RPHFSQIVKRLSQ
Kinase IRAKf_n-2.AA MLK 1033-1043 54 0.114364 1.72 In-house 281-291 (291) Show / Hide 
Range on Protein: 1033-1043
Range on HMM: 281-291/291
Sequence Identity: 54% (6 aa)

RPTMRQVVDRL
||..||.|  |
RPSFRQIVQHL
Kinase IRAKf_n-2.AA Pkinase_Tyr 1033-1043 36 1.774694 2.24 Pfam 260-270 (270) Show / Hide 
Range on Protein: 1033-1043
Range on HMM: 260-270/270
Sequence Identity: 36% (4 aa)

RPTMRQVVDRL
|||..... .|
RPTFSEIHEQL