Gene IRAKg_d-1 (S.moellendorffii)

IRAKg_d-1

Species: S.moellendorffii
Alias: IRAKg_d-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_d-1.AA Protein None 806 None Fasta, JSON
IRAKg_d-1.NA RNA None 2421 None Fasta, JSON
IRAKg_d-1.kin_dom Protein Kinase Domain None 273 None Fasta, JSON

Protein domain

Protein domains of IRAKg_d-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_d-1.AA B_lectin 77-184 29 5e-21 73.84 Pfam 1-137 (137) Show / Hide 
Range on Protein: 77-184
Range on HMM: 1-137/137
Sequence Identity: 29% (41 aa)

PNTVVWSAMSNDTGGFPI-GLI--KGDQLVFQT-DGRLVLTSNAAG--I--IWGT--STSTLA---VTKALLQENGNLQLLT-SN--GVPVWQS--FERP
. ||||.|  .  .| |. .     . .|..|. || |||. ...|  .  .| |  .||. .    . | .|..||| |.. .|  . ..|||  |. |
NQTVVWVANRDL-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TDTLLPYQQL-------IGNTR---LVSSNRKY--DLR
|||.|| . |       |. ..   |.|.      | .
TDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKg_d-1.AA B_lectin 36-158 24 4.5e-13 50.68 SMART 1-126 (126) Show / Hide 
Range on Protein: 36-158
Range on HMM: 1-126/126
Sequence Identity: 24% (34 aa)

IVRGEDPQTWITSPNATFS--AGFGHLNPTSPLYSFSIWYTKM---PNTVVWSAMSNDTGGFPIGLIKG----DQLVFQTDGRLVLTSNAAGIIWGTSTS
     . || . |.| .|.  .||  ...       .||| ..   . ||||.|    ..    .. ..      |..|.|| ||.      ..| ..|.
DNTLSSGQT-LVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQP-NRD----NPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTT

-TLAVTKALLQENGNLQLLTSN----GVPVWQSFERP
 .  .. | ||..||. .  ..    |  .||||. |
RNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_d-1.AA S_locus_glycop 263-325 31 2.8e-13 47.76 Pfam 55-117 (117) Show / Hide 
Range on Protein: 263-325
Range on HMM: 55-117/117
Sequence Identity: 31% (20 aa)

RLTLDDDGNLRIYTLDEIKNRWLITWQAVLLECDIFGKCGRFGICTYRPTATCICPPGFHPTN
|.|.. .| | ..|  .  ..|   | |   .||. . ||..|.|    . .| | .||.| |
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
EGF IRAKg_d-1.AA EGF 294-334 25 0.000329 21.23 SMART 1-32 (32) Show / Hide 
Range on Protein: 294-334
Range on HMM: 1-32/32
Sequence Identity: 25% (12 aa)

ECDIFGKCGRF-----GICTYRPTATCICP-PGFHPTNASDPSQDCV
||.    |.       |.|.   . || || ||..          |.
ECA---PCHHGGCEQHGTCI---SYTC-CPGPGYTG--------RCE
B_lectin IRAKg_d-1.AA B_lectin 263-275 50 9.933461 0.64 Pfam 27-40 (137) Show / Hide 
Range on Protein: 263-275
Range on HMM: 27-40/137
Sequence Identity: 50% (7 aa)

RLTLDD-DGNLRIY
.||... |||| .|
TLTMQNRDGNLVLY
PAN_AP IRAKg_d-1.AA PAN_AP 351-433 15 0.000613 17.15 SMART 1-85 (85) Show / Hide 
Range on Protein: 351-433
Range on HMM: 1-85/85
Sequence Identity: 15% (15 aa)

PRNFKMIQLVRTDFQYNDYNSHP-----LPNPSSQEDCIQRCLRECECLGAAFQMGGAGICWLKGLDPSGLFNGKQ------SVDVDNVFFLKV
.. . .. . ..       .|.           | |.| |.||..|.| ....     . | |   . | |.. .|        ..  ... |.
CCDDCFVRMPNMKL-----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWS-WDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_d-1.AA TKL 506-775 20 6.5e-67 228.61 In-house 1-364 (364) Show / Hide 
Range on Protein: 506-775
Range on HMM: 1-364/364
Sequence Identity: 20% (82 aa)

LGSGGFGTVYKGRLPN---------GTLVAVKELEM----------------------------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNR-
.||||||.||||.. .         |. |||| . .                            |... ...  |.. . ...| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYMPNSS-LEKLLFLNDTEHFCGWASRFNIALGIARGITYLHDEC-----QECILHCDIKPQNILLDESFI------------
              .|.||.|. | |. |.          |  |...||.||||. ||| .         |.|.|.|..|||.|| .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKVADFGLAKLMKRERALSVTT------------------VRGTRGYLAPEWISDL----------------PITTKADVYSFGMVLLEIISGREKYL
  .|..||||.. |...   . |                   ..|| ...||| . .                 . ..|.||||||.|| ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

MTISAINSENNRWCLSDWAYNMYQAGDLESIVDK-------KLVREEVDLVQFK-----------------RLLKVALWCIQHDANARPSMGKVVQMM
                      |.  . ....         ..| ..      .                 .. | . .| .||...|||. .... .
---------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_d-1.AA IRAK 498-697 40 1.6e-57 197.4 In-house 1-221 (317) Show / Hide 
Range on Protein: 498-697
Range on HMM: 1-221/317
Sequence Identity: 40% (91 aa)

FTDNFYDRLGSGGFGTVYKGRLPNGT-LVAVKEL-EMAM----QADKQFQA---EVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNSSLEKLLFLND
|  ..  |.|.||||.||.|.. | |  .||| | |||.    . ...||.   |.|.. ...| |.| |.|||.|     |||.|||| |||  |   |
FHKDN--RIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

TEHF---CGWASRFNIALGIARGITYLHDEC-QECILHCDIKPQNILLDESFIPKVADFGLAKLM----KRERALS----VTTVRGTRGYLAPEWIS--D
.        |  |. |..|.|.|| .||.      | | |||. |||||. | || .||||.        .|.. .    . .||||  |..|| |    
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

LPITTKADVYSFGMVLLEIISGR
  .|.| |||||| ||||...|.
GQLTKKTDVYSFGIVLLEVLTGC
Kinase IRAKg_d-1.AA Pkinase 501-697 28 7.5e-45 159.67 Pfam 2-209 (293) Show / Hide 
Range on Protein: 501-697
Range on HMM: 2-209/293
Sequence Identity: 28% (61 aa)

NFYDRLGSGGFGTVYKGRLPNG-TLVAVKELEMAMQADKQFQA-----EVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNS----SLEKLLF--LND
 .  ..|||.||.|||..  .   .||||...   . ... |.     |.. . ...| | |||.........  .| ||...     .|  ..    . 
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHG

TEHFCGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFIP----KVADFGLAKLMKRERALSVTTVRGTRGYLAPEWIS-DLPITTKADV
.     .    .... |.||. |.|..    |.|.|.||.|||.|.   .    |..||||||...  .    ||. ||..|.|||.|  . ....|.|.
CFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGMVLLEIISGR
.|.| .| | ..||
WSCGCILYEMLCGR
Kinase IRAKg_d-1.AA TKL-Unique 502-696 30 3.9e-43 149.62 In-house 1-224 (290) Show / Hide 
Range on Protein: 502-696
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FYDRLGSGGFGTVYKGRLPNGTLVAVKELEM-AMQADK--Q-FQAEVKTLGKIH-HINLVRLLGYCY----EDNRKLLVYEYMPNSSLEKLLF----LN-
|   .|.||.|.||||   .|. ||.| ..  . .  .  | |  ||... |.| |.|.|.. |||       ..  .| ||.| .|| ..|     .| 
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DTEHFCGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES-----FIPKVADFGLAKLMKRERALSVT--------TVRGTRGYLAPEWI
    ..   .. | ..|. ||.|  ||| .    |.|.|.|..|.|.|.      .  |..||||.|. ... . ...        |. |.  ..||| .
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

SD--LPITTKADVYSFGMVLLEIISG
..    ...|.||||||.|| ||...
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_d-1.AA Dicty4 501-693 36 3.1e-42 138.75 In-house 2-210 (277) Show / Hide 
Range on Protein: 501-693
Range on HMM: 2-210/277
Sequence Identity: 36% (77 aa)

NFYDRLGSGGFGTVYKGRLPNGTLVAVKELEMAMQAD-----KQFQAEVKTLGKIHHINLVRLLGYCY----EDNRKLLVYEYMPNSSLEKLLFLND---
|. .|.|.|.||.||||.   |. |||| |    | .     . | .||. ..|| | |.. ..|.|     .  . . | ||||  .|..|  |.|   
NIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSL--LHDKPS

---TEHFCGWASRFN---IALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERALSV--TTVRGTRGYLAPEWISDLPITTK
    .    |  .     .|. .|||...|| .|   |.| |.|. |.| |...  ||.||||...||..  ..   .|. || .. |||     | . |
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

ADVYSFGMVLLEI
|||||||.|| ||
ADVYSFGIVLWEI
Kinase IRAKg_d-1.AA MLK 501-698 27 4.4e-38 129.72 In-house 2-234 (291) Show / Hide 
Range on Protein: 501-698
Range on HMM: 2-234/291
Sequence Identity: 27% (64 aa)

NFYDRLGSGGFGTVYKGRLPNGT----LVAVKELEM---AMQA----DKQFQAEVKTLGKIHHIN----LVRLLGYCYED-NRKLLVYEYMPNSSLEKLL
.|   .|||.|| |.|||  | .     ||||. .    ...     ...|. |.. | .. | |     ....| | .. .  ..| ||....||  .|
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

FLNDTEHF-----------CGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDE------SFIPKVADFGLAKLMKRERALSVTTVRGTRGYL
  .... .              .. .|.|| .|||. ||| . .  | | |.|..|||.||        . |..|||... ...      .  .||  . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEWI---SDLPITTKADVYSFGMVLLEIISGRE
||| |      . . |.||.|.|.|| |......
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase IRAKg_d-1.AA S_TKc 500-779 23 3.4e-37 130.81 SMART 1-231 (231) Show / Hide 
Range on Protein: 500-779
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

DNFYDRLGSGGFGTVYKGRLPN-GTLVAVKELEMAMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPN--SSLEKLLFLNDTEH----F
  . . .|.|.||.|||.|  . | .||.|..       .... |.. | | || |.|.|...... ..  .| ||...   .| ...  . ..     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERALSVTTVRGTRGYLAPEWISDLPITT-KADVYSFGMVLL
     || ..  |.... |.|   .  |.|.|.||.||||||    |..|||||...        ||. ||. |.||| .   . .. |.|..|.| .| 
PE-HARF-YMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIISGREKYLMTISAINSENNRWCLSDWAYNMYQAGDLESIVDKKLVREEVDLVQFKRLLKVALWCIQHDANARPSMGKVVQ-----MMEDTV
| ..|.  .                           ... . .| .          . ..     | | | . ||.  .. |     ..   .
EMLCGYPPFP--------------------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_d-1.AA LISK 505-698 28 1.2e-36 116.43 In-house 1-237 (296) Show / Hide 
Range on Protein: 505-698
Range on HMM: 1-237/296
Sequence Identity: 28% (69 aa)

RLGSGGFGTVYKGRLP-NGTLVAVKELEM------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYE-DNRKLLVYEYMPNSSLEKLLFLNDT-EHFCGW
 .|.|.|| ||||..   |. .|.|...          . | .. ||... .. | | |.  | ||. | .  .| ||.    |. .|. .|       |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES----FIPKVADFGLAKLMKRER---------------------------------ALSVT
  | .|||.||.| .|||.    .|.| | | .|.|..|.    .  ||.|||.|..|  |.                                 . .  
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TVRGTRGYLAPEWISDLPITTKADVYSFGMVLLEIISGRE
|. ||    ||| . .   ....||.|||.||.||| ...
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKg_d-1.AA STE 503-697 21 2e-34 118.97 In-house 1-265 (359) Show / Hide 
Range on Protein: 503-697
Range on HMM: 1-265/359
Sequence Identity: 21% (61 aa)

YDR---LGSGGFGTVYKGRLPN----------------GTLVAVKELEMAM------------------QADKQFQAEVKTLGKIH--HINLVRLLGYCY
...   .|.|.||||||..  .                |...|.|....                    .  .|.. |.|.. | .  | | |. .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------NRKLLVYEYMPNSSLEKLLF------LNDT----------EHFCGWASRFNIALGIARG-ITYLHDECQECILHCDIKPQNILLDESFIPK
 .       .   .. |||.. ||....        ...          |.  ..     |.  | .|   |||.     | | ||||.||||      |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY-----ICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VK

VADFGLAKLMKRERA--------------LSVT-TVRGTRGYLAPEWIS------DLPITTKADVYSFGMVLLEIISGR
 .|||... .  . |               . . |. ||  . ||| |.      | . .||.|..|.| ...| . |.
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_d-1.AA TK 500-700 18 1.2e-33 109.58 In-house 1-395 (486) Show / Hide 
Range on Protein: 500-700
Range on HMM: 1-395/486
Sequence Identity: 18% (72 aa)

DNFYDRLGSGGFG---TVYKGRLPNG--------------------------TLVAVKELE--MAMQADKQFQ----------------AEVKTLG--KI
  . . ||.| ||   .||||.. ..                          | |||| |    ||... .|.                .| | .   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHINLVRLLGYCYEDNRK------------LLVYEYMPNSS----LEKLLFLNDTEHFCGWASRFN----------------------------------
|| |.|||.|.| ..  |            ..| ||||. .    | . |  .. . ..   .  |                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IALGIARGITYLHDE----CQECILHCDIKPQNILLDESFI-----------PKVADFGLAK
                                      ... ||.|  |||.         . | |.   |.|..|. .            |.|||||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LMKRERALSVTTVRGTRG----------------------------YLAPEWIS---------DLPITTKADVYSFGMVLLEIIS-GREKY
     | ..    .  ......|                            ..||| .          .   ||| ||.||| .. || . |.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPY
Kinase IRAKg_d-1.AA Pkinase_Tyr 501-695 31 1.5e-32 110.9 Pfam 2-209 (270) Show / Hide 
Range on Protein: 501-695
Range on HMM: 2-209/270
Sequence Identity: 31% (69 aa)

NFYDRLGSGGFGTVYKGRLP-----NGTLVAVKEL-EMAMQAD---KQFQAEVKTLGKI-HHINLVRLLGYCYEDNRK---LLVYEYMPNSSLEKLLFLN
 |   ||.| ||.||||..      ... |||| | | ||. .   . | .|.|.. .. || |.|||.| |... .    ..| ||||. .| . |  .
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

--DTEHFCGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLM-----K-RERALSVTTVRGTRGYLAPEWISDLPITT
  | ....      .... ||.|  ||..     . | |.   |.|..|... |..|||||...       | |  .   .. .    ||| |..   ||
REDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTT

KADVYSFGMVLLEIIS
| ||.||| .. ||..
KSDVWSFGVLMWEIFT
Kinase IRAKg_d-1.AA LRRK 490-697 22 6.9e-30 102.91 In-house 1-279 (351) Show / Hide 
Range on Protein: 490-697
Range on HMM: 1-279/351
Sequence Identity: 22% (67 aa)

FTYQQLQNFTDNFYDRLGSGGFG-TVYKGRLPN---------------------------GTLVAVKELEM-----------------------------
. ....          .|.|||| .||.... .                           .. ||.| ...                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNSSLEKLLFLND-TE-HFCG----WASRFNIALGIARGITYLHDECQE-C
      .. |   |. ||  . . .| |.| |.|.| .  .  .| ||.|. .| ..|. .  .. ||      |  .  ||| ||.|. |||.  .   
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPP

ILHCDIKPQNILL---D---------ESFIPKVADFGLAKLMKRERALS--VTTVRGTRGYLAPEWISD---LPITTKADVYSFGMVLLEIISGR
|.|.| |. ||||   .         .  . |.||||.   |     ..  . .. |. |..||| . .      |.|.|.|||||.| |.....
IIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_d-1.AA TyrKc 500-775 23 5.6e-23 83.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 500-775
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

DNFYDRLGSGGFGTVYKGRLPNGTLVAVKELEMAMQADKQFQAEVKTLGKI--HHINLVRLLGYCYED-------NRKLLVYEYMPNSSLEKLLFLNDTE
  . . ||.| ||.||||..   . |||| |       . |  | . . |.  || |.|||.|.| ..          ..| ||||. .| . |  .  .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

HFCGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRE----RALSVTTVR---GTRG-----YLAPEWISDLPIT
    ..   .... ||.|  |||.    .. | |.   |.|..| .. |..||||..  . .     . .. ...   |...      .||| | .   |
--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

TKADVYSFGMVLLEIIS-GREKYL------MTISAINSENNRWCLSDWAYNMYQAGDLESIVDKKLVREEVDLV----QFKRLLKVALWCIQHDANARPS
|| ||.||| .. || . | . |       |. . .             ..  ..|.   . .  .       .      . . .. ..| ..|.. ||.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-------------IEYVKQGYRMPQPPNDY-----P-MSFVCCPDEMYQIMKQCWHEDPEDRPT

MGKVVQMM
.  ... .
FSEIHECF
Kinase IRAKg_d-1.AA ULK 620-697 31 1.2e-19 66.44 In-house 147-249 (324) Show / Hide 
Range on Protein: 620-697
Range on HMM: 147-249/324
Sequence Identity: 31% (32 aa)

ILHCDIKPQNILLDESF------------IPKVADFGLAKLMK---RERALSVTTV-----RGTRGYLAPEWISDL----PIT-TKADVYSFGMVLLEII
| |.||||||||. . .            . |.||||.||       |  .  |.|     .||  | ||. ....    | .  |.|..|.|... |..
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SGR
 |.
YGK
Kinase IRAKg_d-1.AA ULK 501-584 23 3.5e-15 50.35 In-house 2-108 (324) Show / Hide 
Range on Protein: 501-584
Range on HMM: 2-108/324
Sequence Identity: 23% (25 aa)

NFYDRLGSGGFG-TVYKGR-LPN---GTLVAVKELE---MAMQADK--------QFQAEVKTLGKIH---HIN--LVRLLGYCYED--NRKLLVYEYMPN
.  ..||.| || .|||||   .   . .||.|  .   | ..  .        ... |.... |..   | |   |.|. .....  |   ...|| . 
CLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNG

SSLEKLL
  ||...
GDLEQYI
Kinase IRAKg_d-1.AA LRRK 745-777 21 0.000494 10.14 In-house 319-351 (351) Show / Hide 
Range on Protein: 745-777
Range on HMM: 319-351/351
Sequence Identity: 21% (7 aa)

VQFKRLLKVALWCIQHDANARPSMGKVVQMMED
... ....   .| ||| . ||.. ..|. ...
QPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_d-1.AA TK 753-775 17 0.00378 5.55 In-house 464-486 (486) Show / Hide 
Range on Protein: 753-775
Range on HMM: 464-486/486
Sequence Identity: 17% (4 aa)

VALWCIQHDANARPSMGKVVQMM
. . | ..|.. ||..  .....
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_d-1.AA IRAK 748-775 35 0.02597 4.2 In-house 290-317 (317) Show / Hide 
Range on Protein: 748-775
Range on HMM: 290-317/317
Sequence Identity: 35% (10 aa)

KRLLKVALWCIQHDANARPSMGKVVQMM
| .. .|. |  | || |..| .|.| .
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKg_d-1.AA LISK 750-775 30 0.026662 3.05 In-house 271-296 (296) Show / Hide 
Range on Protein: 750-775
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

LLKVALWCIQHDANARPSMGKVVQMM
.|.....|.  | . |||  ..||  
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKg_d-1.AA Dicty4 756-777 37 0.04906 2.78 In-house 254-277 (277) Show / Hide 
Range on Protein: 756-777
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQHDANARPSMGKVVQM--MED
||  || . |||.  ..|   .| 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_d-1.AA Pkinase_Tyr 755-775 19 0.969059 3.13 Pfam 250-270 (270) Show / Hide 
Range on Protein: 755-775
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQHDANARPSMGKVVQMM
. | ..|.. ||..  .....
KQCWHYDPEDRPTFSEIHEQL