Gene IRAKg_b (S.moellendorffii)

IRAKg_b

Species: S.moellendorffii
Alias: IRAKg_b
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_b.AA Protein None 830 None Fasta, JSON
IRAKg_b.NA RNA None 2493 None Fasta, JSON
IRAKg_b.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of IRAKg_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_b.AA B_lectin 77-184 29 3.2e-18 64.17 Pfam 1-137 (137) Show / Hide 
Range on Protein: 77-184
Range on HMM: 1-137/137
Sequence Identity: 29% (41 aa)

PNTVVWSAMSNDTGGFPI-GLI--KGDQLVFQT-DGRLVLTSNAAG--I--IWGT--STSTLG---VTKALLQENANLQLLT-SN--GVPVWQS--FDRP
. ||||.|  .  .| |. .     . .|..|. || |||. ...|  .  .| |  .||. |    . | .|.. || |.. .|  . ..|||  || |
NQTVVWVANRDL-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TDTILPDQQLIG------NAQ----LVSNNRKY--DLQ
|||.|| . |        ..     |.|       |  
TDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKg_b.AA B_lectin 36-158 25 1.4e-14 55.64 SMART 1-126 (126) Show / Hide 
Range on Protein: 36-158
Range on HMM: 1-126/126
Sequence Identity: 25% (35 aa)

NVRGEDPQTWITSPNATFS--TGFSHLNPKSPLYSFSIWYTKM---PNTVVWSAMSNDTGGFPIGLIKG----DQLVFQTDGRLVLTSNAAGIIWGTSTS
.    . || . |.| .|.   ||  ...       .||| ..   . ||||.|    ..    .. ..      |..|.|| ||.      ..| ..|.
DNTLSSGQT-LVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQP-NRD----NPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTT

-TLGVTKALLQENANLQLLTSN----GVPVWQSFDRP
 . |.. | ||.. |. .  ..    |  .||||| |
RNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_b.AA S_locus_glycop 263-325 31 3.9e-14 50.75 Pfam 55-117 (117) Show / Hide 
Range on Protein: 263-325
Range on HMM: 55-117/117
Sequence Identity: 31% (20 aa)

RLTLDDDGNLRIYTLDEIKKRWIITWQAVLLECDIFGKCGRFGICAYRPTATCICPPGFHPTN
|.|.. .| | ..|  .  ..|.  | |   .||. . ||..|.|    . .| | .||.| |
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
B_lectin IRAKg_b.AA B_lectin 263-275 50 9.933461 0.64 Pfam 27-40 (137) Show / Hide 
Range on Protein: 263-275
Range on HMM: 27-40/137
Sequence Identity: 50% (7 aa)

RLTLDD-DGNLRIY
.||... |||| .|
TLTMQNRDGNLVLY
PAN_AP IRAKg_b.AA PAN_AP 351-433 15 0.000602 17.23 SMART 1-85 (85) Show / Hide 
Range on Protein: 351-433
Range on HMM: 1-85/85
Sequence Identity: 15% (15 aa)

PRNFKMIQLVRTDFQYNDYNSHP-----LPSPSSQEDCIQRCLRECECLGAAFQMGGAGICWLKGLDPSGLFNGKQ------SVDVDNVFFLKV
.. . .. . ..       .|.           | |.| |.||..|.| ....     . | |   . | |.. .|        ..  ... |.
CCDDCFVRMPNMKL-----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWS-WDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_b.AA TKL 536-799 21 4.4e-70 239.14 In-house 1-364 (364) Show / Hide 
Range on Protein: 536-799
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGSGGFGTVYKGRLPN---------GTLVAVKELEM----------------------------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNR-
.||||||.||||.. .         |. |||| . .                            |... ...  |.. . ...| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYMPNGS-LDKLLFLDSWASRFNIALGIARGITYLHDEC-----QECILHCDIKPQNILLDESFC--------------PKVA
              .|.||.|.|| |. |.    |  |...||.||||. ||| .         |.|.|.|..|||.|| .               .|..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DFGLAKLMKRERALSVTT------------------VRGTRGYLAPEWISNL----------------PITTKVDVYSFGMVLLEIISGREKYLMTISAI
||||.. |...   . |                   ..|| ...||| . .                 . ..|.||||||.|| ||.....         
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---------

NSENNRWCLSDWAYNMYQAGDLESIVDK-------KLVQEEV-----------------NVVQFKRLLKVALWCIQHDANARPSMGKVVQMM
                |.  . ....         ..| ..                  .    ... | . .| .||...|||. .... .
---------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_b.AA IRAK 528-799 34 1.1e-61 211.29 In-house 1-317 (317) Show / Hide 
Range on Protein: 528-799
Range on HMM: 1-317/317
Sequence Identity: 34% (111 aa)

FTDNFCDKLGSGGFGTVYKGRLPNGT-LVAVKEL-EMAM----QADKQFQA---EVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNGSL-DKLLFLD
|  ..  ..|.||||.||.|.. | |  .||| | |||.    . ...||.   |.|.. ...| |.| |.|||.|     |||.||||||| | |  .|
FHKDN--RIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

--------SWASRFNIALGIARGITYLHDEC-QECILHCDIKPQNILLDESFCPKVADFGLAKLM----KRERALS----VTTVRGTRGYLAPEWIS--N
        ||  |. |..|.|.|| .||.      | | |||. |||||. | || .||||.        .|.. .    . .||||  |..|| |    
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

LPITTKVDVYSFGMVLLEIISGR---------EKYLMTISAINSENNRW---CLS---------DWAYNMYQAGDLESIVDKKLVQEEVNVVQFKRLLKV
  .|.|.|||||| ||||...|.          .||...   . |  .    |.|          ||    .. . |  .|..   . .. .  | .. .
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWA-APRRMQIYEKFIDHRM--PPCPPNMEKEMCQC

ALWCIQHDANARPSMGKVVQMM
|. |  | || |..| .|.| .
ACCCGHHRANRRCDMAWVMQQL
Kinase IRAKg_b.AA Pkinase 535-721 31 5e-47 167.35 Pfam 6-209 (293) Show / Hide 
Range on Protein: 535-721
Range on HMM: 6-209/293
Sequence Identity: 31% (65 aa)

KLGSGGFGTVYKGRLPNG-TLVAVKELEMAMQADKQFQA-----EVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNG----SLDKLLF-------LD
|.|||.||.|||..  .   .||||...   . ... |.     |.. . ...| | |||.........  .| ||...|    .|  ..        . 
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCP----KVADFGLAKLMKRERALSVTTVRGTRGYLAPEWIS-NLPITTKVDVYSFGM
|.    .... |.||. |.|..    |.|.|.||.|||.|.   .    |..||||||...  .    ||. ||..|.|||.|  . ....|||..|.| 
SEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLEIISGR
.| | ..||
ILYEMLCGR
Kinase IRAKg_b.AA TKL-Unique 532-720 31 1.4e-45 157.78 In-house 1-224 (290) Show / Hide 
Range on Protein: 532-720
Range on HMM: 1-224/290
Sequence Identity: 31% (71 aa)

FCDKLGSGGFGTVYKGRLPNGTLVAVKELEM-AMQADK--Q-FQAEVKTLGKIH-HINLVRLLGYCY----EDNRKLLVYEYMPNGSLDKLLF-------
|  |.|.||.|.||||   .|. ||.| ..  . .  .  | |  ||... |.| |.|.|.. |||       ..  .| ||.| |||...|        
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

------LDSWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES-----FCPKVADFGLAKLMKRERALSVT--------TVRGTRGYLAPEWI
        ... | ..|. ||.|  ||| .    |.|.|.|..|.|.|.      .  |..||||.|. ... . ...        |. |.  ..||| .
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

SN--LPITTKVDVYSFGMVLLEIISG
..    ...|.||||||.|| ||...
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_b.AA Dicty4 531-717 35 1.1e-42 140.24 In-house 2-210 (277) Show / Hide 
Range on Protein: 531-717
Range on HMM: 2-210/277
Sequence Identity: 35% (76 aa)

NFCDKLGSGGFGTVYKGRLPNGTLVAVKELEMAMQAD-----KQFQAEVKTLGKIHHINLVRLLGYCY----EDNRKLLVYEYMPNGSLDKLLFLD----
|. ...|.|.||.||||.   |. |||| |    | .     . | .||. ..|| | |.. ..|.|     .  . . | |||| |.| .|| .|    
NIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL-HDKPSE

-------SWASRFN---IALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSV--TTVRGTRGYLAPEWISNLPITTKV
       .|  .     .|. .|||...|| .|   |.| |.|. |.| |...  ||.||||...||..  ..   .|. || .. |||   . | . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGMVLLEI
||||||.|| ||
DVYSFGIVLWEI
Kinase IRAKg_b.AA MLK 531-722 27 3.8e-40 137.0 In-house 2-234 (291) Show / Hide 
Range on Protein: 531-722
Range on HMM: 2-234/291
Sequence Identity: 27% (65 aa)

NFCDKLGSGGFGTVYKGRLPNGT----LVAVKELEM---AMQA----DKQFQAEVKTLGKIHHIN----LVRLLGYCYED-NRKLLVYEYMPNGSLDKLL
.|  ..|||.|| |.|||  | .     ||||. .    ...     ...|. |.. | .. | |     ....| | .. .  ..| ||...|||  .|
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

-----------------FLDSWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDE------SFCPKVADFGLAKLMKRERALSVTTVRGTRGYL
                 .  . .. .|.|| .|||. ||| . .  | | |.|..|||.||          |..|||... ...      .  .||  . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEWI---SNLPITTKVDVYSFGMVLLEIISGRE
||| |    . . . |.||.|.|.|| |......
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase IRAKg_b.AA S_TKc 530-803 23 8.9e-40 139.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 530-803
Range on HMM: 1-231/231
Sequence Identity: 23% (70 aa)

DNFCDKLGSGGFGTVYKGRLPN-GTLVAVKELEMAMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPN--GSLDKLLF----------L
  . .|.|.|.||.|||.|  . | .||.|..       .... |.. | | || |.|.|...... ..  .| ||...  |.| ...           .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DSWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGYLAPEWISNLPITT-KVDVYSFGMVLL
.    || ..  |.... |.|   .  |.|.|.||.||||||  . |..|||||...        ||. ||. |.||| .   . .. |.|..|.| .| 
PE-HARF-YMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIISGREKYLMTISAINSENNRWCLSDWAYNMYQAGDLESIVDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQ-----MMEDIV
| ..|.  .                           ... . .| .          . ..     | | | . ||.  .. |     ..   .
EMLCGYPPFP--------------------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_b.AA LISK 535-722 29 3.6e-39 124.77 In-house 1-237 (296) Show / Hide 
Range on Protein: 535-722
Range on HMM: 1-237/296
Sequence Identity: 29% (70 aa)

KLGSGGFGTVYKGRLP-NGTLVAVKELEM------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYE-DNRKLLVYEYMPNGSLDKLLF-LD------SW
..|.|.|| ||||..   |. .|.|...          . | .. ||... .. | | |.  | ||. | .  .| ||.  | |  .|.  |      .|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES----FCPKVADFGLAKLMKRER---------------------------------ALSVT
  | .|||.||.| .|||.    .|.| | | .|.|..|.    .  ||.|||.|..|  |.                                 . .  
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TVRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGRE
|. ||    ||| .     ....||.|||.||.||| ...
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKg_b.AA STE 530-721 22 1.5e-36 126.62 In-house 1-265 (359) Show / Hide 
Range on Protein: 530-721
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

DNFCDKLGSGGFGTVYKGRLPN----------------GTLVAVKELEMAM------------------QADKQFQAEVKTLGKIH--HINLVRLLGYCY
  . .|.|.|.||||||..  .                |...|.|....                    .  .|.. |.|.. | .  | | |. .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------NRKLLVYEYMPNGSLDKLLF-LDSWASRFN----------------IALGIARG-ITYLHDECQECILHCDIKPQNILLDESFCPKVADFG
 .       .   .. |||..||||...    .   ..|                |.  | .|   |||.     | | ||||.||||      | .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLMKRERA--------------LSVT-TVRGTRGYLAPEWISN------LPITTKVDVYSFGMVLLEIISGR
... .  . |               . . |. ||  . ||| |..       . .||.|..|.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_b.AA Pkinase_Tyr 531-719 32 5.2e-33 112.43 Pfam 2-209 (270) Show / Hide 
Range on Protein: 531-719
Range on HMM: 2-209/270
Sequence Identity: 32% (70 aa)

NFCDKLGSGGFGTVYKGRLP-----NGTLVAVKEL-EMAMQAD---KQFQAEVKTLGKI-HHINLVRLLGYCYEDNRK---LLVYEYMPNGSLDKLLFLD
 |  |||.| ||.||||..      ... |||| | | ||. .   . | .|.|.. .. || |.|||.| |... .    ..| ||||.|.|.. |   
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-------SWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLM-----K-RERALSVTTVRGTRGYLAPEWISNLPITTK
       .     .... ||.|  ||..     . | |.   |.|..|... |..|||||...       | |  .   .. .    ||| |..   |||
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTK

VDVYSFGMVLLEIIS
 ||.||| .. ||..
SDVWSFGVLMWEIFT
Kinase IRAKg_b.AA LRRK 520-721 23 9.2e-33 113.23 In-house 1-279 (351) Show / Hide 
Range on Protein: 520-721
Range on HMM: 1-279/351
Sequence Identity: 23% (69 aa)

FTYQQLQNFTDNFCDKLGSGGFG-TVYKGRLPN---------------------------GTLVAVKELEM-----------------------------
. ....          .|.|||| .||.... .                           .. ||.| ...                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------AMQADKQFQAEVKTLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNGSLDKLLF------L-----D-SWASRFNIALGIARGITYLHDECQE-C
      .. |   |. ||  . . .| |.| |.|.| .  .  .| ||.|.|.|...|.      .     . ||  .  ||| ||.|. |||.  .   
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPP

ILHCDIKPQNILL---D---------ESFCPKVADFGLAKLMKRERALS--VTTVRGTRGYLAPEWIS---NLPITTKVDVYSFGMVLLEIISGR
|.|.| |. ||||   .         .  | |.||||.   |     ..  . .. |. |..||| .    .   |.|||.|||||.| |.....
IIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_b.AA TyrKc 530-799 23 2.6e-28 101.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 530-799
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

DNFCDKLGSGGFGTVYKGRLPNGTLVAVKELEMAMQADKQFQAEVKTLGKI--HHINLVRLLGYCYED-------NRKLLVYEYMPNGSLDKLL-FLD--
  . .|||.| ||.||||..   . |||| |       . |  | . . |.  || |.|||.|.| ..          ..| ||||.|.|.. |      
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

-SWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE----RALSVTTVR---GTRG-----YLAPEWISNLPITTK
 ...   .... ||.|  |||.    .. | |.   |.|..| .. |..||||..  . .     . .. ...   |...      .||| |     |||
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDVYSFGMVLLEIIS-GREKYLM----------TISAINSENNRWCLSD----WAYNMYQAGDLESIVDKKLVQEEVNVVQFKRLLKVALWCIQHDANAR
 ||.||| .. || . | . |             |  . . . . .  .                             |   . . .. ..| ..|.. |
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQIMKQCWHEDPEDR

PSMGKVVQMM
|..  ... .
PTFSEIHECF
Kinase IRAKg_b.AA ULK 644-721 31 4.5e-20 66.84 In-house 151-253 (329) Show / Hide 
Range on Protein: 644-721
Range on HMM: 151-253/329
Sequence Identity: 31% (32 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAKLMK---RERALSVTTV-----RGTRGYLAPEWISNL----PIT-TKVDVYSFGMVLLEII
| |.||||||||... .            . |.||||.|| .     | .. .|.|     .||  | ||. ....    | .  |.|..|.|... |..
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SGR
 |.
YGK
Kinase IRAKg_b.AA ULK 644-721 31 1.8e-19 65.84 In-house 147-249 (324) Show / Hide 
Range on Protein: 644-721
Range on HMM: 147-249/324
Sequence Identity: 31% (32 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAKLMK---RERALSVTTV-----RGTRGYLAPEWISNL----PIT-TKVDVYSFGMVLLEII
| |.||||||||. . .            . |.||||.||       |  .  |.|     .||  | ||. ....    | .  |.|..|.|... |..
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SGR
 |.
YGK
Kinase IRAKg_b.AA ULK 534-614 24 1.5e-16 55.3 In-house 5-108 (324) Show / Hide 
Range on Protein: 534-614
Range on HMM: 5-108/324
Sequence Identity: 24% (25 aa)

DKLGSGGFG-TVYKGR-LPN---GTLVAVKELE---MAMQADK--------QFQAEVKTLGKIH---HIN--LVRLLGYCYED--NRKLLVYEYMPNGSL
..||.| || .|||||   .   . .||.|  .   | ..  .        ... |.... |..   | |   |.|. .....  |   ...|| . | |
HCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDL

DKLL
....
EQYI
Kinase IRAKg_b.AA ULK 534-614 24 4.4e-15 49.17 In-house 5-111 (329) Show / Hide 
Range on Protein: 534-614
Range on HMM: 5-111/329
Sequence Identity: 24% (26 aa)

DKLGSGGFGTVYKGR-LPN----GTLVAVKELE---MAMQADK--------QFQAEVKTLGKIH----HIN----LVRLLGYCYED--NRKLLVYEYMPN
..||.| ||.|||||   .    . .||.| ..   | .. .         ... |.|.. |..    |.|     |.|. .....  |   ...|| . 
HCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNG

GSLDKLL
| |....
GDLEQYI
Kinase IRAKg_b.AA LRRK 768-801 20 0.000432 10.35 In-house 318-351 (351) Show / Hide 
Range on Protein: 768-801
Range on HMM: 318-351/351
Sequence Identity: 20% (7 aa)

VVQFKRLLKVALWCIQHDANARPSMGKVVQMMED
.... ....   .| ||| . ||.. ..|. ...
CQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_b.AA LISK 774-799 30 0.026662 3.05 In-house 271-296 (296) Show / Hide 
Range on Protein: 774-799
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

LLKVALWCIQHDANARPSMGKVVQMM
.|.....|.  | . |||  ..||  
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKg_b.AA Dicty4 780-801 37 0.04906 2.78 In-house 254-277 (277) Show / Hide 
Range on Protein: 780-801
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQHDANARPSMGKVVQM--MED
||  || . |||.  ..|   .| 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_b.AA Pkinase_Tyr 779-799 19 0.969059 3.13 Pfam 250-270 (270) Show / Hide 
Range on Protein: 779-799
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQHDANARPSMGKVVQMM
. | ..|.. ||..  .....
KQCWHYDPEDRPTFSEIHEQL