Gene IRAKg_n-1 (S.moellendorffii)

IRAKg_n-1

Species: S.moellendorffii
Alias: IRAKg_n-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_n-1.AA Protein None 763 None Fasta, JSON
IRAKg_n-1.NA RNA None 2292 None Fasta, JSON
IRAKg_n-1.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of IRAKg_n-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_n-1.AA B_lectin 2-93 32 1.6e-18 65.26 Pfam 1-109 (137) Show / Hide 
Range on Protein: 2-93
Range on HMM: 1-109/137
Sequence Identity: 32% (36 aa)

PNTVIWSAMSNDTGGSPI-GLI--KGDQLAFQT-DGRLILTSNAAG--I--VWGT--STTTLS---VTKALLQENGNLELL-ASN--GVPAWQS--FDRP
. || |.|  .  .|.|. .     . .| .|. || |.|. ...|  .  || |  .|.. .    . | .|..||| |.  .|  . . |||  || |
NQTVVWVANRDL-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TDTILPDQQL
|||.|| . |
TDTWLPGMKL
B_lectin IRAKg_n-1.AA B_lectin 3-83 18 0.000984 -8.71 SMART 1-126 (126) Show / Hide 
Range on Protein: 3-83
Range on HMM: 1-126/126
Sequence Identity: 18% (24 aa)

NTVIWSAMSNDTGGS--------------------------------------PIGLIKG----DQLAFQTDGRLILTSNAAGIVWGTSTT-TLSVTKAL
. ...|  .  .|.|                                        .. ..      | .|.|| |..      .|| ..|| . ... | 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQWCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYVAV

LQENGNLELLASN----GVPAWQSFDRP
||..||. .  ..    |   ||||| |
LQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_n-1.AA S_locus_glycop 186-248 30 3.1e-12 44.18 Pfam 55-117 (117) Show / Hide 
Range on Protein: 186-248
Range on HMM: 55-117/117
Sequence Identity: 30% (19 aa)

RLTVDDDGNLRIYTLDEINKRWIITWQAVLLECNIFGKCGRFGICTYRPTATCTCPLGFHPTN
|.|.. .| | ..|  . ...|.  | |   .| . . ||..|.|    . .|.|  ||.| |
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
Kinase IRAKg_n-1.AA TKL 456-725 20 4e-69 235.94 In-house 1-364 (364) Show / Hide 
Range on Protein: 456-725
Range on HMM: 1-364/364
Sequence Identity: 20% (83 aa)

LGSGGFGTVYKGRLLN---------GTLVAVKELQM----------------------------AMQADKQFQTEVETLGKIHHINLVRLLGYCYEDNR-
.||||||.||||.. .         |. |||| . .                            |... ...  |.  . ...| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYMPNGS-LEKLLFLDDAKHFCSWASRFSIALGIARGITYLHDEC-----QECILHCDIKPQNILLDESFC------------
              .|.||.|.|| |. |.          |  |...||.||||. ||| .         |.|.|.|..|||.|| .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKVADFGLAKLMKRERALSVTT------------------VRGTRGYLAPEWISNL----------------PITTKVDVYSFGMVLLEIISGREKYI
  .|..||||.. |...   . |                   ..|| ...||| . .                 . ..|.||||||.|| ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

MTISAINSENSRWCLSDWAYNMYQAGDMESIVDK-------KLVGEEV-----------------DFVQFKRLLKVALWCIQHDAHARPSMGKVVQMM
                      |.  ......         ..|...                       ... | . .| .||...|||. .... .
---------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_n-1.AA IRAK 448-725 33 4.9e-63 215.74 In-house 1-317 (317) Show / Hide 
Range on Protein: 448-725
Range on HMM: 1-317/317
Sequence Identity: 33% (108 aa)

FTDNFCDKLGSGGFGTVYKGRLLNGT-LVAVKEL-QMAM----QADKQFQT---EVETLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNGSLEKLLFLDD
|  ..  ..|.||||.||.|.. | |  .||| | .||.    . ...||.   |.... ...| |.| |.|||.|     |||.||||||||  |   |
FHKDN--RIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

AKHF---CSWASRFSIALGIARGITYLHDEC-QECILHCDIKPQNILLDESFCPKVADFGLAKLM----KRERALS----VTTVRGTRGYLAPEWIS--N
.       ||  |.||..|.|.|| .||.      | | |||. |||||. | || .||||.        .|.. .    . .||||  |..|| |    
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

LPITTKVDVYSFGMVLLEIISGR---------EKYIMTISAINSENSRW---CLS---------DWAYNMYQAGDMESIVDKKLVGEEVDFVQFKRLLKV
  .|.|.|||||| ||||...|.          .|....   . |  .    |.|          ||    .. ..|  .|..  . . ...  | .. .
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWA-APRRMQIYEKFIDHRMPPCPPNME--KEMCQC

ALWCIQHDAHARPSMGKVVQMM
|. |  | |  |..| .|.| .
ACCCGHHRANRRCDMAWVMQQL
Kinase IRAKg_n-1.AA Pkinase 455-725 23 4.9e-48 170.69 Pfam 6-293 (293) Show / Hide 
Range on Protein: 455-725
Range on HMM: 6-293/293
Sequence Identity: 23% (76 aa)

KLGSGGFGTVYKGRLLNG-TLVAVKELQMAMQADKQFQT-----EVETLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNG----SLEKLLFLDDAKHF-C
|.|||.||.|||..  .   .||||..    . ... ||     |.. . ...| | |||.........  .| ||...|    .|  ..  .. . |  
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDESFCP----KVADFGLAKLMKRERALSVTTVRGTRGYLAPEWIS-NLPITTKVDVYSFGM
|.    .... |.||. |.|..    |.|.|.||.|||.|.   .    |..||||||...  .    ||. ||..|.|||.|  . ....|||..|.| 
SEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLEIISGREKYIMTISAINSENSRWCLSDWAYNMYQAG------DMESIVDKKLVGEEVDFVQF-----------------------KRLLKVALWCIQ
.| | ..||                          ..        |.  ...... | ...|  .                       . ....  ||..
ILYEMLCGR------------------------PPFPGHCWHDNHDQMQMICRIM-GPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

HDAHARPSMGKVVQM--M
 | . ||.   ..|   .
KDPKKRPTAEQILQHPWF
Kinase IRAKg_n-1.AA TKL-Unique 452-646 31 7.9e-46 158.58 In-house 1-224 (290) Show / Hide 
Range on Protein: 452-646
Range on HMM: 1-224/290
Sequence Identity: 31% (71 aa)

FCDKLGSGGFGTVYKGRLLNGTLVAVKELQM-AMQADK--Q-FQTEVETLGKIH-HINLVRLLGYCY----EDNRKLLVYEYMPNGSLEKLLF----LD-
|  |.|.||.|.||||   .|. ||.| .   . .  .  | |  || .. |.| |.|.|.. |||       ..  .| ||.| ||| ..|     .  
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DAKHFCSWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDES-----FCPKVADFGLAKLMKRERALSVT--------TVRGTRGYLAPEWI
    ..  ... | ..|. ||.|  ||| .    |.|.|.|..|.|.|.      .  |..||||.|. ... . ...        |. |.  ..||| .
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

SN--LPITTKVDVYSFGMVLLEIISG
..    ...|.||||||.|| ||...
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_n-1.AA Dicty4 451-643 35 8.3e-44 144.07 In-house 2-210 (277) Show / Hide 
Range on Protein: 451-643
Range on HMM: 2-210/277
Sequence Identity: 35% (76 aa)

NFCDKLGSGGFGTVYKGRLLNGTLVAVKELQMAMQAD-----KQFQTEVETLGKIHHINLVRLLGYCY----EDNRKLLVYEYMPNGSLEKLLFLD----
|. ...|.|.||.||||.   |. |||| |    | .     . |  ||. ..|| | |.. ..|.|     .  . . | |||| |.|..|| .|    
NIEQRIGKGSFGEVYKGT-WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLL-HDKPSE

-DAKHFCSWASRFS---IALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSV--TTVRGTRGYLAPEWISNLPITTKV
   .   .|  . .   .|. .|||...|| .|   |.| |.|. |.| |...  ||.||||...||..  ..   .|. || .. |||   . | . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGMVLLEI
||||||.|| ||
DVYSFGIVLWEI
Kinase IRAKg_n-1.AA LISK 455-648 29 2.2e-42 135.42 In-house 1-237 (296) Show / Hide 
Range on Protein: 455-648
Range on HMM: 1-237/296
Sequence Identity: 29% (71 aa)

KLGSGGFGTVYKGRLL-NGTLVAVKELQM------AMQADKQFQTEVETLGKIHHINLVRLLGYCYE-DNRKLLVYEYMPNGSLEKLLFLDDA-KHFCSW
..|.|.|| ||||...  |. .|.|...          . | .. ||... .. | | |.  | ||. | .  .| ||.  | |. .|.  |  |   .|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDES----FCPKVADFGLAKLMKRER---------------------------------ALSVT
  | .|||.||.| .|||.    .|.| | | .|.|..|.    .  ||.|||.|..|  |.                                 . .  
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TVRGTRGYLAPEWISNLPITTKVDVYSFGMVLLEIISGRE
|. ||    ||| .     ....||.|||.||.||| ...
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKg_n-1.AA MLK 451-648 27 6.8e-41 139.62 In-house 2-234 (291) Show / Hide 
Range on Protein: 451-648
Range on HMM: 2-234/291
Sequence Identity: 27% (65 aa)

NFCDKLGSGGFGTVYKGRLLNGT----LVAVKELQM---AMQA----DKQFQTEVETLGKIHHIN----LVRLLGYCYED-NRKLLVYEYMPNGSLEKLL
.|  ..|||.|| |.|||  | .     ||||.      ...     ...|..|.. | .. | |     ....| | .. .  ..| ||...|||  .|
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

FLDDAKHF-----------CSWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDE------SFCPKVADFGLAKLMKRERALSVTTVRGTRGYL
   . | .            . .. ...|| .|||. ||| . .  | | |.|..|||.||          |..|||... ...      .  .||  . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEWI---SNLPITTKVDVYSFGMVLLEIISGRE
||| |    . . . |.||.|.|.|| |......
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase IRAKg_n-1.AA S_TKc 450-729 24 7.9e-39 136.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 450-729
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

DNFCDKLGSGGFGTVYKGRLLN-GTLVAVKELQMAMQADKQFQTEVETLGKIHHINLVRLLGYCYEDNRKLLVYEYMPN--GSLEKLLFLDDAKH----F
  . .|.|.|.||.|||.|  . | .||.|..       .... |.. | | || |.|.|...... ..  .| ||...  |.| ...     .     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CSWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGYLAPEWISNLPITT-KVDVYSFGMVLL
     || ..  |.... |.|   .  |.|.|.||.||||||  . |..|||||...        ||. ||. |.||| .   . .. |.|..|.| .| 
PE-HARF-YMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIISGREKYIMTISAINSENSRWCLSDWAYNMYQAGDMESIVDKKLVGEEVDFVQFKRLLKVALWCIQHDAHARPSMGKVVQ-----MMEDTV
| ..|.  .                           .|. . .| .          . ..     | | |   ||.  .. |     ..   .
EMLCGYPPFP--------------------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_n-1.AA Pkinase_Tyr 451-645 31 6.5e-34 115.49 Pfam 2-209 (270) Show / Hide 
Range on Protein: 451-645
Range on HMM: 2-209/270
Sequence Identity: 31% (69 aa)

NFCDKLGSGGFGTVYKGRLL-----NGTLVAVKELQM-AMQAD---KQFQTEVETLGKI-HHINLVRLLGYCYEDNRK---LLVYEYMPNGSLEKLLFLD
 |  |||.| ||.||||..      ... |||| |   ||. .   . |  |.... .. || |.|||.| |... .    ..| ||||.|.| . |   
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

--DAKHFCSWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLM-----K-RERALSVTTVRGTRGYLAPEWISNLPITT
  | ....      .... ||.|  ||..     . | |.   |.|..|... |..|||||...       | |  .   .. .    ||| |..   ||
REDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTT

KVDVYSFGMVLLEIIS
| ||.||| .. ||..
KSDVWSFGVLMWEIFT
Kinase IRAKg_n-1.AA LRRK 440-647 23 3.3e-31 107.66 In-house 1-279 (351) Show / Hide 
Range on Protein: 440-647
Range on HMM: 1-279/351
Sequence Identity: 23% (71 aa)

FTYQQLQTFTDNFCDKLGSGGFG-TVYKGRLLN---------------------------GTLVAVKELQM-----------------------------
. ....          .|.|||| .||.... .                           .. ||.| . .                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------AMQADKQFQTEVETLGKIHHINLVRLLGYCYEDNRKLLVYEYMPNGSLEKLLF---LDDAKHFCS----WASRFSIALGIARGITYLHDECQE-
      .. |   |. ||  . . .| |.| |.|.| .  .  .| ||.|.|.| ..|.    |   ||      |  .  ||| ||.|. |||.  .  
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGF-HFMKAHISWMLKLKIALQIAKGMEYLHS--HNP

CILHCDIKPQNILL---D---------ESFCPKVADFGLAKLMKRERALS--VTTVRGTRGYLAPEWIS---NLPITTKVDVYSFGMVLLEIISGR
 |.|.| |. ||||   .         .  | |.||||.   |     ..  . .. |. |..||| .    .   |.|||.|||||.| |.....
PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_n-1.AA TyrKc 450-725 23 1.1e-30 109.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 450-725
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

DNFCDKLGSGGFGTVYKGRLLNGTLVAVKELQMAMQADKQFQTEVETLGKI--HHINLVRLLGYCYED-------NRKLLVYEYMPNGSLEKLL-FLDDA
  . .|||.| ||.||||..   . |||| |.      . |  | . . |.  || |.|||.|.| ..          ..| ||||.|.| . |    . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KHFCSWASRFSIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE----RALSVTTVR---GTRG-----YLAPEWISNLPI
    ...   |... ||.|  |||.    .. | |.   |.|..| .. |..||||..  . .     . .. ...   |...      .||| |     
---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKVDVYSFGMVLLEIIS-GREKYIM----------TISAINSENSRWCLSD----WAYNMYQAGDMESIVDKKLVGEEVDFVQ-FKRLLKVALWCIQHD
||| ||.||| .. || . | . |             |  . . . . .  .                             ||   . . .. ..| ..|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------FVCCPDEMYQIMKQCWHED

AHARPSMGKVVQMM
.. ||..  ... .
PEDRPTFSEIHECF
Kinase IRAKg_n-1.AA ULK 570-647 31 4.5e-20 66.84 In-house 151-253 (329) Show / Hide 
Range on Protein: 570-647
Range on HMM: 151-253/329
Sequence Identity: 31% (32 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAKLMK---RERALSVTTV-----RGTRGYLAPEWISNL----PIT-TKVDVYSFGMVLLEII
| |.||||||||... .            . |.||||.|| .     | .. .|.|     .||  | ||. ....    | .  |.|..|.|... |..
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SGR
 |.
YGK
Kinase IRAKg_n-1.AA STE 551-647 29 7.6e-20 66.84 In-house 156-265 (359) Show / Hide 
Range on Protein: 551-647
Range on HMM: 156-265/359
Sequence Identity: 29% (35 aa)

IALGIARG-ITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERA--------------LSVT-TVRGTRGYLAPEWISN------LPIT
|.  | .|   |||.     | | ||||.||||      | .|||... .  . |               . . |. ||  . ||| |..       . .
ICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

TKVDVYSFGMVLLEIISGR
||.|..|.| ...| . |.
TKCDIWSLGCTIIEMATGK
Kinase IRAKg_n-1.AA ULK 570-647 31 1.8e-19 65.84 In-house 147-249 (324) Show / Hide 
Range on Protein: 570-647
Range on HMM: 147-249/324
Sequence Identity: 31% (32 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAKLMK---RERALSVTTV-----RGTRGYLAPEWISNL----PIT-TKVDVYSFGMVLLEII
| |.||||||||. . .            . |.||||.||       |  .  |.|     .||  | ||. ....    | .  |.|..|.|... |..
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML

SGR
 |.
YGK
Kinase IRAKg_n-1.AA STE 450-534 19 1.1e-16 55.59 In-house 1-128 (359) Show / Hide 
Range on Protein: 450-534
Range on HMM: 1-128/359
Sequence Identity: 19% (25 aa)

DNFCDKLGSGGFGTVYKGRLLN----------------GTLVAVKELQMAM------------------QADKQFQTEVETLGKIH--HINLVRLLGYCY
  . .|.|.|.||||||..  .                |...|.|.. .                    .  .|.. |.... | .  | | |. .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------NRKLLVYEYMPNGSLEKLL
 .       .   .. |||..|||....
KEGHNHKNDDELWICMEYMDGGSLDDII
Kinase IRAKg_n-1.AA ULK 454-534 25 2.4e-16 54.58 In-house 5-108 (324) Show / Hide 
Range on Protein: 454-534
Range on HMM: 5-108/324
Sequence Identity: 25% (26 aa)

DKLGSGGFG-TVYKGR-LLN---GTLVAVKELQ---MAMQADK--------QFQTEVETLGKIH---HIN--LVRLLGYCYED--NRKLLVYEYMPNGSL
..||.| || .|||||   .   . .||.|  .   | ..  .        ... |.... |..   | |   |.|. .....  |   ...|| . | |
HCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDL

EKLL
|...
EQYI
Kinase IRAKg_n-1.AA ULK 454-534 24 5.2e-15 48.92 In-house 5-111 (329) Show / Hide 
Range on Protein: 454-534
Range on HMM: 5-111/329
Sequence Identity: 24% (26 aa)

DKLGSGGFGTVYKGR-LLN----GTLVAVKELQ---MAMQADK--------QFQTEVETLGKIH----HIN----LVRLLGYCYED--NRKLLVYEYMPN
..||.| ||.|||||   .    . .||.| ..   | .. .         ... |.... |..    |.|     |.|. .....  |   ...|| . 
HCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNG

GSLEKLL
| ||...
GDLEQYI
Kinase IRAKg_n-1.AA LRRK 695-727 21 0.002336 7.72 In-house 319-351 (351) Show / Hide 
Range on Protein: 695-727
Range on HMM: 319-351/351
Sequence Identity: 21% (7 aa)

VQFKRLLKVALWCIQHDAHARPSMGKVVQMMED
... ....   .| |||   ||.. ..|. ...
QPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_n-1.AA LISK 700-725 30 0.135375 0.72 In-house 271-296 (296) Show / Hide 
Range on Protein: 700-725
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

LLKVALWCIQHDAHARPSMGKVVQMM
.|.....|.  |   |||  ..||  
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKg_n-1.AA MLK 707-725 42 0.145722 1.35 In-house 273-291 (291) Show / Hide 
Range on Protein: 707-725
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQHDAHARPSMGKVVQMM
| . |.| |||.  .||  
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_n-1.AA Dicty4 706-727 37 0.265323 0.3 In-house 254-277 (277) Show / Hide 
Range on Protein: 706-727
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQHDAHARPSMGKVVQM--MED
||  ||   |||.  ..|   .| 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_n-1.AA Pkinase_Tyr 705-725 19 4.820708 0.77 Pfam 250-270 (270) Show / Hide 
Range on Protein: 705-725
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQHDAHARPSMGKVVQMM
. | ..|.  ||..  .....
KQCWHYDPEDRPTFSEIHEQL