Gene IRAKg_m-2 (S.moellendorffii)

IRAKg_m-2

Species: S.moellendorffii
Alias: IRAKg_m-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_m-2.AA Protein None 813 None Fasta, JSON
IRAKg_m-2.NA RNA None 2439 None Fasta, JSON
IRAKg_m-2.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAKg_m-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_m-2.AA B_lectin 60-146 31 7.8e-20 69.74 Pfam 1-109 (137) Show / Hide 
Range on Protein: 60-146
Range on HMM: 1-109/137
Sequence Identity: 31% (35 aa)

PEEIVWMATTD-NGQFVHASGS----AQLQLRS-DGGLVIIDRA---SI--LWRT--N-SGQA--K--GASLLETGNLVVY-GEN--EQFAWKS--FDVP
.  .|| | .|  |. |  . |    ..|.. . || ||. | .   |.  .|.|  | || .      | ....||||.| ..|    . | |  || |
NQTVVWVANRDLTGNPV-TDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TTTILPEQQF
| |.|| . .
TDTWLPGMKL
B_lectin IRAKg_m-2.AA B_lectin 23-136 30 3e-16 61.22 SMART 1-126 (126) Show / Hide 
Range on Protein: 23-136
Range on HMM: 1-126/126
Sequence Identity: 30% (40 aa)

GSSLKLGSQWNSSGGTFS--LGFR--LMDEAYNLAIWYQID---PEEIVWMA--TTDNGQFVHASG---SAQLQLRSDGGLVIIDRASILWRTNSG---Q
 . |. | .. |....|.  |||    |   .|. |||      .. .|| |   .||    ....   |. | . ||| ||| |  ...|..|..    
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNG-IWYKNISNKQRTVVWVAQPNRDN----PVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTTRNNG

AKGASLLETGNLVVYGEN----EQFAWKSFDVP
   | |...||.|.|...    . | | ||| |
NYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_m-2.AA S_locus_glycop 260-327 23 2.4e-14 51.44 Pfam 50-117 (117) Show / Hide 
Range on Protein: 260-327
Range on HMM: 50-117/117
Sequence Identity: 23% (16 aa)

SNVLRRLKLDDDGNLRMYSFSNDTRSWSIVWQALMQECDVFGACGAFGLCTYRPKKTCSCPPGFHRVD
.... |. .. .| | ..   .....|   | | . .||. ..||..|.|      .|.| .||.   
NSIYSRFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
B_lectin IRAKg_m-2.AA B_lectin 265-291 39 0.077725 7.88 Pfam 68-92 (137) Show / Hide 
Range on Protein: 265-291
Range on HMM: 68-92/137
Sequence Identity: 39% (11 aa)

RLKLDDDGNLRMY-SFSNDTRSWSIVWQ
|... |.|||  | . .||  | ...||
RAQMQDSGNLVLYDD-NND--SNNVLWQ
PAN_AP IRAKg_m-2.AA PAN_AP 344-424 15 0.000507 17.97 SMART 1-85 (85) Show / Hide 
Range on Protein: 344-424
Range on HMM: 1-85/85
Sequence Identity: 15% (15 aa)

EHPTKLVLATRADYYYSDYRFD------AAVTTLEQCKANCLKDCQCLAAAYKAQDGDSLCFLKGGQDRLYNGMQ-------SFDKPNLVYMKV
....  |.  .. .    .           |..||.|.. ||..|.| ...| .   .. | |    |.  ....         .     | |.
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN---TKGCHLWS-WDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_m-2.AA TKL 528-798 21 1.5e-67 230.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 528-798
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGSGGYGTVYRGEIPE--------KGGIVAVKVIKAVT----------------------------HAEKQFKAEVNTIGKVHHVNLVRLLGYCVEGVH-
.||||.|.||.|.           .|  ||||..|                               ....... |.. . . .| |.|...||| .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFMPNGS-LDNYLSSNSGSSDSSWQTRFSIALGIAKGIAYLHEEC-----QECIIHCDIKPQNILLDDQMS------------
              .|.|..|.|| |....          |. |...||.||.|..||| .         |||.|.|..|||.|. .             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKIADFGLAKLTKREHSMSVTT------------------VRGTRGYLAPEWLDGL----------------SVTPKIDVYSFGMLLFDILSGTNKMI
  .||.||||..  ... .|. |                   ..|| ...||| |.|                 . ..|.||||||..|. ||..     
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

FNELAGTSFESFPSGMEDYFQKYIA----SELQCIADPKME-MAETDWPQ-------FKL---LLKVALWCIQQNPSSRPSMSRIVQLL
            |   ..|.. ...     ..  ..| ..     . |..             . | . .| ...|..|||...|.. |
------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_m-2.AA IRAK 523-719 37 5.3e-57 195.68 In-house 2-220 (317) Show / Hide 
Range on Protein: 523-719
Range on HMM: 2-220/317
Sequence Identity: 37% (82 aa)

NFEETLGSGGYGTVYRGEIPEKGGIVAVK-----VIKAVTHAEKQFKA---EVNTIGKVHHVNLVRLLGYCVEGVHRLLVYEFMPNGSLDNYLSSNSGSS
. .  .|.||.|.||||..  ..||.|||     .    .  ...| .   |. .  . .| |.| |.||| |.    |||..||||||   |.   |. 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

D---SSWQTRFSIALGIAKGIAYLHEEC-QECIIHCDIKPQNILLDDQMSPKIADFGLAKL-----TKREHSM---SVTTVRGTRGYLAPEWLD--GLSV
     ||..|.||..|.|.|| .||.      ||| |||. |||||... |||.||||.        |  ..     . .||||  |..|| .       
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TPKIDVYSFGMLLFDILSG
|.| ||||||  |  .|.|
TKKTDVYSFGIVLLEVLTG
Pkinase IRAKg_m-2.AA Pkinase 522-798 24 2.4e-54 191.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 522-798
Range on HMM: 1-293/293
Sequence Identity: 24% (79 aa)

NNFEETLGSGGYGTVYRGEIPEKGGIVAVKVIKAVTHAEKQFKA-----EVNTIGKVHHVNLVRLLGYCVEGVHRLLVYEFMPNG----SLDNYLS--SN
  .....|||..|.||..     | |||||.|| ..  ... ..     |.    ...| | |||.... .. |  .| |....|    .|  |.|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SGSSDSSWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSP----KIADFGLAK-LTKREHSMSVTTVRGTRGYLAPEWLD-GLSVTPKI
 . .  |...  .... |..|..|.|..    |||.|.||.|||.|... .    ||.|||||| .    ..   ||. ||..|.|||..  |   .||.
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGMLLFDILSGTNKMIFNELAGTSFESFPSGMEDYFQKYIA------SELQCIADPKMEMAETDWPQF---------------------KLLLKVA
|..|.| .|.  |.|                        .  . .      ...|.|.  ..   . |||.                      . .... 
DMWSCGCILYEMLCGR-----------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

LWCIQQNPSSRPSMSRIVQL--L
 ||....|..||.   |.|   .
KWCLCKDPKKRPTAEQILQHPWF
Kinase IRAKg_m-2.AA TKL-Unique 524-720 32 2.5e-47 163.55 In-house 1-225 (290) Show / Hide 
Range on Protein: 524-720
Range on HMM: 1-225/290
Sequence Identity: 32% (74 aa)

FEETLGSGGYGTVYRGEIPEKGGIVAVKVIKA---VTHAEKQ-FKAEVNTIGKVH-HVNLVRLLGYCV----EGVHRLLVYEFMPNGSLDNYLS------
| ...|.||||.||.|.   .| .||.|...    .   ..| |. |||.. | | | |.|.. |||.       .. .| |..| |||...|.      
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-SNSGSSDSSWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQ-----MSPKIADFGLAKLTKREHSMSVT--------TVRGTRGYLAPEW
  |. ... ..| | ..|. ||.|  ||| .    |||.|.|..|.|.|       .. ||.||||.|. ...  |...        |. |.  ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

LDG--LSVTPKIDVYSFGMLLFDILSGT
| .     . |.||||||. |  |....
LRMNFCQYSEKSDVYSFGIVLWEIATRK
S_TKc IRAKg_m-2.AA S_TKc 522-798 24 1e-44 155.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 522-798
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

NNFEETLGSGGYGTVYRGEIPEKGGIVAVKVIKAVTHAEKQFKAEVNTIGKVHHVNLVRLLGYCVEGVHRLLVYEFMPN--GSLDNYLSSNSG----SSD
  . ...|.|..|.||..   . | |||.|.||      .... |..   | || |.|.|......  |  .| |....  |.|  |. .. .    .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SSWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGYLAPEWLDGLSVTP-KIDVYSFGMLLF
.  ..|| ..  |.....|.|.     |||.|.||.|||||.    ||.|||||..         ||. ||. |.||| |   . .. |.|..|.| .|.
PE-HARF-YMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

DILSGTN-----KMIFNELAGTSFESFPSGMEDYFQKYIASELQCIADPKMEMAETDWPQFKLLLKVALWCIQQNPSSRPSMSRIVQ---------LL
  |.|       .|.|. .                                          . ..     | | .|. ||.   . |          .
EMLCGYPPFPQMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_m-2.AA Dicty4 523-717 30 2.7e-42 138.96 In-house 2-211 (277) Show / Hide 
Range on Protein: 523-717
Range on HMM: 2-211/277
Sequence Identity: 30% (66 aa)

NFEETLGSGGYGTVYRGEIPEKGGIVAVKVI---KAV--THAEKQFKAEVNTIGKVHHVNLVRLLGYCV----EGVHRLLVYEFMPNGSLDNYLSS----
|.|. .|.|..|.||.|    .| .||||.    . .      . |..||.  .|  | |.. ..|.|     .    . | |.|| |.| . | .    
NIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--NSGSSDSSWQTR-FSIALGIAKGIAYLHE-ECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSV--TTVRGTRGYLAPEWLDGLSVTPK
   | ..|..  .|   .|. .|.|...||.  .   ||| |.|. |.| |. .  |..||||... |.. . .   .|. || .. ||| . . . . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

IDVYSFGMLLFDIL
 ||||||..|. ||
ADVYSFGIVLWEIL
Kinase IRAKg_m-2.AA MLK 522-719 27 7.8e-41 139.41 In-house 1-232 (291) Show / Hide 
Range on Protein: 522-719
Range on HMM: 1-232/291
Sequence Identity: 27% (64 aa)

NNFEETLGSGGYGTVYRGEIPEKG---GIVAVKVIK----AVTHAE---KQFKAEVNTIGKVHHVN----LVRLLGYCVE-GVHRLLVYEFMPNGSLDNY
 .|.| .|||..| |..|.   |     ||||| ..    ..  ..   ..|. |..   .. | |     ....| | . . | ..| |....||| |.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LSS-NSGSSDS----------SWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDD------QMSPKIADFGLAK-LTKREHS-MSVTTVRGTR
| . .|...|.          . .  ...|| .|.|..|||.. .  ||| |.|..|||.|.      ..  ||.|||... ..... . |  .  .|| 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNM--MSNAGTY

GYLAPEWL---DGLSVTPKIDVYSFGMLLFDILSG
 . ||| .    .  .. | ||.|.|..|  .|..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKg_m-2.AA TK 522-714 16 3e-38 125.31 In-house 1-385 (486) Show / Hide 
Range on Protein: 522-714
Range on HMM: 1-385/486
Sequence Identity: 16% (63 aa)

NNFEETLGSGGYG---TVYRGEIPEKGG-------------------------IVAVKVIKAV-THAEKQFKA--------------EVNTIGKVH----
  ....||.| .|   .||.||  ....                          ||||..|.  ......|..              |.. . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLVRLLGYCVEGV------------HRLLVYEFMPNGS----LDNYLSSNSGSSDS-----------------------------------------
 | |.|||.|.|..|.            . ..| |.||.|.    |..|| ....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------SWQTRFSIALGIAKGIAYLHEE----CQECIIHCDIKPQNILLDDQMS-----------PKIADFGLA
                                . ...  ... ||.| .|||.         ..| |.   |.|.....             |||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LTKREHSMSVTTVRGTRG----------------------------YLAPEWLDGLS---------VTPKIDVYSFGMLLF
.     |... .| .  ......|                            ..||| |..            |.| ||.||| |..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW
Kinase IRAKg_m-2.AA LRRK 522-720 25 2.5e-35 122.42 In-house 1-279 (351) Show / Hide 
Range on Protein: 522-720
Range on HMM: 1-279/351
Sequence Identity: 25% (71 aa)

NNFEETLGSGGYG-TVYRGEIP--------------------------EKGGIVAVKVIKA-----------------------------------VTHA
  .|| .|.||.| .|||..                             ..  ||.|...                                     ..|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKQFKAEVNTIGKVHHVNLVRLLGYCVEGVHRLLVYEFMPNGSLDNYLSSNSGSS------DSSWQTRFSIALGIAKGIAYLHEECQE-CIIHCDIKPQN
   |  ||  . . .| |.| |.|.| .  .. .| |..|.|.|. .|.... ..      . ||...  ||| ||||..|||   .   |||.| |. |
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSPN

ILL---D---------DQMSPKIADFGLAK-LTKREHSMSVTTVRGTRGYLAPEWLDG---LSVTPKIDVYSFGMLLFDILSGT
|||   .         ...  ||||||.     .  |.  . .. |. |..||| . .    . | |.|.|||||.|...|...
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_m-2.AA Pkinase_Tyr 523-714 29 8e-35 118.56 Pfam 2-205 (270) Show / Hide 
Range on Protein: 523-714
Range on HMM: 2-205/270
Sequence Identity: 29% (63 aa)

NFEETLGSGGYGTVYRGEIP----EKGGIVAVKVIKAVTHAE----KQFKAEVNTIGKV-HHVNLVRLLGYCV-EGVH--RLLVYEFMPNGSLDNYLSSN
 | ..||.| .|.||.|.      ...  ||||..|  .. |    . | .|...  .  || |.|||.| |. .| .   ..| |.||.|.|..|| ..
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-SGSSDSSWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLT-----K-REHSMSVTTVRGTRGYLAPEWLDGLSVTPK
 ..    . ..  .... |||| .||..     .|| |.   |.|.....  ||.|||||..        | .. .   .. .    ||| .     | |
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTK

IDVYSFGMLLF
 ||.||| |..
SDVWSFGVLMW
Kinase IRAKg_m-2.AA RIPK 528-719 29 5.9e-34 113.08 In-house 1-224 (290) Show / Hide 
Range on Protein: 528-719
Range on HMM: 1-224/290
Sequence Identity: 29% (67 aa)

LGSGGYGTVYRGEIPEKGGIVAVKVIKAVTHA-------EKQFKAEVNTIGKVHHVNLVRLLGYCVEG-----VH-RLLVYEFMPNGSLDNYLSSNS--G
.|.|| |.|..      |  ||.|. .    .       ... | |.    |  . . |...| | .           .| |.|.|||| . |.. .   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SSDSSWQTRFSIALGIAKGIAYLHEECQE-CIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMS-------VTT----VR-GTRGYLAPEWLD---
  .  |  |. .   |. |  |||  ..   ||| | ||.|||.|  .  ||||||||.     ||..       |       | ||  |..|| .    
HHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDN

GLS---VTPKIDVYSFGMLLFDILSG
  .   |||| |||||..... .|..
KKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAKg_m-2.AA TyrKc 522-798 22 5.8e-33 116.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 522-798
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

NNFEETLGSGGYGTVYRGEIPEKGGIVAVKVIKAVTHAEKQFKAEVNTIGKV--HHVNLVRLLGYCVEG-------VHRLLVYEFMPNGSLDNYLSSNSG
  ....||.| .|.||.|.       ||||..|. .  .. |  | .   |.  || |.|||.|.|...          ..| |.||.|.|..|| .. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SSDSSWQTRFSIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKRE----HSMSVTTVR---GTRG-----YLAPEWLDGLSV
    ....  |... ||.| .|||.    ..|| |.   |.|....   ||.||||..  . .     | .. ...   |...      .||| ..    
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TPKIDVYSFGMLLFDILSGTNKMIFNELAGTSFESFPSGMEDYFQ-----KYIASELQCIADPKMEMAETD--------WPQFKLLLKVALWCIQQNPSS
|.| ||.||| ... |..                    |.. |       .  .  .... . .. .   .         |.   . .. ..| . .|..
TTKSDVWSFGVCMWEIFTY-------------------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE--MYQIMKQCWHEDPED

RPSMSRIVQLL
||..| |....
RPTFSEIHECF
Kinase IRAKg_m-2.AA Dicty4-Unclassified 523-719 32 2.9e-30 100.84 In-house 2-204 (263) Show / Hide 
Range on Protein: 523-719
Range on HMM: 2-204/263
Sequence Identity: 32% (68 aa)

NFEETLGSGGYGTVYRGEIPEKGGIVAVKVIKAVTHAEK-----QFKAEVNTIGKVHHVNLVRLLGYCVEG-VHR---LLVYEFMPNGSLDNYLSSNSGS
     .| |    |..|    ||  |||| .              ||.||   | . | |||.. |||.    |.     | |||. | |     |    
QIDQFIGKGHFSKVHKGNW--KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

SDSSWQTRF----SIALGIAKGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGYLAPEWLDGLSVTPKIDVYSF
 . . .        .|. ||.|...||      .|| |||  |||.|     ||||||..  .     |  ||. ||    .|| | . | . | ||||.
QQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSY

GMLLFDILSG
.|.|.  . |
AMMLYELATG
Kinase IRAKg_m-2.AA CZAK 523-719 32 1.1e-29 104.94 In-house 2-218 (279) Show / Hide 
Range on Protein: 523-719
Range on HMM: 2-218/279
Sequence Identity: 32% (71 aa)

NFEETLGSGGYGTVYRGEIPEKGGIVAVKVI-----KAVTHA--EKQFKAEVNTIGKVHHVNLVRLLGYCVEGV--HRLLVYEFMPNGSLDNYLSSNSGS
 |. | | | .| ||..    .|  ||.| |     .  .    |  |  ||  . |  | | |  || | |.   |.  | |.|  |||.  |   .  
KFGQTIGQGFFGEVYKAYW--RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFY

SDSSWQTRFSIALGIAKGIAYLHEECQE-CIIHCDIKPQNILLDDQMS-------------PKIADFGLAKLTKREHSMSVTTVRGTRGYLAPEWLDGLS
       . ..|. ||.|  |||    .  |.| |   .|||||. .               ||.|||| .. ..|     |   |   . |||   | .
HKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSRE-MMEQPFEMTQTMGCLCWMAPECFKGEN

VTPKIDVYSFGMLLFDILSG
 |.| |||||||.|. |. .
YTEKVDVYSFGMILWCIITC
Kinase IRAKg_m-2.AA Dicty4 779-800 45 5e-06 16.39 In-house 254-277 (277) Show / Hide 
Range on Protein: 779-800
Range on HMM: 254-277/277
Sequence Identity: 45% (11 aa)

WCIQQNPSSRPSMSRIVQL--LEH
||   .|..|||.. |.|   |||
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_m-2.AA MLK 780-798 52 1e-05 16.01 In-house 273-291 (291) Show / Hide 
Range on Protein: 780-798
Range on HMM: 273-291/291
Sequence Identity: 52% (10 aa)

CIQQNPSSRPSMSRIVQLL
| .|.|..|||.. ||| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_m-2.AA LRRK 779-800 40 1.2e-05 15.9 In-house 330-351 (351) Show / Hide 
Range on Protein: 779-800
Range on HMM: 330-351/351
Sequence Identity: 40% (9 aa)

WCIQQNPSSRPSMSRIVQLLEH
.| |..| .||..| ||. |. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_m-2.AA TK 776-798 26 7e-05 11.46 In-house 464-486 (486) Show / Hide 
Range on Protein: 776-798
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

VALWCIQQNPSSRPSMSRIVQLL
. . | . .|. ||..| ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_m-2.AA Dicty4-Unclassified 779-798 45 8.2e-05 12.37 In-house 244-263 (263) Show / Hide 
Range on Protein: 779-798
Range on HMM: 244-263/263
Sequence Identity: 45% (9 aa)

WCIQQNPSSRPSMSRIVQLL
||    |  ||.|  |.| |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKg_m-2.AA CZAK 780-798 47 0.00075 10.05 In-house 261-279 (279) Show / Hide 
Range on Protein: 780-798
Range on HMM: 261-279/279
Sequence Identity: 47% (9 aa)

CIQQNPSSRPSMSRIVQLL
|   ||..||| . |.| |
CWNKNPDERPSFKQILQHL
Kinase IRAKg_m-2.AA Pkinase_Tyr 778-798 33 0.001399 12.75 Pfam 250-270 (270) Show / Hide 
Range on Protein: 778-798
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

LWCIQQNPSSRPSMSRIVQLL
. | ...|. ||..| |.. |
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAKg_m-2.AA TKL-Unique 780-798 42 0.001929 8.21 In-house 272-290 (290) Show / Hide 
Range on Protein: 780-798
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CIQQNPSSRPSMSRIVQLL
|  ..|| ||| . |.  |
CWHHDPSQRPSFDEIIHRL