Gene IRAKj_c-2 (S.moellendorffii)

IRAKj_c-2

Species: S.moellendorffii
Alias: IRAKj_c-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKj

Sequence

Name Sequence Type Origin Length Description Download
IRAKj_c-2.AA Protein None 948 None Fasta, JSON
IRAKj_c-2.NA RNA None 2847 None Fasta, JSON
IRAKj_c-2.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAKj_c-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKj_c-2.AA LRRNT_2 45-81 23 6e-05 18.98 Pfam 1-46 (46) Show / Hide 
Range on Protein: 45-81
Range on HMM: 1-46/46
Sequence Identity: 23% (11 aa)

DPTERAVLDAMIQGLTN-----GALLGWG----SGDPCSWKHIQCR
...... | |. ..|..     |.|. |     ..|.|||. . | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_TYP IRAKj_c-2.AA LRR_TYP 129-152 37 3.1e-05 24.66 SMART 1-24 (24) Show / Hide 
Range on Protein: 129-152
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LKNLRTVYLNSNNFATIPGDFFRG
| |||. .|..|.. ..| . |.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 IRAKj_c-2.AA LRR_1 131-153 33 0.004731 14.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 131-153
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLRTVYLNS-N--NFA-TIPGDFFRGL
||.. .|.. |  |.  .|| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_c-2.AA LRR_1 108-129 29 0.027855 12.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 108-129
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLEYLGLQF-N--GFHGALPS--LSGL
||..| |.  |   . | .|.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKj_c-2.AA LRR_TYP 153-180 27 0.927559 0.12 SMART 1-24 (24) Show / Hide 
Range on Protein: 153-180
Range on HMM: 1-24/24
Sequence Identity: 27% (8 aa)

LDSLMVIYLDHNNLNGTAGWQLPDDV-QF
| .| . .|..|.|      .||... | 
LPNLRELDLSNNQL-----THLPPGAFQG
LRR_1 IRAKj_c-2.AA LRR_1 155-181 22 1.732027 5.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 155-181
Range on HMM: 1-26/26
Sequence Identity: 22% (7 aa)

SLMVIYLDH-N--NLNGTAGWQLPDD-VQFS
.| ...|.. |  || |.    .|..     
NLQHLDLSGCNCCNLTGH----IPPSCF-NL
LRR_1 IRAKj_c-2.AA LRR_1 207-229 37 0.007454 14.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 207-229
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLKVLNLAY-N--SLTGGLPAS-FKDS
.|..|.| . |  .||| .| | |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKj_c-2.AA LRR_TYP 205-228 33 0.102489 7.96 SMART 1-24 (24) Show / Hide 
Range on Protein: 205-228
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

MASLKVLNLAYNSLTGGLPASFKD
. .|..|.| .| ||   |  | .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 IRAKj_c-2.AA LRR_1 183-205 25 6.183656 3.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 183-205
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLVNLSLTN-T--SLGGPIPEF-LGTM
.|  |.| . .  .| | ||.  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_c-2.AA LRR_1 253-275 37 0.016039 13.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 253-275
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLAQLWLQG-N--QFTGTIPVG-LSNA
.|  | |.| |  ..||.|| . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKj_c-2.AA LRR_TYP 251-275 32 0.195053 5.67 SMART 1-24 (24) Show / Hide 
Range on Protein: 251-275
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

MTSLAQLWLQGNQFTGTIPVGLSNA
...|  | |..||.| ..| |. . 
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 IRAKj_c-2.AA LRR_1 281-298 34 14.379053 2.64 Pfam 5-26 (26) Show / Hide 
Range on Protein: 281-298
Range on HMM: 5-26/26
Sequence Identity: 34% (8 aa)

LRLND-N--KLKGVVPN--FTAL
| |.. |  .| | .|.  | .|
LDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_c-2.AA LRR_1 299-320 29 34.299044 1.3 Pfam 1-26 (26) Show / Hide 
Range on Protein: 299-320
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

PLSHFSVTN-N--NLMGPIPL--LRAT
 | | .. . |  || | ||   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRRNT_2 IRAKj_c-2.AA LRRNT_2 339-377 26 0.039079 9.83 Pfam 1-46 (46) Show / Hide 
Range on Protein: 339-377
Range on HMM: 1-46/46
Sequence Identity: 26% (12 aa)

CSAEVTALLGFLGGIG--FP-DSIIADWS----GTDPCAVTWVVCD
 . .. ||| |  ..    | ..  ..|.    ..|.|  | | ||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKj_c-2.AA LRR_1 404-426 40 0.00262 15.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 404-426
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

DLRFVMLSN-N--NLSGSIPPE-FATM
 |.   ||. |  ||.|.|||. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_c-2.AA LRR_1 428-449 29 0.020528 12.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 428-449
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLKTLDLRN-N--SLSGPMVK--FSGV
.|..|||.. |  .|.|   .  | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKj_c-2.AA LRR_TYP 402-425 44 0.311851 4.0 SMART 1-24 (24) Show / Hide 
Range on Protein: 402-425
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LADLRFVMLSNNNLSGSIPPE-FAT
|  ||   ||||.|  ..||. |. 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP IRAKj_c-2.AA LRR_TYP 426-448 37 0.39155 3.19 SMART 1-24 (24) Show / Hide 
Range on Protein: 426-448
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

MKSLKTLDLRNNSLSGPMVK-FSG
. .|..||| || |.      |.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 IRAKj_c-2.AA LRR_1 380-402 25 70.873274 0.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 380-402
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

AVIGLKLER-N--QLAGTLSPA-VAGL
    | | . |  .| |...|    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAKj_c-2.AA IRAK 608-814 35 3e-65 223.1 In-house 1-228 (317) Show / Hide 
Range on Protein: 608-814
Range on HMM: 1-228/317
Sequence Identity: 35% (80 aa)

FSRDTILGRGGFGVVYKGVLDDGT-SIAVKRMEASTVVSSKGLSE-FHA---EIAVLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFERG-A
|..|  .| ||||.||.|...  |   |||.  .   .| ... . | .   |. |... || ..|.|.|||.|. .  |||.|.|||.|   |  .. .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

KP---LDWKRRLVIALDVARGMEYLHELA-HRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLA-PEG---KYSI---ET-RLAGTFGYLAPEYAV--TGR
 |   | | .|. |..  |.| ..||..    ..||.| |..|||||..  .| .||||.    | .   | ..   .| .. ||  |..||.    .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTTKADVFSFGVVLMELITGR-RALDES
 |.| ||.|||.||.|..||. ...|..
LTKKTDVYSFGIVLLEVLTGCRAVYDDR
Kinase IRAKj_c-2.AA TKL 614-883 20 1.6e-62 214.03 In-house 1-364 (364) Show / Hide 
Range on Protein: 614-883
Range on HMM: 1-364/364
Sequence Identity: 20% (82 aa)

LGRGGFGVVYKGVLDD---------GTSIAVKRMEASTV------------------------VSSKGLSEFHAEIAVLTKVRHRHLVALLGYCIEGNE-
.|.||||.||||..           |. .|||..    .                         .|.   ..  || .. . || ..| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYLPNGT-LAQHLFERGAKPLDWKRRLVIALDVARGMEYLHELAH-----RSFIHRDLKPSNILLDDDYR-------------
              .|.|| |.|. | ...         | .|. .|||.||||.|||         .  ||||||..|||.|....             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKVSDFGLVKLAPEGKYSIETR------------------LAGTFGYLAPEY---------AV-------TGRVTTKADVFSFGVVLMELITGRRALDE
 .|..|||| .   . . .  |                     ||....|||          .|        .  ..|.||.|||.|| |..|..|    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

SQSEENMHLVTWFRRTHQGRESFARMIDPALLEGTEDKVEGIYT----------------------VAELAKHCTAREPYNRPDMGHAVSVL
                ..  ..   . || . |  .  ..  .                       ...|...| . .| .|| .   .. |
--------------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKj_c-2.AA Pkinase 608-808 27 7.8e-49 173.36 Pfam 1-209 (293) Show / Hide 
Range on Protein: 608-808
Range on HMM: 1-209/293
Sequence Identity: 27% (60 aa)

FSRDTILGRGGFGVVYKGVLDDGTS-IAVKRMEASTVVSSKGLSEFH-AEIAVLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNG----TLAQHLFERGA
. .  ..|.|.||.|||..  .     |||... ..  |.|  . .. .||... ...| . | |.... ....  .| ||...|     |. ..  .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPL--DWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRA----KVSDFGLVK-LAPEGKYSIETRLAGTFGYLAPEYAV-TGRVTTKAD
...  ...    ... ..||.||.|.    ..|||||||.|||.|...      |..|||| | .  . ..|  | ..|| .|.|||        ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSFGVVLMELITGR
..|.|..| |...||
MWSCGCILYEMLCGR
Kinase IRAKj_c-2.AA Dicty4 608-807 32 1.6e-46 153.25 In-house 1-213 (277) Show / Hide 
Range on Protein: 608-807
Range on HMM: 1-213/277
Sequence Identity: 32% (71 aa)

FSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTV-VSSKGLSEFHAEIAVLTKVRHRHLVALLGYCI----EGNEKLLVYEYLPNGTLAQHLFE----
  .. ..|.|.|| ||||    |.  ||| . .  . .... |.||..|.. . | || ... ..|.|.    .  . . | ||.| |.|.  |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RGAKPLDWKRRLV---IALDVARGMEYLHELAHRS--FIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIE--TRLAGTFGYLAPEYAVTGRVTT
    ..||| ...    .|.|.|||| .||.   .   .||||||..|.| |...|.||.|||| ..  ...      .  .|| .. |||  .  . . 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC---CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVFSFGVVLMELITG
||||.||| || |. |.
KADVYSFGIVLWEILTR
Kinase IRAKj_c-2.AA S_TKc 608-887 22 2.1e-44 154.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 608-887
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FSRDTILGRGGFGVVYKGVLDD-GTSIAVKRMEASTVVSSKGLSEFHAEIAVLTKVRHRHLVALLGYCIEGNEKLLVYEYLPN--GTLAQHLFERGA---
.    ..|.|.||.|||..  . |   |.|..             .  ||..| | .| ..| |.... . ..  .| ||...  |.| ... .||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KPLDWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIETRLAGTFGYLAPEYAVTGRVTT-KADVFSFGV
 .|..  .   ..  .....||.|.   . .|||||||.|||||.  . |..|||| ..         | . ||  |.|||       .. |.|. |.|.
RFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLMELITGRRALDESQSEENMHLVTWFRRTHQGRESFARMIDPALLEGTEDKVEGIYTVAELAKHCTAREPYNRPDMGHAVS-----VLAPLV
.| |...|.   .  | .. ....                                  . .. ..|  ..| .||    |        . | .
ILYEMLCGYPPFP--QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKj_c-2.AA TK 608-806 17 7.1e-44 144.5 In-house 1-389 (486) Show / Hide 
Range on Protein: 608-806
Range on HMM: 1-389/486
Sequence Identity: 17% (68 aa)

FSRDTILGRGGFG---VVYKGVLDDG--------------------------TSIAVKRMEASTVVSSKGLSE--------------FHAEIAVLT--KV
      ||.| ||   .|||| . ..                          |  ||| . . .  |..   .              . .|....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVALLGYCIEGNEK------------LLVYEYLPNGT----LAQHLFERGAK--------------------------------------------
.| ..| |.|.| .| .|            ..| || |.|     | ..| ..  |                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLDWKRRLVIALDVARGMEYLHELAHR---SFIHRDLKPSNILLDDDYR-----------AKVSDFG---
                              .|. ...| .....|.||||||..  .    |.||||   |.|......           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LVKLAPEGKYSIETRLAGTFG-------------------------YLAPEYAV---------TGRVTTKADVFSFGVVLMELIT
     | .  .....   ..  || .                         ..|||            .|. ||| ||.||||.. |. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKj_c-2.AA Pkinase_Tyr 608-806 31 1.2e-43 148.41 Pfam 1-209 (270) Show / Hide 
Range on Protein: 608-806
Range on HMM: 1-209/270
Sequence Identity: 31% (67 aa)

FSRDTILGRGGFGVVYKGVLD-----DGTSIAVKRMEASTVVSSKGLSEFHAEIAVLTKV-RHRHLVALLGYCIEGNEK---LLVYEYLPNGTLAQHLFE
 . .  ||.| ||.||||...     ...  ||| .  ..  .   . .| .|......  .| ..| |.| |..  |    ..| || |.| |  .| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--GAKPLDWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLA-PEGKYSIETRLAGTFGY--LAPEYAVTGRVTTKAD
.  . .||. |. | .....|.|||||..   . .|||||   |.|....  .|..|||| ..  ... | . .|  | .    .|||   .|. ||| |
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VFSFGVVLMELIT
| ||||.. |..|
VWSFGVLMWEIFT
Kinase IRAKj_c-2.AA TKL-Unique 612-807 30 6.3e-43 148.93 In-house 3-224 (290) Show / Hide 
Range on Protein: 612-807
Range on HMM: 3-224/290
Sequence Identity: 30% (69 aa)

TILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIAVLTKVR-HRHLVALLGYCI----EGNEKLLVYEYLPNGTLAQHLFE--------
  .|.||.|.||||.   |...|.|. .    .|.. . ||. |. .. | . |  .| . |||.      ..  .| ||.| |.|  .|          
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

RGAKPLDWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDD-----YRAKVSDFGLVKLAPEGKYSIETRL--------AGTFGYLAPEYAVT
.  ..|....|. .|.|.|.||.||| .     ||||||.||.|.| .     ...|..||||.|..     .. ...         |.| ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GRVTTKADVFSFGVVLMELITG
     ..|.||.|||.|| |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKj_c-2.AA LRRK 608-813 24 7.4e-43 148.7 In-house 1-285 (351) Show / Hide 
Range on Protein: 608-813
Range on HMM: 1-285/351
Sequence Identity: 24% (72 aa)

FSRDTILGRGGFG-VVYKGVLDD---------------------------GTSIAVKRMEA----STVVS----------------------------SK
. .   .|||||| .||.. . .                           ....|.| ..     ..  .                            ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

GLSEFHAEIAVLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFERGAKP-------LDWKRRLVIALDVARGMEYLHELAHR-SFIHRDLKPS
 ..||. |.... . .| ..| |.|.||  .   .| ||.|.|.| ..|...   .       ..|  .| |||..|.||||||   |. ..||||||. 
AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSP

NILL---D---------DDYRAKVSDFGLVK---LAPEGKYSIETRLAGTFGYLAPEYAVTG---RVTTKADVFSFGVVLMELITGR-RALDE
||||   .         ... ||..|||.       ..|   .  .. |..|..|||    .     |.|.|..|||..| ||.|.. .. ||
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG---VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAKj_c-2.AA MLK 608-808 28 1.3e-41 142.16 In-house 1-233 (291) Show / Hide 
Range on Protein: 608-808
Range on HMM: 1-233/291
Sequence Identity: 28% (66 aa)

FSRDTILGRGGFGVVYKGVLDDGT----SIAVKRMEAST---VVSSKGLSEFHAEIAVLTKVRHRH----LVALLGYCIE-GNEKLLVYEYLPNGTLAQH
.   ...| |.||.|.||.    .     .|||| .|..   ....    .|  |.  | ...|.      ....| |.. ... ..| ||...| |.  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFERGAKPL------------DWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDD------DYRAKVSDFGLVKLAPEGKYSIETRLAGTFGY
| ..  |.             |    . .||..||||.|||..|    ||||||..|||.|.      .  .|..|||...   . . .  .  |||. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

LAPEY---AVTGRVTTKADVFSFGVVLMELITGR
 |||    .  .... |.||.|.|||| |..|..
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKj_c-2.AA TyrKc 608-883 25 4.6e-41 143.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 608-883
Range on HMM: 1-280/280
Sequence Identity: 25% (79 aa)

FSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIAVLTKV--RHRHLVALLGYCIEG-------NEKLLVYEYLPNGTLAQHLFE
 . . .||.| ||.||||...  .  ||| . ...      . .|. |. ...|.  .| ..|.|.|.|...          ..| || |.| | ..| .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RGAKPLDWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEG--------KYSI----ETRLAGTFGYLAPEYAVTG
.. | | .|  | .....|.||||||.     .|||||   |.|.......|.||||| .   ..         |.      ..       .|||   .|
HRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

RVTTKADVFSFGVVLMELITGRRALDESQSEEN-----MHLVTWFRRTHQGRESFARMIDPALLEGTEDKVEGI------YTVAELAKHCTAREPYNRPD
. ||| ||.||||.. |. |     .  |  ..     |     ...  ||.    ||  |.  .      . .        . .. | | ...| .|| 
KFTTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGY----RMPQPPNDY------P-MSFVCCPDEMYQIMKQCWHEDPEDRPT

MGHAVSVL
.   .. .
FSEIHECF
Kinase IRAKj_c-2.AA DRK 615-806 35 2e-39 131.24 In-house 8-197 (258) Show / Hide 
Range on Protein: 615-806
Range on HMM: 8-197/258
Sequence Identity: 35% (69 aa)

GRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIAVLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFERGAKPLDWKRRLVIAL
|||..| |. |    || .|||.. .  .   . |.||| || .. . ||   .  .| | .  . . . ||.| | |.. | .   . .|| ... ...
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE-MDWPLMKQMMF

DVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVK--LAPEGKYSIETRLAGTFGYLAPEYAVTGRVTTKADVFSFGVVLMELIT
|.|.|| |||       ||||||  | | |. .. ||.||||       . .    |   || .  |||     | | ||||.||..|| |..|
DCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAKj_c-2.AA TK-Unique 608-806 26 1.7e-35 119.87 In-house 1-234 (294) Show / Hide 
Range on Protein: 608-806
Range on HMM: 1-234/294
Sequence Identity: 26% (63 aa)

FSRDTILGRGGFGVVYKGVLDDGT-------SIAVKRMEASTVVSSKGLSEFHAEIAVLTKVR-HRHLVALLGYCIEG-NEKLLVYEYLPNGTLAQHLFE
.  . ..|.| || |..| .  ..       ..|||  ...    .|  ..|  ||... ..  | ..| .||.|..  .  ....||.|.|.|  .| .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDK--QDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

RGAK------------------------PLDWKRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVK-LAPEGKYSIE-TRLA
.. .                        |.. |. . .| ..|.|||||...  . ..||||  .|.|| .|...|..|||. . .  .|.|| . ..  
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTFGYLAPEYAV--TGRV-TTKADVFSFGVVLMELIT
    ..|||.    .|   ||| || ||||.. |. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAKj_c-2.AA LISK 613-756 33 1e-29 93.56 In-house 1-151 (296) Show / Hide 
Range on Protein: 613-756
Range on HMM: 1-151/296
Sequence Identity: 33% (52 aa)

ILGRGGFGVVYKGVLD-DGTSIAVKRMEA--STVVSSKGLSEFHAEIAVLTKVRHRHLVALLGYCIE-GNEKLLVYEYLPNGTLAQHLFERG--AKPLDW
..|.|.|| |||| .  .|. .|.|  .    ..     .  .  |.... . ||.. |   | | .   .  .| ||   |.| | |. ..   .|| |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

KRRLVIALDVARGMEYLHELAHRSFIHRDLKPSNILLD----DDYRAKVSDFGL
. |. ||||.|.||.|||.   .  ||||||  |.|..    ...|.|| |||.
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGF
Kinase IRAKj_c-2.AA LISK 789-810 54 1e-08 24.23 In-house 217-238 (296) Show / Hide 
Range on Protein: 789-810
Range on HMM: 217-238/296
Sequence Identity: 54% (12 aa)

TTKADVFSFGVVLMELITGRRA
....||||||.|| |.||...|
DESCDVFSFGIVLCEIITRVKA
Kinase IRAKj_c-2.AA TK 858-883 23 0.031254 2.42 In-house 461-486 (486) Show / Hide 
Range on Protein: 858-883
Range on HMM: 461-486/486
Sequence Identity: 23% (6 aa)

VAELAKHCTAREPYNRPDMGHAVSVL
...| . | ...|  ||..   .. |
YYDLMQQCWHYDPEDRPTFSQLHEQL