IRAKk_g

Species: S.moellendorffii
Alias: IRAKk_g
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKk

Sequence

Name Sequence Type Origin Length Description Download
IRAKk_g.AA Protein None 314 None Fasta, JSON
IRAKk_g.NA RNA None 945 None Fasta, JSON
IRAKk_g.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of IRAKk_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKk_g.AA IRAK 14-214 36 4.1e-79 269.15 In-house 1-225 (317) Show / Hide
Range on Protein: 14-214
Range on HMM: 1-225/317
Sequence Identity: 36% (81 aa)

FSEENLIGEGGFARVYKAQLDDDH-AIAVKKLSTEND----QADEEFRA---EINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQG
|...|.||||||. ||..|..      |||||  ..|    . ...|..   |. .. |..|||. .|.|.......  |.|..|.||||.|.|.. .. 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

AA---LTWHLRLKIALDAARGLEYLHDHC-DPPVIHRDFKSSNILLDEDFNAKLSDFGLALMV----QEGAGSL------QLQGTFGYVAPEYIL--TGI
 .   |.|| |..|.. .|.|...||.     |.||.| ||.|||||..|..|..||||.          ....       ..||  | .||.|   .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTEKSDVYAFGVVLLELITGRKPID
|| |.||| ||.||||..||... .
LTKKTDVYSFGIVLLEVLTGCRAVY

Kinase IRAKk_g.AA TKL 20-212 24 1.4e-68 234.13 In-house 1-288 (364) Show / Hide
Range on Protein: 20-212
Range on HMM: 1-288/364
Sequence Identity: 24% (74 aa)

IGEGGFARVYKAQLDD---------DHAIAVKKLSTENDQAD---------------------------EEFRAEINLMGRIHHPNLIALLGFSSQGED-
||.|||. |||...           .  .||||....||. .                           .... ||..| |..|||.. ..|.. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCD-----PPVIHRDFKSSNILLDEDFN-------------
              ...|.. .||| ..|.         ||.|...|||.|||..||| .       ||.|||| ||.|||.||...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKLSDFGLALMVQEGAG--------------------SLQLQGTFGYVAPEYIL----------------TGILTEKSDVYAFGVVLLELITGRKP
 .|..||||. ....  .                    .    ||... ||| .                  .  .||.|||.||.|| |..|...|
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

Kinase IRAKk_g.AA LRRK 14-214 27 4.1e-55 189.4 In-house 1-284 (351) Show / Hide
Range on Protein: 14-214
Range on HMM: 1-284/351
Sequence Identity: 27% (79 aa)

FSEENLIGEGGFA-RVYKAQLDD---------------------------DHAIAVKKLSTE-----NDQAD----------------------------
. .|..||.|||. .||.| . .                           .  .|.||. ..     ||  .                            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

--EEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGA------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSN
   ||| |. .| . .|||.. |.||.   . . .. |....|.|.. |. ..| .       ..|.|.|||||. |.|.||||.| .||.|||| || |
AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPN

ILL---D---------EDFNAKLSDFGLAL--MVQEGAGSLQLQGTFGYVAPEYILTG---ILTEKSDVYAFGVVLLELITGR-KPID
|||   .         .. .||..|||.     .   ..   . |..|..||| .  .     |||.|.|.||..| ||.|..  | |
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase IRAKk_g.AA MLK 14-212 27 3.3e-45 154.76 In-house 1-235 (291) Show / Hide
Range on Protein: 14-212
Range on HMM: 1-235/291
Sequence Identity: 27% (66 aa)

FSEENLIGEGGFARVYKAQLDDDH----AIAVKKLS--TENDQAD-----EEFRAEINLMGRIHHPN----LIALLGFSSQ-GEDRLLIYELMTNGSLQD
. ..  ||.|.|  |.|..          .|||.    .. | .|     ..|. |...  .. |||     |...| ..| . . ... | . .||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

QLQG-PAQGA----------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDE------DFNAKLSDFGLALMVQEG-AGSLQLQGTFGY
 | | . ...            . .. ...||. |||..||| .  .|.|||| ||.|||.||      . ..| .|||.. ....  .     .||. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

VAPEYI---LTGILTEKSDVYAFGVVLLELITGRKP
 ||| |     .  .||.||. .|||| |..|.. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase IRAKk_g.AA Pkinase 14-210 26 4.2e-45 160.56 Pfam 1-209 (293) Show / Hide
Range on Protein: 14-210
Range on HMM: 1-209/293
Sequence Identity: 26% (57 aa)

FSEENLIGEGGFARVYKAQLDDDHA-IAVKKLSTENDQADEEFRA-----EINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNG----SLQDQLQGPA
.  .  ||.|.|..|||..  ..    |||... . .. ... ..     || .| |..||| . |...   . .  .. |.. .|    .| | ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

QGAAL--TWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNA----KLSDFGLALM--VQEGAGSLQLQGTFGYVAPEYIL-TGILTEKS
.. ..  ...   ....  .|||||.|..    .|||| |..|||.|.. .     |..|||||       .     . || .|.||| |.     . |.
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYAFGVVLLELITGR
|....|..| |...||
DMWSCGCILYEMLCGR

Kinase IRAKk_g.AA TKL-Unique 18-209 33 8.2e-45 155.19 In-house 3-224 (290) Show / Hide
Range on Protein: 18-209
Range on HMM: 3-224/290
Sequence Identity: 33% (75 aa)

NLIGEGGFARVYKAQL-DDDHAIAVKK-LSTENDQADEEFRAEINLMGRIH-HPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQ-------GPA
|.|||||...|||.    .. || ... ..  . .  .||. |.|.| ..| |||.  . |..     .  .. .. | .  ||| | |.         .
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

QGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDED-----FNAKLSDFGLALMVQEG-AGSLQ---------LQGTFGYVAPEYILTG
.   |.. .|.|.|.|.|.|..||| ||.||.|||| ||||.|.|..     .|.|..||||.       ....           .|.| ..||| .|..
NNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-VLRM

---ILTEKSDVYAFGVVLLELITG
     .||||||.||.|| |..|.
NFCQYSEKSDVYSFGIVLWEIATR

Kinase IRAKk_g.AA Dicty4 14-212 34 6.3e-43 141.1 In-house 1-216 (277) Show / Hide
Range on Protein: 14-212
Range on HMM: 1-216/277
Sequence Identity: 34% (76 aa)

FSEENLIGEGGFARVYKAQLDDDHAIAVKKLSTENDQADE----EFRAEINLMGRIHHPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQG----
   |..||.|.|. |||.      . |||||   |. .||    |||.|...|. | |||.. ..| .     . .. .   |.|  |.|   |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

PAQGAALTWHLRLK---IALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQ----LQGTFGYVAPEYILTGILTEKS
  |   | | |...   .|.|||||. .||  |.| .|||| ||.|.| |.....| .||||. . ...    .      || ...|||       .||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYAFGVVLLELITGRKP
||| || || |. |.  |
DVYSFGIVLWEILTRQEP

Kinase IRAKk_g.AA TK 14-212 17 5.1e-42 138.17 In-house 1-394 (486) Show / Hide
Range on Protein: 14-212
Range on HMM: 1-394/486
Sequence Identity: 17% (69 aa)

FSEENLIGEGGFA---RVYKAQLDDD--------------------------HAIAVKKLSTENDQADEEFRA-----------------EINLMG--RI
   .. .||| |    .|||... ..                          .  ||| |  ......|||..                 |. .|     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNLIALLGFSSQGED------------RLLIYELMTNGS----LQDQLQGPAQGAA------------------------------------------
||||.. |.| ..|||              ... |.| .|.    |.| |.    ..                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTWHLRLKIALDAARGLEYLHDH----CDPPVIHRDFKSSNILLDEDFN-----------AKLSDFGLA
                               || | .| .....|.|.||||..      . ..|||    |.|..|. .           .|..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LMVQEGAGSLQLQGTFGY-----------------------------VAPEYIL---------TGILTEKSDVYAFGVVLLELIT-GRKP
      |    . ..     . ..                              ||| ..         .|. |.||||..|||.. |. | |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP

Kinase IRAKk_g.AA RIPK 20-212 28 1.6e-38 128.86 In-house 1-227 (290) Show / Hide
Range on Protein: 20-212
Range on HMM: 1-227/290
Sequence Identity: 28% (66 aa)

IGEGGFARVYKAQLDDDHAIAVKKLST-EN------DQADEEFRAEINLMGRIHHPNLIALLGFSSQGED------RLLIYELMTNGSLQDQLQGPA--Q
.| |||  |.||.  .    ..|| ..  .      ||  ..   |   | .. . .   ..||  . |.        .  | | |||| . |.     |
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQ-----------------GTFGYVAPEYIL-
   . | ||  .    ..|  |||.  .||.|||| | .|||.| .|..|..|||||   .   .| . |                 ||  | .|| .. 
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMM---WSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

-----TGILTEKSDVYAFGVVLLELITGRKP
     . . |.|.||| |..|. |. |...|
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP

Kinase IRAKk_g.AA Pkinase_Tyr 14-161 31 3.5e-38 129.94 Pfam 1-158 (270) Show / Hide
Range on Protein: 14-161
Range on HMM: 1-158/270
Sequence Identity: 31% (51 aa)

FSEENLIGEGGFARVYKAQLD-----DDHAIAVKKLSTENDQAD---EEFRAEINLMGRI-HHPNLIALLGFSS-QGED--RLLIYELMTNGSLQDQLQG
 .    .||| | .|||. ..     ..   |||.|    .. .   |.| .|...|  . ||||.. |.|  . |||    ... |.| .|.| | |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P-AQGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLA
.  .. .|| .  |..... |.|.|||...     ||||    |.|..|.. .| .|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA

Kinase IRAKk_g.AA DRK 39-208 36 8.9e-37 122.1 In-house 25-197 (258) Show / Hide
Range on Protein: 39-208
Range on HMM: 25-197/258
Sequence Identity: 36% (65 aa)

IAVKKLSTENDQ-AD--EEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCDPPV
.|||.|   |    .   ||. ||||| .  ||| .  .|      | . . | |  |||   |  ..    . | |......|.|.|. |||  |.| .
VAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES--IEMDWPLMKQMMFDCAKGMIYLH-CCNPII

IHRDFKSSNILLDEDFNAKLSDFGLAL----MVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELIT
|||| || | | || .  | .||||.     . | ..      || . .|||       ||| ||| |..|| |..|
IHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT

Kinase IRAKk_g.AA TK-Unique 14-208 25 5.5e-36 121.61 In-house 1-234 (294) Show / Hide
Range on Protein: 14-208
Range on HMM: 1-234/294
Sequence Identity: 25% (61 aa)

FSEENLIGEGGFARVYKAQLDD-------DHAIAVKKLS-TENDQADEEFRAEINLMGRIH-HPNLIALLGFSSQG-EDRLLIYELMTNGSLQDQLQGPA
.  ...|||| |  |.....         .. .|||.|   ..|. . .|  ||..|  .  |||.. .|| .    |. ..|.| . .|.||. |.  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

QG-----------------------AALTWHLRLKIALDAARGLEYLHD--H-CDPPVIHRDFKSSNILLDEDFNAKLSDFGLA--------LMVQEGAG
..                       .... .. . .| . |.|.|||.   . .    .|||  ..|.|| ||...|..|||.|        .. ... |
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

SLQLQGTFGYVAPEYIL--TGIL-TEKSDVYAFGVVLLELIT
 ...     . |||...  .|.  |.||||..|||.. |. |
RIPIR----WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase IRAKk_g.AA TyrKc 14-283 24 5e-34 120.28 SMART 1-280 (280) Show / Hide
Range on Protein: 14-283
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

FSEENLIGEGGFARVYKAQLDDDHAIAVKKLSTENDQADEEFRAEINLMGRI--HHPNLIALLGFSSQG-------EDRLLIYELMTNGSLQDQLQGPAQ
 . .  .||| | .|||....     |||.|  .     |.|. |...| ..  ||||...|.|  .|.       |  ... |.| .|.|.| |. .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEG--------AGSL----QLQ--GTFGYVAPEYILTGIL
   |..   |......|.| ||||..   ..||||    |.|..|.. .| |||||.  . ..          .     .          ||| | .|. 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TEKSDVYAFGVVLLELIT-GRKPIDV---SMPTGCQSLVTWATPQLTDRTRLPLIVD--------AAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGD
|.||||..|||.. |. | | .|        .   | .. .    . .. |.|   .        .  .          .  .   | . .|. ||   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEY----VKQGYRMPQPPNDYPMSFVCCPDE----------MYQIMKQCWHEDPEDRPTFSE

VVNSL
..  .
IHECF

Kinase IRAKk_g.AA S_TKc 14-287 22 4e-33 117.29 SMART 1-231 (231) Show / Hide
Range on Protein: 14-287
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FSEENLIGEGGFARVYKAQLDD-DHAIAVKKLSTENDQADEEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTN--GSLQDQLQGPAQGAA---
.   ..||.|.|..|||..  . ..  |.|...       | .| ||... . ||||.. |...    ..  .. |.. .  |.| | ..    .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELI
..     ...   ...|||.|.|    .|||| | .||||||  . |..|||||  .        . ||  |.||| .  |  ..|.|....|..| |..
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEML

TGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGDVVN-----SLIPLV
.|. | .  | .  . ..                               ..      | | .|. || . .. .      . | .
CGYPPFP-QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAKk_g.AA Pkinase_Tyr 181-212 51 1.2e-07 26.58 Pfam 182-214 (270) Show / Hide
Range on Protein: 181-212
Range on HMM: 182-214/270
Sequence Identity: 51% (17 aa)

APEYILTGILTEKSDVYAFGVVLLELIT-GRKP
||| | .|. |.||||..|||.. |..| |..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP

Kinase IRAKk_g.AA TK-Unique 265-283 36 0.02894 3.76 In-house 276-294 (294) Show / Hide
Range on Protein: 265-283
Range on HMM: 276-294/294
Sequence Identity: 36% (7 aa)

CVQSEPSYRPLIGDVVNSL
| |.||. || . .... |
CWQWEPEERPSFRQIKHRL