Gene IRAKk_a-1 (S.moellendorffii)

IRAKk_a-1

Species: S.moellendorffii
Alias: IRAKk_a-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKk

Sequence

Name Sequence Type Origin Length Description Download
IRAKk_a-1.AA Protein None 360 None Fasta, JSON
IRAKk_a-1.NA RNA None 1083 None Fasta, JSON
IRAKk_a-1.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of IRAKk_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKk_a-1.AA IRAK 72-282 40 6.6e-66 225.28 In-house 1-229 (317) Show / Hide 
Range on Protein: 72-282
Range on HMM: 1-229/317
Sequence Identity: 40% (92 aa)

FSERNIIGRGGFGCVYRGILADGR-VAAIKKL----DLEGKQGEEEFRV---EIEMLSRVQAPKLLELLGYCTEDEHRLLVYEYMAKGNLQQHLYPDDDD
|.. | || ||||||||| .     . |.|||    |.. .. ...|.    |.. ..| . | ...|.||||| .   |||.||. | |.  |   | .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

HGFVPLDWTTRLKIALDAAKGLEFLHEFV-TPPIIHRDFKCSNILLDDKLNAKLSDFGLAKVG---SNKVNGDV----STRVLGTHGYVAPEYVL--TGH
    || | .|..|.. .|.|..|||..    ||||.| | .|||||. ...|..||||.  |   |.|  . .      .| ||  | .||.    .| 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTTKSDVYSFGVVLLEILTGRVPVDMKRP
||.|.||||||.||||.|||. .|.  ||
LTKKTDVYSFGIVLLEVLTGCRAVYDDRP
Kinase IRAKk_a-1.AA TKL 78-347 20 4.6e-65 222.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 78-347
Range on HMM: 1-364/364
Sequence Identity: 20% (81 aa)

IGRGGFGCVYRGILAD---------GRVAAIKKLDLEGKQGE---------------------------EEFRVEIEMLSRVQAPKLLELLGYCTEDEH-
||.||||.||.|..           |.. |.||.  .  . .                           .....|| |.|| . | .. ..|||.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEYMAKGNLQQHLYPDDDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVT-----PPIIHRDFKCSNILLDDKLN----------
              .|.||. .|.|  .|             |  |...|||.|.|...||   .     ||||||| | .|||.|....          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----AKLSDFGLAKVGSNK-----------------VNGDVSTRVLGTHGYVAPEYVL----------------TGHLTTKSDVYSFGVVLLEILTGRVP
    .|..||||... |..                 .|.  . .. || .. |||                    .  ..|.||||||.|| ||||... 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-

VDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQ-------ALAGQYSMKELIQ------------------VAAIAAMCIQPEADYRPLMIDVVQSL
                     . ..   |. |       ..... ... .|                   .. .. .| ..... || . .... |
-------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKk_a-1.AA LRRK 72-278 28 3.6e-45 156.39 In-house 1-284 (351) Show / Hide 
Range on Protein: 72-278
Range on HMM: 1-284/351
Sequence Identity: 28% (81 aa)

FSERNIIGRGGFG-CVYRGILAD---------------------------GRVAAIKKLDLEG---------------------KQGE------------
. . . |||||||  |||... .                           .  .||||.....                      |.|            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-EEFRVEIEMLSRVQAPKLLELLGYCTEDEHRLLVYEYMAKGNLQQHLYPDDDDH-GFVP--LDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNI
  ||| |. ..|. . | .. |.|.|   ... .| ||.  |.|...|     |   |..  ..|...|||||. |||.|.|| . .||||||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LL---D---------DKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTG---HLTTKSDVYSFGVVLLEILTGR-VPVD
||   .         .  .||..|||.  .    .   |  ...|. |..||| .  .     |.|.|.||||..| |.||..  | |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAKk_a-1.AA Pkinase 72-276 27 4.2e-45 160.56 Pfam 1-211 (293) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-211/293
Sequence Identity: 27% (61 aa)

FSERNIIGRGGFGCVYRGILADGRV-AAIKKLDLEGKQGEEEFRV-----EIEMLSRVQAPKLLELLGYCTEDEHRLLVYEYMAKG----NLQQHLYPDD
.    .||.|.|||||...  . .   |.|..... .. ... .      ||... |.. |  ..|....... |  .| ||. .|     |  ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

DDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNA----KLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVL-TGHLTT
.. .|  ... .  ....  ..|||..|.     ||||| | .|||.|.. .     |..||||||. .   |.   | . || .|.||| ..   . ..
RHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVYSFGVVLLEILTGRVP
|.|..|.|..| | |.|| |
KVDMWSCGCILYEMLCGRPP
Kinase IRAKk_a-1.AA TKL-Unique 76-276 32 4e-44 152.9 In-house 3-233 (290) Show / Hide 
Range on Protein: 76-276
Range on HMM: 3-233/290
Sequence Identity: 32% (76 aa)

NIIGRGGFGCVYRGILADGRVAAIKKLD-LEGKQGE--EEFRVEIEMLSRVQ-APKLLELLGYCT----EDEHRLLVYEYMAKGNLQQHLY----PDDDD
| ||.||.| ||.|. .   | |||..  .|..  |  .||. |.  ... . .| .. . |||.       .. .| ||.  |.|  .|          
NKIGEGGYGQVYKGKWRGYPV-AIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

HGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDK-----LNAKLSDFGLAKVGSNKVNGDVS-------TRVLGTHGYVAPEYVLT
    .|..  |.|.|.|.|.|...||   .| ||||| | ||.|.| .     .|.|..||||.|. |.  .. ..       . ..|.  ..||| ||.
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-VLR

G---HLTTKSDVYSFGVVLLEILTGRV------P
.   . ..||||||||.|| ||.|. .      |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAKk_a-1.AA TK 72-276 17 7e-42 137.68 In-house 1-394 (486) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-394/486
Sequence Identity: 17% (68 aa)

FSERNIIGRGGFG---CVYRGILADGR--------------------------VAAIKKLDLEGKQGEEE-----------------FRVEIEMLS--RV
    . .|.| ||    ||.|.. ...                            |.| | ..  . .||                 .  |..|..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QAPKLLELLGYCTED------------EHRLLVYEYMAKGN----LQQHLY--PDDDDHGFV--------------------------------------
. | .. |.|.||..            |. ..| |||..|.    |...|   ...  |                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLDWTTRLKIALDAAKGLEFLHEF----VTPPIIHRDFKCSNILLDDKLN-----------AKLSDFGLA
                              .|.  ..| .....|.|.|.||.     . . ..|||  . |.|......           .|..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KVGS----NKVNGDVSTRVLGTHG----------------------------YVAPEYVL---------TGHLTTKSDVYSFGVVLLEILT-GRVP
..||     ... |   .. ...|                            . ||| ..         .|. ||||||.||||.. ||.| |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAKk_a-1.AA Dicty4 72-273 35 3.2e-41 135.32 In-house 1-213 (277) Show / Hide 
Range on Protein: 72-273
Range on HMM: 1-213/277
Sequence Identity: 35% (76 aa)

FSERNIIGRGGFGCVYRGILADGRVAAIKKL--DLEG--KQGEEEFRVEIEMLSRVQAPKLLELLGYCT----EDEHRLLVYEYMAKGNLQQHLYP-DDD
    ..||.|.|| ||.|.     | |.|||  . ..      .||| |.. ..  . | .. ..|.||    . .  . | ||| ||||   |     .
INIEQRIGKGSFGEVYKGTWRGKEV-AVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

DHGFVPLDWTTRLK---IALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDFGLAK-VGSNKVNGD-VSTRVLGTHGYVAPEYVLTGHL-TT
    ..|||.....   .|.|||.|.  ||.  .| ||||| | .|.| |. ...| .||||..     . ..|  .| . || ...||| |. ..  . 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPE-VMMHQPYNE

KSDVYSFGVVLLEILTG
|.|||||| || ||||.
KADVYSFGIVLWEILTR
Kinase IRAKk_a-1.AA S_TKc 72-351 23 3.8e-37 130.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 72-351
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

FSERNIIGRGGFGCVYRGILAD-GRVAAIKKLDLEGKQGEEEFRVEIEMLSRVQAPKLLELLGYCTEDEHRLLVYEYMAK--GNLQQHLYPDDDDHGFVP
.   ..||.|.||.||...  . ||. |||...       | .| ||..|.. . | .  |.... . .|  .| ||.    |.| ...       . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTGHLTT-KSDVYSFGVVL
..  .  ...   ...||..|.     ||||| | .|||||.  . |..|||||..          | . ||  |.||| .   . .. |.|..|.|..|
FPE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEILTGRVPVDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQALAGQYSMKELIQVAAIAAMCIQPEADYRPLMIDVVQ-----SLAPLV
 | |.|. | .                       .  | .. .          ..  .   | | . . ||   .. |      . | .
YEMLCGYPPFP----------------------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKk_a-1.AA Pkinase_Tyr 72-276 30 6.1e-37 125.73 Pfam 1-214 (270) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-214/270
Sequence Identity: 30% (69 aa)

FSERNIIGRGGFGCVYRGILA-----DGRVAAIKKLDLEGKQGE----EEFRVEIEMLSRV-QAPKLLELLGYCT-EDEH--RLLVYEYMAKGNLQQHLY
 .    .|.| || ||.|..      ..   |.|.|  ||   |    |.|  |.....   . |... |.| || ..|.   ..| |||..|.|  .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

PDDDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDFGLAKVG-------SNKVNGDVSTRVLGTHGYVAPEYVLT
     ..  ||.  . |..... |||.|.|..     .||||  . |.|..... .| .|||||.           . .|..  . .      |||   .
KHR--EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM------APECINY

GHLTTKSDVYSFGVVLLEILT-GRVP
|  ||||||.||||.. ||.| |. |
GKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAKk_a-1.AA MLK 72-276 25 2.9e-36 123.34 In-house 1-235 (291) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-235/291
Sequence Identity: 25% (62 aa)

FSERNIIGRGGFGCVYRGILADGR----VAAIKKLD--LEGKQGE-----EEFRVEIEMLSRVQAPK----LLELLGYCTEDEH-RLLVYEYMAKGNLQQ
. .  .|| |.|| |..|     .    . |.|. .   .   ..     ..|. |.. |.... |       ...| |.....  ..| ||...| |  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLYPDDDDHGF---------VPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDD------KLNAKLSDFGLAKVGSNKVNGDVSTRVLGT
 |. . .....         .  |    ...||. |.|...||.   .|||||| | .|||.|.      ....| .|||...  ...   .  .   ||
VLH-GARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

HGYVAPEYVL----TGHLTTKSDVYSFGVVLLEILTGRVP
  . ||| |.     .  . |.||.|.|||| |.||..||
YAWMAPE-VIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAKk_a-1.AA RIPK 78-276 27 3.8e-35 117.21 In-house 1-227 (290) Show / Hide 
Range on Protein: 78-276
Range on HMM: 1-227/290
Sequence Identity: 27% (64 aa)

IGRGGFGCVYRGILADGRVAAIKKL------DLE-GKQGEEEFRVEIEMLSRVQAPKLLELLGYCTEDEH------RLLVYEYMAKGNLQQHLYPDDD-D
.|.|||| |..   .. .. ..||       . .  .| ...   | ... . .    . ..| | . |         .| |||..|.|   | .  .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

HGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDFGLAKV--GS--NK-------VNGDVSTRVLGTHGYVAPEYVLTG
|  .|.. . |  .    . |  .||   .||||||| | .|||.|  ...|..|||||.   .|  ..       | .  |    ||. | .||  .|.
HHPDPWPLRCR--MIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

HLTT------KSDVYSFGVVLLEILTGRVP
          |.|||||..|. |.||.. |
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAKk_a-1.AA STE 72-276 21 1.5e-33 115.92 In-house 1-267 (359) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-267/359
Sequence Identity: 21% (60 aa)

FSERNIIGRGGFGCVYRGILAD----------------GRVAAIKKLDLEGKQG-----------------EEEFRVEIEMLSRVQ--APKLLELLGYCT
.    .||.|.|| ||...  .                |.. |||...|| ..                  ....  ||..... .   |   . .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------EHRLLVYEYMAKGNLQ---QHLYPDDDD------HGFVPLDWTTRLKIALDAAKG-LEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDF
 .       ..  .. |||. | |    .| |   ..      | . ... .   .|. .  || |..||.     ||||| |..||||     .||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLAKVGSNKVN--------------GDVSTRVLGTHGYVAPEYVLT------GHLTTKSDVYSFGVVLLEILTGRVP
|...  ....               .  .. . ||  . ||| ..       .. .||.|..|.| ...| .||..|
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase IRAKk_a-1.AA CZAK 72-276 30 2.5e-33 117.07 In-house 1-221 (279) Show / Hide 
Range on Protein: 72-276
Range on HMM: 1-221/279
Sequence Identity: 30% (70 aa)

FSERNIIGRGGFGCVYRGILADGRVAAIKKL------DLEGKQGEEEFRVEIEMLSRVQAPKLLELLGYCTEDE--HRLLVYEYMAKGNLQQHLYPDDDD
.     ||.| || ||..    | . |||..      .. . . |. |  |.  .|    |  .  || |.||   |.  | |.|  | | . |    .|
LKFGQTIGQGFFGEVYKAYWR-GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL----TD

HGFVPLD-WTTRLKIALDAAKGLEFLHEFVTP-PIIHRDFKCSNILLDDKLN-------------AKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEY
| |  .     ....|.| |.|  .||   .| ||.|||   .|||||. .              .| .|||| .    .  .   |   |   . ||| 
HYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSRE--MMEQPFEMTQTMGCLCWMAPEC

VLTGHLTTKSDVYSFGVVLLEILTGRVP
      | |.|||||| .| .|.|.. |
FKGENYTEKVDVYSFGMILWCIITCDQP
Kinase IRAKk_a-1.AA TyrKc 72-347 22 3.1e-30 107.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 72-347
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FSERNIIGRGGFGCVYRGILADGRVAAIKKLDLEGKQGEEEFRVEIEMLSRV--QAPKLLELLGYCTED-------EHRLLVYEYMAKGNLQQHL-YPDD
 .   ..|.| || ||.|..   .  |.|.|  .    .|.|. |.......  . | .. |.|.||..       |  ..| |||..|.|...| .. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

DDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHRDFKCSNILLDDKLNAKLSDFGLAKVGSNK-VNGDVSTRVLGT----HGY-------VAPEYV
.      | . . |......|.| |.||.    ..||||  . |.|..... .| |||||.. . ..  .| .|. .  .    .|         |||  
K------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI

LTGHLTTKSDVYSFGVVLLEILTGRVPVDMKRPAGEG----VLVSWALPRLTDRDKLVGMVD----QALAGQYSMKELIQVAAIAAMCIQPEADYRPLMI
 .|  ||||||.||||.. ||.|     . . |  .     .  . .. .. ... .  . .           .      .  |  .| . ... || . 
NYGKFTTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------FVCCPDEMYQIMKQCWHEDPEDRPTFS

DVVQSL
.... .
EIHECF