Gene IRAKm_k-1 (S.moellendorffii)

IRAKm_k-1

Species: S.moellendorffii
Alias: IRAKm_k-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_k-1.AA Protein None 856 None Fasta, JSON
IRAKm_k-1.NA RNA None 2571 None Fasta, JSON
IRAKm_k-1.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of IRAKm_k-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_k-1.AA B_lectin 95-193 27 2.4e-22 78.35 Pfam 1-137 (137) Show / Hide 
Range on Protein: 95-193
Range on HMM: 1-137/137
Sequence Identity: 27% (38 aa)

SGVCVWAANRD---SPV-----TENATVRVTG-QGALEVADWD-G-KV--VWSS------PGGVS--EMELRDTGNFVLY-NST--GGISWQS--FDHPT
.   || ||||   .||     ..|.|  ...  | | . | . | .|  |||.       |...   ... |.||.||| ..   . . |||  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DILLEGQVMVT------KQR----LISSANSS--SLA
| .| |. . .       ..    |.|.....    .
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_k-1.AA B_lectin 52-167 29 1.3e-21 79.02 SMART 1-126 (126) Show / Hide 
Range on Protein: 52-167
Range on HMM: 1-126/126
Sequence Identity: 29% (38 aa)

RLLRAGDSPLMSQSGRFG--LSFFRFHNSAEFYFALVLGSSNNTNSGVCVWAA--NRDSPVTE---NATVRVTGQGALEVADWDGKVVWSSPGG----VS
...  ..  | | .. |   | ||.| ..  ..   . ....|     .||.|  |||.||..   ..... .  | | . |  ...||||  .    ..
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNK-QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNY

EMELRDTGNFVLYNST----GGISWQSFDHP
 ..|.|.||||.|..     |.. |||||||
VAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAKm_k-1.AA PAN_AP 379-455 17 4.5e-07 30.74 SMART 1-85 (85) Show / Hide 
Range on Protein: 379-455
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

AENHHFLNVSGAGYFSNNYT----KADRVSTLSECWSLCLANFSCSALFYNKQSSTCFFVD--RMYGGLT------RDPNFDGFLKLQN
 . ..|. .... .  .. .    .   | .| ||...|| |.|| .  |.. ...| . .  .. |. .        ||.  ..  .|
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKm_k-1.AA TKL 531-808 20 2e-68 233.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 531-808
Range on HMM: 1-364/364
Sequence Identity: 20% (82 aa)

LGKGGFGTVYEGTLAD---------GRKVAVKRLENRN----------------------------QSDRGFLAEMASLGRISHHNVVQLYGFCSEKNQ-
.|.||||.|| |..           |. ||||..  .|                            .    .  |. .. |..| |.||..|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LMLVYEYVVNGSLDKWLFEDRCLDWQSRRDIALGVAQGLAYLHEESR-----QLIIHLDIKPENVLLDDKFR--------------PK
            |..|.||. .|||   |       |. | ..||..|.|..||| .         ||| |.|..|.|.|....              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LSDFGMAKLLKTR-----------------DVSQTVTDVRGTPGYLAPEWLLHS----------------VATKKCDVYSYGMVLLELIGGRRNLSKLGG
..||| .. ....                 . ..|   ..|||...||| |  .                 ...||||||.|.|| |.. ..|       
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------

HGGEDCCEAPMDEEEQALWWYFPAWVVARVSKREFLKVVDTRIRDSVD------------EDEVKSMLQVALWCIQDNPSQRPPMDTVVQML
              .. .. . . .     .. .| .|.| . |  ..            .|  .|| . . .| . .|..|| ...... |
-------------PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAKm_k-1.AA Pkinase 525-720 29 2.4e-59 208.28 Pfam 1-209 (293) Show / Hide 
Range on Protein: 525-720
Range on HMM: 1-209/293
Sequence Identity: 29% (63 aa)

GNFASSLGKGGFGTVYEGTLADGRK-VAVKRLENRNQSDRGF-----LAEMASLGRISHHNVVQLYGFCSEKNQLMLVYEYVVNG----SLDKWLF--ED
  . . .|.|.||.||...  . .| ||||... |....        |.| . . |..| |.|.||... .|. . .| ||. .|    .|  ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RCL--DWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRP----KLSDFGMAKLLKTRDVSQTVTDVRGTPGYLAPEWLL-HSVATKKCD
.|.  ...  ..... ...||.|.|..    ||| |.||||.|.|..  .    |..||| ||...    ..  |.. |||.|.|||... ..  ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGMVLLELIGGR
..|.| .| |.. ||
MWSCGCILYEMLCGR
Kinase IRAKm_k-1.AA IRAK 527-808 32 6.4e-53 182.12 In-house 1-317 (317) Show / Hide 
Range on Protein: 527-808
Range on HMM: 1-317/317
Sequence Identity: 32% (104 aa)

FASS--LGKGGFGTVYEGTLADGR-KVAVKRLENR-----NQSDRGFLA---EMASLGRISHHNVVQLYGFCSEKNQLMLVYEYVVNGSL-DKWLFEDR-
|. .  .|.||||.|| | .      .|||.| .      |.... |..   |. .. |. | |.| |||.|.|  .. |||.|  |||| |     |  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-C---LDWQSRRDIALGVAQGLAYLHEES-RQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLL--KTRDVSQTV-----TDVRGTPGYLAPEWLL--HSV
     | |. | .|..| | |. .||. .    ||| |||. |.|||. | ||..|||..     .    .||.       ||||  |..|| .      
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ATKKCDVYSYGMVLLELIGGRRNLSKLGGH--GGEDCCEAPMDEEEQ------ALWWYFPAWVVARVSKR-EFLKVVDTRIRDSVDEDEVKSMLQVALWC
 ||| |||| | ||||.. |.|   . . .  .  | ||  |.|. .       ||    .   |   .     | .| |. . ......|.|.|.|. |
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPP-CPPNMEKEMCQCACCC

IQDNPSQRPPMDTVVQML
       |..|. |.| |
GHHRANRRCDMAWVMQQL
Kinase IRAKm_k-1.AA MLK 525-717 27 1.7e-41 141.69 In-house 1-230 (291) Show / Hide 
Range on Protein: 525-717
Range on HMM: 1-230/291
Sequence Identity: 27% (65 aa)

GNFASSLGKGGFGTVYEGTLADGRK-----VAVKRLE-------NRNQSDRGFLAEMASLGRISHHN----VVQLYGFCSEKNQ-LMLVYEYVVNGSLDK
 .|   .|.|.|| |. |.   ..      ||||| .           ... |  |   | ..|| |    ..|.|| |.. .. . .| ||. .|||  
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLFE--------------DRCLDWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDD------KFRPKLSDFGMAKLLKTRDVSQTVTDVRGTP
 | .              ||  | ..  ..|| .|.|..|||.. ...||| |.|. |.|.|.      .   | .||| .. .....  .. .. .||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY

GYLAPEWL---LHSVATKKCDVYSYGMVLLELI
 . ||| .    ..  ..||||.|.|.|| |..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_k-1.AA TKL-Unique 527-717 28 8.6e-41 141.61 In-house 1-222 (290) Show / Hide 
Range on Protein: 527-717
Range on HMM: 1-222/290
Sequence Identity: 28% (64 aa)

FASSLGKGGFGTVYEGTLADGRKVAVKRLEN----RNQSDRGFLAEMASLGRIS-HHNVVQLYGFCS----EKNQLMLVYEYVVNGSLDKWLF-------
| ...| ||.|.|| |. . | .||.|....    .|.. . |  |   . ..  | |.|...|.|       ... .| ||.  |||.. |        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---EDRCLDWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDK-----FRPKLSDFGMAKLLKTRDVSQTV-------TDVRGTPGYLAPEWL
   .   |..| | ..|. .|||. ||| ..   |||.|.|. |.|.| .     .. |..||| .|...... . .        ... |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LH--SVATKKCDVYSYGMVLLELI
    .  ..|.||||.|.|| |..
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_k-1.AA S_TKc 525-815 23 1.5e-39 138.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 525-815
Range on HMM: 1-231/231
Sequence Identity: 23% (71 aa)

GNFASSLGKGGFGTVYEGTLAD-GRKVAVKRLENRNQSDRGFLAEMASLGRISHHNVVQLYGFCSEKNQLMLVYEYVVN--GSLDKWLFEDRC------L
  .   .|||.||.|| ..  . ||.||.|..       . .. |.. | .  | |.|.||... . . | .| ||. .  |.| . . . ..      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLLKTRDVSQTVTDVRGTPGYLAPEWLLHSVATK-KCDVYSYGMVLL
.    | ..  ....|.|.|.   . ||| |.||||.|||.  . |..|||.|..|         | . ||| |.||| |     .| |||..| | .| 
PE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELIGGRR---NLSKLGGHGGEDCCEAPMDEEEQALWWYFPAWVVARVSKREFLKVVDTRIRDSVDEDEVKSMLQVALWCIQDNPSQRPPMDTVVQ--MLE
|.. |.    .. ..  . |                                                 .....    | | .|..||    . |  .. 
EMLCGYPPFPQMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

GRKEIL
   . .
KCHPWF
Kinase IRAKm_k-1.AA LISK 530-721 30 2.1e-38 122.25 In-house 1-237 (296) Show / Hide 
Range on Protein: 530-721
Range on HMM: 1-237/296
Sequence Identity: 30% (72 aa)

SLGKGGFGTVYEGTLA-DGRKVAVKRLE------NRNQSDRGFLAEMASLGRISHHNVVQLYGFCSE-KNQLMLVYEYVVNGSLDKWLF-EDR---CLDW
..|||.|| || ||.  .|. .|.| ..      |..   . .| |.. . ...| |.|| .| | . . ||..| ||.  | |   |. .|     | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDK----FRPKLSDFGMAKLLKTRDVS---------------------QTVTDV-----R---
. | .|||..|.|..|||.   . ||| | |  |.|....    .| |. ||| |...  .. |                      .  .      .   
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

---GTPGYLAPEWLLHSVATKKCDVYSYGMVLLELIGGRR
   |||   ||| || .  . .|||.|.|.||.|.|....
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_k-1.AA Dicty4 526-716 33 1.1e-37 123.32 In-house 2-210 (277) Show / Hide 
Range on Protein: 526-716
Range on HMM: 2-210/277
Sequence Identity: 33% (70 aa)

NFASSLGKGGFGTVYEGTLADGRKVAVKRLENRNQSD-----RGFLAEMASLGRISHHNVVQLYGFCS----EKNQLMLVYEYVVNGSLDKWLFE-----
|. . .|||.||.|| ||   | .|||| | |.|| .       |..| . .. |.| |.....| |     ..  .. | ||.  |.| . |       
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--DRCLDWQSRRD---IALGVAQGLAYLHE-ESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLLKTRDVSQT-VTDVRGTPGYLAPEWLLHSVATKKC
     |||  ..    .|. .|.|...||.  ..  |||.|.|. | | |. .| | .||| ... |.    ..  . . |||.. ||| . |   . | 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGMVLLEL
||||.|.|| |.
DVYSFGIVLWEI
Kinase IRAKm_k-1.AA TK 525-716 15 1.1e-36 119.93 In-house 1-387 (486) Show / Hide 
Range on Protein: 525-716
Range on HMM: 1-387/486
Sequence Identity: 15% (62 aa)

GNFASSLGKGGFG---TVYEGTLADGR--------------------------KVAVKRLENR-NQSDRGFLA--------------EMASLGRIS----
  .   ||.| ||   .||.|.. ...                          .|||| |    ..|.. |..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHNVVQLYGFCSEK------------NQLMLVYEYVVNGS----LDKWLFEDRC---------------------------------------------
 | |.|.||| |...              .|.| ||. .|.    |...| . |                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWQSRRDIALGVAQGLAYLHEE----SRQLIIHLDIKPENVLLDDKFR-----------PKLSDFGMA
                               |. . .  ... .|.|..|||.       | ..| |.   |.|.... .            |..|||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLL---KTRDVSQ----TVTDVRGTPG-------------------------YLAPEWLLHSV---------ATKKCDVYSYGMVLLEL
.      .||. .    .... .||..                         ..||| |.. |          | | ||.|.| .. |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase IRAKm_k-1.AA Dicty4-Unclassified 526-719 32 2.6e-36 121.86 In-house 2-204 (263) Show / Hide 
Range on Protein: 526-719
Range on HMM: 2-204/263
Sequence Identity: 32% (69 aa)

NFASSLGKGGFGTVYEGTLADGRKVAVKRLENRNQSDR-----GFLAEMASLGRISHHNVVQLYGFC----SEKNQLMLVYEYVVNGSLDKWLF-----E
     .||| |  |. |    |. |||| .     . |      |..| . || |.| | |..|| |    | |  .. | |    | |           
QIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

DRCLDWQS--RRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLLKTRDVSQTVTDVRGTPGYLAPEWLLHSVATKKCDVYSY
.. .   .     .|. .|||...||  .|  .|| |||  |.|.|  |  |  |||..      |  .. | . |||   .|| | |   . | |||||
QQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GMVLLELIGG
.|.| ||. |
AMMLYELATG
Kinase IRAKm_k-1.AA CAMK 530-713 17 3e-36 113.79 In-house 1-324 (425) Show / Hide 
Range on Protein: 530-713
Range on HMM: 1-324/425
Sequence Identity: 17% (59 aa)

SLGKGGFGTVYEGTLA-DG------------RKVAVKRLENR----------------------------NQSDRG-FLAEMASLGR-------ISHHNV
 ||.|.||.|....   ..            .|||.| .. .                            ...||  .. |.. . .       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYG--------------------FCSEKNQLMLVY---EYVVNG----SLDKWLFEDRC---------------LDWQSRRDIALGVAQGLAYLHEES
..||                     | . .... .|    ||. .|     |  .. | .|               .. .  | .   ......|.|.  
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--

RQLIIHLDIKPENVLLDDK-----------------FRPKLSDFGMAKLLKTRDV---------------------SQTVTDVRGTPGYLA-PEWLLH--
 . |.|.|.||||.||||.                 .  |..|||.|. ..  .                       |  ... |||.| | ||.|.   
-HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

------------SVATKKCDVYSYGMVL
               ..|||. | | .|
HCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase IRAKm_k-1.AA DRK 532-717 34 3.1e-31 103.08 In-house 8-196 (258) Show / Hide 
Range on Protein: 532-717
Range on HMM: 8-196/258
Sequence Identity: 34% (66 aa)

GKGGFGTVYEGTLADGRKVAVKRLENRNQSDRGFLAEMAS----LGRISHHNVVQLYGFCSEKNQLMLVYEYVVNGSLDKWLFEDRC-LDWQSRRDIALG
|.|..| |. ||   | .||||.| | |  |  || |..     . .  | |..|  | | .      . ||   ||| . | ..   .||  .  ... 
GRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFD

VAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAK-LLKTRDVSQTVTDVRGTPGYLAPEWLLHSVATKKCDVYSYGMVLLELI
.| |. |||  .   ||| | |  | | |. .. | .||| .    | ..   . | . |||.  ||| |     | | ||||.. || |..
CAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKm_k-1.AA Pkinase_Tyr 531-717 26 5.6e-31 105.54 Pfam 7-208 (270) Show / Hide 
Range on Protein: 531-717
Range on HMM: 7-208/270
Sequence Identity: 26% (56 aa)

LGKGGFGTVYEGTLA-----DGRKVAVKRL-ENRNQSD---RGFLAEMASLGRI-SHHNVVQLYGFCS-EKNQ--LMLVYEYVVNGSLDKWLFE----DR
||.| ||.||.||.      .. .|||| | |.  ...   . |..|.. .  . .|.|.|.||| |. .. .  ...| ||. .|.|.. | .    ..
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

CLDWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLLKTRDVSQ-TVTD-----VRGTPGYLAPEWLLHSVATKKCDVY
 |. .   .... .|.|..||..     .|| |.   |.|.....  | .|||.|... . |    ....     .. .    ||| . ... | | ||.
PLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVW

SYGMVLLELI
|.| .. |..
SFGVLMWEIF
Kinase IRAKm_k-1.AA TyrKc 525-808 23 1e-25 92.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 525-808
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

GNFASSLGKGGFGTVYEGTLADGRKVAVKRLENRNQSDRGFLAEMASLGRI--SHHNVVQLYGFCSEK-------NQLMLVYEYVVNGSLDKWLFEDRC-
  .   || | ||.||.||.   ..|||| | .     . |. |.  . ..  .| |.|.||| |...        .||.| ||. .|.|.. | . |  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LDWQSRRDIALGVAQGLAYLHEESRQLIIHLDIKPENVLLDDKFRPKLSDFGMAKLLKTRD---VSQTVTDVR---GTPG-----YLAPEWLLHSVATKK
| ..   .... .|.| .|||.     .|| |.   |.|...... | ||||... ..  |   .|. . ...   |. .      .||| . ... | |
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDVYSYGMVLLELIGGRRNLSKLGGHGGEDCCEAPMDEEEQALWWYFPAWVVARVSKREFLKVVDTRIRDSVDED--------EVKSMLQVALWCIQDNP
 ||.|.| .. |.                  .. |  ...|             .| .| .. |... |    ..          . | |. ..| . .|
SDVWSFGVCMWEIF---------------TYGQQPYPGMIQQ-----------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

SQRPPMDTVVQML
..|| . .... .
EDRPTFSEIHECF
Kinase IRAKm_k-1.AA DRK 790-810 33 4.7e-05 13.11 In-house 238-258 (258) Show / Hide 
Range on Protein: 790-810
Range on HMM: 238-258/258
Sequence Identity: 33% (7 aa)

CIQDNPSQRPPMDTVVQMLEG
|   .|..|| |. ... || 
CWNEDPQHRPSMQECLERLEA
Kinase IRAKm_k-1.AA TK 785-808 20 9e-05 11.08 In-house 463-486 (486) Show / Hide 
Range on Protein: 785-808
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

QVALWCIQDNPSQRPPMDTVVQML
.. . | . .|..|| .......|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKm_k-1.AA Dicty4-Unclassified 789-808 40 0.000576 9.43 In-house 244-263 (263) Show / Hide 
Range on Protein: 789-808
Range on HMM: 244-263/263
Sequence Identity: 40% (8 aa)

WCIQDNPSQRPPMDTVVQML
||  . |  || |. ..| |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_k-1.AA LISK 784-808 32 0.000821 8.04 In-house 272-296 (296) Show / Hide 
Range on Protein: 784-808
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

LQVALWCIQDNPSQRPPMDTVVQML
|.....|.  .|. ||  ...|| |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKm_k-1.AA MLK 790-808 36 0.003485 7.05 In-house 273-291 (291) Show / Hide 
Range on Protein: 790-808
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CIQDNPSQRPPMDTVVQML
| ...|..|| .. .|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_k-1.AA Dicty4 789-810 33 0.017316 4.31 In-house 254-277 (277) Show / Hide 
Range on Protein: 789-810
Range on HMM: 254-277/277
Sequence Identity: 33% (8 aa)

WCIQDNPSQRPPMDTVVQM--LEG
||   .|..|| .  ..|   || 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKm_k-1.AA TKL-Unique 790-808 42 0.018191 4.73 In-house 272-290 (290) Show / Hide 
Range on Protein: 790-808
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CIQDNPSQRPPMDTVVQML
|  ..|||||  |...  |
CWHHDPSQRPSFDEIIHRL
Kinase IRAKm_k-1.AA Pkinase_Tyr 788-808 23 0.247102 5.14 Pfam 250-270 (270) Show / Hide 
Range on Protein: 788-808
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LWCIQDNPSQRPPMDTVVQML
. | . .|..|| .  ....|
KQCWHYDPEDRPTFSEIHEQL