Gene IRAKm_m (S.moellendorffii)

IRAKm_m

Species: S.moellendorffii
Alias: IRAKm_m
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_m.AA Protein None 872 None Fasta, JSON
IRAKm_m.NA RNA None 2619 None Fasta, JSON
IRAKm_m.kin_dom Protein Kinase Domain None 225 None Fasta, JSON

Protein domain

Protein domains of IRAKm_m.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_m.AA B_lectin 96-196 26 8.1e-17 59.37 Pfam 1-137 (137) Show / Hide 
Range on Protein: 96-196
Range on HMM: 1-137/137
Sequence Identity: 26% (36 aa)

AAVPVWIANR-------TGST-GDGSSLMLTGTHKKFILLNSQ-G-SL--TWKL-DVTGIAG------IELEESGNLAFF-DES--GARIWQS--FDSPG
   .|| |||       |.|. . ...| ....    .|.... | |    |   ..|  .|       .. .||||  . |..  .. .|||  || |.
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTMLPGQALKS------GMS----LTSSARNG--SAA
||.|||. |        .|.    |||.. |.    .
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_m.AA B_lectin 50-170 23 3e-06 20.39 SMART 1-126 (126) Show / Hide 
Range on Protein: 50-170
Range on HMM: 1-126/126
Sequence Identity: 23% (32 aa)

YRILGNGSVDFVSDNGTFA--LAFFDPNATGDFFLCVMMQGRASGKERAAVPVWIA--NRTGSTGDG---SSLMLTGTHKKFILLNSQGSLTWKLDVT--
  .|..| .  ||.|..|   | || ..    . ...   .          .|| |  ||..   ||   . | .. ..  .....  ..  |  ..|  
DNTLSSGQTL-VSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNK---QRTVVWVAQPNRDNPVHDGNNSCYLTMQ-SDGNLVIYD--NRPVWSSNTTRN

-GIAGIELEESGNLAFFDES----GARIWQSFDSP
 |    .| ..||.  .|..    |  ||||||.|
NGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAKm_m.AA PAN_AP 364-439 19 0.00021 21.79 SMART 1-85 (85) Show / Hide 
Range on Protein: 364-439
Range on HMM: 1-85/85
Sequence Identity: 19% (17 aa)

IYNHHFLNATGIRYFSTGF---VAPSKRSSLQECSTDCLSNCQCMALFYNDRSRECFFVG--DALIGSM-------AEDPAVDAFIKF
   ..|.   .... ....   |  .   ||.||   || ||.|..  |.. ...| .    . |...         ..  || ..| 
CCDDCFVRMPNMKL-FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKm_m.AA TKL 529-823 19 3.8e-59 202.82 In-house 1-364 (364) Show / Hide 
Range on Protein: 529-823
Range on HMM: 1-364/364
Sequence Identity: 19% (81 aa)

LGAGGFGSVYEGFLGD---------GRHVAVKKLEGTGTQGA---------------------------RQFIAEVATIGSINHMNVVRLCG--------
.| |||| || | .           |. |||||.  .  .                              ... |.  . ...| |.|.. |        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FCLE----DSQRMLVYEFMPNGSLDRWLFGGGGSSGGSGGGGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHE----ECSEP--IIH
 .|..    ..| ..|.|..|.|||   |                                     |..|. .||..|||..|||      |  .  |||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIH

LDVKPQNILLDDRFV--------------AKVADFGMSKQLDDHDVSQVITC-----------------VRGTPGYLAPEWLLHS---------------
 | |..|||.|. .               .|..||| |. .. .  .. .                   ..|||...||| |  .               
RDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKG

-IATKKCDVYSFGMVLLEIIGGRKNLEVSRMNIDLAWYFPAWVVNEVR---LGNLMGVVDPKVRSSAS------------EKVATRLVHIALWCIQENAG
  ...||||||||.|| ||. ...            .| .     ...      .|.|.| . |                . . ...  .. .| .... 
FEYSEKCDVYSFGIVLWEILTRCR-----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPE

SRPAMDEVVRMI
.|| ..|..  .
KRPSFQEILKRL
Kinase IRAKm_m.AA Pkinase 525-749 25 1.1e-48 172.86 Pfam 3-209 (293) Show / Hide 
Range on Protein: 525-749
Range on HMM: 3-209/293
Sequence Identity: 25% (61 aa)

FSRKLGAGGFGSVYEGFLGDGRH-VAVKKLEGTGTQG--ARQFIA--EVATIGSINHMNVVRLCGFCLEDSQRMLVYEFMPNG----SLDRWLFGGGGSS
. ||.|.|.||.||..   . .. ||||...  ..     .. .   |..   ..|| |.||| ... ...   .| |....|    .| ... .     
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----

GGSGGGGGGGGGGAEGIGDGNRSPELRTL--GWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDRFVA----KVADFGMSKQLDDHDVSQVI
                        . ...   ..  . ... ..|||.|.|..    ||| |.||.|||.|.. .     |..||| .||.| .  ..  
-----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-M

TCVRGTPGYLAPEWLL-HSIATKKCDVYSFGMVLLEIIGGR
| . |||.|.|||... ..  ..|.|..|.| .| | . ||
TTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKm_m.AA LISK 528-750 26 2.4e-38 122.09 In-house 1-237 (296) Show / Hide 
Range on Protein: 528-750
Range on HMM: 1-237/296
Sequence Identity: 26% (70 aa)

KLGAGGFGSVYEGFLG-DGRHVAVKKLEG-----TGTQGARQFIAEVATIGSINHMNVVRLCGFCLE-DSQRMLVYEFMPNGSLDRWLFGGGGSSGGSGG
..| |.||.|| | .  .|. .|.|...            . .. ||... .. | |.|.  | | . |.| ..| |..  | | . |.  .        
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK-------

GGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDR----FVAKVADFGMSKQLDDHDVS----------
                       | |. |. |||. |.|..|||. .   ||| | | .|.|....    . .||.|||  . .|. . |          
-------------------HKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDES

-----------------------QVITCVRGTPGYLAPEWLLHSIATKKCDVYSFGMVLLEIIGGRK
                       .  |.. |||   ||| || .  . .|||.|||.||.|||...|
DPCMDNDMPMKRKIPKKCMNQRKRRMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_m.AA MLK 523-746 26 3.3e-37 126.67 In-house 1-230 (291) Show / Hide 
Range on Protein: 523-746
Range on HMM: 1-230/291
Sequence Identity: 26% (65 aa)

KGFSRKLGAGGFGSVYEGFLGDGRH-----VAVKKLE-------GTGTQGARQFIAEVATIGSINHMN----VVRLCGFCLED-SQRMLVYEFMPNGSLD
  |....|.|.||.|. |    ..      ||||. .        |... ...|  |.     ..| |    .... | ||.. ..  .| |....||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCE-QWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

RWLFGGGGSSGGSGGGGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDD------RFVAKVADFGMSKQ
. | |. . . ..                ...    |.   |  . .||  |||..|||..   |||| | |..|||.|.        ..|..||| |. 
NVLHGARSKWMDAN--------------HNQK--NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD

LDDHDVSQVITCVRGTPGYLAPEWL---LHSIATKKCDVYSFGMVLLEII
. ...  .  .. .||. . ||| .    ..  ..||||.|.|.|| |..
WHQMC--TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_m.AA Pkinase_Tyr 525-746 25 9.1e-37 125.15 Pfam 3-208 (270) Show / Hide 
Range on Protein: 525-746
Range on HMM: 3-208/270
Sequence Identity: 25% (62 aa)

FSRKLGAGGFGSVYEGFLG-----DGRHVAVKKL-EGTGTQG--ARQFIAEVATIGSI-NHMNVVRLCGFCL-EDSQ--RMLVYEFMPNGSLDRWLFGGG
| .|||.| ||.||.| .      .. .||||.| ||.  .    . |..|...  .. .| |.||| | |. .. .   ..| |.||.|.|.  |    
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

GSSGGSGGGGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQL--DDHD-VSQV-
                          .. . |   . .....  |.|..||..     .|| |.   |.|... .|.|..|||... .  ||   ...  
--------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGG

-ITCVRGTPGYLAPEWLLHSIATKKCDVYSFGMVLLEII
    .. .    ||| . ... | | ||.||| .. ||.
GKLPIKWM----APECINYGKFTTKSDVWSFGVLMWEIF
Kinase IRAKm_m.AA IRAK 644-750 41 6.8e-32 110.37 In-house 106-222 (317) Show / Hide 
Range on Protein: 644-750
Range on HMM: 106-222/317
Sequence Identity: 41% (49 aa)

LGWDRRIEIALGTARGLAYLHEECSE-PIIHLDVKPQNILLDDRFVAKVADFGMSKQL--DDHDVSQVI-----TCVRGTPGYLAPEWLL--HSIATKKC
| | .|..|..|||.|. .||.  .  |||| |.|. |||||..|..| .|||.        |  .|..       ||||  |..|| .     . ||| 
LSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKT

DVYSFGMVLLEIIGGRK
|||||| ||||.. |..
DVYSFGIVLLEVLTGCR
Kinase IRAKm_m.AA RIPK 529-750 23 5.7e-31 102.75 In-house 1-226 (290) Show / Hide 
Range on Protein: 529-750
Range on HMM: 1-226/290
Sequence Identity: 23% (62 aa)

LGAGGFGSVYEGFLGDGRHVAVKKL-EGTG------TQGARQFIAEVATIGSINHMNVVRLCGFCLED-----SQ-RMLVYEFMPNGSLD-----RWLFG
.| |||| |.  .  . .....||   .         |   . . |..   .. . ..|.. ||| .      ..   .| |.|.||||      .| . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY-

GGGSSGGSGGGGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHEECSE-PIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDHDVSQVI
                               . . |. |  .   ...|  |||  .   ||||.| ||.|||.|  | .|.|||| .. .     |.. 
-----------------------------QHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWM---MWSHSH

T--C-----------VR-GTPGYLAPEWLL----HS--IATKKCDVYSFGMVLLEIIGGRK
.  |            | ||  |..|| ..     .  ..|.| |||||..|. |.  ...
QDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKH
Kinase IRAKm_m.AA TK 525-745 15 6.4e-30 96.89 In-house 3-387 (486) Show / Hide 
Range on Protein: 525-745
Range on HMM: 3-387/486
Sequence Identity: 15% (65 aa)

FSRKLGAGGFG---SVYEGFL--------------------------GDGRHVAVKKLEGTGTQGARQFIA--------------EVATIGSIN-----H
. .|||.| ||    ||.| .                          |    |||| |  . .. ...|..              |.. .   .     |
LGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHH

MNVVRLCGFCLED------------SQRMLVYEFMPNGS----LDRWLFGGGG----------------------SSGGSGGGGGGGGGGAEGIGDGNRS
 |.||| | |...               |.| |.||.|.    |. .|    .                      ..                       
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC-----------------------

PELRT---------------------------------------------------LGWDRRIEIALGTARGLAYLHEE----CSEPIIHLDVKPQNILL
    .                                                   |   ... ...  |.|..|||.         ..| |.   |.|.
----MKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLV

DDRFV-----------AKVADFGMSK-------QLDDHDVSQVITCVRGTPG-------------------------YLAPEWLLHSI---------ATK
... |           .|.||||.|.         ...|   . .  .||..                         ..||| |.. .          | 
GENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTT

KCDVYSFGMVLLEI
| ||.||| .. ||
KSDVWSFGVLMWEI
Kinase IRAKm_m.AA TyrKc 525-823 22 1.4e-28 102.22 SMART 3-280 (280) Show / Hide 
Range on Protein: 525-823
Range on HMM: 3-280/280
Sequence Identity: 22% (73 aa)

FSRKLGAGGFGSVYEGFLGDGRHVAVKKLEGTGTQGARQFIAEVATIGSI--NHMNVVRLCGFCLED-------SQRMLVYEFMPNGSLDRWLFGGGGSS
. .||| | || ||.| .   . ||||.|        . |. |     ..  .| |.||| | |...        . |.| |.||.|.|.  |   ..  
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

GGSGGGGGGGGGGAEGIGDGNRSPELRTLGWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDHD---VSQVITCV
                            | ..  .....  |.| .|||.    ..|| |    |.|.......|..|||.|. ..|.|   .|.    .
----------------------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

R---GTPG-----YLAPEWLLHSIATKKCDVYSFGMVLLEIIGGRKNLEVS-----RMNIDLAWYFPAWVVNEVRLGNLMGVVDPKVRSSASEKVATRLV
.   |. .      .||| . ... | | ||.||| .. ||    .            |...     ..| .  |.     .  | . .       . . 
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI----EYVKQGYRMPQPPNDY-P-MSF---VCCPDEMY

HIALWCIQENAGSRPAMDEVVRMI
 | ..| .|.. .|| . |... .
QIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKm_m.AA Dicty4-Unclassified 650-748 39 2.4e-25 83.73 In-house 112-204 (263) Show / Hide 
Range on Protein: 650-748
Range on HMM: 112-204/263
Sequence Identity: 39% (39 aa)

IEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDHDVSQVITCVRGTPGYLAPEWLLHSIATKKCDVYSFGMVLLEIIGG
| .|.  |.|...||   .  .|| |.|  |||.|  | .|.||||.|      |  .  | . |||   .|| | |   . | ||||..|.| | . |
IKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKm_m.AA Dicty4 646-745 38 3.6e-25 81.05 In-house 108-210 (277) Show / Hide 
Range on Protein: 646-745
Range on HMM: 108-210/277
Sequence Identity: 38% (40 aa)

WDRRIE---IALGTARGLAYLHE-ECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDHDVSQV-ITCVRGTPGYLAPEWLLHSIATKKCDVYSFGM
| ...    .|. .|||...||.  .   |||.| |. |.| |. ...||.||| |.    |   .   . . |||.. ||| . |   . | ||||||.
WPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGI

VLLEI
|| ||
VLWEI
Kinase IRAKm_m.AA STE 652-749 31 6.6e-23 77.8 In-house 156-265 (359) Show / Hide 
Range on Protein: 652-749
Range on HMM: 156-265/359
Sequence Identity: 31% (37 aa)

IALGTARG-LAYLHEECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDH--------------DVSQVITCVRGTPGYLAPEWLLHSI------AT
|.  . .| |.|||.     ||| |.||.||||     .| .||| ..||.|.              . .|  . . ||| . ||| ..          .
ICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKCDVYSFGMVLLEIIGGR
 |||..|.| ...| . |.
TKCDIWSLGCTIIEMATGK
Kinase IRAKm_m.AA S_TKc 523-799 22 2.2e-21 78.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 523-799
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

KGFSRKLGAGGFGSVYEGFLGD-GRHVAVKKLEGTGTQGARQFIAEVATIGSINHMNVVRLCGFCLEDSQRMLVYEFMPN--GSLDRWLFGGGGSSGGSG
  . ||.| |.||.|| .   . ||.||.|..        .... |..   . .| |.|.| ... . .   .| |....  |.| . .           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI-----------

GGGGGGGGGAEGIGDGNRSPEL-RTLGWDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDRFVAKVADFGMSKQLDDHDVSQVITCVRGTPGY
              . .... | . .   .   ..  ....|.|.|.     ||| |.||.|||||.  . |..|||...||         | . ||| |
--------------KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWY

LAPEWLLHSIATKKCDVYSFGMVLLEIIGGRKNLEVSRMNIDLAWYFPAWVVNEVRLGNLMGVVDPKVRSSASEKVA-------TRLV
.||| |  .  ..|||..|.| .| | . |.   .    .... .           . . . ..||. | .| |  .          .
MAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKm_m.AA TKL-Unique 646-746 33 4.2e-21 71.28 In-house 109-222 (290) Show / Hide 
Range on Protein: 646-746
Range on HMM: 109-222/290
Sequence Identity: 33% (39 aa)

WDRRIEIALGTARGLAYLHEECSEPIIHLDVKPQNILLDDR-----FVAKVADFGMSKQLDDHDVSQVI-------TCVRGTPGYLAPEWLLH--SIATK
. .|. .|.  |.|. |||  |. ||||.| |..|.|.| .     . .|..||| || ..  . . ..       . . |.. ..||| |    .  ..
MQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSE

KCDVYSFGMVLLEII
|.||||||.|| ||.
KSDVYSFGIVLWEIA
Kinase IRAKm_m.AA IRAK 526-604 35 2.1e-15 51.21 In-house 4-90 (317) Show / Hide 
Range on Protein: 526-604
Range on HMM: 4-90/317
Sequence Identity: 35% (31 aa)

SRKLGAGGFGSVYEG-FLGDGRHVAVKKLEGTG----TQGARQFIA---EVATIGSINHMNVVRLCGFCLEDSQRMLVYEFMPNGSL
....| |||| || | . . .  .|||||  .     ..  ..| .   |. .  .. | |.| | |.|.| ..  |||..||||||
DNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSL
Kinase IRAKm_m.AA TKL-Unique 525-605 30 1.6e-13 44.19 In-house 1-88 (290) Show / Hide 
Range on Protein: 525-605
Range on HMM: 1-88/290
Sequence Identity: 30% (27 aa)

FSRKLGAGGFGSVYEGFLGDGRHVAVKKLEG---TGTQGARQFIAEVATIGSIN-HMNVVRLCGFCL----EDSQRMLVYEFMPNGSLD
|. |.|.||.|.|| |  . |  ||.|...       .  . |. || ..  .. | |.|.. |.|       ... .| |..| |||.
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLY
Kinase IRAKm_m.AA Dicty4-Unclassified 525-604 33 2.8e-12 38.32 In-house 3-89 (263) Show / Hide 
Range on Protein: 525-604
Range on HMM: 3-89/263
Sequence Identity: 33% (30 aa)

FSRKLGAGGFGSVYEGFLGDGRHVAVKKLEGTGTQGAR-----QFIAEVATIGSINHMNVVRLCGFCLED----SQRMLVYEFMPNGSL
  . .| | |  |. |    |. |||||.   .   .|      | .||.  ||| | | |.. | |.      |  . | |||. | |
IDQFIGKGHFSKVHKGNW-KGKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL
Kinase IRAKm_m.AA Dicty4 525-604 31 2.9e-07 20.45 In-house 3-89 (277) Show / Hide 
Range on Protein: 525-604
Range on HMM: 3-89/277
Sequence Identity: 31% (28 aa)

FSRKLGAGGFGSVYEGFLGDGRHVAVKKL--EGTG--TQGARQFIAEVATIGSINHMNVVRLCGFCL----EDSQRMLVYEFMPNGSL
.  ..| |.||.|| |    |  ||||||    ..        | .||.  ..| | |.. . | |.    . .  . | |.|| |.|
IEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL
Kinase IRAKm_m.AA STE 525-605 18 4.5e-07 21.14 In-house 1-125 (359) Show / Hide 
Range on Protein: 525-605
Range on HMM: 1-125/359
Sequence Identity: 18% (23 aa)

FSR--KLGAGGFGSVYEGFLGD----------------GRHVAVKKLE----------------GTGTQGAR-QFIAEVATIGSIN--HMNVVRLCGFCL
. .  |.| |.||.|| .   .                |. .|.|...                 .  .  . |.. |. .    |  | |.|.  | ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------SQRMLVYEFMPNGSLD
 .       ..  .. |.|..||||
KEGHNHKNDDELWICMEYMDGGSLD
Kinase IRAKm_m.AA TK 801-823 13 0.009789 4.14 In-house 464-486 (486) Show / Hide 
Range on Protein: 801-823
Range on HMM: 464-486/486
Sequence Identity: 13% (3 aa)

IALWCIQENAGSRPAMDEVVRMI
. . | ....  || ........
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKm_m.AA MLK 805-823 21 0.05385 2.87 In-house 273-291 (291) Show / Hide 
Range on Protein: 805-823
Range on HMM: 273-291/291
Sequence Identity: 21% (4 aa)

CIQENAGSRPAMDEVVRMI
| ......|| ....|   
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_m.AA Dicty4-Unclassified 804-823 25 0.096515 1.7 In-house 244-263 (263) Show / Hide 
Range on Protein: 804-823
Range on HMM: 244-263/263
Sequence Identity: 25% (5 aa)

WCIQENAGSRPAMDEVVRMI
||  .    || |....   
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_m.AA IRAK 792-823 18 0.12994 1.69 In-house 286-317 (317) Show / Hide 
Range on Protein: 792-823
Range on HMM: 286-317/317
Sequence Identity: 18% (6 aa)

EKVATRLVHIALWCIQENAGSRPAMDEVVRMI
....  .   |. |  . |  |..|..|.  .
PNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_m.AA Pkinase_Tyr 803-823 19 1.457142 2.53 Pfam 250-270 (270) Show / Hide 
Range on Protein: 803-823
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQENAGSRPAMDEVVRMI
. | ....  || . |.....
KQCWHYDPEDRPTFSEIHEQL