IRAKm_d-2

Species: S.moellendorffii
Alias: IRAKm_d-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_d-2.AA Protein None 848 None Fasta, JSON
IRAKm_d-2.NA RNA None 2547 None Fasta, JSON
IRAKm_d-2.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAKm_d-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_d-2.AA B_lectin 99-197 32 1.7e-24 85.77 Pfam 1-137 (137) Show / Hide
Range on Protein: 99-197
Range on HMM: 1-137/137
Sequence Identity: 32% (44 aa)

SGVCVWSANRD---NPV-----TENATLQLSD-QGLLQVMDSD-G-RV--VWNS----PRGV--S--GIEVQDSGNVVLY-DST--GGVSWQS--FDHPT
.   ||.||||   |||     ..|.||....  | | ..|.. | .|  ||..    ...   .    . ||||| ||| |.   . | |||  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DVLLEGQVIVT------GQS----LVSSSSSS--SLS
| .| |. . .      ...    |.|..|..    |
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS

B_lectin IRAKm_d-2.AA B_lectin 53-171 29 2.4e-20 74.86 SMART 1-126 (126) Show / Hide
Range on Protein: 53-171
Range on HMM: 1-126/126
Sequence Identity: 29% (40 aa)

RLLQAGNTSLVSQDGRFA--LSFFRFNDSPRYYFALVFGASNYTSSSASGVCVWSA--NRDNPVTE---NATLQLSDQGLLQVMDSDGRVVWNSPRG---
...  .. .||| .. |   | ||.|. .   .   ... ..         .||.|  ||||||..   ...| ... | | . |  .|.|| |  .   
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNK----QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNN

-VSGIEVQDSGNVVLYDST----GGVSWQSFDHP
 ..  ..||.||.|.||.     |.. |||||||
GNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP

PAN_AP IRAKm_d-2.AA PAN_AP 374-450 17 3.9e-05 24.3 SMART 1-85 (85) Show / Hide
Range on Protein: 374-450
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

AENHHFFNVTGAGYFSNNYT----KADRVSTLSDCWNLCLSNCSCSALFYNKQASTCFFVD--RMYGGLT------RDPNFDGFLKLQN
 . ..|  . .. .  .. .    .   | .| .|. .|| |||| .  |..  ..| . .  .. |. .        ||.  ..  .|
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN

Kinase IRAKm_d-2.AA TKL 526-803 20 1.6e-69 237.31 In-house 1-364 (364) Show / Hide
Range on Protein: 526-803
Range on HMM: 1-364/364
Sequence Identity: 20% (81 aa)

VGKGGYGTVFKGTLAD---------GRQVAVKRLE----------------------------DPKHSEKGFIAEMASLGRISHHNVVQLYGFCSEKNQ-
.|.||.|.|.||..           |. ||||..                             .... .. .. |. .. |..| |.||..|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LILVYEFMANGSLDKWLFEDGCLGWEIRRSIALGLARGLAYLHEESR-----QLIIHLDIKPDNVLLDDKFC--------------PK
            | .|.|.. .|||   |       |. | ..||. |||..||| .         ||| |.|..|.|.|...               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LADFGLAKLAKSR-----------------DASQTVTDVRGTPGYLAPEWLLNS----------------AATKKCDVYSYGMVLLELIGGRRNLSKRFI
..||||..  . .                 . ..|   ..|||...||| | ..                 ...||||||.|.|| |.. ..|       
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------

FGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVVDAKIRDTVE------------EDQVRKLVQVALWCIQDDPRRRPSMDAVVQML
              .. .. . . .   .  . .|  |.| . | ..             .|  . . . . .| . ||. |||.. ... |
-------------PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Pkinase IRAKm_d-2.AA Pkinase 520-715 27 1.9e-58 205.25 Pfam 1-209 (293) Show / Hide
Range on Protein: 520-715
Range on HMM: 1-209/293
Sequence Identity: 27% (60 aa)

ASFSSSVGKGGYGTVFKGTLADGRQ-VAVKRLEDPKHSEKGFIA-----EMASLGRISHHNVVQLYGFCSEKNQLILVYEFMANG----SLDKWLF--ED
  . . .|.|..|.|.|..  . .. ||||... .. ...  ..     | . . |..| |.|.||... .|. . .| |.. .|    .|  ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GCL--GWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCP----KLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLL-NSAATKKCD
||.   ..  ..... ..|||.|.|..    ||| |.||.|.|.|..  .    |..||||||...    ..  |.. |||.|.|||... ..  ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGMVLLELIGGR
..|.| .| |.. ||
MWSCGCILYEMLCGR

Kinase IRAKm_d-2.AA IRAK 522-716 37 2.5e-53 183.5 In-house 1-222 (317) Show / Hide
Range on Protein: 522-716
Range on HMM: 1-222/317
Sequence Identity: 37% (84 aa)

FSSS--VGKGGYGTVFKGTLADGR-QVAVKRLED-----PKHSEKGFIA---EMASLGRISHHNVVQLYGFCSEKNQLILVYEFMANGSL-DKWLFEDG-
|. .   |.||.|.|..| .      .|||.|       .. ... | .   |. .. |. | |.| |||.|.|  .. |||..|.|||| |     || 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-C---LGWEIRRSIALGLARGLAYLHEES-RQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLA--KSRDASQTV-----TDVRGTPGYLAPEWLL--NSA
     | | .| ||..|.|.|. .||. .    ||| |||. |.|||. | ||..||||.     .|   .||.       ||||  |..|| .      
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ATKKCDVYSYGMVLLELIGGRR
 ||| |||| | ||||.. |.|
LTKKTDVYSFGIVLLEVLTGCR

Kinase IRAKm_d-2.AA MLK 520-712 27 1.3e-40 138.66 In-house 1-230 (291) Show / Hide
Range on Protein: 520-712
Range on HMM: 1-230/291
Sequence Identity: 27% (64 aa)

ASFSSSVGKGGYGTVFKGTLADGRQ-----VAVKRLE---DPKHSE-----KGFIAEMASLGRISHHN----VVQLYGFCSEKNQ-LILVYEFMANGSLD
  |.  .|.|..| |.||.   ..      ||||| .   .   |.     . |  |   | ..|| |    ..|.|| |.. .. . .| |....||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

KWLFE--------------DGCLGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDD------KFCPKLADFGLAKLAKSRDASQTVTDVRGT
  | .              |.    .   ..||  |||..|||.. ...||| |.|. |.|.|.      .   | .|||...  ....  .. .. .||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

PGYLAPEWL---LNSAATKKCDVYSYGMVLLELI
. . ||| .    ..  ..||||.|.|.|| |..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML

Kinase IRAKm_d-2.AA TKL-Unique 522-712 28 1.3e-40 140.94 In-house 1-222 (290) Show / Hide
Range on Protein: 522-712
Range on HMM: 1-222/290
Sequence Identity: 28% (64 aa)

FSSSVGKGGYGTVFKGTLADGRQVAVKRLE---DPK-HSEKGFIAEMASLGRIS-HHNVVQLYGFCS----EKNQLILVYEFMANGSLDKWLF-------
|....| ||||.|.||. . | .||.|...   |.   ... |. |   . ..  | |.|...|.|       .....| |..  |||.. |        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--EDGC-LGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDK-----FCPKLADFGLAKLAKSRDASQTV-------TDVRGTPGYLAPEWL
  .. | | .. | ..|.  |.|. ||| ..   |||.|.|. |.|.| .     .  |..||||.|........ .        ... |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LN--SAATKKCDVYSYGMVLLELI
 .  .  ..|.||||.|.|| |..
RMNFCQYSEKSDVYSFGIVLWEIA

Kinase IRAKm_d-2.AA S_TKc 520-803 23 2.6e-39 137.85 SMART 1-231 (231) Show / Hide
Range on Protein: 520-803
Range on HMM: 1-231/231
Sequence Identity: 23% (71 aa)

ASFSSSVGKGGYGTVFKGTLAD-GRQVAVKRLEDPKHSEKGFIAEMASLGRISHHNVVQLYGFCSEKNQLILVYEFMAN--GSLDKWLFEDGC------L
  .   .|||..|.|.|..  . ||.||.|..       . .. |.. | .  | |.|.||... . . | .| |.. .  |.| . . . |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLLNSAATK-KCDVYSYGMVLL
     |...  ....|.|.|.   . ||| |.||.|.|||.  . |..|||||..          | . ||| |.||| |     .| |||..| | .| 
PE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELIGGRR--NLSKRFIFGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVVDAKIRDTVEEDQVRKLVQVALWCIQDDPRRRPSMDAVVQ------
|.. |.         .|   |                                               . . .    | | ||..||.   . |      
EMLCGYPPFP-QMQMMFKKIG----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

---ML
    .
CHPWF

Kinase IRAKm_d-2.AA LISK 525-716 28 2.8e-38 121.83 In-house 1-237 (296) Show / Hide
Range on Protein: 525-716
Range on HMM: 1-237/296
Sequence Identity: 28% (68 aa)

SVGKGGYGTVFKGTLA-DGRQVAVKRLE------DPKHSEKGFIAEMASLGRISHHNVVQLYGFCSE-KNQLILVYEFMANGSLDKWLF-EDG---CLGW
. |||..| |.|||.  .|. .|.| ..      . .  .| .. |.. . ...| |.|| .| | . . || .| |..  | |   |. .|     | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDK----FCPKLADFGLAKLAKSRDAS---------------------QTVTDV-----R---
. | .|||. |.|..|||.   . ||| | |  |.|....    .  |..|||.|...  .. |                      .  .      .   
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

---GTPGYLAPEWLLNSAATKKCDVYSYGMVLLELIGGRR
   |||   ||| || .  . .|||.|.|.||.|.|....
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK

Kinase IRAKm_d-2.AA STE 520-715 22 4.9e-37 128.34 In-house 1-265 (359) Show / Hide
Range on Protein: 520-715
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

ASFSSSVGKGGYGTVFKGTLAD----------------GRQVAVKRLE----DP--------------KHSEKGFIAEMASLGRIS--HHNVVQLYGFCS
  . . .|||..|||.|.   .                |. .|.|...    ..              .  .. .. |.  . . .  | |.|. || . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EK-------NQLILVYEFMANGSLDKWLFED-GCLG-------------WEIRRSIALGLARG-LAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFG
 .       ..| .. |.|..||||. . .  ||..              .. . |.  . .| |.|||.     ||| ||||.|.||      ||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAK-LAKSRD-------------ASQTVTDVRGTPGYLAPEWLLN------SAATKKCDVYSYGMVLLELIGGR
... |..| .              .|  . . ||| . ||| ...      .  . |||..| | ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

Kinase IRAKm_d-2.AA RIPK 526-715 28 2.8e-35 117.68 In-house 1-225 (290) Show / Hide
Range on Protein: 526-715
Range on HMM: 1-225/290
Sequence Identity: 28% (65 aa)

VGKGGYGTVFKGTLADGRQVAVKRLEDPKH--------SEKGFIAEMASLGRISHHNVVQLYGFCSEKNQ------LILVYEFMANGSLDKWLFEDGC--
||.|| |.||| . .. . ...|     ||         ..  . | . . .. . ..|..|||| ....      . .| |.|.|||| . |       
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LGWEIRRSIALGLARGLAYLHEESRQ-LIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVR--------------GTPGYLAPEWLL
   . |  |  .    ..|  |||  | .  |||.| || |.|.|  |  |.||||||.    .  |.  .| .              ||  |..|| ..
HHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATW---MMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

--NSAA----TKKCDVYSYGMVLLELIGGR
  |...    |.| ||||...|. |.  ..
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQK

Kinase IRAKm_d-2.AA Dicty4-Unclassified 521-714 33 5.5e-35 117.25 In-house 2-204 (263) Show / Hide
Range on Protein: 521-714
Range on HMM: 2-204/263
Sequence Identity: 33% (70 aa)

SFSSSVGKGGYGTVFKGTLADGRQVAVKRLEDPKHSEK-----GFIAEMASLGRISHHNVVQLYGFC----SEKNQLILVYEFMANGSLDKWLF-----E
     .|||    | ||    |. |||| . . | .        | .| . || |.| | |..|| |    | |  .. | |||  | |           
QIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

DGCLGWEI--RRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLLNSAATKKCDVYSY
.  .  .      .|.  |.|...||  .|  .|| |||  |.|.|  |  | ||||..      |  .. | . |||   .|| |   . . | |||||
QQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GMVLLELIGG
.|.| ||. |
AMMLYELATG

Kinase IRAKm_d-2.AA Dicty4 521-711 30 4.8e-33 107.68 In-house 2-210 (277) Show / Hide
Range on Protein: 521-711
Range on HMM: 2-210/277
Sequence Identity: 30% (65 aa)

SFSSSVGKGGYGTVFKGTLADGRQVAVKRL--EDPKHSE---KGFIAEMASLGRISHHNVVQLYGFCS----EKNQLILVYEFMANGSLDKWLFE-----
 . .  |||..|.|.|||   | .|||| |     . .|   . | .| . .. |.| |.....| |     ..  .  | |.|  |.| . |       
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--DGCLGWEIRRS---IALGLARGLAYLHE-ESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQT-VTDVRGTPGYLAPEWLLNSAATKKC
     | |. ...   .|.  |||...||.  ..  |||.|.|..| | |. .  | .||||... |     ..  . . |||.. ||| . . . . | 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGMVLLEL
||||.|.|| |.
DVYSFGIVLWEI

Kinase IRAKm_d-2.AA TK 520-711 15 4.1e-32 104.37 In-house 1-387 (486) Show / Hide
Range on Protein: 520-711
Range on HMM: 1-387/486
Sequence Identity: 15% (59 aa)

ASFSSSVGKGGYG---TVFKGTLADGR--------------------------QVAVKRLEDP-KHSEKGFIA--------------EMASLGRIS----
  .    |.| .|   .|.||.. ...                          .|||| | .   .|.. |..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHNVVQLYGFCSEK------------NQLILVYEFMANGS----LDKWLFEDGC---------------------------------------------
 | |.|.||| |...              ...| |.|..|.    |...| .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGWEIRRSIALGLARGLAYLHEE----SRQLIIHLDIKPDNVLLDDKFC-----------PKLADFGLA
                               |  . .  ... .|.|..|||.       | ..| |.   |.|....              |.|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LAKSRDA--SQTVTDVRGTPG-------------------------YLAPEWLL---------NSAATKKCDVYSYGMVLLEL
.     ||.  .     .... .||..                         ..||| |.         .   | | ||.|.| .. |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

Kinase IRAKm_d-2.AA Pkinase_Tyr 520-712 26 8.2e-30 101.6 Pfam 1-208 (270) Show / Hide
Range on Protein: 520-712
Range on HMM: 1-208/270
Sequence Identity: 26% (57 aa)

ASFSSSVGKGGYGTVFKGTLA-----DGRQVAVKRL-EDPKHSE---KGFIAEMASLGRI-SHHNVVQLYGFCS-EKNQ--LILVYEFMANGSLDKWLFE
 .|    |.| .|.|.|||.      .. .|||| | |.  |..   . |..|.. .  . .|.|.|.||| |. .. .  ...| |.|..|.|.. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----DGCLGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQ-TVTD-----VRGTPGYLAPEWLLNSAAT
    .. |  .   ....  |.|..||..     .|| |.   |.|...... | .|||||..    |    ....     .. .    ||| . ..  |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWM----APECINYGKFT

KKCDVYSYGMVLLELI
 | ||.|.| .. |..
TKSDVWSFGVLMWEIF

Kinase IRAKm_d-2.AA TyrKc 520-803 22 2.9e-21 77.88 SMART 1-280 (280) Show / Hide
Range on Protein: 520-803
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

ASFSSSVGKGGYGTVFKGTLADGRQVAVKRLEDPKHSEKGFIAEMASLGRI--SHHNVVQLYGFCSEK-------NQLILVYEFMANGSLDKWLFEDGC-
 ..    | | .|.|.|||.   .||||| | . .  .. |. |.  . ..  .| |.|.||| |...        .| .| |.|..|.|.. | . .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRD---ASQTVTDVR---GTPG-----YLAPEWLLNSAATKK
| ..   |...  |.| .|||.     .|| |.   |.|...... | .||||..  .. |   .|. . ...   |. .      .||| .  .  | |
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDVYSYGMVLLELIGGRRNLSKRFIFGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVVDAKIRDTVEED--------QVRKLVQVALWCIQDDP
 ||.|.| .. |.              . |    . ....      .  .        | .. |..  |    ..           .. |. ..| . ||
SDVWSFGVCMWEIF-------------TYGQQPYPGMIQQ------MMSNQ-------EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

RRRPSMDAVVQML
  ||.. .... .
EDRPTFSEIHECF

Kinase IRAKm_d-2.AA Dicty4-Unclassified 784-803 45 2e-06 17.65 In-house 244-263 (263) Show / Hide
Range on Protein: 784-803
Range on HMM: 244-263/263
Sequence Identity: 45% (9 aa)

WCIQDDPRRRPSMDAVVQML
||  .||..||.|. ..| |
WCWHNDPNKRPTMNQIIQYL

Kinase IRAKm_d-2.AA TK 780-803 25 3.3e-05 12.57 In-house 463-486 (486) Show / Hide
Range on Protein: 780-803
Range on HMM: 463-486/486
Sequence Identity: 25% (6 aa)

QVALWCIQDDPRRRPSMDAVVQML
.. . | . ||..||........|
DLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAKm_d-2.AA MLK 785-803 47 0.000122 12.17 In-house 273-291 (291) Show / Hide
Range on Protein: 785-803
Range on HMM: 273-291/291
Sequence Identity: 47% (9 aa)

CIQDDPRRRPSMDAVVQML
| ..||..|||.. .|| |
CWNQDPHKRPSFRQIVQHL

Kinase IRAKm_d-2.AA Dicty4 784-805 41 0.001034 8.45 In-house 254-277 (277) Show / Hide
Range on Protein: 784-805
Range on HMM: 254-277/277
Sequence Identity: 41% (10 aa)

WCIQDDPRRRPSMDAVVQM--LEG
||   || .|||.  ..|   || 
WCWDHDPQHRPSFEEIIQRRILEH

Kinase IRAKm_d-2.AA LISK 776-803 32 0.001386 7.29 In-house 269-296 (296) Show / Hide
Range on Protein: 776-803
Range on HMM: 269-296/296
Sequence Identity: 32% (9 aa)

RKLVQVALWCIQDDPRRRPSMDAVVQML
. .......|.  ||. ||| . .|| |
PPFLDLCFDCCKYDPKNRPSFKEIVQWL

Kinase IRAKm_d-2.AA IRAK 770-803 26 0.002698 7.73 In-house 284-317 (317) Show / Hide
Range on Protein: 770-803
Range on HMM: 284-317/317
Sequence Identity: 26% (9 aa)

VEEDQVRKLVQVALWCIQDDPRRRPSMDAVVQML
.... . .. |.|. |     .||..|. |.| |
CPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase IRAKm_d-2.AA TKL-Unique 785-803 42 0.061922 2.83 In-house 272-290 (290) Show / Hide
Range on Protein: 785-803
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CIQDDPRRRPSMDAVVQML
|  .||  ||| | ..  |
CWHHDPSQRPSFDEIIHRL

Kinase IRAKm_d-2.AA Pkinase_Tyr 783-803 28 0.079393 6.81 Pfam 250-270 (270) Show / Hide
Range on Protein: 783-803
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LWCIQDDPRRRPSMDAVVQML
. | . || .||.. .....|
KQCWHYDPEDRPTFSEIHEQL

Kinase IRAKm_d-2.AA Pkinase 784-803 31 1.176968 3.4 Pfam 272-293 (293) Show / Hide
Range on Protein: 784-803
Range on HMM: 272-293/293
Sequence Identity: 31% (7 aa)

WCIQDDPRRRPSMDAVVQM--L
||.. || .||. . ..|   .
WCLCKDPKKRPTAEQILQHPWF