Gene IRAKm_g (S.moellendorffii)

IRAKm_g

Species: S.moellendorffii
Alias: IRAKm_g
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_g.AA Protein None 860 None Fasta, JSON
IRAKm_g.NA RNA None 2583 None Fasta, JSON
IRAKm_g.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of IRAKm_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_g.AA B_lectin 129-197 31 5.3e-17 60.0 Pfam 39-137 (137) Show / Hide 
Range on Protein: 129-197
Range on HMM: 39-137/137
Sequence Identity: 31% (31 aa)

LSDLD-G-NT--VWST-D----PS--NATTIELQESGNLVLR-DAG--DREVWQS--FDNPSDVILEGQKMFT------GQR----LTSSKNRS----S
|.| . |  .  |||| .     .  |... ..|.||||||. |..  .. .|||  ||.|.| .| |.|. .      ...    |||.|. .    |
LYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_g.AA B_lectin 55-173 31 8.8e-17 63.0 SMART 1-126 (126) Show / Hide 
Range on Protein: 55-173
Range on HMM: 1-126/126
Sequence Identity: 31% (42 aa)

PAPSSPGEKLVSANGTFA--LCFFTFRGTEKSHLSIVIRSANSPNTSAAVVWTA--NRRDPIRGG---GALRWNSTKKSLDLSDLDGNTVWSTDPS---N
  . | |. ||| |..|   |.|||| .     . . |   |..|    ||| |  ||  | ..|   . |. .|    | . |  ...|||.. .   .
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ----WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSD-GNLVIYD--NRPVWSSNTTRNNG

ATTIELQESGNLVLRDAG----DREVWQSFDNP
 .. .||..||.|..| .    .. .|||||.|
NYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
B_lectin IRAKm_g.AA B_lectin 99-117 30 0.254447 6.11 Pfam 1-26 (137) Show / Hide 
Range on Protein: 99-117
Range on HMM: 1-26/137
Sequence Identity: 30% (8 aa)

SAAVVWTANRR---DPI----RGGGA
.  |||.|||    .|.     .|..
NQTVVWVANRDLTGNPVTDSSNNGNY
PAN_AP IRAKm_g.AA PAN_AP 389-464 17 0.000238 21.26 SMART 1-85 (85) Show / Hide 
Range on Protein: 389-464
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

ARNHHFLNVSGASYFSNRYST-----PDRVSSFQDCSRLCLANCSCRVFFYNTDGSCFFVN--RVYGSLT------ADSSSTAYLKIQN
 . ..|. ......   .. .        | | ..| ..|| ||||| | |. ...| . .  .  |. .         . .  . ..|
CCDDCFVRMPNMKL---FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYNTKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKm_g.AA TKL 540-812 21 1.1e-65 224.51 In-house 1-364 (364) Show / Hide 
Range on Protein: 540-812
Range on HMM: 1-364/364
Sequence Identity: 21% (82 aa)

VGSGGSGTVFQGTFLD---------GTKVAIKKLEN----------------------------TSQGQKEFVAEVNSIGSISHMNIIKLCGFCAERSH-
.||||.|.|..|..           |. ||.||.                              .|. ..... |.... ...| ||... |.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFIANGSLDHWLFHDGAASQDSSANFLDWRTRFGIALGVARGLSYLHEESR-----QLIMHLDIKPQNILLDEQFV-------
              .|.|.. .||| | |                |  |. .||..|||..||| .         | | |.|..|||.|| .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY

-------AKIADFGTSKLMASREISQE-----------------TTNVRGTPGYLAPEWLLHS----------------VATKKCDVYSYGMVLLEIIAG
       .||.|||.|. |  .. ..                  | ...|||...||| |  .                 ...||||||.|.|| ||...
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

RRNLMSSCEDEDLAWYFPALAVKKASQGMIREIYDRRIAGEVE------------EKEGERIARVALWCIQENPAMRPSMESVVKML
.|        .|.  . . ..    .. |.  ..|..   ..             .   ..... . .| ...|  |||.. ..| |
CR------PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAKm_g.AA Pkinase 534-812 20 2.6e-49 174.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 534-812
Range on HMM: 1-293/293
Sequence Identity: 20% (65 aa)

ANFSSMVGSGGSGTVFQGTFLDGTK-VAIKKLENTSQGQKEFVA-----EVNSIGSISHMNIIKLCGFCAERSHRLLVYEFIANG----SLDHWLFHDGA
  . . .|||..|.|....  .  | ||.|...  ..  .. ..     |.    ...| ||..| ... ...|  .| |.  .|    .| ...     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

ASQDSSANFL--DWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDEQFVA----KIADFGTSKLMASREISQETTNVRGTPGYLAPEWLL-HS
    .. . .  ....   ... ..||| |.|..    |.| |.||.|||.|.. .     ||.||| .|..     .. .| . |||.|.|||... ..
----WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQ

VATKKCDVYSYGMVLLEIIAGRRNLMSSCEDEDLAWYFPALAVKKASQGMIREIYDRRIAGEVEEKEG-----------------------ERIARVALW
  ..|.|..|.| .| | . ||               ||       .    .....|.  ..... .                        |    .  |
YYGPKVDMWSCGCILYEMLCGR-------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CIQENPAMRPSMESVVKM--L
|.. .|. ||. | ...   .
CLCKDPKKRPTAEQILQHPWF
Kinase IRAKm_g.AA IRAK 535-812 27 1.3e-44 154.54 In-house 2-317 (317) Show / Hide 
Range on Protein: 535-812
Range on HMM: 2-317/317
Sequence Identity: 27% (89 aa)

NFSSMVGSGGSGTVFQGTFLDGTK--VAIKKLEN-----TSQGQKEFVA---EVNSIGSISHMNIIKLCGFCAERSHRLLVYEFIANGSLDHWLFHDGAA
. .   |.|| |.|..|  ...|   .|.||| .     . .  ..| .   |. .  .. | ||  | |.|.||.   |||....||||   |     .
HKDNRIGEGGFGCVYRGQ-WKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRL-----W

SQDSSANF--LDWRTRFGIALGVARGLSYLHEES-RQLIMHLDIKPQNILLDEQFVAKIADFGTSK------LMASREI-SQETTNVRGTPGYLAPEWLL
 || .     | | .|. |..| |.|. .||. .    | | |||. |||||..|..||.|||          . . ..   .|  ||||  |..|| . 
CQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIR

--HSVATKKCDVYSYGMVLLEIIAGRRNLMSS-CEDEDLAWYFPALAVKKAS--------------------QGM-IREIYDRRIAGEVEEKEGERIARV
      ||| |||| | ||||...|.|   .   | . |  .   .. . ..                      | |.|..  . .. ....... .. .
DPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQC

ALWCIQENPAMRPSMESVVKML
|. |  .  . |..|. |.. |
ACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_g.AA MLK 534-738 28 1.4e-40 138.47 In-house 1-233 (291) Show / Hide 
Range on Protein: 534-738
Range on HMM: 1-233/291
Sequence Identity: 28% (68 aa)

ANFSSMVGSGGSGTVFQGTFLDGTK-----VAIKKLE-------NTSQGQKEFVAEVNSIGSISHMN----IIKLCGFCAER-SHRLLVYEFIANGSLDH
 .|.  .|||..| |. |..  ..      ||.|. .        |.  |..|  |..    .|| |    ||.. | |..  .| ..| |....||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WL---FHDGAAS---QDSSANFLDWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDE------QFVAKIADFGTSKLMASREISQETTNVRGT
 |      ....   |  ..   |    . .|| .|||..|||.. ...| | |.|..|||.||      . ..||.|||||. . ...  .  .. .||
VLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

PGYLAPEWL---LHSVATKKCDVYSYGMVLLEIIAGR
. . ||| .    ..  ..||||.|.|.|| |.....
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKm_g.AA TKL-Unique 536-735 29 2.1e-40 140.22 In-house 1-222 (290) Show / Hide 
Range on Protein: 536-735
Range on HMM: 1-222/290
Sequence Identity: 29% (67 aa)

FSSMVGSGGSGTVFQGTFLDGTKVAIKKLE-NTSQG-Q--KEFVAEVNSIGSIS-HMNIIKLCGFCA----ERSHRLLVYEFIANGSLDHWLFHDGAAS-
|.. .|.||.|.|..|..  |..||||... | ..  .  .||  ||| .  .  | || .. |.|.      ... .| |..  |||.  |      . 
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

QDSSANFLDWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDEQ-----FVAKIADFGTSKLMA--SREISQET-----TNVRGTPGYLAPEWL
  .. . |..  |  .|. .|.|. ||| ..   |.|.|.|..|.|.|.      . .||.|||.||. .  ..... |      . . |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LH--SVATKKCDVYSYGMVLLEII
    .  ..|.||||.|.|| ||.
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_g.AA Dicty4 535-734 34 1.2e-33 109.69 In-house 2-210 (277) Show / Hide 
Range on Protein: 535-734
Range on HMM: 2-210/277
Sequence Identity: 34% (73 aa)

NFSSMVGSGGSGTVFQGTFLDGTKVAIKKL--ENT---SQGQKEFVAEVNSIGSISHMNIIKLCGFCA----ERSHRLLVYEFIANGSLDHWLFHDGAAS
|. .  |.|. |.|. ||   |..||.|||   |.   .   .|| .||.  ..|.| ||... | |     . .  . | |.   |.| . | ||  . 
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL-YSLLHDKPSE

QDSSANFLDWRTRFG---IALGVARGLSYLHE-ESRQLIMHLDIKPQNILLDEQFVAKIADFGTSKLMASREISQE-TTNVRGTPGYLAPEWLLHSVATK
| .|   ||| ..     .|. .|||. .||.  ..  | |.|.|. |.| |. ...|..||| |..|   |  .  .. . |||.. ||| . |   . 
QQQSIK-LDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KCDVYSYGMVLLEI
| ||||.|.|| ||
KADVYSFGIVLWEI
Kinase IRAKm_g.AA Dicty4-Unclassified 556-737 36 2.8e-31 104.36 In-house 22-204 (263) Show / Hide 
Range on Protein: 556-737
Range on HMM: 22-204/263
Sequence Identity: 36% (71 aa)

GTKVAIKKLENTSQGQK-----EFVAEVNSIGSISHMNIIKLCGFC-AERSHR---LLVYEFIANGSLDHWLFHDGAASQDSSANFLDWRTRFGIALGVA
|  ||.||.   .         .| .||   |||.| | .|. | | . |||.     | ||.  | |   . |   . |. .   ||      .|. .|
GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL-FEVIHSKPSEQQQPIK-LDDTLIIKYAFDIA

RGLSYLHEESRQLIMHLDIKPQNILLDEQFVAKIADFGTSKLMASREIS--QETTNVRGTPGYLAPEWLLHSVATKKCDVYSYGMVLLEIIAG
.|. .||  .| .| | |||  |||.|  | .||||||      ||.|.  .  | . |||   .|| | |   . | |||||.|.| | . |
QGMQHLH--TRNFI-HRDIKSSNILMDKHFNIKIADFG-----ISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKm_g.AA LRRK 534-739 23 1.5e-30 105.29 In-house 1-281 (351) Show / Hide 
Range on Protein: 534-739
Range on HMM: 1-281/351
Sequence Identity: 23% (68 aa)

ANFSSMVGSGGSG-TVFQGTFLD---------------------------GTKVAIKKLENT-----------------------------------SQG
  . ...|.||.| .|..... .                           ...|||||.. .                                   .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QKEFVAEVNSIGSISHMNIIKLCGFCAERSHRLLVYEFIANGSLDHWLFHDGAASQDSSAN-FLDWRTRFGIALGVARGLSYLHEESRQL--IMHLDIKP
  ||  ||  . .  | ||..| |||   ... .| |.. .|.|.| |..    .. .     ..| ..  ||| .|.|. |||   ..   | | | |.
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGF-HFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKS

QNILL---D---------EQFVAKIADFGTSKLMASREISQE-TTNVRGTPGYLAPEWLL---HSVATKKCDVYSYGMVLLEIIAGR-R
 ||||   .         .. .|||||||.|  |    .  . .  . |.||..||| .     .. | | |.||.||.| |.. .. .
PNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAKm_g.AA RIPK 540-738 28 1.9e-29 97.52 In-house 1-225 (290) Show / Hide 
Range on Protein: 540-738
Range on HMM: 1-225/290
Sequence Identity: 28% (65 aa)

VGSGGSGTVFQGTFLDGTKVAIKKLEN--------TSQGQKEFVAEVNSIGSISHMNIIKLCGFCAER-----SH-RLLVYEFIANGSLDHWLFHDGAAS
||.||.|.||. .  .   ...||  .         .| ...   |.    .. . .| .. ||| .      .    .| |. .|||| | |     ..
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFL-----HT

QDS-SANFLDWRTRFGIALGVARGLSYLHEESRQ-LIMHLDIKPQNILLDEQFVAKIADFGTSK-LMAS---------REISQETTNVR-GTPGYLAPEW
. .     . |  |. .   ...|  |||  | .  | |.| ||.|||.|  | .|||||| .. .| |         || . ..   | ||  |..|| 
KWPYQHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEH

LL----HS--VATKKCDVYSYGMVLLEIIAGR
..     .  |.|.| ||||...|. |. ...
FRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKm_g.AA TK 534-734 16 3.2e-28 91.1 In-house 1-387 (486) Show / Hide 
Range on Protein: 534-734
Range on HMM: 1-387/486
Sequence Identity: 16% (64 aa)

ANFSSMVGSGGSG---TVFQGTFLDG--------------------------TKVAIKKLENT-SQGQKEFVA--------------EVNSIGSIS----
  .    |.|  |   .|..|.  ..                          |.||.| |  . .. |.|| .              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HMNIIKLCGFCAER------------SHRLLVYEFIANGS----LDHWLFHDGA---ASQDSSAN----------------------------------
 | ||..| | | .              . ..| |. ..|.    |...|         .||...|                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FLDWRTRFGIALGVARGLSYLHEE----SRQLIMHLDIKPQNILLDEQFV-----------AKIADFGTS
                              .|. ...  ... .|.|..|||.       | . | |.   |.|..|. |           .|||||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

KLM---ASREISQETTNVRGTPGY-----------------------------LAPEWLLHSV---------ATKKCDVYSYGMVLLEI
. .    .|.| ...  .| ....                             .||| |.. |          | | ||.|.| .. ||
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase IRAKm_g.AA TK-Unique 534-734 24 5.6e-28 93.62 In-house 1-232 (294) Show / Hide 
Range on Protein: 534-734
Range on HMM: 1-232/294
Sequence Identity: 24% (56 aa)

ANFSSMVGSGGSGTVFQGTFLDGT-------KVAIKKLENTSQGQK--EFVAEVNSIGSIS-HMNIIKLCGFCAERS-HRLLVYEFIANGSLDHWLFHDG
 .. . .|.|  |.|. |..  ..       .||.|.|.  .....  .|  | .   ..  | ||....| | . .   ....|....|.|.| |   .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

AA--SQ---------------DSSANFLDWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDEQFVAKIADFGTSK-LMASREISQETTNVRGT
 |  ..               . . .... .. . .| ..|.|..||..  |. | | |.   |.|| | .|.||.||| .. ... ...| ...  |  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

PGYLAPEWLL--HSVA-TKKCDVYSYGMVLLEI
  ..||| |.  | .. | | ||.|.| .. ||
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase IRAKm_g.AA S_TKc 534-819 22 1.6e-26 95.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 534-819
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

ANFSSMVGSGGSGTVFQGTFLD-GTKVAIKKLENTSQGQKEFVAEVNSIGSISHMNIIKLCGFCAERSHRLLVYEFIAN--GSLDHWLFHDGAASQDSSA
  .   .|.|. |.|....  . | .||||..       . .  |..   .  | ||.|| ... . .|  .| |.. .  |.| . . . |    .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR--F

NFLDWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDEQFVAKIADFGTSKLMASREISQETTNVRGTPGYLAPEWLLHSVATK-KCDVYSYGM
 |   ..|| ..  ....| |.|.   . |.| |.||.||||||  . ||.||| ....         | . ||| |.||| |     .| |||..| | 
PFPE-HARF-YMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLLEIIAGRRNLMSSCEDEDLAWYFPALAVKKASQGMIREIYDRRIAGEVEEKEGERIARVALWCIQENPAMRPSMESVVK--MLEGLEEVL
.| | ..|.         .. . .   .                           .        | | .|. ||.   . .  ..  . . .
ILYEMLCGYPPFP-----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKm_g.AA TyrKc 534-812 20 7.5e-23 83.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 534-812
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

ANFSSMVGSGGSGTVFQGTFLDGTKVAIKKLENTSQGQKEFVAEVNSIGSI--SHMNIIKLCGFCAER-------SHRLLVYEFIANGSLDHWL-FHDGA
  .  . |.|  |.|..||    ..||.|.| . .  ...|  | .   ..  .| ||..| | | .           ..| |. ..|.|.. |  | . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ASQDSSANFLDWRTRFGIALGVARGLSYLHEESRQLIMHLDIKPQNILLDEQFVAKIADFGTSKLMASR---EISQETTNVR---GTPG-----YLAPEW
         | ...   ... .|.| .|||.     . | |.   |.|..|....||.||| |.   .      |...  ..   |. .      .||| 
---------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLHSVATKKCDVYSYGMVLLEIIAGRRNLMSS-----CEDEDLAWYFPALAVKKASQGMIREIYDRRIAGEVEE-----KEGERIARVALWCIQENPAMR
. ... | | ||.|.| .. ||        .      ......        ...  ||. ... .        .        |    . ..| .|.|..|
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV--------IEYVKQGYRMPQPPNDY-----PMSFVCCPDEMYQ-IMKQCWHEDPEDR

PSMESVVKML
|... ... .
PTFSEIHECF
Kinase IRAKm_g.AA Pkinase_Tyr 534-654 23 3.2e-18 62.33 Pfam 1-129 (270) Show / Hide 
Range on Protein: 534-654
Range on HMM: 1-129/270
Sequence Identity: 23% (31 aa)

ANFSSMVGSGGSGTVFQGTFL-----DGTKVAIKKL-ENTSQGQ---KEFVAEVNSIGSI-SHMNIIKLCGFCA-ERSH--RLLVYEFIANGSLDHWLFH
  |  . |.|  |.|..||       ....||.|.| |.... |   ..| .|..   .. .| ||..| | |  .. .   ..| |. ..|.|.. |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

DGAASQDSSANFLDWRTRFGIALGVARGLSYLHE
       .. . |.  .  .... .|.|..||..
HR-----EDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAKm_g.AA Pkinase_Tyr 669-735 29 4e-06 21.34 Pfam 141-208 (270) Show / Hide 
Range on Protein: 669-735
Range on HMM: 141-208/270
Sequence Identity: 29% (20 aa)

NILLDEQFVAKIADFGTSKLMASREIS-QETTNVRGTPGYLAPEWLLHSVATKKCDVYSYGMVLLEII
|.|..|..|.||.||| .... . .   . ... .     .||| . ... | | ||.|.| .. ||.
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase IRAKm_g.AA TK 785-812 21 1.9e-05 13.43 In-house 459-486 (486) Show / Hide 
Range on Protein: 785-812
Range on HMM: 459-486/486
Sequence Identity: 21% (6 aa)

ERIARVALWCIQENPAMRPSMESVVKML
| .... . | ...|. ||... ....|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKm_g.AA Dicty4-Unclassified 793-812 35 6.8e-05 12.66 In-house 244-263 (263) Show / Hide 
Range on Protein: 793-812
Range on HMM: 244-263/263
Sequence Identity: 35% (7 aa)

WCIQENPAMRPSMESVVKML
||  . |  ||.|. ... |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_g.AA TK-Unique 794-812 36 8.6e-05 12.6 In-house 276-294 (294) Show / Hide 
Range on Protein: 794-812
Range on HMM: 276-294/294
Sequence Identity: 36% (7 aa)

CIQENPAMRPSMESVVKML
|.|..| .||| ......|
CWQWEPEERPSFRQIKHRL
Kinase IRAKm_g.AA Dicty4 793-814 37 0.000198 10.88 In-house 254-277 (277) Show / Hide 
Range on Protein: 793-814
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQENPAMRPSMESVVKM--LEG
||  ..|  |||.| ...   || 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKm_g.AA LRRK 793-814 36 0.000848 9.3 In-house 330-351 (351) Show / Hide 
Range on Protein: 793-814
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCIQENPAMRPSMESVVKMLEG
.| |..|  ||.....|| |. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKm_g.AA MLK 794-812 36 0.000959 9.02 In-house 273-291 (291) Show / Hide 
Range on Protein: 794-812
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CIQENPAMRPSMESVVKML
| ...|. |||. ..|. |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_g.AA Pkinase_Tyr 785-812 21 0.004267 11.11 Pfam 243-270 (270) Show / Hide 
Range on Protein: 785-812
Range on HMM: 243-270/270
Sequence Identity: 21% (6 aa)

ERIARVALWCIQENPAMRPSMESVVKML
. | .. . | ...|..||... .. .|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase IRAKm_g.AA TKL-Unique 794-812 31 0.142238 1.54 In-house 272-290 (290) Show / Hide 
Range on Protein: 794-812
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CIQENPAMRPSMESVVKML
|   .|  ||| ..... |
CWHHDPSQRPSFDEIIHRL