Gene LRR10a_a-2 (S.moellendorffii)

LRR10a_a-2

Species: S.moellendorffii
Alias: LRR10a_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR10a

Sequence

Name Sequence Type Origin Length Description Download
LRR10a_a-2.AA Protein None 1100 None Fasta, JSON
LRR10a_a-2.NA RNA None 3303 None Fasta, JSON
LRR10a_a-2.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of LRR10a_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR10a_a-2.AA LRRNT_2 2-41 39 9.2e-12 41.12 Pfam 6-46 (46) Show / Hide 
Range on Protein: 2-41
Range on HMM: 6-46/46
Sequence Identity: 39% (17 aa)

QALLSFKASIVA-HNPGKSSILDGWNPSD--GDPCKWGGIQCS
||||.||.|..  ..   .. |  ||||.  .|.| | |. |.
QALLAFKSSLNDSDP--HHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR10a_a-2.AA LRR_1 48-70 40 0.002316 16.09 Pfam 1-26 (26) Show / Hide 
Range on Protein: 48-70
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HVTAIDLSS-N--NLAGSIPEG-LANL
. . .|||. |  || |.||.. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 96-119 44 0.000412 18.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 96-119
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLAELDLSS-N--QLHDTIPPSLLDEL
.| .||||. |  .| ..|||| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10a_a-2.AA LRR_TYP 94-118 44 0.200049 5.58 SMART 1-24 (24) Show / Hide 
Range on Protein: 94-118
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

CSSLAELDLSSNQLHDTIPPSLLDE
 ..| |||||.|||  ..|| ... 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR10a_a-2.AA LRR_TYP 119-143 32 0.223846 5.18 SMART 1-24 (24) Show / Hide 
Range on Protein: 119-143
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LPSLATINLAYNDLVGGIPDEFFSP
||.| . .| .| |   .|.. |..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10a_a-2.AA LRR_1 121-143 29 0.520988 7.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 121-143
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLATINLAY-N--DLVGGIPDE-FFSP
.| ...| . |   |.| ||.. | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 72-94 22 1.227693 6.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 72-94
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

YLSSLSLAL-N--SFSGRLPGD-LSRC
 | .|.|   |  ...| .| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 148-171 44 0.002689 15.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 148-171
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLQALNLSS-N-PGLGGPLPGS-LKNC
||| |.||. | . | | .| | . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 173-196 37 0.001786 16.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 173-196
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

AIELLDVSSC---NLTGSLPDDTIARL
 .. ||.|.|   ||||..|....  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 198-221 25 1.379913 6.25 Pfam 1-26 (26) Show / Hide 
Range on Protein: 198-221
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

LLSNLVLRE-N--GFVGEVSPEFFSSC
 |  | |.  |   ..|...|. | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 223-245 48 0.000324 19.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 223-245
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLESLDLAL-N--NLTGDIPAQ-IENC
||..|||   |  ||||.||   . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10a_a-2.AA LRR_TYP 268-291 29 0.029101 12.44 SMART 1-24 (24) Show / Hide 
Range on Protein: 268-291
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LSALERLLATHNGFTELPAELERC
|..|..|   .| .|.||... ..
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR10a_a-2.AA LRR_1 270-291 18 0.504344 7.8 Pfam 1-26 (26) Show / Hide 
Range on Protein: 270-291
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

ALERLLATH-N--GFT-ELPAE-LERC
 |..|   . |   .| ..| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 247-268 22 3.874613 4.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 247-268
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KLVNLAVSA-N--SFH-SLPRE-IGGL
.|  | .|  |  ..  ..| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 293-315 25 0.56321 7.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 293-315
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KIRVLAVSG-N--SLSGPLPGF-IAKF
....| .|| |  .|.| .|   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 341-363 37 0.001869 16.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 341-363
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLRHLDASN-N--LFTGEIPVE-ISGA
.|.||| |. |   .||.|| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10a_a-2.AA LRR_TYP 339-363 40 0.146444 6.69 SMART 1-24 (24) Show / Hide 
Range on Protein: 339-363
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LRSLRHLDASNNLFTGEIPVEISGA
|..||.|| ||| .| ..| .. . 
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR10a_a-2.AA LRR_1 317-339 22 0.320119 8.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 317-339
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SLEFLSVYT-N--RFVGAVPAW-LGGL
.|. |..   |  ...| .| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 390-412 55 6.5e-07 28.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 390-412
Range on HMM: 1-26/26
Sequence Identity: 55% (15 aa)

NLQVLDLSH-N--QISGRIPPS-LGNL
|||.||||. |  ...| |||| . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10a_a-2.AA LRR_TYP 388-412 44 0.00734 16.75 SMART 1-24 (24) Show / Hide 
Range on Protein: 388-412
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LLNLQVLDLSHNQISGRIPPSLGNL
| ||..||||.||.  ..|| . . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10a_a-2.AA LRR_1 365-388 40 0.146853 9.7 Pfam 1-26 (26) Show / Hide 
Range on Protein: 365-388
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

ELQFLLLAG-N--ALSGEIPREIGSKL
 || | | | |   |.|.|| ..  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 414-436 33 0.20451 9.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 414-436
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLLWLMLAS-N--DLEGEIPAE-LGNC
 |  | | . |   |.|.|| . . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 438-460 25 0.216819 9.1 Pfam 1-26 (26) Show / Hide 
Range on Protein: 438-460
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLLWLNAAS-N--RLSGSLPES-IASI
.|  |.  . |  .|.|..|.| . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 536-558 25 4.215854 4.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 536-558
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SMGYIQLAS-N--RLTGPIPGT-LDRC
.  .. | . |  .||| ||   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 560-578 45 39.557764 1.08 Pfam 1-22 (26) Show / Hide 
Range on Protein: 560-578
Range on HMM: 1-22/26
Sequence Identity: 45% (10 aa)

HLGLLFLDQ-N--NLTGSMPQS
.|  | |.  |  ||||. | |
NLQHLDLSGCNCCNLTGHIPPS
LRR_1 LRR10a_a-2.AA LRR_1 606-628 44 0.000523 18.38 Pfam 1-26 (26) Show / Hide 
Range on Protein: 606-628
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

CVVSLDLSY-N--NLSGRIPSE-LQNL
   .||||. |  ||.| ||.. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10a_a-2.AA LRR_1 582-604 33 0.058399 11.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 582-604
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALTGLNVSR-N--ALSGSVPRS-IGAL
 |. |..|. |   |.|..| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10a_a-2.AA LRR_TYP 604-627 36 0.557863 1.93 SMART 1-24 (24) Show / Hide 
Range on Protein: 604-627
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LSCVVSLDLSYNNLSGRIPSEL-QN
|.   .||||.|.|  ..|... |.
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10a_a-2.AA LRR_1 630-689 10 3.702454 4.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 630-689
Range on HMM: 1-26/26
Sequence Identity: 10% (7 aa)

KLNRFNISY-N-PELVGPVPSGQQFSTFGPSVYEGDLKLCSSSSSVMGMKNPNSSLPS--CGKL
.| . ..|. | . |.|                                      .|.  . .|
NLQHLDLSGCNCCNLTGH-------------------------------------IPPSCF-NL
Kinase LRR10a_a-2.AA IRAK 801-1003 36 1.5e-67 230.76 In-house 1-224 (317) Show / Hide 
Range on Protein: 801-1003
Range on HMM: 1-224/317
Sequence Identity: 36% (82 aa)

FDETNVVGSGGFGIVYKAKLADGS-TVAIKKLIQEGP----QADREFLA---EMETLGHLHHENLVPLLGCSSYGTQKLLVYKYMEKGSLDDWLH-EKPG
|.. |. |.|||| ||....     ..|.|||...      . ...|..   |....  ..|.|.|||.| .. . .  ||| ||  ||| | |.  .. 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GA-QALEWPIRLNIALGIARGLKFLHHNCSP-PIVHRDMKASNILLDDNFEPRLTDFGLAR------VLGAQET---HVSTVVAGTLGYVPPEYCQ--TW
.. ..|.|..|. |..|.|.|. ||| | .  || |.| | .|||||..|.| ..||||.|      .. .|.    ..|.|. ||. | |||.    . 
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVR-GTTWYMPPEFIRDPQG

RATARGDVYSFGVVLLELVTGRRPM
. | . ||||||.||||..||.|..
QLTKKTDVYSFGIVLLEVLTGCRAV
Kinase LRR10a_a-2.AA TKL 807-1077 22 1.1e-63 217.86 In-house 1-364 (364) Show / Hide 
Range on Protein: 807-1077
Range on HMM: 1-364/364
Sequence Identity: 22% (88 aa)

VGSGGFGIVYKAKLAD---------GSTVAIKKLIQEG--------------------------PQADRE-FLAEMETLGHLHHENLVPLLGCSSYGTQ-
.||||||.|||.|.           | .||.||. ..                           ..  |. .  |.  .  |.|.|.|...|.. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYKYMEKGSLDDWLHEKPGGAQALEWPIRLNIALGIARGLKFLHHNCS-----PPIVHRDMKASNILLDDNFE------------
              .|. |...||| . ||          |. |...||.||||. .|| .       |||.||| | .|||.|.|..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PRLTDFGLARVL------GAQETH------------VSTVVAGTLGYVPPEY----------------CQTWRATARGDVYSFGVVLLELVTGRRPMS
  . ..||||.|..       ...|.             .  . ||... .||                 |. . .. . ||||||.|| |..|..|   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

ISFGGENKDHGCGNLIEWSAYHVK--------KGIAAEVCD---RIVLR---------SAAPGELLAFLRLAVVCTAELPIRRPTMREVLKVL
                 .. |.          . ... |||   |  .          .  |  .  . .|.  | .. |  ||.. |.|| |
----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR10a_a-2.AA Pkinase 801-1000 26 8.8e-44 155.89 Pfam 1-209 (293) Show / Hide 
Range on Protein: 801-1000
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FDETNVVGSGGFGIVYKAKLADGST-VAIKKLIQEGPQA--DREFLA--EMETLGHLHHENLVPLLGCSSYGTQKLLVYKYMEKG----SLDDWLH-EKP
.    ..|||.|| |||..  . .  ||.|..  ..     |.. .   | . . .|.|.| | |...  ...   .|  |.|.|    .| |... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGAQALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDNFEP----RLTDFGLARVLGAQETHVSTVVAGTLGYVPPEYCQ-TWRATARGD
|.   ...    .... |.|||...| .    |.|||.| .|||.|.| ..    ...|||||...     .  |...||..|..|| ..     . . |
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGVVLLELVTGR
..|.|..| |...||
MWSCGCILYEMLCGR
Kinase LRR10a_a-2.AA TK 801-1002 17 6.3e-38 124.2 In-house 1-394 (486) Show / Hide 
Range on Protein: 801-1002
Range on HMM: 1-394/486
Sequence Identity: 17% (68 aa)

FDETNVVGSGGFG---IVYKAKLADGS--------------------------TVAIKKLIQEGPQADREFLA-----------------EMETLGH--L
    .. |.| ||    |||... ...                          .||.| |  . .....||..                 ||. . |  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHENLVPLLGCSSYGTQK------------LLVYKYMEKGS----LDDWLHEKPGGAQA-----------------------------------------
||.|.| |.|... |  |            ..|  ||..|.    |.|.|.......|                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LEWPIRLNIALGIARGLKFLHHN----CSPPIVHRDMKASNILLDDNFE-----------PRLTDFG--
                               |  . .| ... ||.|. .|| .      . .||||  | |.|...|              ...|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARVLGAQETHVSTVVAGTLG-------------------------YVPPEYCQ---------TWRATARGDVYSFGVVLLELVT-GRRP
      ||| ..  .  ...   || .                         . .||  .         . . |   ||.||||.. |..| |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR10a_a-2.AA MLK 801-1002 27 4.3e-37 126.25 In-house 1-235 (291) Show / Hide 
Range on Protein: 801-1002
Range on HMM: 1-235/291
Sequence Identity: 27% (65 aa)

FDETNVVGSGGFGIVYKAKLADGS----TVAIKKLIQEG--PQA----DREFLAEMETLGHLHHEN----LVPLLGC-SSYGTQKLLVYKYMEKGSLDDW
...  ..|||.|| |.|..         .||.|.  ..    .     ...|  | . | .| |.|     ....|. .... . ..|  |.|.||| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHE-KPGGAQA---------LEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDD------NFEPRLTDFGLARVLGAQ-ETHVSTVVAGTLG
||. ..... |               .|.|| .|||. .|| .  .||.||| | .|||.|.      .   . .|||..| .    ... |.  |||. 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGTYA

YVPPEY-----CQTWRATARGDVYSFGVVLLELVTGRRP
.  ||      |...   .  ||.|.|||| |..|.. |
WMAPEVIQQFRCEKYSEKC--DVWSWGVVLWEMLTREVP
Kinase LRR10a_a-2.AA RIPK 807-1002 32 6.8e-37 123.25 In-house 1-227 (290) Show / Hide 
Range on Protein: 807-1002
Range on HMM: 1-227/290
Sequence Identity: 32% (74 aa)

VGSGGFGIVYKAKLADGSTVAIKKL-----IQEG--PQADREFLAEMETLGHLHHENLVPLLGCSSYG----TQKL--LVYKYMEKGSLDDWLHEKPG-G
||.|||| |.||  ..  ....||      ...    |   . . | . .  | .|. ||..|         . ||  .| .|||.||| . || |.   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

AQALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDNFEPRLTDFGLARVLGAQETHV------------STVVAGTLGYVPPEYCQTWRA
 . . || |  .   |..|  .| |.  ||| ||| | .|||.| ||   . |||||  ..  . |             |    ||| | |||   |  .
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

TA------RGDVYSFGVVLLELVTGRRP
 .        |||||..|. |. |.. |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR10a_a-2.AA S_TKc 801-1077 21 5.6e-36 126.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 801-1077
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FDETNVVGSGGFGIVYKAKLAD-GSTVAIKKLIQEGPQADREFLAEMETLGHLHHENLVPLLGCSSYGTQKLLVYKYMEK--GSLDDWLHEKPGGA--QA
..  ...|.|.|| |||..  . |  ||||..        . .. |.. | . ||.|.| |...    .   .|  |..   |.| | .......   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDNFEPRLTDFGLARVLGAQETHVSTVVAGTLGYVPPEYCQTWRATA-RGDVYSFGVVLL
.       ..  |...|...| .    |.||| | .|||||.  .  ..||||||.|        | . ||. |..|| .     .  . |..|.|..| 
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELVTGRRPMSISFGGENKDHGCGNLIEWSAYHVKKGIAAEVCDRIVLRSAAPGELLAFLRLAVVCTAELPIRRPTMREVLK---------VL
|...|. | .                .   ... .                      .. .   |    | .|||  |.|.          .
EMLCGYPPFP---------------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR10a_a-2.AA LRRK 801-1003 25 2.4e-34 118.93 In-house 1-283 (351) Show / Hide 
Range on Protein: 801-1003
Range on HMM: 1-283/351
Sequence Identity: 25% (74 aa)

FDETNVVGSGGFG-IVYKAKLAD---------------------------GSTVAIKKLIQEG----------------------------------PQA
. . . .|.|||| .||.||. .                           ...|||||.. ..                                  . |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DREFLAEMETLGHLHHENLVPLLGCSSYGTQKLLVYKYMEKGSLDDWLHEKPGGAQ-----ALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNI
 |||  |.  . ||.| |.|.|.| .       .|  |.  |.|.. ||.|   ..      . | ..| ||| ||.|...| |...|||.||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------DNFEPRLTDFGLARVLGAQETH-VSTVVAGTLGYVPPEYCQ---TWRATARGDVYSFGVVLLELVTGR-RPM
||   .         ..    . |||. |.  .  .. |   . |. |.. ||  .   .   |   |.||||..| ||.|.. .|.
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF
Kinase LRR10a_a-2.AA TK-Unique 801-998 23 6.3e-32 107.44 In-house 1-234 (294) Show / Hide 
Range on Protein: 801-998
Range on HMM: 1-234/294
Sequence Identity: 23% (55 aa)

FDETNVVGSGGFGIVYKAKLADGS-------TVAIKKLI-QEGPQADREFLAEMETLGHLH-HENLVPLLGCSSYGT-QKLLVYKYMEKGSLDDWLHEKP
.   .|.|.| || |.....  ..        ||.|.|   . .. ...|| | . . .|  |.|.| .|||.   . . .... |...|.|.. |... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

GG------------------AQALEWPIR----LNIALGIARGLKFLHH---NCSPPIVHRDMKASNILLDDNFEPRLTDFGLARVLGAQETHVSTV--V
..                  .. .. ||     ...| .||.|...|.    ..    ||||  |.|.|| ....  ..|||.|| . . . ....    
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

AGTLGYVPPEYCQ--TWRA-TARGDVYSFGVVLLELVT
   . . .||. .  .  . | ..||.||||.. |..|
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase LRR10a_a-2.AA TKL-Unique 804-1002 30 1.4e-31 108.71 In-house 2-233 (290) Show / Hide 
Range on Protein: 804-1002
Range on HMM: 2-233/290
Sequence Identity: 30% (71 aa)

TNVVGSGGFGIVYKAKLADGSTVAIKKLI-QEGPQAD--REFLAEMETLGHLH-HENLVPLLGCSS----YGTQKLLVYKYMEKGSLDDWLHE-------
 |..|.||.| |||.| . |. ||||..  .|..  .  .||  |  ..  || |.|.| . | .     |  .  .|  |.. |||.| ||        
WNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-KPGGAQALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDN-----FEPRLTDFGLARVLGAQ-ETHVS-------TVVAGTLGYVPPEY
 ..     | .  |...|. ||.|. .|||.  | | |||.| ||.|.| |     .  .. ||||....    .. ..       ... |.. ...|| 
NNNN--CKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

CQT--WRATARGDVYSFGVVLLELVTGRR------P
        .   ||||||.|| |..|. .      |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR10a_a-2.AA STE 801-1004 22 5e-31 106.84 In-house 1-269 (359) Show / Hide 
Range on Protein: 801-1004
Range on HMM: 1-269/359
Sequence Identity: 22% (63 aa)

FDETNVVGSGGFGIVYKAKLAD----------------GSTVAIKKLIQEGP-----------------QADREFLAEMETLGHLH--HENLVPLLGCSS
..   ..|.|.|| ||||.  .                |  .|||..  |                   .   ..| |.... ...  |.| |  .||  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YG-------TQKLLVYKYMEKGSLDDWLHEKPGGAQALE----------WPIRLNIALGIARG-LKFLHHNCSPPIVHRDMKASNILLDDNFEPRLTDFG
..       ..  ..  ||. ||||| ...| |  . |            ..   |.  | .| |..|| .    |.||| |..||||       |.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARVLGAQ--------------ETH-VSTVVAGTLGYVPPEYCQ----TWR---ATARGDVYSFGVVLLELVTGRRPMS
..  |                  .   .. ..||  .  ||  |    . |    ... |..|.| ...|..||. |..
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWH
Kinase LRR10a_a-2.AA Pkinase_Tyr 801-952 29 4.5e-30 102.48 Pfam 1-161 (270) Show / Hide 
Range on Protein: 801-952
Range on HMM: 1-161/270
Sequence Identity: 29% (49 aa)

FDETNVVGSGGFGIVYKAKLA-----DGSTVAIKKLIQEGPQAD----REFLAEMETLGHL-HHENLVPLLGCSSYGTQK---LLVYKYMEKGSLDDWLH
     . |.| || |||...      .. .||.|.|  ||   .    ..|..|.... .| ||.|.| |.|. .   .    ..|  ||..|.|.| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EKPGGAQALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDNFEPRLTDFGLARVL
..  . |.|  .  |.... ||.|. .|. .    ..|||  | |.|...|.  . .|||||| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LRR10a_a-2.AA LISK 806-956 30 1e-27 87.0 In-house 1-159 (296) Show / Hide 
Range on Protein: 806-956
Range on HMM: 1-159/296
Sequence Identity: 30% (50 aa)

VVGSGGFGIVYKAKLA-DGSTVAIKKLIQ-----EGPQADREFLAEMETLGHLHHENLVPLLGCSSY-GTQKLLVYKYMEKGSLDDWLHEKPGGAQALEW
. |.|.|| |||  .  .|. .|||....     . | . . .| |....  | | | |   | .     |  .|  |.. | | . |. ..     | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDN----FEPRLTDFGLARVLGAQE
| |..|||.||.|. .|| ..   |.||| |. |.|...|    .. ...|||.||..  ..
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN
Kinase LRR10a_a-2.AA TyrKc 801-1077 22 1.5e-17 61.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 801-1077
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FDETNVVGSGGFGIVYKAKLADGSTVAIKKLIQEGPQADREFLAEMETLGHL--HHENLVPLLGCSSYG-------TQKLLVYKYMEKGSLDDWLHEKPG
     . |.| ||.|||...    .||.|.|  .     ..|. |.. . .|  ||.|.| |.|. . .        . ..|  ||..|.|.| |... .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GAQALEWPIRLNIALGIARGLKFLHHNCSPPIVHRDMKASNILLDDNFEPRLTDFGLARVLGAQ-------ETHVST---VVA--GTLGYVPPEYCQTWR
    | ..  |.... ||.|  .||..   ...|||  | |.|...|.  . .||||.| ..         .. ...          .   .||  .. .
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

ATARGDVYSFGVVLLELVTGRRPMSISFGGENKDHGCGNLIE--WSAYHVKKGIAAE-VCDRIVL----RSAAPGELLAFLRLAVVCTAELPIRRPTMRE
 |   ||.||||.. |. |        .|..         |.   |...| . . .    ..        .  ..   .  ..   | .| |  |||..|
FTTKSDVWSFGVCMWEIFT--------YGQQPYPG----MIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSE

VLKVL
. . .
IHECF
Kinase LRR10a_a-2.AA LISK 985-1002 50 1e-06 17.09 In-house 221-238 (296) Show / Hide 
Range on Protein: 985-1002
Range on HMM: 221-238/296
Sequence Identity: 50% (9 aa)

DVYSFGVVLLELVTGRRP
||.|||.||.|..|....
DVFSFGIVLCEIITRVKA
Kinase LRR10a_a-2.AA LRRK 1059-1079 28 0.001146 8.83 In-house 331-351 (351) Show / Hide 
Range on Protein: 1059-1079
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CTAELPIRRPTMREVLKVLEE
| .. | .||.. ...|.|..
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR10a_a-2.AA IRAK 1050-1077 25 0.001157 9.05 In-house 290-317 (317) Show / Hide 
Range on Protein: 1050-1077
Range on HMM: 290-317/317
Sequence Identity: 25% (7 aa)

LAFLRLAVVCTAELPIRRPTMREVLKVL
.... .|. |...   ||..|..|.. |
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR10a_a-2.AA TK 1059-1077 31 0.005783 4.92 In-house 468-486 (486) Show / Hide 
Range on Protein: 1059-1077
Range on HMM: 468-486/486
Sequence Identity: 31% (6 aa)

CTAELPIRRPTMREVLKVL
| .. | .|||...... |
CWHYDPEDRPTFSQLHEQL
Kinase LRR10a_a-2.AA Pkinase_Tyr 985-1002 52 0.051733 7.44 Pfam 196-214 (270) Show / Hide 
Range on Protein: 985-1002
Range on HMM: 196-214/270
Sequence Identity: 52% (10 aa)

DVYSFGVVLLELVT-GRRP
||.||||.. |..| |. |
DVWSFGVLMWEIFTYGEQP
Kinase LRR10a_a-2.AA LISK 1051-1077 33 0.074318 1.58 In-house 270-296 (296) Show / Hide 
Range on Protein: 1051-1077
Range on HMM: 270-296/296
Sequence Identity: 33% (9 aa)

AFLRLAVVCTAELPIRRPTMREVLKVL
.||.|.. |.   |  ||.  |....|
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR10a_a-2.AA MLK 1064-1077 35 0.076198 2.34 In-house 278-291 (291) Show / Hide 
Range on Protein: 1064-1077
Range on HMM: 278-291/291
Sequence Identity: 35% (5 aa)

PIRRPTMREVLKVL
| .||..|.... |
PHKRPSFRQIVQHL
Kinase LRR10a_a-2.AA TK-Unique 1059-1077 31 0.093488 1.98 In-house 276-294 (294) Show / Hide 
Range on Protein: 1059-1077
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTAELPIRRPTMREVLKVL
|. . |  ||. |.....|
CWQWEPEERPSFRQIKHRL
Kinase LRR10a_a-2.AA TKL-Unique 1059-1077 31 0.364515 0.08 In-house 272-290 (290) Show / Hide 
Range on Protein: 1059-1077
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CTAELPIRRPTMREVLKVL
| .  |  ||.  |... |
CWHHDPSQRPSFDEIIHRL
Kinase LRR10a_a-2.AA Pkinase_Tyr 1066-1077 41 6.864558 0.25 Pfam 259-270 (270) Show / Hide 
Range on Protein: 1066-1077
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

RRPTMREVLKVL
.|||..|..  |
DRPTFSEIHEQL