Gene LRR10b_b-2 (S.moellendorffii)

LRR10b_b-2

Species: S.moellendorffii
Alias: LRR10b_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR10b

Sequence

Name Sequence Type Origin Length Description Download
LRR10b_b-2.AA Protein None 1220 None Fasta, JSON
LRR10b_b-2.NA RNA None 3663 None Fasta, JSON
LRR10b_b-2.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of LRR10b_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR10b_b-2.AA LRRNT_2 26-60 30 6e-06 22.19 Pfam 8-46 (46) Show / Hide 
Range on Protein: 26-60
Range on HMM: 8-46/46
Sequence Identity: 30% (13 aa)

LLDFRSGLTN----SQALGDWIIG---SSPCGAKKWTGISCA
||.|.|.|..    . .| .|      |..|    |||..| 
LLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS---WTGVTCD
LRR_1 LRR10b_b-2.AA LRR_1 169-191 51 2.1e-05 23.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 169-191
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLQILDLAN-N--SLTGEIPPS-IGDL
.||.||| . |  .|||.|||| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 90-112 44 0.000268 19.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 90-112
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

VLEELDLSN-N--ALSGEIPPQ-LWQL
 |..||||. |   |.|.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 146-166 50 0.006095 14.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 146-166
Range on HMM: 1-26/26
Sequence Identity: 50% (13 aa)

ALRQLDLSS-N--LLSGTIPAS--NL
 |. ||||. |   |.|.|| |  ||
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR10b_b-2.AA LRR_1 114-144 34 0.010723 13.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 114-144
Range on HMM: 1-26/26
Sequence Identity: 34% (12 aa)

KIKRLDLSH-N--LLQGASFDRLFGHIPPS-IFSL
....||||. |   |.|         |||| . .|
NLQHLDLSGCNCCNLTGH--------IPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 193-216 44 0.036117 11.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 193-216
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLTELSLGL-N-SALLGSIPPS-IGKL
||..|.|.  | . | |.|||| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 88-111 52 0.044609 10.92 SMART 1-24 (24) Show / Hide 
Range on Protein: 88-111
Range on HMM: 1-24/24
Sequence Identity: 52% (13 aa)

LPVLEELDLSNNALSGEIPPQL-WQ
|| |.|||||||.|  ..||.. . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR10b_b-2.AA LRR_TYP 112-136 36 0.044735 10.91 SMART 1-24 (24) Show / Hide 
Range on Protein: 112-136
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LPKIKRLDLSHNLLQGASFDRLFGH
||. ..||||.| |.    ...|..
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_TYP LRR10b_b-2.AA LRR_TYP 144-169 38 0.118949 7.43 SMART 1-24 (24) Show / Hide 
Range on Protein: 144-169
Range on HMM: 1-24/24
Sequence Identity: 38% (10 aa)

LAALRQLDLSSNLLSGTIPASNLSRS
| .|| ||||.| |  ..| ... ..
LPNLRELDLSNNQL-THLP-PGAFQG
LRR_TYP LRR10b_b-2.AA LRR_TYP 191-216 38 0.407259 3.05 SMART 1-24 (24) Show / Hide 
Range on Protein: 191-216
Range on HMM: 1-24/24
Sequence Identity: 38% (10 aa)

LSNLTELSLGLNSALLGSIPPSIGKL
|.||.||.|. |   | ..|| .   
LPNLRELDLSNN--QLTHLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 218-237 34 0.222525 9.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 218-237
Range on HMM: 1-26/26
Sequence Identity: 34% (9 aa)

KLEILYAANC---KLTGPIPR---SL
.|..|.  .|   .||| ||    .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR10b_b-2.AA LRR_1 240-262 39 0.000123 20.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 240-262
Range on HMM: 1-26/26
Sequence Identity: 39% (11 aa)

SLRKLDLSN-N--PLQ-SPIPDS-IGDL
.|..||||. |  .|. . ||.| .  |
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 239-262 45 0.179788 5.96 SMART 2-24 (24) Show / Hide 
Range on Protein: 239-262
Range on HMM: 2-24/24
Sequence Identity: 45% (11 aa)

PSLRKLDLSNNPLQSPIPDSIGDL
|.||.|||||| | . .|. . . 
PNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 264-286 22 4.800431 4.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 264-286
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RIQSISIAS-A--QLNGSIPAS-LGRC
..|.... .    .| |.|| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 288-310 29 0.001134 17.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 288-310
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLELLNLAF-N--QLSGPLPDD-LAAL
.|. |.|   |  .|.| .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 312-334 22 10.394168 3.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 312-334
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KIITFSVVG-N--SLSGPIPRW-IGQW
.. . .. | |  .|.| || . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 342-358 33 4.411882 4.46 Pfam 7-26 (26) Show / Hide 
Range on Protein: 342-358
Range on HMM: 7-26/26
Sequence Identity: 33% (7 aa)

LST-N--SFSGSIPPE-LGQC
||  |  ...|.|||. . ..
LSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 360-382 33 0.679917 7.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 360-382
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

AVTDLGLDN-N--QLTGSIPPE-LCDA
  . | |.. |  .|||.|||. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 384-407 25 4.298777 4.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 384-407
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

LLSQLTLDH-N--TLTGSLAGGTLRRC
 |  | |.. |   |||..  ...  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 409-431 48 0.000157 20.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 409-431
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLTQLDVTG-N--RLTGEIPRY-FSDL
||. ||. | |  .|||.||   |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 433-455 29 0.021483 12.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 433-455
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLVILDIST-N--FFVGSIPDE-LWHA
.| .||.|  |   ..|.||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 431-455 32 0.36499 3.44 SMART 1-24 (24) Show / Hide 
Range on Protein: 431-455
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LPKLVILDISTNFFVGSIPDELWHA
||.|  || | | .  ..|..... 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 481-503 40 0.000186 19.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 481-503
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLQHLYLDR-N--RLSGPLPSE-LGLL
|||||.|.. |  .|.| .|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 530-552 44 0.003003 15.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 530-552
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

GLTTLDLGG-N--RLGGAIPPE-IGKL
 |..|||.| |  .| | |||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 503-527 32 0.016449 14.47 SMART 1-24 (24) Show / Hide 
Range on Protein: 503-527
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LKSLTVLSLAGNAFDGVIPREIFGG
| .|..|.| .|..   .|...|.|
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR10b_b-2.AA LRR_TYP 479-502 29 0.234799 5.01 SMART 1-24 (24) Show / Hide 
Range on Protein: 479-502
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

MENLQHLYLDRNRLSGPLPSELGL
. ||..|.|..|.|.   |  .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 505-528 33 0.243703 8.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 505-528
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLTVLSLAG-N--AFDGVIPREIFGGT
.|..|.| | |   . | || ..| . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 528-552 32 0.409554 3.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 528-552
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

TTGLTTLDLGGNRLGGAIPPEIGKL
 . |..|||..|.|  ..||..   
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 457-479 22 28.234809 1.6 Pfam 1-26 (26) Show / Hide 
Range on Protein: 457-479
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QLMEIYASD-N--LLEGGLSPL-VGGM
.| ... |. |   |.| ..|    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 554-576 37 0.033627 11.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 554-576
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

GLDCLVLSH-N--RLSGQIPAE-VASL
 |  | ||. |  .|.|.|| .   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 593-612 41 0.015935 13.12 Pfam 4-26 (26) Show / Hide 
Range on Protein: 593-612
Range on HMM: 4-26/26
Sequence Identity: 41% (10 aa)

VLDLSH-N--SLTGPIPSG-IGQC
.||||. |  .||| ||.. . ..
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 638-660 40 0.00147 16.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 638-660
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTTLDLSS-N--MLQGRIPWQ-LGEN
||..||||. |   |.| ||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 614-636 44 0.004463 15.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 614-636
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

VLVELDLSN-N--LLQGRIPPE-ISLL
 | .||||. |   |.| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 636-660 40 0.098536 8.1 SMART 1-24 (24) Show / Hide 
Range on Protein: 636-660
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LANLTTLDLSSNMLQGRIPWQLGEN
| ||..||||.| |  ..| .. ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 662-684 48 0.000106 20.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 662-684
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

KLQGLNLGF-N--RLTGQIPPE-LGNL
.|| |.|.  |  .|||.|||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 686-708 40 0.000362 18.95 Pfam 1-26 (26) Show / Hide 
Range on Protein: 686-708
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLVKLNISG-N--ALTGSIPDH-LGQL
.| .|..|| |   |||.||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-2.AA LRR_TYP 684-708 36 0.102489 7.96 SMART 1-24 (24) Show / Hide 
Range on Protein: 684-708
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LERLVKLNISGNALTGSIPDHLGQL
|  | .|. |.|.|| ..|. . | 
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR10b_b-2.AA LRR_1 710-732 51 0.000146 20.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 710-732
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

GLSHLDASG-N--GLTGSLPDS-FSGL
 | ||| || |   |||..|.| | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 740-753 35 70.41588 0.19 Pfam 11-26 (26) Show / Hide 
Range on Protein: 740-753
Range on HMM: 11-26/26
Sequence Identity: 35% (6 aa)

N--SLTGEIPSE-IGGI
|  .|||.||.. . . 
NCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 755-777 44 0.028961 12.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 755-777
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

QLSYLDLSV-N--KLVGGIPGS-LCEL
.| .||||  |  .|.| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-2.AA LRR_1 779-803 32 1.204008 6.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 779-803
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

ELGFFNVSD-N--GLTGDIPQEGICKNF
 |   ..|. |   |||.|| . .. |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR10b_b-2.AA IRAK 935-1140 36 2.8e-63 216.56 In-house 1-220 (317) Show / Hide 
Range on Protein: 935-1140
Range on HMM: 1-220/317
Sequence Identity: 36% (83 aa)

FSKANVIGDGGYGTVYRAVLPDGRT--VAVKKLAPVRDYRAVSSGSSCREFLA---EMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRN
|.|.|.|| ||.|.|||... .. |  .|||||   . .. .| ... ..|..   |.... .  | |.| |.|||. ...  |||.|| ||||   |. 
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKL---KEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC

RTD--ALEALTWDRRLRIAVGAARGLAFLHHGI--VPHVIHRDVKASNILLDADFEPRVADFGLARLI---SAYDTHVS-----TDIAGTFGYIPPEYGM
..   .. .|.| .|. |. |.|.|. |||     .| .||.|.| .|||||..|.|  .||||.|     |.   ...       . ||  | |||.  
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTP-IIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIR

--TWRATSKGDVYSYGVILLELVTG
  . . | | |||| |. |||..||
DPQGQLTKKTDVYSFGIVLLEVLTG
Kinase LRR10b_b-2.AA TKL 941-1215 20 6.5e-52 178.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 941-1215
Range on HMM: 1-364/364
Sequence Identity: 20% (76 aa)

IGDGGYGTVYRAVLPD---------GRTVAVKKLAPVR-DYRAVSSGS-------------------SCREFLAEMETLGKVKHRNLVTLLGYCSYGEE-
|| ||.|.||....           |..|||||.     | .  .|                      . ..  |.  . . .| |.| ..||| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYDYMVNGS-LDVWLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIV-----PHVIHRDVKASNILLDADFE-----------
              .|..|. .|| |.. .           |..|.|.| ..|||...||  .      | .|||| | .|||.| ...           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---PRVADFGLARLISAY--DTHVSTD----------------IAGTFGYIPPEY----------------GMTWRATSKGDVYSYGVILLELVTGKEPT
   . ..||||.| .|    ... .|.                . ||... .||                  . . .. | ||||.|..| |..|...| 
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

G-PDFKDTEIG----NLVGWVRSMVRQGKSDEVLD-VAVATRATWRS--CMHQVLHIAMVCTADEPMKRPPMMEVVRQL
  ... . ...        .| .  ..   ...   .     . .    |....  ... | . .| ||| . |.. .|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR10b_b-2.AA Pkinase 935-1143 23 4.4e-38 135.74 Pfam 1-211 (293) Show / Hide 
Range on Protein: 935-1143
Range on HMM: 1-211/293
Sequence Identity: 23% (53 aa)

FSKANVIGDGGYGTVYRAVLPDGRT-VAVKKLAPVRDYR--------AVSSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNG----
. .  .|| |..|.||...  . .  ||||..  ...          .           .| . . ...| | |.|.... .. .  .| .|. .|    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM

SLDVWLR-NRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEP----RVADFGLARLISAYDTHVSTDIAGTFGYIPPEYG
.|  ...  |  ..  ....   ...   .|||...|      .||||.| .|||.| . ..    ...|||||....    .  |...|| .|..||  
DLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI

M-TWRATSKGDVYSYGVILLELVTGKEP
.     ..| |..|.|.|| |...|. |
RGGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase LRR10b_b-2.AA TK 935-1215 14 4.4e-38 124.72 In-house 1-486 (486) Show / Hide 
Range on Protein: 935-1215
Range on HMM: 1-486/486
Sequence Identity: 14% (77 aa)

FSKANVIGDGGYG---TVYRAVLPDGR--------------------------TVAVKKLAPV--RDYRA------------VSSGSSCREFLAEMETLG
    ...| | .|   .||.. . ...                          .|||| | .    . ..            .       .||.|.| . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGE-------DFLEEAEEMK

KVK-----HRNLVTLLGYCSYG------------EERLLVYDYMVNGS----LDVWLRNRTDALEA----------------------------------
. .     | |.| |.|.|. |            |  ..|  || .|.    |. .||.. .                                      
MMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSP

--------------------------------------LTWDRRLRIAVGAARGLAFLHHG----IVPHVIHRDVKASNILLDADFE-----------PR
                                      ||  ..| ... .|.|...||      | ....|||. | |.|.. .              .
CPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

VADFG--------LARLISAYDTHVSTDIAGTFG-------------------------YIPPEYGM---------TWRATSKGDVYSYGVILLELVT-G
.||||        ||| |   |  ....  || .                         . .||  .         . . |.| ||.|.|| . |..| |
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG

KEPTGP---------DFKDTEIGNLVGWVRSMVRQGKSDEVLDVAVATR-----------------ATWRSCMH-------------QVLHI-AMVCTAD
.|| ..         |                   | ... .   . .                  .    |               .....  . | . 
QEPYYGGMSNQDVWKD-------------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHY

EPMKRPPMMEVVRQL
.| .|| . ....||
DPEDRPTFSQLHEQL
Kinase LRR10b_b-2.AA MLK 935-1143 23 9.7e-34 114.46 In-house 1-235 (291) Show / Hide 
Range on Protein: 935-1143
Range on HMM: 1-235/291
Sequence Identity: 23% (56 aa)

FSKANVIGDGGYGTVYRAVLPDGRT-----VAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKVKHRN----LVTLLGYCSYGEE-RLLVYDYMVNGSLD
.    .|| |..| |....   ...     ||||. .   .  ....... ..|  | . | ...|.|     . ..| |.  .   ..|  |. .||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

VWLRNRTDALE----------ALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDA------DFEPRVADFGLARLISAYDTHVSTDIAGTF
  |.....  .            . |  ...|.  |||...||   .. .|||| | .|||.|.      .   ...|||..| ..  .    .. |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYIPPEY-----GMTWRATSKGDVYSYGVILLELVTGKEP
 .  ||      . ..   .  ||.|.||.| |..|...|
AWMAPEVIQQFRCEKYSEKC--DVWSWGVVLWEMLTREVP
Kinase LRR10b_b-2.AA RIPK 941-1143 28 1.8e-33 111.43 In-house 1-227 (290) Show / Hide 
Range on Protein: 941-1143
Range on HMM: 1-227/290
Sequence Identity: 28% (65 aa)

IGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEE------RLLVYDYMVNGSLDVWLRNRTD-A
.| || |.|..|.  . .....|| .|     .    .   . . | . . | .... | ..| |   |         .|  || ||||   |  ...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

LEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLA--RLIS--AYDTH--------VSTDIAGTFGYIPPEYGMTWRA
   . |. | |. .  ..|  .| |.. | .|||| | .|||.|..|   .||||||  .  |    | .         | .  ||  |.|||   |  .
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

TS------KGDVYSYGVILLELVTGKEP
 .      | ||||..... |. |.|.|
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR10b_b-2.AA TKL-Unique 937-1141 30 1.6e-32 112.03 In-house 1-225 (290) Show / Hide 
Range on Protein: 937-1141
Range on HMM: 1-225/290
Sequence Identity: 30% (71 aa)

KANVIGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKVK-HRNLVTLLGYCS----YGEERLLVYDYMVNGSLDVWLR---
  |.|| ||||.||... . |  ||.|...|     . || .. .||  |  .. | . | |.|.. |||     |  .. .| .|.  |||.  |    
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-N---EDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN

---NRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDAD-----FEPRVADFGLARLISAYDTHVSTDI--------AGTFGYIP
   |       |.. .|...|  .|.|. .||| . | .|||| | ||.|.| .     .  ...||||... |  ..  .. .         |.| ...
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEYGMT--WRATSKGDVYSYGVILLELVTGK
||  .      . | ||||.|..| |..|.|
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase LRR10b_b-2.AA S_TKc 935-1191 22 7.5e-30 106.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 935-1191
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

FSKANVIGDGGYGTVYRAVLPD-GRTVAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVN--GSLDVWLRNRT
. . ..|| |..|.||...  . || ||.|..               . .. |.. | | .| |.|.|....   ..  .| .|. .  |.|   ...| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

DAL--EALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVSTDIAGTFGYIPPEYGMTWRATS-KGDVY
       ..  .  ...   ...|...|     ..||||.| .|||||   .  ..||||||..        | . ||  |..||       .  | |..
RHGLRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWW

SYGVILLELVTGKEPTGPDFKDTEIGNLVGWVRSMVRQGKSDEVL-------DVAVATRATWRSCM--------HQVL
| |.|| |...|. |      . .. ...|          |.|..       ..  . | |   ..        |. .
SCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR10b_b-2.AA Dicty4 935-1143 30 1.7e-29 95.63 In-house 1-216 (277) Show / Hide 
Range on Protein: 935-1143
Range on HMM: 1-216/277
Sequence Identity: 30% (67 aa)

FSKANVIGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKVKHRNLVTLLGYCS----YGEERLLVYDYMVNGSLDVWLRN-
  . . ||.|..|.||..    |  ||||||        ... .   ||..| . ..|  | |.....|.|       .. . |  ||  |.|   |.. 
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKL---NNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK

RTDALEALTWD--RRLR---IAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVS--TDIAGTFGYIPPEYGMTWRAT
  .  .  . |  ...|   .|  ||||.. ||  . | .|||| |..|.| |...   |.||||....    .|    .  .|| ..  ||  |  . .
PSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN-PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

SKGDVYSYGVILLELVTGKEP
.| ||||.| .| |..|..||
EKADVYSFGIVLWEILTRQEP
Kinase LRR10b_b-2.AA TyrKc 935-1215 22 3.5e-29 104.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 935-1215
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FSKANVIGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVSSGSSCREFLAEMETLGKV--KHRNLVTLLGYCSYG-------EERLLVYDYMVNGSLDV
 ..  ..| | .|.||....   ..||||.| .             ..|. |.. . |.  .| |.| |.|.|. .       |  ..|  || .|.|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

WLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAY-------DTHVS----TDIA-GTFGYIPP
 ||.. .    |...  | ... .|.| ..||.    ..||||  | |.|.....  ...||||.| |  .       |. ..       .       .|
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYGMTWRATSKGDVYSYGVILLELVT-GKEPTGPD----FKDTEIGNLVGWVRSMVRQGK----SDEVLDVAVATRATWRSCMHQVLHIAMVCTADEPMK
|  .. . |.| ||.|.|| . |. | |..|   .     ...|. ..|   . | .       |                |   .  |   | . .| .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------FVCCPDEMYQIMKQCWHEDPED

RPPMMEVVRQL
|| . |.....
RPTFSEIHECF
Kinase LRR10b_b-2.AA LRRK 935-1143 25 7.4e-28 95.62 In-house 1-282 (351) Show / Hide 
Range on Protein: 935-1143
Range on HMM: 1-282/351
Sequence Identity: 25% (72 aa)

FSKANVIGDGGYG-TVYRAVLPD---------------------------GRTVAVKKLAPVR---------------------------DYRAVSSGSS
. . . ||.||.| .|||| . .                           . .||.||.   .                           | .. ..  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

CREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRNRT-DAL----EALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNI
 |||  |.  . . .| |.| |.|.|   . . .| .|. .|.|.  |.|.  |..      ..|  .|.||.  |.|...| |   | .|||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ADFEPRVADFGLARLISAYDTH-VSTDIAGTFGYIPPE--YGM-TWRATSKGDVYSYGVILLELVTGK-EP
||   .         |.    .||||. |.  ..... |  .  |..|.  ||   .. .   | | |.||.|.|| ||.|..  |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR10b_b-2.AA Dicty4-Unclassified 1043-1143 42 1.3e-27 91.57 In-house 112-207 (263) Show / Hide 
Range on Protein: 1043-1143
Range on HMM: 112-207/263
Sequence Identity: 42% (43 aa)

LRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVSTDIAGTFGYIPPEYGMTWRATSKGDVYSYGVILLELVTGKE
...|   |.|...||      .||||.|.||||.| .|  ..||||..| |.   .   | ||||     ||  |    ..| |||||...| ||.|| |
IKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDE

P
|
P
Kinase LRR10b_b-2.AA UTK 941-1105 24 4.2e-27 89.77 In-house 7-201 (296) Show / Hide 
Range on Protein: 941-1105
Range on HMM: 7-201/296
Sequence Identity: 24% (49 aa)

IGDGGYGTVYRAVLPDGR------TVAVKKLAPVRDYRAVSSGSSCR-EFLAEME---TLGKVK-HRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRN
.| | .|.|..| . . .       ||||.. .  | .  . .     .|. |      ..... |.|.. |.|.|...|  ..|. ||.||.|.  ||.
LGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEP---YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRR

RTDALE----ALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDAD-------FEPRVADFG---LARLISA-----------YDTHVSTDI
 .....    .|| ..||  |.  |||...||     ...|||. | |.|....          ..||||   ..|....           | .. . |.
HRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

A
.
W
Kinase LRR10b_b-2.AA Pkinase_Tyr 935-1098 27 4.6e-27 92.29 Pfam 1-164 (270) Show / Hide 
Range on Protein: 935-1098
Range on HMM: 1-164/270
Sequence Identity: 27% (49 aa)

FSKANVIGDGGYGTVYRAVLP-----DGRTVAVKKLAPVRDYRAVSSGSSCRE-----FLAEMETLGKV-KHRNLVTLLGYCS-YGEE--RLLVYDYMVN
 ..  ..| | .|.||....      .. .||||.| .         |.. ..     |..|.... .  .| |.| |.| |.  ||    ..|  || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GSLDVWLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDT
|.|.  ||.. .  ..||  . | ...  |.|...|.     . ||||. | |.|.. ..  ...||||||.|  |..
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDI--YND
Kinase LRR10b_b-2.AA Dicty4-Unclassified 957-1005 35 4e-06 16.98 In-house 22-67 (263) Show / Hide 
Range on Protein: 957-1005
Range on HMM: 22-67/263
Sequence Identity: 35% (19 aa)

GRTVAVKKLAPVRDYRAVSSGSSCR-----EFLAEMETLGKVKHRNLVTLLGYC
|. |||||.   ..        . |     .|..| | || . | |||.. |||
GKDVAVKKFNENKF--------KFREEMIQDFKKEVEILGSIQHPNLVKCYGYC
Kinase LRR10b_b-2.AA ABC1 947-963 55 0.000191 17.23 Pfam 25-42 (126) Show / Hide 
Range on Protein: 947-963
Range on HMM: 25-42/126
Sequence Identity: 55% (10 aa)

GTVYRAVLPD-GRTVAVK
. |.||.|.| |..||||
AQVHRARLKDDGEEVAVK
Kinase LRR10b_b-2.AA LRRK 1197-1217 33 0.003545 7.07 In-house 331-351 (351) Show / Hide 
Range on Protein: 1197-1217
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CTADEPMKRPPMMEVVRQLKE
| . .| ||| . ..| .|..
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR10b_b-2.AA Dicty4-Unclassified 1197-1215 36 0.006864 5.69 In-house 245-263 (263) Show / Hide 
Range on Protein: 1197-1215
Range on HMM: 245-263/263
Sequence Identity: 36% (7 aa)

CTADEPMKRPPMMEVVRQL
|  ..| ||| | ...  |
CWHNDPNKRPTMNQIIQYL
Kinase LRR10b_b-2.AA UTK 1122-1140 47 0.019785 4.13 In-house 218-236 (296) Show / Hide 
Range on Protein: 1122-1140
Range on HMM: 218-236/296
Sequence Identity: 47% (9 aa)

TSKGDVYSYGVILLELVTG
|.| ||.|.|| . |..|.
TTKSDVWSFGVVCWEIWTW
Kinase LRR10b_b-2.AA Dicty4 1201-1217 26 0.163656 1.01 In-house 259-277 (277) Show / Hide 
Range on Protein: 1201-1217
Range on HMM: 259-277/277
Sequence Identity: 26% (5 aa)

EPMKRPPMMEVVRQ--LKE
.| .|| . |.. .  | .
DPQHRPSFEEIIQRRILEH
Kinase LRR10b_b-2.AA IRAK 1194-1215 31 0.186097 1.13 In-house 296-317 (317) Show / Hide 
Range on Protein: 1194-1215
Range on HMM: 296-317/317
Sequence Identity: 31% (7 aa)

AMVCTADEPMKRPPMMEVVRQL
|  |..    .|..| .|. ||
ACCCGHHRANRRCDMAWVMQQL
Kinase LRR10b_b-2.AA MLK 1200-1215 37 0.206186 0.82 In-house 276-291 (291) Show / Hide 
Range on Protein: 1200-1215
Range on HMM: 276-291/291
Sequence Identity: 37% (6 aa)

DEPMKRPPMMEVVRQL
..| ||| . ..| .|
QDPHKRPSFRQIVQHL
Kinase LRR10b_b-2.AA Pkinase_Tyr 1122-1143 47 0.39501 4.45 Pfam 192-214 (270) Show / Hide 
Range on Protein: 1122-1143
Range on HMM: 192-214/270
Sequence Identity: 47% (11 aa)

TSKGDVYSYGVILLELVT-GKEP
|.| ||.|.|| . |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP