LRR11_d

Species: S.moellendorffii
Alias: LRR11_d
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR11

Sequence

Name Sequence Type Origin Length Description Download
LRR11_d.AA Protein None 1036 None Fasta, JSON
LRR11_d.NA RNA None 3111 None Fasta, JSON
LRR11_d.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of LRR11_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR11_d.AA LRRNT_2 50-68 50 6.6e-05 18.83 Pfam 25-46 (46) Show / Hide
Range on Protein: 50-68
Range on HMM: 25-46/46
Sequence Identity: 50% (11 aa)

LSSWSRN---SSCCQWRGVRCA
||||. .   |.||.|.|| | 
LSSWNPSSSDSDCCSWTGVTCD

LRR_TYP LRR11_d.AA LRR_TYP 130-156 55 0.005226 17.24 SMART 1-24 (24) Show / Hide
Range on Protein: 130-156
Range on HMM: 1-24/24
Sequence Identity: 55% (15 aa)

LPRLERLDLSANNLSGPILLPPGSFQA
|| |..|||| |.|     |||| || 
LPNLRELDLSNNQL---THLPPGAFQG

LRR_1 LRR11_d.AA LRR_1 132-157 41 0.005249 14.83 Pfam 1-26 (26) Show / Hide
Range on Protein: 132-157
Range on HMM: 1-26/26
Sequence Identity: 41% (12 aa)

RLERLDLSA-N--NLSGPILLPPGSFQAA
.|..||||  |  ||.|   .||..| . 
NLQHLDLSGCNCCNLTGH--IPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 108-130 40 0.006016 14.62 Pfam 1-26 (26) Show / Hide
Range on Protein: 108-130
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

GLSHLDLSS-N--ALSGSFPGN-VSSL
 | |||||. |   |.|..| .   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRR11_d.AA LRR_TYP 106-125 45 0.353882 3.55 SMART 1-24 (24) Show / Hide
Range on Protein: 106-125
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LRGLSHLDLSSNALS----GSFPG
|. | .||||.|.|.    | | |
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRR11_d.AA LRR_1 178-197 42 0.017339 12.99 Pfam 1-26 (26) Show / Hide
Range on Protein: 178-197
Range on HMM: 1-26/26
Sequence Identity: 42% (11 aa)

KLQVLDLSN-N--ALSGQIFE---SL
.||.||||. |   |.|.| .   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL

LRR_1 LRR11_d.AA LRR_1 205-227 33 0.00097 17.43 Pfam 1-26 (26) Show / Hide
Range on Protein: 205-227
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLRVLSFSG-N--DISGRIPAS-ITKC
.|..|..|| |   ..| || | . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 253-275 33 0.003649 15.39 Pfam 1-26 (26) Show / Hide
Range on Protein: 253-275
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLRSIRLSF-N--SLSGSIPSE-LSSL
 |... ||  |  .|.|.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRR11_d.AA LRR_TYP 251-275 36 0.141588 6.81 SMART 1-24 (24) Show / Hide
Range on Protein: 251-275
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LPLLRSIRLSFNSLSGSIPSELSSL
|| ||. .||.| |  ..|... . 
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 LRR11_d.AA LRR_1 237-251 36 7.811693 3.58 Pfam 9-26 (26) Show / Hide
Range on Protein: 237-251
Range on HMM: 9-26/26
Sequence Identity: 36% (7 aa)

D-N--RLQGRIPSS-LSQL
. |  .|.| ||.| . .|
GCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 277-288 33 16.371904 2.44 Pfam 1-15 (26) Show / Hide
Range on Protein: 277-288
Range on HMM: 1-15/26
Sequence Identity: 33% (5 aa)

NLEELWLNK-N--SI
||..| |.  |  ..
NLQHLDLSGCNCCNL

LRR_1 LRR11_d.AA LRR_1 300-322 18 4.161463 4.55 Pfam 1-26 (26) Show / Hide
Range on Protein: 300-322
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SLRVFSARE-N--RLSGQIAVN-CSST
.|.. . .  |  .|.|.|  . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 325-347 37 0.005215 14.84 Pfam 1-26 (26) Show / Hide
Range on Protein: 325-347
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLAYLDLSY-N--LLNGTIPAA-IGEC
.| .||||. |   | |.||   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 373-396 40 0.001519 16.74 Pfam 1-26 (26) Show / Hide
Range on Protein: 373-396
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTTLMLSK-N--NLVGRIPLESLREC
||..| ||  |  ||.| || ...  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 349-371 37 0.006806 14.43 Pfam 1-26 (26) Show / Hide
Range on Protein: 349-371
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLETLALTG-N--FLEGRIPSQ-LGSL
.|..| | | |   |.| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRR11_d.AA LRR_TYP 371-395 36 0.130141 7.11 SMART 1-24 (24) Show / Hide
Range on Protein: 371-395
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LRNLTTLMLSKNNLVGRIPLESLRE
|.||..| || |.|  ..| . .. 
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 LRR11_d.AA LRR_1 398-413 31 73.680515 0.12 Pfam 1-19 (26) Show / Hide
Range on Protein: 398-413
Range on HMM: 1-19/26
Sequence Identity: 31% (6 aa)

SLVALVLSK-N--YFSGTL
.|  | ||  |   ..|..
NLQHLDLSGCNCCNLTGHI

LRR_1 LRR11_d.AA LRR_1 425-447 37 0.73026 7.23 Pfam 1-26 (26) Show / Hide
Range on Protein: 425-447
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLQLLAVGN-S--NLSGTIPLW-LTNS
||| | ...    ||.|.|| . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 449-471 37 0.008163 14.15 Pfam 1-26 (26) Show / Hide
Range on Protein: 449-471
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLQVLDLSW-N--IFTGKVPLW-IGDF
.||.||||  |   .||..| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 473-495 33 0.001049 17.31 Pfam 1-26 (26) Show / Hide
Range on Protein: 473-495
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLFYVDLSN-N--SFSGALPEE-LANL
.| . |||. |  ...| .|.. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 558-580 44 0.013286 13.4 Pfam 1-26 (26) Show / Hide
Range on Protein: 558-580
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLVSLDLGI-N--LLSGVIPAS-LGNL
.| .|||.  |   |.| || | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR11_d.AA LRR_1 582-604 40 0.026617 12.33 Pfam 1-26 (26) Show / Hide
Range on Protein: 582-604
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLESMDLSQ-N--SLGGAIPTT-LTRL
||.. |||  |  .| | ||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRR11_d.AA LRR_TYP 580-604 36 0.110258 7.7 SMART 1-24 (24) Show / Hide
Range on Protein: 580-604
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LSNLESMDLSQNSLGGAIPTTLTRL
|.||.. ||| | |  ..|  . . 
LPNLRELDLSNNQL-THLPPGAFQG

LRR_TYP LRR11_d.AA LRR_TYP 556-579 33 0.200049 5.58 SMART 1-24 (24) Show / Hide
Range on Protein: 556-579
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LRRLVSLDLGINLLSGVIPASLGN
|. | .|||. | |. . |  ...
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRR11_d.AA LRR_1 606-630 35 0.266898 8.78 Pfam 1-26 (26) Show / Hide
Range on Protein: 606-630
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

SLARLNLSF-N--KLEGPIPLGNQFSTF
.| .|.||  |  .|.| || .  |  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL

Kinase LRR11_d.AA TKL 767-1029 21 5.7e-58 198.9 In-house 1-364 (364) Show / Hide
Range on Protein: 767-1029
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

VGCGGFGLVFVASLPD---------GTKVAIKRLTG---------------------------DCLQVEREFEAEVQALAMADHPNLVTLQGYSSYGEH-
.| |||| |. . .           |. ||.|..                             .  . . ..| |.  . . .|||.| . ||. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLIYSYMENGSLDSWLHESAKRLDWSTRLDIARGAARGLAYLHL----GCQPH--IVHRDIKSSNILLDGRFV--------------
              ... |...||| . ||       |. |...|...|||..|||     .|.    |.|||.||.|||.|  .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AHVADFGLARLMLPTATHVSTE------------------MVGTLGYIPPEYAQ----------------SWMASPKGDVYSFGVVLLELLSRRRPVDVC
. ..||||.| | ..     |.                   .||... .||  .                .. .|.| ||||||.|| |.|.|.|| .  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

RANGVYDLVAWVREMKGAGRGVEVLDPALRE--------RGNEEEMERMLEVACQCLNPNPARRPGIEEVVTWL
  . ..     . ||  ...... | | . .          ..  ...| . . .| ...|  ||  .|.. .|
PYMPMIFQDP-FEEMF-MMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase LRR11_d.AA IRAK 761-961 34 1.8e-51 177.29 In-house 1-225 (317) Show / Hide
Range on Protein: 761-961
Range on HMM: 1-225/317
Sequence Identity: 34% (79 aa)

FDQSNIVGCGGFGLVFVASLPDGTK--VAIKRLTG----DCLQVEREFEA---EVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAK
|...|  | |||| |. . . ..|   .|.|.|       . .....| .   |.....   |||.| | ||.. ..   |.| || ||||   |.  . 
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

--R---LDWSTRLDIARGAARGLAYLH-LG-CQPHIVHRDIKSSNILLDGRFVAHVADFGLAR------LMLPTAT---HVSTEMVGTLGYIPPEYAQ--
      | | .|..|. |.|.|. .|| .. | |.| |.||||.||||| .|..  .||||.|       .. .     ..|.  .||. | |||.    
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSH-VRGTTWYMPPEFIRDP

SWMASPKGDVYSFGVVLLELLSRRRPVD
.   ..| ||||||.||||.|. .|.|.
QGQLTKKTDVYSFGIVLLEVLTGCRAVY

Kinase LRR11_d.AA Pkinase 761-1029 20 8.1e-44 156.02 Pfam 1-293 (293) Show / Hide
Range on Protein: 761-1029
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

FDQSNIVGCGGFGLVFVASLPDGTK-VAIKRLTGDCLQVEREFEA-----EVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENG----SLDSWLH-ES
.    ..| |.|| |. .   .  | ||.|..  .  . . . ..     |.| ... .||| |.| ..  .. |  ..  |.|.|    .| .... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

AKRL--DWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVA----HVADFGLARLM-LPTATHVSTEMVGTLGYIPPEYAQ-SWMASPKG
 ...  .. .  ....  .|||.|.|  .   |.|||.|..|||.| . .     ...|||||... .   .   |  .||..|..||  . . . .|| 
HGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELLSRRRPVDVC------RANGVYDLVAW-----------------VREMKGAGRGVEVLDPALRERGNEEEMERMLEVACQCLNPNPAR
|..|.|..| |.|..| | . .      . . ..... .                 .|  . .           ...   .  | .... . ||...|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H---------F-HWTF-HNWSEECKDFIKWCLCKDPKK

RPGIEEVVTW--L
||..|...    .
RPTAEQILQHPWF

Kinase LRR11_d.AA S_TKc 761-1029 21 5.1e-42 146.83 SMART 1-231 (231) Show / Hide
Range on Protein: 761-1029
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FDQSNIVGCGGFGLVFVASLPD-GTKVAIKRLTGDCLQVEREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMEN--GSLDSWLHESAKR-----
..  ...| |.|| |. .   . | .||||..        . .. |.| | . .|||.|.| ..    .|  ..  |...  |.| . ...  ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLARLMLPTATHVSTEMVGTLGYIPPEYAQSWMASP-KGDVYSFGVVLL
..  .   ...  ...|.|.|   . .|.|||.| .|||||   .  ..||||||..        | ..||. |..||       .. | |..|.|..| 
FPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLSRRRPVDVCRANGVYDLVAWVREMKGAGRGVEVLDPALRERGNEEEMERMLEVACQCLNPNPARRPGIEEVVT---------WL
|.|... | .        .. .  . ..                      . ...  ..||. .|..||.. |. .         |.
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase LRR11_d.AA TKL-Unique 763-973 28 7.9e-39 134.59 In-house 1-247 (290) Show / Hide
Range on Protein: 763-973
Range on HMM: 1-247/290
Sequence Identity: 28% (71 aa)

QSNIVGCGGFGLVFVASLPDGTKVAIKRLTG--DCL-QVEREFEAEVQALAMAD-HPNLVTLQGYSS----YGEHRLLIYSYMENGSLDSWLH-------
 .| .| ||.| |. .  . |..||||..    |   ....||| ||  . . . |||.|.. ||.     |  .. .. .|.. |||.. ||       
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--ESAKRLDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGR-----FVAHVADFGLARLML-PTATHVS-------TEMVGTLGYIPPEYA
  .. . |... |...|. .|.|. |||  |.| | |||.||||.|.| .     . . ..||||...    ... ..       .. .|.. ...||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QS--WMASPKGDVYSFGVVLLELLSRRR------PVDVCRANGVYDLVA
 .   . | | ||||||.|| |...| .      | . .  .... .|.
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVH

Kinase LRR11_d.AA LRRK 761-961 25 9.1e-36 124.01 In-house 1-284 (351) Show / Hide
Range on Protein: 761-961
Range on HMM: 1-284/351
Sequence Identity: 25% (75 aa)

FDQSNIVGCGGFG-LVFVASLPD---------------------------GTKVAIKRLTGD----------------------------------CLQV
.   . .| |||| .|. | . .                           ...|||| .. |                                  |. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAK--------RLDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNI
 |||  ||  .   .|||.| | |..   ... ..  |. .|.|.. ||....        ...|...| ||   |.|..|||  . | |.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------GRFVAHVADFGLARLMLPTATHV--STEMVGTLGYIPPEYAQSW---MASPKGDVYSFGVVLLELLSRR-RPVD
||   .            .|..||||. | |  ...|      .||. |.  ||  .       . | |.||||..| |||.|. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase LRR11_d.AA MLK 761-959 26 1.2e-34 117.72 In-house 1-235 (291) Show / Hide
Range on Protein: 761-959
Range on HMM: 1-235/291
Sequence Identity: 26% (63 aa)

FDQSNIVGCGGFGLVFVASLPDGTK-----VAIKRLT---GDCLQVE----REFEAEVQALAMADHPN-----LVTLQGYSSYGEHRLLIYSYMENGSLD
.. . ..| |.|| |. .    ..      ||.|| .     . ...    ..|| |.  |.. .|||      . . . .... | ...  |.|.||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

SWLHESAK-------------RLDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLD------GRFVAHVADFGLARLMLPT-ATHVSTEMVGT
. ||.  .             . | .  ...|   |||..|||   .. |.|||.||.|||.|      .  .. ..|||..| .  . ...  . . ||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM--MSNAGT

LGYIPPEY---AQSWMASPKGDVYSFGVVLLELLSRRRP
. .  ||    ... . | | ||.|.|||| |.|.|. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase LRR11_d.AA TK 761-956 15 3.3e-34 111.49 In-house 1-390 (486) Show / Hide
Range on Protein: 761-956
Range on HMM: 1-390/486
Sequence Identity: 15% (60 aa)

FDQSNIVGCGGFG---LVFVASLPDG--------------------------TKVAIKRLTGDCLQVEREFEA--------------EVQALAMAD----
    .  | | ||    |. . . ..                          |.||.| |. .. . ..||..              |.....| .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVTLQGYSSYG------------EHRLLIYSYMENGS----LDSWLHESAKR--------------------------------------------
 |||.| | |... |            |. ...  ||..|.    |...|... ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWSTRLDIARGAARGLAYLHLGCQP----HIVHRDIKSSNILLDGRFV-----------AHVADFG--
                               |.  ..| ... .|.|..|||  ..     ..||||.   |.|.. . |           . .||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLMLPTATHVSTEMVGTLG-------------------------YIPPEYAQSWM---------ASPKGDVYSFGVVLLELLSR
      ||| . .    ....  || .                         . .||  ..            ..| ||.||||.. |....
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY

Kinase LRR11_d.AA Pkinase_Tyr 761-909 25 3.9e-29 99.31 Pfam 1-161 (270) Show / Hide
Range on Protein: 761-909
Range on HMM: 1-161/270
Sequence Identity: 25% (42 aa)

FDQSNIVGCGGFGLVFVASLP-----DGTKVAIKRLTGDCLQVE---REFEAEVQALAMA-DHPNLVTLQGYSS-YGEH--RLLIYSYMENGSLDSWLHE
       | | || |. . .      ....||.| |  .. . .   ..| .|.. .    .|||.| | |  .  ||.   ...  ||..|.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---AKRLDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLARLM
     ..|. .. |....  |.|..||.      ..|||.   |.|..  .|. ..||||||..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI

Kinase LRR11_d.AA Dicty4 761-954 31 3.6e-28 91.17 In-house 1-211 (277) Show / Hide
Range on Protein: 761-954
Range on HMM: 1-211/277
Sequence Identity: 31% (68 aa)

FDQSNIVGCGGFGLVFVASLPDGTKVAIKRL----TGDCLQVEREFEAEVQALAMADHPNLVTLQGYSS----YGEHRLLIYSYMENGSLDSWLHE----
 .  .. | |.|| |. ..   |..||.| |    ... .    || .||  ..   |||.... |..       .  .    ||  |.| | ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--SAKRLDWSTRLD---IARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLARLMLPTATHVS--TEMVGTLGYIPPEYAQSWMASPKG
  . . |||....    .|. ||||...|| .| | |.|||.||.|.| |  ... |.||||...| .  .|    . ..|| ..  ||  ..     | 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELL
|||||| || |.|
DVYSFGIVLWEIL

Kinase LRR11_d.AA TyrKc 761-1029 20 1.1e-27 99.2 SMART 1-280 (280) Show / Hide
Range on Protein: 761-1029
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FDQSNIVGCGGFGLVFVASLPDGTKVAIKRLTGDCLQVEREFEAEVQALAMA--DHPNLVTLQGYSSYG-------EHRLLIYSYMENGSLDSWLHESAK
     . |.| || |. . .   ..||.| |  |.   ...|  | . . .   .|||.| | |. . .       |  ...  ||..|.|.. |... .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RLDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLARLMLPT--------ATHV----STEMVGTLGYIPPEYAQSWMASP
.| ... |...  .|.| .|||     ...|||.   |.|.. .... ..||||.|               ..    .. ..  .   .||  .  . ..
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KGDVYSFGVVLLELLSR-RRPVDV---CRANGVYDLVAWVREMKGAGRGVEVLDPALRERGNEEEM------ERMLEVACQCLNPNPARRPGIEEVVTWL
| ||.||||.. |....   |            ......|.. .   .  ...          . |      . | ..  || . .|. ||  .|..  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY----------P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF





Kinase LRR11_d.AA RIPK 767-959 31 1e-26 88.07 In-house 1-227 (290) Show / Hide
Range on Protein: 767-959
Range on HMM: 1-227/290
Sequence Identity: 31% (71 aa)

VGCGGFGLVFVASLPD-GTKVAIKRLTGDC------LQVEREFEAEVQALAMADHPNLVTLQGYSSYGEH------RLLIYSYMENGSLDSWLHESAKR-
|| |||| || |   . |. ||.|  ..         |.. .   |......... . | . |     |         .   |||||||   ||   .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWSTRLDIARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLARLMLPTATHV------------STEMVGTLGYIPPEYAQ--SW
   . |. |  .    ..|  ||| . .| | ||| | .|||.|. | . .||||||  |     |             | .  ||| |.|||       
HHPDPWPLRCRMIHEISCGMCYLH-SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

MA----SPKGDVYSFGVVLLELLSRRRP
 .    .|| |||||..|. |.|... |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP

Kinase LRR11_d.AA CZAK 783-959 29 1.3e-26 93.78 In-house 22-221 (279) Show / Hide
Range on Protein: 783-959
Range on HMM: 22-221/279
Sequence Identity: 29% (59 aa)

GTKVAIKRLTGDCLQVERE------FEAEVQALAMADHPNLVTLQGYSSYGE--HRLLIYSYMENGSLDSWLHESAKRLDW--STRLDIARGAARGLAYL
|. |||| .. .      |      |. ||  .    ||| |   |  | .   |.  .  .|. |||.  | .    .    . .. .|.  |||  ||
GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYL

HLGCQP-HIVHRDIKSSNILLDGRFV-------------AHVADFGLARLMLPTATHVSTEMVGTLGYIPPEYAQSWMASPKGDVYSFGVVLLELLSRRR
|    |  |.|||  |.|||||                 . ..|||| |.| . ..   |  .| | .  ||       ..| |||||| .| ...  . 
HDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEM-TQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQ

P
|
P

Kinase LRR11_d.AA DRK 764-959 32 3.1e-26 85.87 In-house 4-201 (258) Show / Hide
Range on Protein: 764-959
Range on HMM: 4-201/258
Sequence Identity: 32% (66 aa)

SNIVGCGGFGLVFVASLPDGTKVAIKRLTGDCLQ---VEREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAKRLDWSTRLD
 | .| |..| ||  .   ||.||.|.|  .         ||  |.  .    ||| .   |        . .  ||  ||| . ||. .  .||. .. 
GNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQ

IARGAARGLAYLHLGCQPHIVHRDIKSSNILLDGRFVAHVADFGLAR----LMLPTATHVSTEMVGTLGYIPPEYAQSWMASPKGDVYSFGVVLLELLSR
..  .|.|. ||| .| | |.||| || | | |  .   ||||||.         ...     |.|| . . ||   .     | |||||..|| |.. |
MMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT---MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR

RRP
  |
QDP

Kinase LRR11_d.AA Dicty4 1011-1031 34 0.000184 10.99 In-house 255-277 (277) Show / Hide
Range on Protein: 1011-1031
Range on HMM: 255-277/277
Sequence Identity: 34% (8 aa)

CLNPNPARRPGIEEVVTW--LEE
|....| .||  ||..    ||.
CWDHDPQHRPSFEEIIQRRILEH

Kinase LRR11_d.AA DRK 1011-1031 38 0.000218 10.81 In-house 238-258 (258) Show / Hide
Range on Protein: 1011-1031
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CLNPNPARRPGIEEVVTWLEE
|.| .|  ||  .|..  || 
CWNEDPQHRPSMQECLERLEA

Kinase LRR11_d.AA TK 998-1029 18 0.000476 8.62 In-house 454-486 (486) Show / Hide
Range on Protein: 998-1029
Range on HMM: 454-486/486
Sequence Identity: 18% (6 aa)

EEEMERML-EVACQCLNPNPARRPGIEEVVTWL
..... .. .. .|| ...|..||  ....  |
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase LRR11_d.AA MLK 1010-1029 40 0.003328 7.12 In-house 272-291 (291) Show / Hide
Range on Protein: 1010-1029
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

QCLNPNPARRPGIEEVVTWL
|| |..|..||   ..|. |
QCWNQDPHKRPSFRQIVQHL

Kinase LRR11_d.AA IRAK 997-1029 24 0.003398 7.37 In-house 285-317 (317) Show / Hide
Range on Protein: 997-1029
Range on HMM: 285-317/317
Sequence Identity: 24% (8 aa)

NEEEMERMLEVACQCLNPNPARRPGIEEVVTWL
.... . |. .||.|.    .||. ...|.  |
PPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase LRR11_d.AA TKL-Unique 1010-1029 35 0.030468 3.93 In-house 271-290 (290) Show / Hide
Range on Protein: 1010-1029
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

QCLNPNPARRPGIEEVVTWL
|| ...|  ||  .|... |
QCWHHDPSQRPSFDEIIHRL

Kinase LRR11_d.AA Pkinase_Tyr 942-956 46 0.566365 3.92 Pfam 196-210 (270) Show / Hide
Range on Protein: 942-956
Range on HMM: 196-210/270
Sequence Identity: 46% (7 aa)

DVYSFGVVLLELLSR
||.||||.. |....
DVWSFGVLMWEIFTY

Kinase LRR11_d.AA Pkinase_Tyr 1009-1029 33 5.124829 0.68 Pfam 250-270 (270) Show / Hide
Range on Protein: 1009-1029
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

CQCLNPNPARRPGIEEVVTWL
.|| ...|..||  .|..  |
KQCWHYDPEDRPTFSEIHEQL