Gene LRR2_b (S.moellendorffii)
LRR2_b
Species: S.moellendorffii
Alias: LRR2_b
External Links:
Annotation:
Sequence
Protein domains of LRR2_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | LRR2_b.AA | TKL | 1-175 | 22 | 5.8e-44 | 152.37 | In-house | 131-364 (364) | Show / Hide |
Range on Protein: 1-175 Range on HMM: 131-364/364 Sequence Identity: 22% (53 aa) WDSRMKIILGTAKGLAYMHEAI-----EPKIVHRDIKASNILLDSHWN--------------AKVSDFGLAKFLGCEKTHVMTR---------------- |. |....|..|.|..|.| . |.|.|||.| .|||.|..|. .|..||||..|. .. .| WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTT --VMGTFGYVAPEYAN----------------TGLLNERSDVYSFGVLLMEVVTGRDPVD-YSRPPGEVNLVDWLKLMLATRRMDDIADPRLEE------ . ||... ||| . . .|..||||||..| |..|.. | . | .| ... . ...|.. . . |. .. MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHK -KPSPRALKKALITAFQCVHPDVRKRPTMGHVVHLL | | ... . .| ..| .|||.. ... | MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | LRR2_b.AA | IRAK | 1-175 | 31 | 1.1e-35 | 124.01 | In-house | 108-317 (317) | Show / Hide |
Range on Protein: 1-175 Range on HMM: 108-317/317 Sequence Identity: 31% (68 aa) WDSRMKIILGTAKGLAYMHEAIEPK--IVHRDIKASNILLDSHWNAKVSDFGLAKFL----GCEKTHV---MT-RVMGTFGYVAPEYAN--TGLLNERSD | | .| .|||.|. . |.. .|. | |.||| .||||| | ..| .||||. | . ||. . || .| || | .||. . .| | ..| WHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTD VYSFGVLLMEVVTGRDPVDYSRPP--GEVNLVDWLKLMLAT--------------------RRM---DDIADPRLEEKPSPRALKKALIT-AFQCVHPDV |||||. |.||.||. .|. ||. . ..|.. .. . ||| . |.| . | |... |.. | .|.| . VYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMP--PCPPNMEKEMCQCACCCGHHRA RKRPTMGHVVHLL ..|..| |. .| NRRCDMAWVMQQL |
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| Kinase | LRR2_b.AA | Dicty4 | 4-105 | 37 | 1.7e-27 | 88.91 | In-house | 113-216 (277) | Show / Hide |
Range on Protein: 4-105 Range on HMM: 113-216/277 Sequence Identity: 37% (39 aa) R-MKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDSHWNAKVSDFGLAKFLGCEKTHVM--TRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVV | |.. . .|.|... |. . | |.|||.|..|.| | .|..||.||||.. ...| . . || ...||| || .|||||| .| | . RAMRMAFDAARGMNWLHCCN-PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL TGRDP |. .| TRQEP |
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| Kinase | LRR2_b.AA | Dicty4-Unclassified | 5-105 | 36 | 3.5e-25 | 83.17 | In-house | 112-207 (263) | Show / Hide |
Range on Protein: 5-105 Range on HMM: 112-207/263 Sequence Identity: 36% (37 aa) MKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDSHWNAKVSDFGLAKFLGCEKTHVMTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRD .|. . |.|....| ..|||||.||||.| | |.|. |||.. . . || . || .|| | .|||||....| | .|| IKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDE P | P |
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| Kinase | LRR2_b.AA | Pkinase | 6-175 | 23 | 6.2e-25 | 89.25 | Pfam | 112-293 (293) | Show / Hide |
Range on Protein: 6-175 Range on HMM: 112-293/293 Sequence Identity: 23% (46 aa) KIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDSHWNA----KVSDFGLAKFL-GCEKTHVMTRVMGTFGYVAPEYANTGLLN------ERSDVYSFGV .... ...||.|.|. .|.|||.| .|||.|.. . |..||||||.. .. || . || .|.||| .. ..|..|.|. FYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEV-----IRGGQYYGPKVDMWSCGC LLMEVVTGRDPVDYSRPPGEVNLVDWLKLMLATRRMDDIADPRLEEKPS-------------PRALKKALITAFQCVHPDVRKRPTMGHVVHL--L .| |...|| | . ... .. | .| .... ... . | . .| ... . .. | ..| |||| .... . ILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | LRR2_b.AA | RIPK | 1-105 | 31 | 9e-25 | 81.33 | In-house | 106-227 (290) | Show / Hide |
Range on Protein: 1-105
Range on HMM: 106-227/290
Sequence Identity: 31% (39 aa)
WDSRMKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDSHWNAKVSDFGLAKFLGCEKTHV----------MTRVM--GTFGYVAPEYANTGLLNE---
|. | .| .. | | | . | | ||| | .|||.|.. ..|..|||||.... . | |. || | .|| .|.. .
WPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKV
---RSDVYSFGVLLMEVVTGRDP
.|||||.... || |.. |
VTPKYDVYSFAIVMWEVLTQKHP
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| Kinase | LRR2_b.AA | TKL-Unique | 4-102 | 35 | 9.6e-25 | 84.29 | In-house | 112-224 (290) | Show / Hide |
Range on Protein: 4-102 Range on HMM: 112-224/290 Sequence Identity: 35% (41 aa) RMKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDSH-----WNAKVSDFGLAKFLGCEKTHVMTRV--------MGTFGYVAPEYANT--GLLNERSD |.|... |.|. | | . | | |||.| ||.|.|.. ||.|..||||.||. . . .. .|.| ..||| . . .| || RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD VYSFGVLLMEVVTG |||||. | | .|. VYSFGIVLWEIATR |
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| Kinase | LRR2_b.AA | MLK | 2-105 | 32 | 5.7e-24 | 80.12 | In-house | 124-235 (291) | Show / Hide |
Range on Protein: 2-105 Range on HMM: 124-235/291 Sequence Identity: 32% (37 aa) DSRMKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLDS------HWNAKVSDFGLAKFLGCEKTHVMTRVMGTFGYVAPEY---ANTGLLNERSDVYSF |. |.. | |.|..| |. ..|.|||.| .|||.| | ..|..|||..... . . |. .||. . ||| . . .| .||.|. DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSW GVLLMEVVTGRDP ||.| |..|.. | GVVLWEMLTREVP |
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| Kinase | LRR2_b.AA | LRRK | 4-107 | 35 | 1.8e-23 | 79.85 | In-house | 166-284 (351) | Show / Hide |
Range on Protein: 4-107 Range on HMM: 166-284/351 Sequence Identity: 35% (43 aa) RMKIILGTAKGLAYMHEAIEPKIVHRDIKASNILL---D---------SHWNAKVSDFGLAK-FLGCEKTHVMTRVMGTFGYVAPEYANTG---LLNERS . || | |||..|.| . |.|.||| | |||| . | .||..|||. | | .. | .. |..|..||| . . .| . KLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKV DVYSFGVLLMEVVTGR-DPVD |.||||..| | .|.. .| | DCYSFGMILWELLTRQHHPFD |
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| Kinase | LRR2_b.AA | LISK | 1-112 | 28 | 4.2e-21 | 65.12 | In-house | 100-247 (296) | Show / Hide |
Range on Protein: 1-112 Range on HMM: 100-247/296 Sequence Identity: 28% (43 aa) WDSRMKIILGTAKGLAYMHEAIEPKIVHRDIKASNILLD----SHWNAKVSDFGLAKFLGCEK--------------------------------THV-- |. |.|| |. |.|..| |. .|.||| |. |.|.. . |..|| |||.|. . ||. . WPQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR MTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVD--YSRPP || . || .||| . .|..||.|||..| | .|.... . |.| MT-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTP |
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| Kinase | LRR2_b.AA | TK | 4-105 | 23 | 9.5e-21 | 65.59 | In-house | 237-394 (486) | Show / Hide |
Range on Protein: 4-105
Range on HMM: 237-394/486
Sequence Identity: 23% (37 aa)
RMKIILGTAKGLAYMHEA----IEPKIVHRDIKASNILLDSHWN-----------AKVSDFG--------LAKFLGCEKTHVMTRVMGTFG---------
.. . . |.|..|.|. | ...||||. | |.|.... . .|..||| ||. .. .. . .. || .
LL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDP
----------------YVAPEYAN---------TGLLNERSDVYSFGVLLMEVVT-GRDP
. ||| | .| . |||.|||||. |..| |. |
WQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
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| Kinase | LRR2_b.AA | Pkinase_Tyr | 25-105 | 32 | 1.3e-11 | 39.98 | Pfam | 131-214 (270) | Show / Hide |
Range on Protein: 25-105 Range on HMM: 131-214/270 Sequence Identity: 32% (29 aa) KIVHRDIKASNILLDSHWNAKVSDFGLAKFL-----G-CEKTHVMTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVT-GRDP ...|||. | |.|... .|..|||||. . ... . . . ||| |.| .. |||.|||||. |..| |. | NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP |
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| Kinase | LRR2_b.AA | TK | 156-175 | 40 | 0.001292 | 7.14 | In-house | 467-486 (486) | Show / Hide |
Range on Protein: 156-175 Range on HMM: 467-486/486 Sequence Identity: 40% (8 aa) QCVHPDVRKRPTMGHVVHLL || |.| ..|||. ... | QCWHYDPEDRPTFSQLHEQL |
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| Kinase | LRR2_b.AA | Dicty4-Unclassified | 157-175 | 47 | 0.006553 | 5.76 | In-house | 245-263 (263) | Show / Hide |
Range on Protein: 157-175 Range on HMM: 245-263/263 Sequence Identity: 47% (9 aa) CVHPDVRKRPTMGHVVHLL | | | .||||| .. | CWHNDPNKRPTMNQIIQYL |
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| Kinase | LRR2_b.AA | MLK | 156-175 | 40 | 0.014722 | 4.85 | In-house | 272-291 (291) | Show / Hide |
Range on Protein: 156-175 Range on HMM: 272-291/291 Sequence Identity: 40% (8 aa) QCVHPDVRKRPTMGHVVHLL || ..| .|||.. ..| | QCWNQDPHKRPSFRQIVQHL |
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| Kinase | LRR2_b.AA | TKL-Unique | 156-175 | 40 | 0.16391 | 1.32 | In-house | 271-290 (290) | Show / Hide |
Range on Protein: 156-175 Range on HMM: 271-290/290 Sequence Identity: 40% (8 aa) QCVHPDVRKRPTMGHVVHLL || |.| .||. ..| | QCWHHDPSQRPSFDEIIHRL |
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| Kinase | LRR2_b.AA | Pkinase_Tyr | 156-175 | 40 | 0.344791 | 4.65 | Pfam | 251-270 (270) | Show / Hide |
Range on Protein: 156-175 Range on HMM: 251-270/270 Sequence Identity: 40% (8 aa) QCVHPDVRKRPTMGHVVHLL || |.| .|||. ... | QCWHYDPEDRPTFSEIHEQL |
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| Kinase | LRR2_b.AA | TKL | 330-598 | 22 | 1.5e-61 | 210.77 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 330-598
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)
LGRGGFGKVYKGRLSD---------GSLVAVKRLKEERSPGGE------------------------LQFQTEVEMISMAV--HRNLLRLRGFCMTPTE-
.|.||||.||||.. | ||||..|.. . . ..|. |.|. .| | |.... |.|. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------RLLVYPYMANGSVASRLRERNPGEPSLDWPTRKRIALGSARGLSYLHDHCD-----PKIIHRDVKAANILLDEEYE------------
.|. |. .|| ..| |. | |.||. |||..||| . |.||||| | .|||.|| ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD
--AVVGDFGLAKLM----DYKDTHVTTA--------------VRGTIGHIAPEYLS----------------TGKSSEKTDVFGYGIMLLELITGQRAFD
. ..||||.. | . .|| |. ..||... ||| | .. |||.||. .||.| |..|..| ..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
--LARLANDDDVMLLDWVKGLLREKKVVQLVDSDLHN----TYDLGEVEELIQVALLCTQVSPNDRPKMADVVRML
. | ... . .|. .... | ..... . | . |..|| . ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | LRR2_b.AA | IRAK | 324-526 | 36 | 7.7e-60 | 205.11 | In-house | 1-223 (317) | Show / Hide |
Range on Protein: 324-526 Range on HMM: 1-223/317 Sequence Identity: 36% (82 aa) FSNKNILGRGGFGKVYKGRLSDGS-LVAVKRLKEERSP---GGELQFQT---EVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERNPG |. | .| |||| ||.|... .|||.|||.... . . .||. |.. . | |.. | |.| . . ||||||.||| ||. ... FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ EP--SLDWPTRKRIALGSARGLSYLHDHCDPK--IIHRDVKAANILLDEEYEAVVGDFGLAKLM----DYKDTHV----TTAVRGTIGHIAPEYLS--TG | | |..|. |..|.|.|. .||. .|. |||.|.| ||||||. .. .||||. . ... . | |||| .||.. .| CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG KSSEKTDVFGYGIMLLELITGQRA . . ||||. || |||..||.|| QLTKKTDVYSFGIVLLEVLTGCRA |
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| Kinase | LRR2_b.AA | Pkinase | 324-524 | 26 | 1.1e-43 | 155.51 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 324-524 Range on HMM: 1-209/293 Sequence Identity: 26% (57 aa) FSNKNILGRGGFGKVYKGRLSDGSL-VAVKRLKEERSPGGELQFQT---EVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANG----SVASRLR--ER . . ..|.|.||.|||.. . . ||||..| .. ...| . |... . | | .||......... .| .|. .| . ..... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH NPGEPSL--DWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEA----VVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLS-TGKSSE .. . .. . |.... .||| |.|.. .|||||.| .|||.|.... ..||||||..|| . .| . ||.. .||| . . . GC----FYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP KTDVFGYGIMLLELITGQ | |....|..| |...|. KVDMWSCGCILYEMLCGR |
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| Kinase | LRR2_b.AA | TK | 324-522 | 17 | 6.6e-42 | 137.78 | In-house | 1-389 (486) | Show / Hide |
Range on Protein: 324-522
Range on HMM: 1-389/486
Sequence Identity: 17% (68 aa)
FSNKNILGRGGFG---KVYKGRLSDGS--------------------------LVAVKRLKEERSPGGELQFQ-------------TEVEMISMAV----
. ||.| || .||||.. ... |||| |||. . | .|. |.|...|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HRNLLRLRGFCMTPTE------------RLLVYPYMANGS----VASRLRERNPGEPS-----------------------------------------
| |..|| | |. . . ..| ||..|. . ||.. |..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LDWPTRKRIALGSARGLSYLHDH----CDPKIIHRDVKAANILLDEEYE-----------AVVGDFG--
|. ... ... |.|..|||.. ....|||. | |.|..|.. . ..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
------LAKLMDYKDTHVTTAVRGTI-------------------GH------IAPEYLS---------TGKSSEKTDVFGYGIMLLELIT
||. ....| ... .|| | ||| | .|| ..|.||. .|... |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
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| Kinase | LRR2_b.AA | Pkinase_Tyr | 324-522 | 28 | 2.1e-38 | 130.71 | Pfam | 1-209 (270) | Show / Hide |
Range on Protein: 324-522 Range on HMM: 1-209/270 Sequence Identity: 28% (61 aa) FSNKNILGRGGFGKVYKGRLS-----DGSLVAVKRLKEERSPGG--ELQFQTEVEMISMA-VHRNLLRLRGFCMTPTER---LLVYPYMANGSVASRLRE . ||.| ||.||||.. .. |||| ||| .. | |... . | |..|| | |. | ..| .||..|. . ||. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK RNPGEPSLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYKDTH-VTTA-----VRGTIGHIAPEYLSTGKSSE . .....|. .. ... |.|..||... .||||. | |.|..|. . ..|||||... .|. ... .. . ||| ...|| .. HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTT KTDVFGYGIMLLELIT |.|| .|. . |..| KSDVWSFGVLMWEIFT |
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| Kinase | LRR2_b.AA | S_TKc | 324-598 | 22 | 4.1e-38 | 133.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 324-598 Range on HMM: 1-231/231 Sequence Identity: 22% (65 aa) FSNKNILGRGGFGKVYKGRLSD-GSLVAVKRLKEERSPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMAN--GSVASRLRERNPGEPS- . ...|.|.||||||.| . | .||.|..| ... |... .. | |. .| ... . .. .| |. . |.. .....|... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLL .. . .... ...| |.|.| |||||.| .|||||| . ..|||||... | . || .||| | | . .| |. |..| PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILY ELITGQRAFDLARLANDDDVMLLDWVKGLLREKKVVQLVDSDLHNTYDLGEVEELIQVALLCTQVSPNDRPKMADVVR---------ML |...|. |. .. |... .. .|... | |. |..|| .. . . EMLCGYPPFP-------QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | LRR2_b.AA | MLK | 324-524 | 27 | 9.8e-38 | 128.51 | In-house | 1-233 (291) | Show / Hide |
Range on Protein: 324-524 Range on HMM: 1-233/291 Sequence Identity: 27% (64 aa) FSNKNILGRGGFGKVYKGRLSDGSL-----VAVKRLK--EERSPGGE----LQFQTEVEMISMAVHRN----LLRLRGFCMTPTE-RLLVYPYMANGSVA . .. ..| |.||||.||| . . ||||| . . . . . .|..|.. .. |.| ...| | |. ..| |...|| . IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY SRLRERNPGEP----------SLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDE------EYEAVVGDFGLAKLMDYKDTHVTTAVRGTI . |....... | ..|| |||..||| . ..||||| | |||.|| . ... |||... . .. . .|| NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY GHIAPEYL---STGKSSEKTDVFGYGIMLLELITGQ ||| . .| ||| ||. .|..| |..|.. AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE |
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| Kinase | LRR2_b.AA | TyrKc | 324-598 | 23 | 1.4e-37 | 132.06 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 324-598 Range on HMM: 1-280/280 Sequence Identity: 23% (72 aa) FSNKNILGRGGFGKVYKGRLSDGSLVAVKRLKEERSPGGELQFQTEVEMISMA--VHRNLLRLRGFCMTP-------TERLLVYPYMANGSVASRLRERN . . .||.| ||.||||... |||| |||. . | | .. .. | |..|| | |... ..| ||..|. ..||.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR PGEPSLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYK-------DTHVTT---AVR--GTIGHIAPEYLSTG | | ... ... |.| .|||.. ..|||| | |.|..|.. . ..||||.. . . |. ... . | ||| . .| PK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG KSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDV---MLLDWVKGLLREKKVVQLVDSDLHNTYDLGE------VEELIQVALLCTQVSPNDRPKMAD | ..|.||. .|... |. | . ... | . | .... . ..|. . .|. |. . | . |.||| ... KFTTKSDVWSFGVCMWEIFT------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE VVRML ... . IHECF |
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| Kinase | LRR2_b.AA | Dicty4 | 324-524 | 34 | 3.1e-35 | 115.07 | In-house | 1-214 (277) | Show / Hide |
Range on Protein: 324-524
Range on HMM: 1-214/277
Sequence Identity: 34% (74 aa)
FSNKNILGRGGFGKVYKGRLSDGSLVAVKRL--KEERSPGGELQ-FQTEVEMISMAVHRNLLRLRGFCM----TPTERLLVYPYMANGSVASRLRE---R
...|.|.||.||||. |. |||| | . . . .|. | ||. . | |.. . | | .| . . | || |...| |.
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE
NPGEPSLDWPTRKR---IALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYKDTHVT--TAVRGTIGHIAPEYLSTGKSSEKT
. .||||..|| .|. |||. .|| |.| ||||| |..|.| |. . . |.||||...| .| . ... || . ||| . ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA
DVFGYGIMLLELITGQ
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DVYSFGIVLWEILTRQ
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| Kinase | LRR2_b.AA | TKL-Unique | 328-525 | 31 | 7.4e-30 | 102.56 | In-house | 3-226 (290) | Show / Hide |
Range on Protein: 328-525 Range on HMM: 3-226/290 Sequence Identity: 31% (71 aa) NILGRGGFGKVYKGRLSDGSLVAVKRLK-EERSPGGELQ-FQTEVEMISMAV-HRNLLRLRGFCM----TPTERLLVYPYMANGSVASRLR------ERN | .|.||.|.|||| |. ||.|... .| | ..| | || ... | |.... |.|| .| .. .| |. || . | | NKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN PGEPSLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEE-----YEAVVGDFGLAKLMDYKDTHVTT--------AVRGTIGHIAPEYLST . . |.. | ..|. |.|. ||| ||.|.||||| | |.|.|.. . . . ||||.|. . .. .. . |.. .||| |. NNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM --GKSSEKTDVFGYGIMLLELITGQR . ||| ||. .||.| |..|... NFCQYSEKSDVYSFGIVLWEIATRKI |
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| Kinase | LRR2_b.AA | RIPK | 330-527 | 26 | 8.2e-30 | 98.76 | In-house | 1-228 (290) | Show / Hide |
Range on Protein: 330-527 Range on HMM: 1-228/290 Sequence Identity: 26% (60 aa) LGRGGFGKVYKGRLSDGSLVAVKRLKE--ERS----PGGELQFQTEVEMISMAVHRNLLRLRGFCMTP-----TE-RLLVYPYMANGSVASRLRERNP-G .|.||||.|.| | . ...| | .. . . |... .. ... ... ||| . . .| ||.||| . | . | VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ EPSLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYKDTHV-----------TTAVR-GTIGHIAPEYLS--TG .. . || | |. ..| |||. .| ||||| | .|||.| .. . . |||||. | | . . | ||. ...|| . HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK KS----SEKTDVFGYGIMLLELITGQRAF |. ..| || ..| . |. |. .. KPIKVVTPKYDVYSFAIVMWEVLTQKHPY |
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| Kinase | LRR2_b.AA | LRRK | 378-528 | 31 | 6.1e-25 | 85.15 | In-house | 116-284 (351) | Show / Hide |
Range on Protein: 378-528 Range on HMM: 116-284/351 Sequence Identity: 31% (54 aa) HRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERNPGE-----PSLDWPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILL---D--------- | |.. | |||. | . .| |. .|. ..|... . ....| .. .||| |.|. |||.| .|.||||| | |||| . HPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNILLWSSPQNHSPNYPN EEYEAVVGDFGLAKLMDYKDTH-VTTAVRGTIGHIAPEYLSTG---KSSEKTDVFGYGIMLLELITGQ-RAFD ... | ..|||. | . ... |. . |..| ||| . . .||.|.. .|. | ||.|.| ..|| AHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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| Kinase | LRR2_b.AA | Dicty4-Unclassified | 427-523 | 35 | 7.5e-25 | 82.02 | In-house | 113-204 (263) | Show / Hide |
Range on Protein: 427-523 Range on HMM: 113-204/263 Sequence Identity: 35% (34 aa) RIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEEYEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITG ..|. |.|. .|| .||||.|..|||.| . . ..|||.. |. . |.. || .|| | | ||. |..|| ||.|| KYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG |
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| Kinase | LRR2_b.AA | LISK | 422-526 | 31 | 2e-24 | 76.08 | In-house | 100-238 (296) | Show / Hide |
Range on Protein: 422-526 Range on HMM: 100-238/296 Sequence Identity: 31% (45 aa) WPTRKRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEE----YEAVVGDFGLAKLMDYKDTH---------------------------------VT || | .|||. |.|.||||. . ||||| |. |.|..| ....|.|||.|..|| .. . WPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR TAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRA .. || ||| | . .|. ||| .||.|.|.||. .| MTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA |
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| Kinase | LRR2_b.AA | LISK | 329-383 | 30 | 7e-09 | 24.78 | In-house | 1-60 (296) | Show / Hide |
Range on Protein: 329-383 Range on HMM: 1-60/296 Sequence Identity: 30% (18 aa) ILGRGGFGKVYKGRLS-DGSLVAVKRLKEE----RSPGGELQFQTEVEMISMAVHRNLLR ..|.|.|||||||.. .|. .|.| ... | . .. ||.|. . |.| .. EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQ |
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| Kinase | LRR2_b.AA | LRRK | 324-355 | 18 | 7.3e-07 | 20.3 | In-house | 1-60 (351) | Show / Hide |
Range on Protein: 324-355 Range on HMM: 1-60/351 Sequence Identity: 18% (11 aa) FSNKNILGRGGFG-KVYKGRLSD---------------------------GSLVAVKRLK . . .|||||| .||.... . .. ||.| .. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN |
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| Kinase | LRR2_b.AA | Dicty4-Unclassified | 327-391 | 35 | 1.2e-05 | 15.25 | In-house | 4-70 (263) | Show / Hide |
Range on Protein: 327-391 Range on HMM: 4-70/263 Sequence Identity: 35% (24 aa) KNILGRGGFGKVYKGRLSDGSLVAVKRLKEERSPGG-EL--QFQTEVEMISMAVHRNLLRLRGFCMTP .|.| | ||.|| | |||| . | . |. | |||. | ||....| |. | DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINP |
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| Kinase | LRR2_b.AA | TK | 568-598 | 25 | 0.000107 | 10.83 | In-house | 456-486 (486) | Show / Hide |
Range on Protein: 568-598 Range on HMM: 456-486/486 Sequence Identity: 25% (8 aa) GEVEELIQVALLCTQVSPNDRPKMADVVRML .. ||. .. . | . |.||| .......| CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | LRR2_b.AA | LISK | 571-598 | 21 | 0.000239 | 9.81 | In-house | 269-296 (296) | Show / Hide |
Range on Protein: 571-598 Range on HMM: 269-296/296 Sequence Identity: 21% (6 aa) EELIQVALLCTQVSPNDRPKMADVVRML ........ |. . |..||. ...|. | PPFLDLCFDCCKYDPKNRPSFKEIVQWL |
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| Kinase | LRR2_b.AA | IRAK | 569-598 | 33 | 0.016363 | 4.92 | In-house | 288-317 (317) | Show / Hide |
Range on Protein: 569-598 Range on HMM: 288-317/317 Sequence Identity: 33% (10 aa) EVEELIQVALLCTQVSPNDRPKMADVVRML ...|. |.|. |. | |..|| |. | MEKEMCQCACCCGHHRANRRCDMAWVMQQL |
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| Kinase | LRR2_b.AA | MLK | 585-598 | 35 | 0.045717 | 3.12 | In-house | 278-291 (291) | Show / Hide |
Range on Protein: 585-598 Range on HMM: 278-291/291 Sequence Identity: 35% (5 aa) PNDRPKMADVVRML |..||... .| | PHKRPSFRQIVQHL |
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| Kinase | LRR2_b.AA | LRRK | 579-600 | 31 | 0.074731 | 2.32 | In-house | 330-351 (351) | Show / Hide |
Range on Protein: 579-600 Range on HMM: 330-351/351 Sequence Identity: 31% (7 aa) LCTQVSPNDRPKMADVVRMLEG .| | |..||.. ..| |. HCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | LRR2_b.AA | Dicty4-Unclassified | 580-598 | 36 | 0.093991 | 1.74 | In-house | 245-263 (263) | Show / Hide |
Range on Protein: 580-598 Range on HMM: 245-263/263 Sequence Identity: 36% (7 aa) CTQVSPNDRPKMADVVRML | .|| || | ... | CWHNDPNKRPTMNQIIQYL |
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| Kinase | LRR2_b.AA | Pkinase_Tyr | 571-598 | 25 | 0.147392 | 5.9 | Pfam | 243-270 (270) | Show / Hide |
Range on Protein: 571-598 Range on HMM: 243-270/270 Sequence Identity: 25% (7 aa) EELIQVALLCTQVSPNDRPKMADVVRML .|. .. ..| . |.||| .......| DEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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