LRR25_c

Species: S.moellendorffii
Alias: LRR25_c
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR25

Sequence

Name Sequence Type Origin Length Description Download
LRR25_c.AA Protein None 257 None Fasta, JSON
LRR25_c.NA RNA None 774 None Fasta, JSON
LRR25_c.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of LRR25_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRR25_c.AA TKL 13-233 22 9e-47 161.7 In-house 72-364 (364) Show / Hide
Range on Protein: 13-233
Range on HMM: 72-364/364
Sequence Identity: 22% (68 aa)

FEKELHLLGRAHHSCLVNLIGYCEVDK---------------LLVFEFMPRGT-LSQNIYTKTPPLDWVSRIRIAEQAARGLEYLHRYAS-----PSIIH
.|.|. .. | .|  .| ..|||   .                .| |..|.|. |.. .        |  |.|.| ..|||..|||         | |||
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIH

RDVKSSNILLDYNWN--------------AHVSNFGLCS-LEETQ--------------------ASGTTITTPGYLDPEY----------------GSC
|| ||.|||.| ||.              . .. |||.  .....                    ...| . ||... ||                   .
RDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKG

LRLTAKSDVYSFGVVLLELLSGEKPIDSSRNIQDLAA----WVLDLVGRDEWNSVLDQKLAL----PPQPEPLYNAVKLSLECTKVRGKDRPTMSEVAQR
.  . |.||||||.|| |.|....| .   ... ...    . . .|. .     ..         .| |  .    ||  .| .   ..||...|. .|
FEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKR

L
|
L

Kinase LRR25_c.AA IRAK 4-170 33 6.6e-35 121.19 In-house 38-228 (317) Show / Hide
Range on Protein: 4-170
Range on HMM: 38-228/317
Sequence Identity: 33% (64 aa)

SDENRSEKMFEK---ELHLLGRAHHSCLVNLIGYC-EVDKL-LVFEFMPRGTLSQNIYTKT---PP--LDWVSRIRIAEQAARGLEYLHRYASP-SIIHR
. .| ... |     || .. | .|  .| | ||| | ... ||...|| |.|       .   ||  | |  |. |.. .|.|...||   .  .|||.
MSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHG

DVKSSNILLDYNWNAHVSNFGLCS------LEETQAS-----GTTITTPGYLDPEYGS--CLRLTAKSDVYSFGVVLLELLSGEKPIDSSR
|.||.||||| . ..  . |||.         | | .      ....|  |. ||.      .|| |.||||||.||||.|.|... .. |
DIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDR

Kinase LRR25_c.AA TKL-Unique 6-165 28 4.1e-31 107.03 In-house 35-233 (290) Show / Hide
Range on Protein: 6-165
Range on HMM: 35-233/290
Sequence Identity: 28% (57 aa)

ENRSEKMFEKELHLLGRAH-HSCLVNLIGYCE---VDKL---LVFEFMPRGTLSQNIY---------TKTPPLDWVSRIRIAEQAARGLEYLHRYASPSI
.|.... ||.|. .. . | |  .| ..|||    |.     .| |..|.|.|  ..           .  .|..  |...|...|.|..|||..  | |
SNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-I

IHRDVKSSNILLDYN-----WNAHVSNFGLCSLEETQASGTTI-----------TTPGYLDPEYGSC--LRLTAKSDVYSFGVVLLELLSGEK------P
|||| ||||.|.| |     ||. .. |||. .  .   .|..           ... .. ||  .      . ||||||||.|| |.....       |
IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP





Kinase LRR25_c.AA Dicty4-Unclassified 13-165 34 5.5e-30 99.87 In-house 45-207 (263) Show / Hide
Range on Protein: 13-165
Range on HMM: 45-207/263
Sequence Identity: 34% (59 aa)

FEKELHLLGRAHHSCLVNLIGYCEVD------KLLVFEFMPRGTLSQNIY----TKTPPLDWVS--RIRIAEQAARGLEYLHRYASPSIIHRDVKSSNIL
| ||  .||   |  || . |||            | |||..|.|   |      .  |.   .   |..|   |.|. .||   .  .||||.||||||
FKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNIL

LDYNWNAHVSNFGLCSLEETQASGTTIT-TPGYLDPEYGSCLR---LTAKSDVYSFGVVLLELLSGEKP
.| . |. .  ||.    .     |||  ||    ||   ||.    . ||||||....| ||. |. |
MDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPE---CLMHESYNQKSDVYSYAMMLYELATGDEP

Kinase LRR25_c.AA LRRK 13-167 31 3.5e-25 86.01 In-house 104-284 (351) Show / Hide
Range on Protein: 13-167
Range on HMM: 104-284/351
Sequence Identity: 31% (58 aa)

FEKELHLLGRAHHSCLVNLIGYCEVDKLLVFEFMPRGTLSQNIYTKT--------PPLDWVSRIRIAEQAARGLEYLHRYASPSIIHRDVKSSNILL---
| .|.... . .|...|.|.|.|     .| |..| |.|.. .  |         . ..|  ...|| | |.|.||||. ..|.||||| || ||||   
FRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILLWSS

D---------YNWNAHVSNFGLCS----LEETQASGTTITTPGYLDPEYGSCLR------LTAKSDVYSFGVVLLELLSGE-KPID
.          . .|... ||. .    . .. |.| . ..||.. ||   ..|       | |.|.||||..| |||...  | |
PQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE---IMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase LRR25_c.AA DRK 40-160 36 1.1e-23 77.11 In-house 73-196 (258) Show / Hide
Range on Protein: 40-160
Range on HMM: 73-196/258
Sequence Identity: 36% (45 aa)

LLVFEFMPRGTLSQNIYTKTPPLDWVSRIRIAEQAARGLEYLHRYASPSIIHRDVKSSNILLDYNWNAHVSNFGLCS----LEETQASGTTITTPGYLDP
. . |.|||| | .        .||  .....  .|.|. |||    | ||||| || | | | .|   |. |||       ..  .  | . ||.   |
CICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAP

EYGSCLRLTAKSDVYSFGVVLLELL
|     | | | |||||..|| |..
EVLRNQRYTEKADVYSFAIVLWECV

Kinase LRR25_c.AA Dicty4 44-165 36 1.3e-23 75.81 In-house 82-216 (277) Show / Hide
Range on Protein: 44-165
Range on HMM: 82-216/277
Sequence Identity: 36% (51 aa)

EFMPRGTLSQNIYT------KTPPLDWVSRIR---IAEQAARGLEYLHRYAS--PSIIHRDVKSSNILLDYNWNAHVSNFGLCS----LEETQA-SGTTI
|.||.|.|   .        .  .|||  ..|   .|  ||||. .||   .  | ||||| ||.|.| | ||.. |. |||       |. ..   |..
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC

TTPGYLDPEYGSCLRL---TAKSDVYSFGVVLLELLSGEKP
 ||..  ||   ...    . |.|||||| || |.| .. |
GTPCWMAPE---VMMHQPYNEKADVYSFGIVLWEILTRQEP

Kinase LRR25_c.AA TK 4-233 14 1.4e-22 71.81 In-house 65-486 (486) Show / Hide
Range on Protein: 4-233
Range on HMM: 65-486/486
Sequence Identity: 14% (63 aa)

SDENRSEKM--------------FEKELHLLG--RAHHSCLVNLIGYCEVDK--------------LLVFEFMPRGT----LSQNIYTKTPP--------
... . ...              .  |. ..     ||  .|.|.|.|  ..              ..| |.|| |     | .   .. |.        
AMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCP

-------------------------------------------------------------------LDWVSRIRIAEQAARGLEYLHRY----ASPSII
                                                                   |.   .. .. |.|.|.||||.       . ..
DNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFV

HRDVKSSNILLDYNWN-----------AHVSNFG--------LCSLEETQASGTTITTPG----------------------------YLDPEYGSCLR-
|||.   |.|.. | .           . .. ||        |.   .     .. ...|                            .. ||   ||. 
HRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE---CLND

-----------LTAKSDVYSFGVVLLELLS-GEKPIDSSRNIQDLAAW-----VLDLVGRD-------EWNSVLDQKLALP-PQPEPLY-----------
            | ||||.||||.. |... |..|     . || ..      |.... |          |   ..   .. |||.              
RVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGL-N---EVGYRMRMPQPPHCPDWMRYRMHPPH

---NAVKL-SLECTKVRGKDRPTMSEVAQRL
    .. .  ..| .   .||||.|.. ..|
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase LRR25_c.AA Pkinase 6-163 25 1.3e-21 77.5 Pfam 35-209 (293) Show / Hide
Range on Protein: 6-163
Range on HMM: 35-209/293
Sequence Identity: 25% (45 aa)

ENRSEKMFEK-----ELHLLGRAHHSCLVNLIGYCEVDKLLV--FEFMPRG----TLSQNIY-TKTPPL--DWVSRIRIAEQAARGLEYLHRYASPSIIH
....... .      |.... | .| . | |....| .. .   .|... |     |.  |   .  ..  ..   .... | .|||||.|.    .|||
RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIH

RDVKSSNILLDYNWNA----HVSNFGLCS---LEETQASGTTITTPGYLDPEYGS-CLRLTAKSDVYSFGVVLLELLSGE
||.|..|||.| | .     ... |||.    .   .   |   ||.|. ||    .   . |.|..|.|..| |.|.|.
RDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

Kinase LRR25_c.AA RIPK 41-165 30 1.6e-21 70.05 In-house 79-227 (290) Show / Hide
Range on Protein: 41-165
Range on HMM: 79-227/290
Sequence Identity: 30% (46 aa)

LVFEFMPRGTLSQNIYTKT----PPLDWVSRIRIAEQAARGLEYLHRYASPSIIHRDVKSSNILLDYNWNAHVSNFGLCSLEETQASGT--------TI-
.| |.|. | |.    ||.    .|. |  | |.  . ..|  |||    | ||||| | .|||.| | .. .. ||| .  ..  |..         . 
IVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSM

------TTPGYLDPEYGS---CLR---LTAKSDVYSFGVVLLELLSGEKP
       |  |..||        .    | |.|||||..|. |.|.. .|
KSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP

Kinase LRR25_c.AA MLK 4-165 26 2.6e-21 70.79 In-house 43-235 (291) Show / Hide
Range on Protein: 4-165
Range on HMM: 43-235/291
Sequence Identity: 26% (52 aa)

SDENRSEKMFEKELHLLGRAHHSC----LVNLIGYCEVD-K--LLVFEFMPRGTLSQNIYTKTP-------------PLDWVSRIRIAEQAARGLEYLHR
||.  . . ||.|  .| .  |       . . | |  . .  ..| |... | |.  ......               |  . ...| | |||..||| 
SDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS

YASPSIIHRDVKSSNILLD------YNWNAHVSNFGL-CSLEETQAS-GTT-ITTPGYLDPEY---GSCLRLTAKSDVYSFGVVLLELLSGEKP
 | . ||||| ||.|||.|       . .. .. ||. ... ... .  .  . |. .  ||      | . . |.||.|.|||| |.|..| |
MAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase LRR25_c.AA S_TKc 4-237 20 4.3e-13 15.13 SMART 19-231 (231) Show / Hide
Range on Protein: 4-237
Range on HMM: 19-231/231
Sequence Identity: 20% (53 aa)

SDEN----------RSEKMFEKELHLLGRAHHSCLVNLIGYCE-VDKLLVFEFMPR--GTLSQNIYTKTPP-----LDWVSRIRIAEQAARGLEYLHRYA
 . .          .  .....|. .| . ||  .|.|.....  .  .|.|...   |.| . |  . ..     ..     ... | ...|||.|.  
RHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG

SPSIIHRDVKSSNILLDYNWNAHVSNFGLCSLEETQASGTTITTPGYLDPEYGSCLRLTA-KSDVYSFGVVLLELLSGEKPIDSSRNIQDLAAWVLDLVG
   |||||.| .|||||   .  .. |||. .       | . || |. ||       .  |.|..|.|..| |.|.|. | .   ..| .   ..    
---IIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----

RDEWNSVLDQKLALPPQPEPLYNAVKLSLECTKVRGKDRPTMSEVAQ-----RLEEIL
                       |  .   | ..  ..|||  |. |     .. . .
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

TyrKc LRR25_c.AA TyrKc 3-233 19 4.5e-12 -27.44 SMART 1-280 (280) Show / Hide
Range on Protein: 3-233
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

LS---------------------------DENRSEKMFEKELHLLGRA--HHSCLVNLIGYCEVD---------KLLVFEFMPRGTLSQNIYTKTPPLDW
..                            |.  ...| .|. .. .   || ..|.|.|.|  .          ..|.|.|| | | . .  . | | .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

VSRIRIAEQAARGLEYLHRYASPSIIHRDVKSSNILLDYNWNAHVSNFGLCSLEETQ-ASGTTITTPGYLDPEYGSCLR------------L-----TAK
   . .. |.|.| ||||.     .||||    |.|.. |  . .| |||.   .   ..|       | ..  ... .            .     | |
KDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

SDVYSFGVVLLELLSGEKPIDSS-----RNIQDLAAWVLDLVGRDEWNSVLDQKLALPPQ---------PEPLYNAVKLSLECTKVRGKDRPTMSEVAQR
|||.||||.. |...  ..  .       . |.. ..| .              .  ||          |. .|.     ..| .   .||||.||. ..
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-----------GYRMPQPPNDYPMSFVCCPDEMYQIM---KQCWHEDPEDRPTFSEIHEC

L
.
F

Kinase LRR25_c.AA Pkinase_Tyr 11-94 27 1.6e-10 36.27 Pfam 48-137 (270) Show / Hide
Range on Protein: 11-94
Range on HMM: 48-137/270
Sequence Identity: 27% (26 aa)

KMFEKELHLLGRA-HHSCLVNLIGYCE-VDK----LLVFEFMPRGTLSQNIYTK---TPPLDWVSRIRIAEQAARGLEYLHRYASPSIIHRDV
..| .|. ..    ||  .|.|.| |   ..    ..|.|.|| | |     ..    .||.    . .. | |.|.|||..     .||||.
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL

Kinase LRR25_c.AA Pkinase_Tyr 142-165 52 0.000274 15.15 Pfam 190-214 (270) Show / Hide
Range on Protein: 142-165
Range on HMM: 190-214/270
Sequence Identity: 52% (13 aa)

RLTAKSDVYSFGVVLLELLS-GEKP
. | ||||.||||.. |... ||.|
KFTTKSDVWSFGVLMWEIFTYGEQP

Kinase LRR25_c.AA Dicty4 223-235 46 0.000843 8.75 In-house 263-277 (277) Show / Hide
Range on Protein: 223-235
Range on HMM: 263-277/277
Sequence Identity: 46% (7 aa)

RPTMSEVAQR--LEE
||...|. ||  ||.
RPSFEEIIQRRILEH

Kinase LRR25_c.AA LRRK 221-235 40 0.008763 5.66 In-house 337-351 (351) Show / Hide
Range on Protein: 221-235
Range on HMM: 337-351/351
Sequence Identity: 40% (6 aa)

KDRPTMSEVAQRLEE
|.||..|.. .||..
KKRPHFSQIVKRLSQ

Kinase LRR25_c.AA IRAK 213-233 33 0.012823 5.3 In-house 297-317 (317) Show / Hide
Range on Protein: 213-233
Range on HMM: 297-317/317
Sequence Identity: 33% (7 aa)

LECTKVRGKDRPTMSEVAQRL
..|.  | . |..| .| |.|
CCCGHHRANRRCDMAWVMQQL

Kinase LRR25_c.AA DRK 223-235 53 0.040116 3.03 In-house 246-258 (258) Show / Hide
Range on Protein: 223-235
Range on HMM: 246-258/258
Sequence Identity: 53% (7 aa)

RPTMSEVAQRLEE
||.| |. .||| 
RPSMQECLERLEA

Kinase LRR25_c.AA Dicty4-Unclassified 221-233 46 0.051436 2.65 In-house 251-263 (263) Show / Hide
Range on Protein: 221-233
Range on HMM: 251-263/263
Sequence Identity: 46% (6 aa)

KDRPTMSEVAQRL
. |||| .. |.|
NKRPTMNQIIQYL

Kinase LRR25_c.AA MLK 221-233 30 0.101647 1.9 In-house 279-291 (291) Show / Hide
Range on Protein: 221-233
Range on HMM: 279-291/291
Sequence Identity: 30% (4 aa)

KDRPTMSEVAQRL
..||..... | |
HKRPSFRQIVQHL

Kinase LRR25_c.AA Pkinase_Tyr 221-233 53 0.514944 4.06 Pfam 258-270 (270) Show / Hide
Range on Protein: 221-233
Range on HMM: 258-270/270
Sequence Identity: 53% (7 aa)

KDRPTMSEVAQRL
.||||.||. ..|
EDRPTFSEIHEQL