Gene LRR8_x-2 (S.moellendorffii)

LRR8_x-2

Species: S.moellendorffii
Alias: LRR8_x-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_x-2.AA Protein None 1023 None Fasta, JSON
LRR8_x-2.NA RNA None 3072 None Fasta, JSON
LRR8_x-2.kin_dom Protein Kinase Domain None 219 None Fasta, JSON

Protein domain

Protein domains of LRR8_x-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_x-2.AA LRRNT_2 22-62 47 6.3e-18 61.14 Pfam 1-46 (46) Show / Hide 
Range on Protein: 22-62
Range on HMM: 1-46/46
Sequence Identity: 47% (22 aa)

LTPDGQSLLAFKASIE--DP-ATHLRDWNESD--ATPCRWTGITCD
.  |||.|||||.|.   || .  |..|| |.  ...|.|||.|||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 LRR8_x-2.AA LRR_1 66-89 29 1.602189 6.02 Pfam 1-26 (26) Show / Hide 
Range on Protein: 66-89
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RVSSLTLSN-M--SLSGSIAPGTLSRL
.  .| ||.    .|.|.| |...  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 91-114 29 38.296005 1.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 91-114
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALANLSLDV-N--DLGGALPAELLGAL
 |  |.|.  |   | | .| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 116-138 25 0.002377 16.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 116-138
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

LLRYLNISHC---NFSGDFPAN-LSSA
 |..|..|.|   |..|..| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 141-163 33 0.035191 11.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 141-163
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLAILDAYN-N--NFTGALPIG-LSAL
.| .||  . |  |.|| .| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 189-211 44 0.00148 16.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 189-211
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLQYLALSG-N--DLSGEIPAE-MGDL
.||.| ||| |   |.|.|| .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 213-236 37 0.117759 10.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 213-236
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLEQLYLGYYN--HFSGGIPRS-FGRL
.|. |.|.. |  ...| || | |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 238-260 29 0.046526 11.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 238-260
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLRRLDLAS-A--GINGSIPIE-LGGL
.|..||| .     . |.|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 262-284 33 0.716172 7.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 262-284
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLDTLFLQL-N--SLAGSIPDA-IGGL
.| .| |.  |  .| |.||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 286-308 51 9.7e-05 20.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 286-308
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

ALQSLDLSC-N--QLTGGIPAS-LEKL
 ||.||||. |  .||| || | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 310-332 33 0.116997 10.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 310-332
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ELKLLNLFR-N--NLSGEIPSF-VGDM
 |. |.| . |  ||.|.||.     .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 334-356 33 0.036589 11.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 334-356
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLEVLFLWG-N--GFVGAIPEF-LGGN
||..| | | |   ..| ||.  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 382-404 29 0.005215 14.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 382-404
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLATLILQQ-N--RLSGSIPEE-LGSC
.| .| |.  |  .|.|.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 358-381 37 2.411991 5.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 358-381
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLWMLDLSK-N--ALNGSVPSSLCRGG
.|  ||||  |   | |..|.| . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 406-428 29 0.112526 10.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 406-428
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLEKVRLGD-N--LLSGAIPRG-LFAL
.|..  |.. |   |.| || . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 454-476 33 0.043885 11.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 454-476
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLEKIDLSE-N--LLRGEISEG-IGAL
.|...|||  |   | |.|... . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 478-500 25 0.270387 8.76 Pfam 1-26 (26) Show / Hide 
Range on Protein: 478-500
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

MLKELQISY-N--RLAGAVPAG-LGRM
 |..| .|. |  .| | .| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 502-524 29 0.371686 8.27 Pfam 1-26 (26) Show / Hide 
Range on Protein: 502-524
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

WLLQLNLTH-N--FFSGGIPPE-VGSC
 |  |.| . |   ..| |||.   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 526-548 44 0.001134 17.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 526-548
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLTMLDLSV-N--QLSGEIPRS-LEAL
.|. ||||  |  .|.|.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 550-572 33 2.350151 5.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 550-572
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

VLGVLNLSR-N--AFSGGIPRG-IALL
 | .|.||. |   ..| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_x-2.AA LRR_1 574-590 40 2.037303 5.65 Pfam 1-20 (26) Show / Hide 
Range on Protein: 574-590
Range on HMM: 1-20/26
Sequence Identity: 40% (8 aa)

SLNSVDFSY-N--RLSGAIP
.| . |.|. |  .|.| ||
NLQHLDLSGCNCCNLTGHIP
Kinase LRR8_x-2.AA TKL 710-993 21 7.1e-59 201.91 In-house 1-364 (364) Show / Hide 
Range on Protein: 710-993
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

IGRGGSGIVYKGVMPS---------GEIVAVKKLSG-------------FNPAAAAGVARGKIGGSMSHSD---------------HGFSAEVQTLGKIR
||.||.|.||||.            |. |||||..               .  .                .                 .  |.  . ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENND-NN----------------NYSDMQLNDPEASWFRFFEEEEIMMMSRLR

HRNIVKLLGFCSNKET-------------NVLVYEYMPNGSLGEALHGSSKGAVMLDWATRYKIALQAANGLCYLHHDCS-----PLIVHRDVKSNNILL
| |||...|.| . .                .|.||.|.||| . ||          |  | ..||..| |..||| .       | |.||| ||.|||.
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV

DAEFQ--------------ARVADFGLAKLFQDSGKSESMSS-----------------IAGSYGYIAPEYA-----YT-----------LKVNEKSDIY
|  ..              . ..||||.. .. ||... ...                 . |.... |||       ||           .. .||.|.|
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

SFGVVLLELVSGRRPIEPEFGDGVDIVQWVRKKIQTKDGVLEVLDSRIREENLP-------LQEIMLVLRVALLCTSDLPVDRPTMRDVVQML
|||.|| |.....|| . .  . ...   .  ..  .  ... |   | .. .         .    . . .  | .  | .||.. .... |
SFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_x-2.AA IRAK 704-922 34 1.4e-55 190.94 In-house 1-223 (317) Show / Hide 
Range on Protein: 704-922
Range on HMM: 1-223/317
Sequence Identity: 34% (81 aa)

SNEDNIIGRGGSGIVYKGVMPSGE-IVAVKKLSGFNPAAAAGVARGKIGGSMSHSDHGFSA---EVQTLGKIRHRNIVKLLGFCSNKETNVLVYEYMPNG
...|| || || | ||.|..   . |.|||||      . | .       |   ..  | .   |.... ..|| ||| |.|.|.  .   |||.|||||
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKL-----KEMADM-------SWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNG

SLGEALHGSSKGAVM---LDWATRYKIALQAANGLCYLHHDCS--PLIVHRDVKSNNILLDAEFQARVADFGLAKL--FQDSGKSESM-----SSIAGSY
||   |..  .|...   | | .| .|.. .|.|. .|| . .  |.| |.|.|| |||||. |..  .||||.    .  . .. .      | . |. 
SLEDRLWC-QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTT

GYIAPEYAY--TLKVNEKSDIYSFGVVLLELVSGRRP
 | .||. .  . .   |.|.||||.||||...|.|.
WYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase LRR8_x-2.AA MLK 704-922 30 8.7e-45 153.3 In-house 1-235 (291) Show / Hide 
Range on Protein: 704-922
Range on HMM: 1-235/291
Sequence Identity: 30% (75 aa)

SNEDNIIGRGGSGIVYKGVMPSGE----IVAVKKLSGFNPAAAAGVARGKIGGSMSHS---DHGFSAEVQTLGKIRHRN----IVKLLGFCSNKETN-VL
 ..  .|| |..| |.||..   .    |||||.            .|  |  ..| .   .  |  |.  | ...|.|    |....| |.. . . ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKR------------VRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCI

VYEYMPNGSLGEALHG-SSKGA---------VMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDA------EFQARVADFGLAKLFQDSG
| ||...||| . ||| .||..         .  | .   ..||| |.|. ||| .  ..|.||| || |||.|.      . .....|||... .....
VMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC

KSESMSSIAGSYGYIAPEY---AYTLKVNEKSDIYSFGVVLLELVSGRRP
  . | | ||.| . |||    .   |..||.|..|.|||| |..... |
--TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_x-2.AA Pkinase 704-920 26 3e-41 146.91 Pfam 1-209 (293) Show / Hide 
Range on Protein: 704-920
Range on HMM: 1-209/293
Sequence Identity: 26% (60 aa)

SNEDNIIGRGGSGIVYKGVMPSGEI-VAVKKLSGFNPAAAAGVARGKIGGSMSHSDHGFSAEVQTLGKIRHRNIVKLLGFCSNKETNVLVYEYMPNG---
     .||.|..| |||..  . .. ||||...  .      ... ..            .|.| . ...| |||.|.... .|    .| ||...|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-SLGEALHGSSKGAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQA----RVADFGLAKLFQDSGKSESMSSIAGSYGYIAPEY
 .| . ......|...... .  ....| . || |.|      |.|||.|. |||.| . .     ...||||||.|.   ... |....|...|.||| 
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV

AY-TLKVNEKSDIYSFGVVLLELVSGR
     .   |.|..|.|..| |...||
IRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase LRR8_x-2.AA TKL-Unique 761-922 31 1e-38 134.16 In-house 42-233 (290) Show / Hide 
Range on Protein: 761-922
Range on HMM: 42-233/290
Sequence Identity: 31% (61 aa)

FSAEVQTLGKIR-HRNIVKLLGFCS----NKETNVLVYEYMPNGSLGEALH---GSS---KGAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKS
|. || .. |.. | |||.. |.|           .| ||.| ||| . ||     .   .    |... |.|.|...| |..||||   | | ||| ||
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKS

NNILLDAE-----FQARVADFGLAKLFQ-DSGKSESMS------SIAGSYGYIAPEYAYT--LKVNEKSDIYSFGVVLLELVSGRR------P
 |.|.| .     ......||||.|.   .. .. ...      .  ||. ..|||       . .||||.||||.|| |.... .      |
SNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_x-2.AA Dicty4 761-917 35 1.5e-37 122.9 In-house 45-211 (277) Show / Hide 
Range on Protein: 761-917
Range on HMM: 45-211/277
Sequence Identity: 35% (60 aa)

FSAEVQTLGKIRHRNIVKLLGFCS----NKETNVLVYEYMPNGSLGEALHG---SSKGAVMLDWATRYK---IALQAANGLCYLHHDCSPLIVHRDVKSN
| .||  ..|||| ||....| |     .... . | |||| |.| . ||      .  . ||| .. .   .|. || |. .||  | | |.||| || 
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSH

NILLDAEFQARVADFGLAKLFQDSGKSES-MSSIAGSYGYIAPEYAYTLKVNEKSDIYSFGVVLLELV
|.| |. ... |.||||.....        ... .|. .. |||       |||.| |||| || |..
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL
Kinase LRR8_x-2.AA TK 704-993 14 8.9e-37 120.28 In-house 1-486 (486) Show / Hide 
Range on Protein: 704-993
Range on HMM: 1-486/486
Sequence Identity: 14% (74 aa)

SNEDNIIGRGGSG---IVYKGVMPSG--------------------------EIVAVKKLSGFNPAAAAGVAR-------GKIGGSMSHSDHG-----FS
    . .|.|  |    |||| . ..                          . |||| |   ......           |           |     . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG-----------GEDFLEEA

AEVQTLG--KIRHRNIVKLLGFCSNKET------------NVLVYEYMPNGS----LGEALHGSSKGAVM------------------------------
.| . .   . .| |||.|.| |. .|.              .| ||||.|.    | . |. .....                                
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE

------------------------------------------LDWATRYKIALQAANGLCYLHHD-CSPL---IVHRDVKSNNILLDAEFQ---------
                                          |. ...  ...|.|.|. |||   |. .   .||||.   |.|.. . .         
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCG

--ARVADFGLAK-----LFQDSGKSESMSSIAGSYG---------------------------YIAPEYAY---------TLKVNEKSDIYSFGVVLLEL
  ...|||||..     |  | ....   .  . ..                           . |||            . |  .|||..||||.. |.
PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

VS-GRRPIEP---------EFGDGVDIVQWVRKKIQTKDGVLEVLDSRIREE-------------NLPLQ--EIML---------------VL-RVALLC
.. |. |  .                            . ... .  ..|..              ...   . .                .. .. . |
FTYGQEPYYGGMSNQDVWKD------------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQC

TSDLPVDRPTMRDVVQML
 .  | ||||.......|
WHYDPEDRPTFSQLHEQL
Kinase LRR8_x-2.AA RIPK 710-927 28 1.1e-34 115.59 In-house 1-232 (290) Show / Hide 
Range on Protein: 710-927
Range on HMM: 1-232/290
Sequence Identity: 28% (70 aa)

IGRGGSGIVYKGVMPSGEIVAVKKLS-GFNPAAA-AGVARGKIGGSMSHSDHGFSAEVQTLGKIRHRNIVKLLGFCSNKET------NVLVYEYMPNGSL
.|.||.| |.| .  .   ...|| . . .....     | ..           . |.. . |.|...||...|||  .|         .| |||.||||
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQ-----------KEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSL

GEALHGSSK-GAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQARVADFGLAKLFQDS--GK-------SESMSSIA--GSYGY
 . ||  ..     . |  |  .  . . | ||| |.  | | ||| |  |||.|..| . .||||||.  . |  ..         || |    |   |
WHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSY

IAPEYAY--TLKV----NEKSDIYSFGVVLLELVSGRRPIEPEF
..||       |     ..|.|.|||..|. |. ... | |...
MPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRK
Kinase LRR8_x-2.AA S_TKc 704-993 22 1.6e-34 121.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 704-993
Range on HMM: 1-231/231
Sequence Identity: 22% (70 aa)

SNEDNIIGRGGSGIVYKGVMPS-GEIVAVKKLSGFNPAAAAGVARGKIGGSMSHSDHGFSAEVQTLGKIRHRNIVKLLGFCSNKETNVLVYEYMPN--GS
    ..||.|. | |||..  . |.|||.|...                         .  |.| | | .| |||||.... . .   .| ||...  |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD

LGEALHGSSKG---AVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQARVADFGLAKLFQDSGKSESMSSIAGSYGYIAPEYAYT
| . ..   ..    ..    .|. .. | ...| |.|      |.|||.|  |||||   .  ..|||||...         ... |.  |.|||    
LFDYIKKRGRHGLRFPFPE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--

LKVNE-KSDIYSFGVVLLELVSGRRPIEPEFGDGVDIVQWVRKKIQTKDGVLEVLDSRIREENLPLQEIMLVLRVALLCTSDLPVDRPTMRDVVQ-----
 . .  |.|..|.|..| |...|. | .         .| . |||                   . . . .. .    |    | .|||  .. |     
-GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG------------------SPEAKDFIRK----CLQKDPEKRPTA-EALQDEWDI

----ML
     .
KCHPWF
Kinase LRR8_x-2.AA LRRK 764-922 35 6.3e-32 110.22 In-house 107-282 (351) Show / Hide 
Range on Protein: 764-922
Range on HMM: 107-282/351
Sequence Identity: 35% (63 aa)

EVQTLGKIRHRNIVKLLGFCSNKETNVLVYEYMPNGSLGEALHGSSKGAV-----MLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILL---D
||  . . .| |||.|.||| .  .  .| ||.|.|.| . || ... .       ..| ...||||| | |. || |...| |.||| || ||||   .
EVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSP

---------AEFQARVADFGLAKLFQDSGKSESMSSIAGSYGYIAPEYAY---TLKVNEKSDIYSFGVVLLELVSGR-RP
         |.  | .||||.  .|  . ...  .   |  |. |||      .   .||.|.||||..| ||.... .|
QNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR8_x-2.AA DRK 761-917 37 7.4e-32 105.19 In-house 44-196 (258) Show / Hide 
Range on Protein: 761-917
Range on HMM: 44-196/258
Sequence Identity: 37% (59 aa)

FSAEVQTLGKIRHRNIVKLLGFCSNKETNVLVYEYMPNGSLGEALHGSSKGAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQA
|  |.  . . || ||.  .| | |      . |||| |||   ||  |   . .||  . .... .| |. |||  | | |.||| || | | |  .| 
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES---IEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQV

RVADFGLAKLFQDSGKSESMSSIAGSYGYIAPEYAYTLKVNEKSDIYSFGVVLLELV
 ||||||.  |.            |  . .|||        || |.|||..|| |.|
KVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase LRR8_x-2.AA STE 705-922 21 1.9e-30 104.78 In-house 1-267 (359) Show / Hide 
Range on Protein: 705-922
Range on HMM: 1-267/359
Sequence Identity: 21% (62 aa)

NED-NIIGRGGSGIVYKG--VMPS--------------GEIVAVKKLS--GFNPAAAAGVARGKIGGSMS-----------HSDHGFSAEVQTLGKIR--
 |.  .||.|..| |||.  . ..              |||.|.|...    |.               .                .  |.... | .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E-----------NQENQELENKNHEEMQQILKEIKIMKKCNHM

HRNIVKLLGFCSNK-------ETNVLVYEYMPNGSLGEALHGSSKGAVMLD----------WATRYKIALQAANG-LCYLHHDCSPLIVHRDVKSNNILL
| |||| .| . ..       ..  .. |||..||| . ..   .   .|.               .|. |   | | |||      |.|||.|. ||||
HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL

DAEFQARVADFGLAKLFQDSGK--------------SESMSSIAGSYGYIAPEYAYT------LKVNEKSDIYSFGVVLLELVSGRRP
     .  .|||... ..||.               ..   ...|.  . |||           . ..|.||.|.| ...|.. |. |
-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Pkinase_Tyr LRR8_x-2.AA Pkinase_Tyr 703-922 26 3.8e-29 99.33 Pfam 1-214 (270) Show / Hide 
Range on Protein: 703-922
Range on HMM: 1-214/270
Sequence Identity: 26% (62 aa)

LSNEDNIIGRGGSGIVYKGVMP-----SGEIVAVKKLSGFNPAAAAGVARGKIGGSMSHS--DHGFSAEVQTLGKI-RHRNIVKLLGFCS-NKET--NVL
..     .|.|  | ||||..       .  ||||.|                 |.|..      | .|.... .. .| |||.|.| |.  .|     .
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---------------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYI

VYEYMPNGSLGEALHGS--SKGAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQARVADFGLAKLFQDSGKS-ESMSSIAGSYG
| ||||.|.| . |.    .|... . .    ....| |.|. ||.      ..|||.   |.|.. .......|||||.. .. .    . ..      
VMEYMPHGDLLDYLRKHREDKQPLTMKD--LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

YIAPEYAYTLKVNEKSDIYSFGVVLLELVS-GRRP
  |||   . | ..|||..||||.. |... |. |
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_x-2.AA TyrKc 704-993 23 6e-21 76.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 704-993
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

SNEDNIIGRGGSGIVYKGVMPSGEIVAVKKLSGFNPAAAAGVARGKIGGSMSHSDHGFSAEVQTLGKI--RHRNIVKLLGFCSNK-------ETNVLVYE
   . ..|.|  |.||||..   . ||||.|                          |  | . . |.  .| |||.|.| |. .       |   .| |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

YMPNGSLGEALHGSSKGAVMLDWATRYKIALQAANGLCYLHHDCSPLIVHRDVKSNNILLDAEFQARVADFGLAKLFQDS------GKSESM----SSIA
|||.|.| . |. . .    | ...  ....|.|.|  |||.     ..|||    |.|..........||||..   |       ..  ..    .. .
YMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-GSYGYIAPEYAYTLKVNEKSDIYSFGVVLLELVSGRRPIEPEFGDGVDIVQWVRKKIQTKDGVLEVLDSRIREENLPL--------QEIMLVLRVALLC
   .   |||   . | ..|||..||||.. |. .  .  .|  |.   | |    ..  .. |.| .... | .  |             .   . . |
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGM---IQQ----MMSNQE-VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQC

TSDLPVDRPTMRDVVQML
    | ||||...... .
WHEDPEDRPTFSEIHECF
Kinase LRR8_x-2.AA LRRK 704-734 20 2.3e-05 14.92 In-house 1-59 (351) Show / Hide 
Range on Protein: 704-734
Range on HMM: 1-59/351
Sequence Identity: 20% (12 aa)

SNEDNIIGRGGSG-IVYKGVMPS---------------------------GEIVAVKKL
  . . |||||.| .||.. . .                           .. ||.||.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase LRR8_x-2.AA Dicty4 705-734 53 0.002201 7.34 In-house 2-30 (277) Show / Hide 
Range on Protein: 705-734
Range on HMM: 2-30/277
Sequence Identity: 53% (16 aa)

NEDNIIGRGGSGIVYKGVMPSGEIVAVKKL
| ...||.|. | ||||    | .||||||
NIEQRIGKGSFGEVYKGTW-RGKEVAVKKL
Kinase LRR8_x-2.AA LRRK 974-995 27 0.01104 5.3 In-house 330-351 (351) Show / Hide 
Range on Protein: 974-995
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

LCTSDLPVDRPTMRDVVQMLGD
.| .  | .||.. ..|. |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_x-2.AA TKL-Unique 708-735 50 0.021931 4.44 In-house 3-29 (290) Show / Hide 
Range on Protein: 708-735
Range on HMM: 3-29/290
Sequence Identity: 50% (14 aa)

NIIGRGGSGIVYKGVMPSGEIVAVKKLS
| ||.||.| ||||. . |..||.|...
NKIGEGGYGQVYKGKWR-GYPVAIKQFH
Kinase LRR8_x-2.AA DRK 707-738 46 0.033253 3.31 In-house 4-34 (258) Show / Hide 
Range on Protein: 707-738
Range on HMM: 4-34/258
Sequence Identity: 46% (15 aa)

DNIIGRGGSGIVYKGVMPSGEIVAVKKLSGFN
 | ||||. | |. |    | .||||.|   |
GNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHN
Kinase LRR8_x-2.AA MLK 980-993 50 0.102987 1.88 In-house 278-291 (291) Show / Hide 
Range on Protein: 980-993
Range on HMM: 278-291/291
Sequence Identity: 50% (7 aa)

PVDRPTMRDVVQML
| .||..| .|| |
PHKRPSFRQIVQHL
Kinase LRR8_x-2.AA Pkinase_Tyr 980-993 42 0.193455 5.5 Pfam 257-270 (270) Show / Hide 
Range on Protein: 980-993
Range on HMM: 257-270/270
Sequence Identity: 42% (6 aa)

PVDRPTMRDVVQML
| ||||.......|
PEDRPTFSEIHEQL
Kinase LRR8_x-2.AA TKL-Unique 975-993 26 0.337387 0.2 In-house 272-290 (290) Show / Hide 
Range on Protein: 975-993
Range on HMM: 272-290/290
Sequence Identity: 26% (5 aa)

CTSDLPVDRPTMRDVVQML
|  . |..||.  ...  |
CWHHDPSQRPSFDEIIHRL