Gene LRR8_e-2 (S.moellendorffii)

LRR8_e-2

Species: S.moellendorffii
Alias: LRR8_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_e-2.AA Protein None 996 None Fasta, JSON
LRR8_e-2.NA RNA None 2991 None Fasta, JSON
LRR8_e-2.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of LRR8_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR8_e-2.AA LRRNT_2 34-79 26 2.5e-10 36.45 Pfam 1-46 (46) Show / Hide 
Range on Protein: 34-79
Range on HMM: 1-46/46
Sequence Identity: 26% (13 aa)

FAQEVAILIRFKQNLEKQAQGELP--DLFQSWKSTD--SSPCKWEGISCD
 ..... |..||. | .      |  . ..||....  |..| |.|..||
HNDDGQALLAFKSSLND----SDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_TYP LRR8_e-2.AA LRR_TYP 108-132 40 0.007652 16.69 SMART 1-24 (24) Show / Hide 
Range on Protein: 108-132
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LPSLESLNLGNNEIGGGFPQHLFQC
||.|..|.|.|| .    |. .||.
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 110-132 22 0.173864 9.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 110-132
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SLESLNLGN-N--EIGGGFPQH-LFQC
.|..|.|.. |   . | .|   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 158-180 51 1.6e-05 23.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 158-180
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

KLENLDLCG-N--NFTGEIPPG-FGRL
.|. ||| | |  |.||.|||. |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 206-229 34 0.010313 13.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 206-229
Range on HMM: 1-26/26
Sequence Identity: 34% (10 aa)

NLQRLDLAY-N--PMA-EGPIPEE-LGRL
|||.||| . |  ..  .  ||.. .  |
NLQHLDLSGCNCCNLTGH--IPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 134-156 29 0.029917 12.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 134-156
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLKSLNLSM-N--LFVGLLPNN-ISAL
.|..|.||  |   ..| .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 204-229 30 0.10541 7.86 SMART 1-24 (24) Show / Hide 
Range on Protein: 204-229
Range on HMM: 1-24/24
Sequence Identity: 30% (8 aa)

LSNLQRLDLAYNPMAEGPIPEELGRL
|.||..||| .|   .  .|... . 
LPNLRELDLSNNQLTH--LPPGAFQG
LRR_TYP LRR8_e-2.AA LRR_TYP 156-179 44 0.135744 6.96 SMART 1-24 (24) Show / Hide 
Range on Protein: 156-179
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LTKLENLDLCGNNFTGEIPPG-FGR
|..|. ||| .|..| ..||| |. 
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 182-204 29 0.255037 8.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 182-204
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLLELNLTN-N--LLNGTVPGF-LGQL
.| .|.| . |   | |..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 180-203 45 0.36808 3.41 SMART 1-24 (24) Show / Hide 
Range on Protein: 180-203
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LPSLLELNLTNNLLNGTVPGFLGQ
||.| ||.| || |    || .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 280-302 37 0.003143 15.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 280-302
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLKLLELYD-N--QLEGEIPAN-IFNL
.|. | | . |  .|.|.|| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 258-278 44 0.010585 13.75 Pfam 3-26 (26) Show / Hide 
Range on Protein: 258-278
Range on HMM: 3-26/26
Sequence Identity: 44% (11 aa)

EILDLSW-N--GLSGSLPAS-LFNL
..||||  |   |.|..| | . ||
QHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 278-302 36 0.028938 12.46 SMART 1-24 (24) Show / Hide 
Range on Protein: 278-302
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LHKLKLLELYDNQLEGEIPANIFNL
|..|. | | .|||  ..|...|. 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 231-253 40 0.185529 9.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 231-253
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLRNLILTK-I--NLVGKIPES-LGNL
.|. | |      ||.|.||.| . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 253-277 36 0.400451 3.11 SMART 1-24 (24) Show / Hide 
Range on Protein: 253-277
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LVELEEILDLSWNGLSGSLPASLFN
|..| . ||||.| |.   |  . .
LPNL-RELDLSNNQLTHLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 304-326 33 0.001141 17.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 304-326
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SITDIDISN-N--RLTGSIPSG-ITQL
... .|.|. |  .|||.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 328-350 37 0.026273 12.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 328-350
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLRLLHLWQ-N--ELTGFIPEG-IQDL
.|. |.|   |   ||| ||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 326-349 41 0.198928 5.6 SMART 1-24 (24) Show / Hide 
Range on Protein: 326-349
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LKSLRLLHLWQNELTGFIPEGIQD
| .|| |.|  | ||   |.  |.
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 355-374 37 15.644822 2.51 Pfam 4-26 (26) Show / Hide 
Range on Protein: 355-374
Range on HMM: 4-26/26
Sequence Identity: 37% (9 aa)

ELRLFK-N--NLTGRIPQK-LGSN
.| |   |  |||| ||   . . 
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 376-398 33 0.007601 14.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 376-398
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLEVFDVSN-N--MLEGPIPPE-LCKS
.|.. |.|. |   |.| |||. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 400-422 33 0.142161 9.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 400-422
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLVELILFN-N--GITGGIPDS-YGSC
.| .| | . |   .|| ||.|   ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 424-446 25 0.893106 6.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 424-446
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SVERILMNN-N--KLNGSIPPG-IWNT
. ... ... |  .| |.|||. . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 448-470 25 6.471157 3.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 448-470
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

HAYIVDLSE-N--ELSGSISSE-ISKA
.  . |||  |   |.|.|... . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 472-494 37 0.001674 16.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 472-494
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLTTLNLYG-N--KLSGPLPPE-LGYI
||..|.| | |  .|.| .||. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 496-518 29 0.033627 11.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 496-518
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

DLTRLQLYG-N--MFEGELPSQ-LGQL
 |..| | | |   ..|..|.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR8_e-2.AA LRR_TYP 518-542 24 0.456981 2.64 SMART 1-24 (24) Show / Hide 
Range on Protein: 518-542
Range on HMM: 1-24/24
Sequence Identity: 24% (6 aa)

LSRLNVLFVHDNKLEGQIPKALGMC
|. | .|  ..|.|  ..|  .  .
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR8_e-2.AA LRR_1 520-542 25 0.485071 7.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 520-542
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLNVLFVHD-N--KLEGQIPKA-LGMC
.| .| . . |  .|.|.||.  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 544-566 40 0.01229 13.52 Pfam 1-26 (26) Show / Hide 
Range on Protein: 544-566
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

DLAQLNLAG-N--QLTGSIPES-LGDI
 |  |.| | |  .|||.||.| .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 568-590 44 0.00954 13.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 568-590
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

GLTLLDLSR-N--MLTGDIPLS-IGEI
 |. ||||. |   |||.|| | .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8_e-2.AA LRR_1 591-613 22 7.179485 3.71 Pfam 1-26 (26) Show / Hide 
Range on Protein: 591-613
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KFSSFNVSY-N--RLSGRVPDG-LANG
.  . ..|. |  .|.| .|.. . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8_e-2.AA IRAK 715-912 35 7.5e-54 185.22 In-house 2-223 (317) Show / Hide 
Range on Protein: 715-912
Range on HMM: 2-223/317
Sequence Identity: 35% (81 aa)

DEDNVLGSGGAGKVYLGKLSNGQ-AVAVKKLWSAAKKGDDSASQKYERSFQA---EVETLGKLRHKNIVKLLFCYTCDDDKF-LVYDYMENGSLGDMLHS
..||..|.|| | || |...|    .|||||    |.. |.   . ...||.   |.... ..||.||| |.  |  . ... |||.|| |||| | |. 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKL----KEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLY-GYCTERQCHCLVYPYMPNGSLEDRLWC

KKAGRA---LDWPARHRIALGAAEGLAYLHHDY-KPQVLHCDVKSNNILLDAELEP-------HQHG-------NGVS---MTS-IAGTYGYIAPEYAY-
 ..  .   | |. |. |..|.| |. .|| .  .  . | |.|| |||||. ..|       | .|        ...   ||| . ||  | .||. . 
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRD

-TLKVTEKSDIYSFGVVLLELVTGKRP
 . . | |.|.||||.||||..|| |.
PQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase LRR8_e-2.AA TKL 720-981 21 1.9e-53 183.86 In-house 1-364 (364) Show / Hide 
Range on Protein: 720-981
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGSGGAGKVYLGKLSN---------GQAVAVKKLWSAAKKGDDS-------------------ASQKYERSFQAEVETLGKLRHKNIVKLLFCYTCDDD-
.|||| |.|| ||. .         |. |||||. |   . ...                    .....  .  |.  . .||| |||... . .| .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KFLVYDYMENGS-LGDMLHSKKAGRALDWPARHRIALGAAEGLAYLHHDY-----KPQVLHCDVKSNNILLDAELEPHQ---------
             ..|..|...|| | ...          |. |.|.||..| |..||| .      ||...|.| ||.|||.|  ....          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

-----HGNGVSMTS----------------------------IAGTYGYIAPEYA-----YT-----------LKVTEKSDIYSFGVVLLELVTGKRPIE
        | | .                             . ||... |||       ||           .. .||.|.||||.|| |..|..|| .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

AEFGDGVDIVRWVCDKIQARNSLAEIFDSRIP---------SYFHEDMMLMLRVGLLCTSALPVQRPGMKEVVQML
 .  . ... . .  .. .     .     ||         .  .  .  | .    | .. | .|| ..|... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase LRR8_e-2.AA Pkinase 714-910 25 9.7e-30 106.24 Pfam 1-209 (293) Show / Hide 
Range on Protein: 714-910
Range on HMM: 1-209/293
Sequence Identity: 25% (55 aa)

LDEDNVLGSGGAGKVYLGKLSNGQA-VAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLRHKNIVKLLFCYTCDDDKFLVYDYMENG----SLGDMLH
.    ..|||. |.||...  . .  ||||...   |....|  ... |   .|.. . .|.|.|||.|. ... .|.  .| .|.|.|    .| |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK---KRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

SKKAGRAL--DWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAELEP------------HQ--HGNGVSMTSIAGTYGYIAPEYAY-TLKVT
  ......  ..    ....  ..||.|.|      ..|.|.|. |||.| . ..             |  . |.. ||...||..|.|||      . .
T-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

EKSDIYSFGVVLLELVTGK
 |.|..|.|..| |...|.
PKVDMWSCGCILYEMLCGR
S_TKc LRR8_e-2.AA S_TKc 714-981 20 2.4e-26 94.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 714-981
Range on HMM: 1-231/231
Sequence Identity: 20% (59 aa)

LDEDNVLGSGGAGKVYLGKLSN-GQAVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLRHKNIVKLLFCYTCDDDKFLVYDYMEN--GSLGDMLHSK
 .  ...|.|. ||||...  . |. ||.|..                .... |.. | | .|.|||||. ..   |. ..| .|...  |.| |.....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

KAGRA---LDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLD-----------AELEPHQHGNGVSMTSIAGTYGYIAPEYAYTLKVTE-KSD
. ..    ..     ...   ...|.|.|   . ...|.|.|  |||||           ..|           |.. ||  |.|||     . .  |.|
GRHGLRFPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDEHIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCD

IYSFGVVLLELVTGKRPIEAEFGDGVDIVRWVCDKIQARNSLAEIFDSRIPSYFHEDMMLMLRVGLLCTSALPVQRPGMKEVVQ---------ML
..|.|..| |...|. | .    .   . . ..                      ...  ..|    |    | .||.  |. |          .
WWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_e-2.AA MLK 714-860 27 2.5e-26 88.43 In-house 1-164 (291) Show / Hide 
Range on Protein: 714-860
Range on HMM: 1-164/291
Sequence Identity: 27% (46 aa)

LDEDNVLGSGGAGKVYLGKLSNGQ----AVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLRHKN----IVKLLFCYTCD-DDKFLVYDYMENGSLG
...  ..|||. |||..|.  |       ||||. . | .  | | .    . |. |.. | .|.|.|    |.... . ...  . ..|  |.|.||| 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKR-VRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DMLHSKKAGRA-----------LDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAELE
. ||... . .            |     ..||  |.|..||| . .... | | || |||.|.  .
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-IC
Kinase LRR8_e-2.AA STE 714-912 19 9e-25 84.47 In-house 1-267 (359) Show / Hide 
Range on Protein: 714-912
Range on HMM: 1-267/359
Sequence Identity: 19% (55 aa)

LDEDNVLGSGGAGKVYLGKLSN----------------GQAVAVKKLWSAAKKG---------DDSASQKYERSFQAEVETLGKLR--HKNIVKLLFCYT
..   ..|.|. |.||...  .                |. .|.|..    ..          ...  .. . ... |.... |..  |.|||| . || 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

CD-------DDKFLVYDYMENGSLGDMLHSK-KAGRALD----------WPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAELEPHQHGNGV
 .       |. ...  ||..||| |....| . |. |.           .   .|.    .|| |..|. .  . | |.|. ||||            |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------------V

SMT--------------------------------SIAGTYGYIAPEYAYT------LKVTEKSDIYSFGVVLLELVTGKRP
  .                                ...||  . |||           . ..|.||.|.| ...|..||| |
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase LRR8_e-2.AA Pkinase_Tyr 714-836 25 1.1e-22 77.43 Pfam 1-128 (270) Show / Hide 
Range on Protein: 714-836
Range on HMM: 1-128/270
Sequence Identity: 25% (34 aa)

LDEDNVLGSGGAGKVYLGKLS-----NGQAVAVKKLWSAAKKGDDSASQKY--ERSFQAEVETLGKL-RHKNIVKLLFCYTCDDDK---FLVYDYMENGS
.  . .||.|  |.||.|..      ... ||||.|        ..|...    ..| .|.... .| .|.|||.|. . |....    ..|  ||..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGD

LGDMLHSK-KAGRALDWPARHRIALGAAEGLAYLH
| | |...   ...|. .    ...  |.|..||.
LLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase LRR8_e-2.AA TKL-Unique 718-856 32 2.2e-22 75.84 In-house 3-146 (290) Show / Hide 
Range on Protein: 718-856
Range on HMM: 3-146/290
Sequence Identity: 32% (50 aa)

NVLGSGGAGKVYLGKLSNGQAVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLR-HKNIVKLLFCYTCD---DDK--FLVYDYMENGSLGDMLH---
|..|.||.|.|| ||  .|  ||.|..    ..   . | . .. |  || .. ||. |.||| ... |. |   . .  ..| .|.. ||| | ||   
NKIGEGGYGQVYKGKW-RGYPVAIKQF----HP-NEDSSNEMMQEFENEVNWMKKLHYHPNIV-HYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN

----SKKAGRALDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLD
      .    |..  | ..|. .| |. ||||  .| ..|.| || |.|.|
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVD
Kinase LRR8_e-2.AA Ciliate-E2-Unclassified 715-916 20 1.9e-21 71.2 In-house 2-273 (352) Show / Hide 
Range on Protein: 715-916
Range on HMM: 2-273/352
Sequence Identity: 20% (55 aa)

DEDNVLGSGGAGKVYLG-KLSNGQAVAVKKLWSAAKKGDDSA-SQKYERSFQAEVETLGK-----------------LRHKNIVKLLFCYTCDDDKFLVY
    ..|.|| ||||.  . ...|. | | . .. .. . .  ... | ..... .   |                 . | .|||...| . ..  ..|.
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYMENGSLGDMLHSKKA--------------GRALDWPARH-----RIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAEL---EPHQHGNGVS----
.|.|.|.| ... ..|               .. ..  .       ...    .|| ||||     ..| | | .|||.| .    ..   . | |    
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------------MTSIAGTYGYI----APEYAYTLKVT----EKSDIYSFGVVLLELVTGKRPIEAE
                    |....||..|.    |||.    .      .|.||.|.||.| |...|..| ...
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN
Kinase LRR8_e-2.AA RIPK 720-859 27 2.5e-20 65.93 In-house 1-146 (290) Show / Hide 
Range on Protein: 720-859
Range on HMM: 1-146/290
Sequence Identity: 27% (41 aa)

LGSGGAGKVYLGKLSNGQAVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLRHKNIVKLLFCYTCDDD------KFLVYDYMENGSLGDMLHSKK--
.|.|| |.|..        ...||     ..      .. .     |.. . |||...||...    | ..        .|  ||||||| . ||.|   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY

AGRALDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAEL
  . . || | |.    ..|  || |. .| ..| | |  |||.|...
QHHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNF
Kinase LRR8_e-2.AA LRRK 714-855 25 1.5e-19 65.87 In-house 1-199 (351) Show / Hide 
Range on Protein: 714-855
Range on HMM: 1-199/351
Sequence Identity: 25% (52 aa)

LDEDNVLGSGGAG-KVYLGKLSN---------------------------GQAVAVKKLWSAAKKG-------------------------------DDS
| . . .|.|| | .|| .|. .                           .| ||.||.    ...                               ...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW----NRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHED

ASQKYERSFQAEVETLGKLRHKNIVKLL-FCYTCDDDKFLVYDYMENGSLGDMLHSKK-AGR-----ALDWPARHRIALGAAEGLAYLHHDYKPQVLHCD
.. .. |.|. ||  . .|.| |||.|. ||    .   .| .|. .|.| . ||.||  |.      ..|  ...|||  |.|..|| |. .| ..|.|
CCRAF-REFRHEVWIMSHLNHPNIVSLKGFCI---HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRD

VKSNNILL
 || ||||
LKSPNILL
Kinase LRR8_e-2.AA LISK 719-856 31 2.3e-19 59.41 In-house 1-135 (296) Show / Hide 
Range on Protein: 719-856
Range on HMM: 1-135/296
Sequence Identity: 31% (45 aa)

VLGSGGAGKVYLGKLS-NGQAVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKLRHKNIVKLLFCYTC-DDDKFLVYDYMENGSLGDMLHSKKA-GRA
..|.|. |||| | .   || .|.|..    .. .|.    |.. .. ||... .|||.|||.    .   |.  ..|  |.. | | . |....     
EIGKGFFGKVYKGTHRQTGQVMAIKMI---HRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIP

LDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLD
| || | .|||. |.|..|||     ...| | ||.|.|..
LPWPQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVR
Kinase LRR8_e-2.AA TK 714-836 14 2.7e-17 53.83 In-house 1-251 (486) Show / Hide 
Range on Protein: 714-836
Range on HMM: 1-251/486
Sequence Identity: 14% (36 aa)

LDEDNVLGSGGAG---KVYLGKLSNG--------------------------QAVAVKKLWSAAKKGDDSASQKYER-------------SFQAEVETLG
.   ..||.|  |   .||.|.. ..                          . |||| |    |.||.....  .              .. .| . . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKML----KEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMC

--KLRHKNIVKLLFCYTCDDDK------------FLVYDYMENGS----LGDMLHSKKAGRA--------------------------------------
  ...|.|||.|. . | .. |             .|  ||..|.    | | |.... ..                                       
HSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPE

-----------------------------------LDWPARHRIALGAAEGLAYLH
                                   |. . .. ... .|.|..|||
EQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Kinase LRR8_e-2.AA TyrKc 714-981 20 6.4e-16 34.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 714-981
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

LDEDNVLGSGGAGKVYLGKLSNGQAVAVKKLWSAAKKGDDSASQKYERSFQAEVETLGKL--RHKNIVKLLFCYTCD-------DDKFLVYDYMENGSLG
.  . .||.|  |.||.|...  . ||||.| . |           .. |  | . . ||  .|.|||.|. . | .       .  ..|  ||..|.| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

DMLHSKKAGRALDWPARHRIALGAAEGLAYLHHDYKPQVLHCDVKSNNILLDAEL----------EPHQHG-----NGVSMTS----IA---GTYGYIAP
| |....    | ..  . ... .|.| .|||.    .. | |    |.|.....            . ..     ..   ..     .     .   ||
DYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYAYTLKVTEKSDIYSFGVVLLELVT-GKRPIEAEFGDGVDIVRWVCDKIQARNSLAEIFDSRIPSY--------FHEDMMLMLRVGLLCTSALPVQRPG
|   . | |.|||..||||.. |. | |. | . .      | . ... ..... . . .  ..| .         ...|  .    . |  . | .|| 
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGM------IQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM---KQCWHEDPEDRPT

MKEVVQML
..|... .
FSEIHECF
Kinase LRR8_e-2.AA MLK 870-912 45 7.7e-11 33.97 In-house 190-235 (291) Show / Hide 
Range on Protein: 870-912
Range on HMM: 190-235/291
Sequence Identity: 45% (21 aa)

MTSIAGTYGYIAPEY---AYTLKVTEKSDIYSFGVVLLELVTGKRP
|.| |||| . |||    .   |..||.|..|.|||| |..|.. |
MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR8_e-2.AA RIPK 867-914 37 4.1e-09 27.17 In-house 174-229 (290) Show / Hide 
Range on Protein: 867-914
Range on HMM: 174-229/290
Sequence Identity: 37% (21 aa)

GVSMTSIA--GTYGYIAPEYAY--TLKV----TEKSDIYSFGVVLLELVTGKRPIE
. ||.|    ||  |..||       |     |.|.|.|||..|. |. |.| | |
VYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYE
Kinase LRR8_e-2.AA TKL-Unique 875-912 39 1.6e-08 26.36 In-house 188-233 (290) Show / Hide 
Range on Protein: 875-912
Range on HMM: 188-233/290
Sequence Identity: 39% (18 aa)

GTYGYIAPEYAYT--LKVTEKSDIYSFGVVLLELVTGKR------P
|.. ..|||       . .||||.||||.|| |..|.|.      |
GSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase LRR8_e-2.AA LRRK 875-912 42 1.9e-08 25.99 In-house 241-282 (351) Show / Hide 
Range on Protein: 875-912
Range on HMM: 241-282/351
Sequence Identity: 42% (18 aa)

GTYGYIAPEYAY---TLKVTEKSDIYSFGVVLLELVTGK-RP
|. |. |||      .   |||.|.||||..| ||.|.. .|
GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR8_e-2.AA LISK 891-912 40 5.7e-08 21.78 In-house 217-238 (296) Show / Hide 
Range on Protein: 891-912
Range on HMM: 217-238/296
Sequence Identity: 40% (9 aa)

TEKSDIYSFGVVLLELVTGKRP
.|..|..|||.||.|..|....
DESCDVFSFGIVLCEIITRVKA
Kinase LRR8_e-2.AA TK 881-912 38 1.7e-05 13.59 In-house 353-394 (486) Show / Hide 
Range on Protein: 881-912
Range on HMM: 353-394/486
Sequence Identity: 38% (16 aa)

APEYAY---------TLKVTEKSDIYSFGVVLLELVT-GKRP
|||            . | |.|||..||||.. |..| |. |
APECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase LRR8_e-2.AA Pkinase_Tyr 891-912 52 0.000649 13.88 Pfam 192-214 (270) Show / Hide 
Range on Protein: 891-912
Range on HMM: 192-214/270
Sequence Identity: 52% (12 aa)

TEKSDIYSFGVVLLELVT-GKRP
|.|||..||||.. |..| |. |
TTKSDVWSFGVLMWEIFTYGEQP
Kinase LRR8_e-2.AA TK 961-981 23 0.012482 3.78 In-house 466-486 (486) Show / Hide 
Range on Protein: 961-981
Range on HMM: 466-486/486
Sequence Identity: 23% (5 aa)

LLCTSALPVQRPGMKEVVQML
. | .. | .|| .......|
QQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_e-2.AA LRRK 962-983 27 0.095981 1.93 In-house 330-351 (351) Show / Hide 
Range on Protein: 962-983
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

LCTSALPVQRPGMKEVVQMLVE
.| .. | .|| . ..|. | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_e-2.AA MLK 968-981 42 0.172771 1.09 In-house 278-291 (291) Show / Hide 
Range on Protein: 968-981
Range on HMM: 278-291/291
Sequence Identity: 42% (6 aa)

PVQRPGMKEVVQML
| .|| ....|| |
PHKRPSFRQIVQHL
Kinase LRR8_e-2.AA Pkinase_Tyr 968-981 35 3.598887 1.2 Pfam 257-270 (270) Show / Hide 
Range on Protein: 968-981
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PVQRPGMKEVVQML
| .|| ..|....|
PEDRPTFSEIHEQL