PERK_b-1

Species: S.moellendorffii
Alias: PERK_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: PERK

Sequence

Name Sequence Type Origin Length Description Download
PERK_b-1.AA Protein None 660 None Fasta, JSON
PERK_b-1.NA RNA None 1983 None Fasta, JSON
PERK_b-1.kin_dom Protein Kinase Domain None 215 None Fasta, JSON

Protein domain

Protein domains of PERK_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PERK_b-1.AA IRAK 274-394 32 7.7e-36 124.53 In-house 1-134 (317) Show / Hide
Range on Protein: 274-394
Range on HMM: 1-134/317
Sequence Identity: 32% (43 aa)

FSRANLLGEGGFGCVYKGFLHGGQ-VVAVKQLR----VGSRQGEREFRA---EVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNGTLEHHLHGEGRT
|...|..|||||||||.| ...   ..||| |.    .   . ...|..   |... .| .| ..|.| |||..  .  |||.. |||.||  |.. . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VM----DWPTRLKIAAGFARGLAYLHEDC-KISI
..     |..|..|. | |.|. .||..  ...|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPI

Kinase PERK_b-1.AA IRAK 414-561 32 3e-34 118.83 In-house 139-317 (317) Show / Hide
Range on Protein: 414-561
Range on HMM: 139-317/317
Sequence Identity: 32% (59 aa)

IKSSNILLDNNFDAQVSDFGLAKLA----SDTYTHV----TTRVMGTVGYLAPEYAS--TGKLTEKSDVYSFGVVLLELITGKRPVDTT--QPVGKDSLV
|||.||||| .| .  .||||.       .  .. .    | .| ||  |..||.    .|.|| |.||||||.||||..|| |.|..    . ... |.
IKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLC

E------------------------WARPYLMQAIEKGHLDGIVDERLANYNEDEMLRMVEAAAACVRHSASERPRMAEVVPAL
|                        || |  || .||      .|.| .  .... . |  .|  |. | | .|. ||.|.  |
EEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEK-----FIDHRMPPCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase PERK_b-1.AA TK-Unique 274-484 21 1.6e-30 102.51 In-house 1-234 (294) Show / Hide
Range on Protein: 274-484
Range on HMM: 1-234/294
Sequence Identity: 21% (55 aa)

FSRANLLGEGGFGCVYKGFLHG-------GQVVAVKQLRVGSRQGE-REFRAEVEIISRVH-HRHLVSLVGYCIADA-QRLLVYDFVPNGTLEHHLHGEG
.   ...||| ||.|..| . |        ..||||.|. .... . ..|  | .. . .  | ..|...|.|. .  . .... ..|.|.|.|.|.  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RT-----------------VMDWPTR-LK------IAAGFARGLAYLHE-DCKISISPLELNLKVIRSCRPSSNHIKSSNILLDNNFDAQVSDFGLAKLA
..                  .. .|  ..      .| . |.|..||..  .||                   ... ..|.|| ... . ..|||.|.  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-----------------VHRDLCARNVLLTEDKVCKICDFGMARDV

SD--TYTHVTTRVMGTVGYLAPEYAS--TGKL-TEKSDVYSFGVVLLELIT
..   |   ... .  . ..|||. .  .|   |.||||.||||.. |. |
YTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase PERK_b-1.AA TKL 280-387 24 2.8e-30 106.24 In-house 55-203 (364) Show / Hide
Range on Protein: 280-387
Range on HMM: 55-203/364
Sequence Identity: 24% (39 aa)

LGEGGFGCVYKGFLHG---------GQVVAVKQLRVGSRQGE---------------------------REFRAEVEIISRVHHRHLVSLVGYCIADAQ-
.|.||||.|||| ..|         |..||||.... . . .                            ... |. ..|| .| ..|...|||..  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYDFVPNGTLEHHLHGEGRTVMDWPTRLKIAAGFARGLAYLH
              .|....|.|.|.|.||        |. |...| . |||..|||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLH

Kinase PERK_b-1.AA TyrKc 274-561 23 1.3e-25 92.29 SMART 1-280 (280) Show / Hide
Range on Protein: 274-561
Range on HMM: 1-280/280
Sequence Identity: 23% (76 aa)

FSRANLLGEGGFGCVYKGFLHGGQVVAVKQLRVGSRQGEREFRAEVEIISRV--HHRHLVSLVGYCIAD-------AQRLLVYDFVPNGTLEHHLHGEGR
 .    |||| || |||| .   . |||| |. ..   ...|. | .| ...  || ..| |.|.|. .        . ..|  ..|.| | ..|.  ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TVMDWPTRLKIAAGFARGLAYLHEDCKISISPLELNLKVIRSCRPSSNHI----KSSNILLDNNFDAQVSDFGLAKLASDT--------YTHV----TTR
.   ... |...   |.| .|||.                       | |       |.|...|. . .|||||..   |         | ..     ..
K-LCMKDLLSFCWQIACGMEYLHSK----------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

VMGTVGYLAPEYASTGKLTEKSDVYSFGVVLLELIT-GKRPVDT-TQPVGKDSLVEWARPYLMQAIEKGHLDGIVDERLANYNEDEM------LRMVEAA
 |  .  .|||   .|| |.||||.||||.. |. | |. |    .|   . |  |     ... ...|.   . .. .      .|        | .  
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQE-----VIEYVKQGYRMPQPPNDY------PMSFVCCPDEMYQIM

AACVRHSASERPRMAEVVPAL
  | .. ...||...|..  .
KQCWHEDPEDRPTFSEIHECF

Kinase PERK_b-1.AA TKL 414-561 20 1.6e-25 88.83 In-house 166-364 (364) Show / Hide
Range on Protein: 414-561
Range on HMM: 166-364/364
Sequence Identity: 20% (42 aa)

IKSSNILLDNNFD--------------AQVSDFGLAKLA----SDTYTHVTTR--------------VMGTVGYLAPEYAS----------------TGK
.||.|||.|.|.               . ..||||..      ... |  |..              . || ...|||                    ..
LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFE

LTEKSDVYSFGVVLLELITGKRPV---DTTQPVGKDSLVEWARPYLMQAIEKGHLDGIVDE--RLANYNEDEMLR-MVEAAAACVRHSASERPRMAEVVP
 .||.||||||.|| |..|..||    .  .... |  .|.   .  .  ..  .. |  .  . . .... ... | . .  |  | ...|| . |.. 
YSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK

AL
 |
RL

Kinase PERK_b-1.AA Pkinase_Tyr 274-388 27 6.2e-24 81.69 Pfam 102-230 (270) Show / Hide
Range on Protein: 274-388
Range on HMM: 102-230/270
Sequence Identity: 27% (35 aa)

FSRANLLGEGGFGCVYKGFLH-----GGQVVAVKQLRVGSRQGE---REFRAEVEIISRV-HHRHLVSLVGYCI-ADAQ--RLLVYDFVPNGTLEHHLHG
 .    |||| || |||| ..     ... |||| |. |. . .   ..| .|..| .   || ..|.|.| |.  . .   ..|  ..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E--GRTVMDWPTRLKIAAGFARGLAYLHE
   ..   . .. |....  |.|..||..
HREDKQPLTMKDLLQMCWQIAKGMEYLES

Kinase PERK_b-1.AA TK 274-388 14 7.8e-23 72.7 In-house 80-331 (486) Show / Hide
Range on Protein: 274-388
Range on HMM: 80-331/486
Sequence Identity: 14% (37 aa)

FSRANLLGEGGFG---CVYKGFLHGG--------------------------QVVAVKQLRVGSRQGEREFRA--------------EVEIISRVH----
    . |||| ||    |||| ..|.                          . ||||.|. |. . ..||..              |.|...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRHLVSLVGYCIADAQ------------RLLVYDFVPNGT----LEHHLH--GEGRTV-----------------------------------------
 | ..|.|.|.|  ..              ..|  ..|.|     | ..|.   ....                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MDWPTRLKIAAGFARGLAYLHE
                               .. ...| ...  |.|..|||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS

Kinase PERK_b-1.AA LRRK 274-387 26 1.2e-22 76.99 In-house 71-251 (351) Show / Hide
Range on Protein: 274-387
Range on HMM: 71-251/351
Sequence Identity: 26% (48 aa)

FSRANLLGEGGFG-CVYKGFLHG---------------------------GQVVAVKQLRVG---------------------SRQGE------------
. . ...|.||||  ||.. . |                           .| ||.|.. ..                     | |.|            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFRAEVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNGTLEHHLH---GEGR----TVMDWPTRLKIAAGFARGLAYLH
 |||| || |.|. .| ..|||.|.||    . .| ...|.|.| |.||     |.    ....| ..||||   |.|..|||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH

Kinase PERK_b-1.AA TKL-Unique 276-387 31 7.3e-22 74.0 In-house 180-306 (290) Show / Hide
Range on Protein: 276-387
Range on HMM: 180-306/290
Sequence Identity: 31% (40 aa)

RANLLGEGGFGCVYKGFLHGGQVVAVKQLRV---GSRQGEREFRAEVEIISRVH-HRHLVSLVGYCI----ADAQRLLVYDFVPNGTLEHHLHG------
  |..||||.| ||||  . |  ||.||. .    | . ..||. || .... | |  .| ..|||.    . ... .| ...| |.|  .||       
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--EGRTVMDWPTRLKIAAGFARGLAYLH
  .  . ...  |.|.|   |.|. |||
NNNNNCKLNMQQRVKMAIDIAQGMYYLH

Kinase PERK_b-1.AA S_TKc 274-561 19 1.1e-21 79.24 SMART 1-231 (231) Show / Hide
Range on Protein: 274-561
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

FSRANLLGEGGFGCVYKGFLHG-GQVVAVKQLRVGSRQGEREFRAEVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPN--GTLEHHLHGEGR----TV
.   ...|.|.||.|||.  .. |..||.|...       . .| |..| .. || ..| | ...       .| .....  |.| ....  ||     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDWPTRLKIAAGFARGLAYLHEDCKISISPLELNLKVIRSCRPSSNH--IKSSNILLDNNFDAQVSDFGLAKLASDTYTHVTTRVMGTVGYLAPEYASTG
..  .  ....  ...|.|.|.   |                    |  .| .|||||.     ..|||||..         | . ||  |.|||     
FPE-HARFYMYQICCALEYCHSHGII--------------------HRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---

KLTE-KSDVYSFGVVLLELITGKRPVDTTQPVGKDSLVEWARPYLMQAIEKGHLDGIVDERLANYNEDEMLRMVEAAAACVRHSASERPRMAEVV-----
. .  |.|..|.|..| |...|. | .                 ... |                  .|.. ...    | .   ..||   |.      
GYGKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG----------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWD

----PAL
    | .
IKCHPWF

Kinase PERK_b-1.AA TKL-Unique 414-488 34 4e-20 67.81 In-house 138-233 (290) Show / Hide
Range on Protein: 414-488
Range on HMM: 138-233/290
Sequence Identity: 34% (33 aa)

IKSSNILLDNN-----FDAQVSDFGLAKLAS-DTYTHVT-------TRVMGTVGYLAPEYAST--GKLTEKSDVYSFGVVLLELITGKR------P
.||||.|.|||     . ....||||.|..| .. . ..       . ..|.  ..|||  .    . .|||||||||.|| |..|.|.      |
LKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP

Kinase PERK_b-1.AA Dicty4-Unclassified 414-488 38 1e-18 60.7 In-house 135-207 (263) Show / Hide
Range on Protein: 414-488
Range on HMM: 135-207/263
Sequence Identity: 38% (29 aa)

IKSSNILLDNNFDAQVSDFGLAKLASDTYTHVTTRVMGTVGYLAPEYASTGKLTEKSDVYSFGVVLLELITGKRP
|||||||.| .| . . |||..   . ...   | . ||.   .||       . ||||||....| ||.||  |
IKSSNILMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP

Kinase PERK_b-1.AA Dicty4 274-392 28 9.6e-18 55.91 In-house 1-135 (277) Show / Hide
Range on Protein: 274-392
Range on HMM: 1-135/277
Sequence Identity: 28% (39 aa)

FSRANLLGEGGFGCVYKGFLHGGQVVAVKQL---RVGSRQGE-REFRAEVEIISRVHHRHLVSLVGYCI----ADAQRLLVYDFVPNGTLEHHLHG----
  . ...|.|.|| ||||    |. |||| |    ..... .  |||.||.| .   | ... . |.|.    .    . |  ..| |.|.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-EGRTVMDWPTRLK---IAAGFARGLAYLHE-DCKI
   .. .|||....   .|   |||...||. .. |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI

Kinase PERK_b-1.AA Pkinase 274-388 22 9.7e-17 60.27 Pfam 1-126 (293) Show / Hide
Range on Protein: 274-388
Range on HMM: 1-126/293
Sequence Identity: 22% (28 aa)

FSRANLLGEGGFGCVYKGFLHGGQV-VAVKQLRVGSRQG--EREFRA--EVEIISRVHHRHLVSLVGYCIADAQRLLVYDFVPNG----TLEHHLHGEGR
. .   .|.|.||||||.  .| .  ||||.... ..    ... |   |..|  |..| . | | ...  .    .| .....|     | ...... .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TVM--DWPTRLKIAAGFARGLAYLHE
...  .. .  ...   .|||.|.|.
GCFYFSEWECKFYMYQILRGLEYCHS

Kinase PERK_b-1.AA Dicty4 414-488 37 1.2e-16 52.23 In-house 140-216 (277) Show / Hide
Range on Protein: 414-488
Range on HMM: 140-216/277
Sequence Identity: 37% (29 aa)

IKSSNILLDNNFDAQVSDFGLAK-LASDTYTHV-TTRVMGTVGYLAPEYASTGKLTEKSDVYSFGVVLLELITGKRP
.||.|.| | |. . |.||||..    ..     .. . ||... |||       .||.|||||| || |. |.. |
LKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP

Kinase PERK_b-1.AA LRRK 415-490 32 2.9e-16 54.01 In-house 193-284 (351) Show / Hide
Range on Protein: 415-490
Range on HMM: 193-284/351
Sequence Identity: 32% (30 aa)

KSSNILL---D---------NNFDAQVSDFGLAKLASDTYTH-VTTRVMGTVGYLAPEYASTG---KLTEKSDVYSFGVVLLELITGK-RPVD
|| ||||   .         ..  | ..|||.  .   .... |. .. |. |..|||    .     |||.|.||||..| ||.|.. .| |
KSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase PERK_b-1.AA MLK 413-488 31 6.9e-16 51.7 In-house 152-235 (291) Show / Hide
Range on Protein: 413-488
Range on HMM: 152-235/291
Sequence Identity: 31% (27 aa)

HIKSSNILLDN------NFDAQVSDFGLAKLASDTYTHVTTRVMGTVGYLAPEY---ASTGKLTEKSDVYSFGVVLLELITGKRP
..||.|||.|.      . .. ..|||...  ...     .  .||. . |||    .  .| .||.||.|.|||| |..|.. |
DLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase PERK_b-1.AA STE 414-488 26 2.2e-15 50.86 In-house 178-267 (359) Show / Hide
Range on Protein: 414-488
Range on HMM: 178-267/359
Sequence Identity: 26% (25 aa)

IKSSNILLDNNFDAQVSDFGLAKLASD---------------TYTHVTTRVMGTVGYLAPEYAST------GKLTEKSDVYSFGVVLLELITGKRP
||..||||     .  .|||...  .|               |    .. . ||  . |||  .       .. ..|.|..|.| ...|..||| |
IKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

Kinase PERK_b-1.AA TK 418-488 24 3.6e-15 46.58 In-house 270-394 (486) Show / Hide
Range on Protein: 418-488
Range on HMM: 270-394/486
Sequence Identity: 24% (30 aa)

NILLDNNFD-----------AQVSDFGLAK-----LASDTYTHVTTRVMGTVG----------------------------YLAPEYAS---------TG
|.|...|             . ..||||..     || | | .   ..... |                            ..|||            .|
NCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYG

KLTEKSDVYSFGVVLLELIT-GKRP
| |.||||.||||.. |. | |. |
KFTTKSDVWSFGVLMWEIFTYGQEP

Kinase PERK_b-1.AA Pkinase 414-486 35 6e-15 53.93 Pfam 134-209 (293) Show / Hide
Range on Protein: 414-486
Range on HMM: 134-209/293
Sequence Identity: 35% (28 aa)

IKSSNILLDNNFDA----QVSDFGLAKLA-SDTYTHVTTRVMGTVGYLAPEYAS-TGKLTEKSDVYSFGVVLLELITGK
.|..|||.||| .      ..||||||..    ..  ||.. || .|.|||      . . |.|..|.|..| |...|.
LKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR

Kinase PERK_b-1.AA MLK 274-389 22 3.2e-14 45.86 In-house 206-348 (291) Show / Hide
Range on Protein: 274-389
Range on HMM: 206-348/291
Sequence Identity: 22% (32 aa)

FSRANLLGEGGFGCVYKGFLHGGQ----VVAVKQLR------VGSRQGEREFRAEVEIISRVHHRH----LVSLVGYCIADAQ-RLLVYDFVPNGTLEHH
.     .|.|.|| |.||  ..      .||||. |      . .    ..|. |... ... |.      . ..| |. . .  ..|  ....| | . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGEGR------------TVMDWPTRLKIAAGFARGLAYLHED
|||.               |.|    ...|   |||..|||..
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM

Kinase PERK_b-1.AA Pkinase_Tyr 418-488 37 4.9e-13 44.76 Pfam 141-214 (270) Show / Hide
Range on Protein: 418-488
Range on HMM: 141-214/270
Sequence Identity: 37% (28 aa)

NILLDNNFDAQVSDFGLAKLA-SDTYT-HVTTRVMGTVGYLAPEYASTGKLTEKSDVYSFGVVLLELIT-GKRP
|.|...|. . ..|||||..  .| |  ....  .  .  .|||  ..|| |.||||.||||.. |..| |. |
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP

Kinase PERK_b-1.AA Dicty4-Unclassified 277-387 28 1.9e-12 38.87 In-house 4-126 (263) Show / Hide
Range on Protein: 277-387
Range on HMM: 4-126/263
Sequence Identity: 28% (35 aa)

ANLLGEGGFGCVYKGFLHGGQVVAVKQLRVGSRQGE----REFRAEVEIISRVHHRHLVSLVGYCIAD----AQRLLVYDFVPNGTLEHHLH---GEGRT
   .|.| |  |.||   |   |||| .  .. .       .|..||||   . |  || . ||||.     .    |  | . |.|    |    |   
DQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

VMDWPT--RLKIAAGFARGLAYLH
 .       .|.|   |.|...||
PIKLDDTLIIKYAFDIAQGMQHLH

Kinase PERK_b-1.AA STE 274-392 16 5.9e-09 27.88 In-house 34-207 (359) Show / Hide
Range on Protein: 274-392
Range on HMM: 34-207/359
Sequence Identity: 16% (29 aa)

FSRANLLGEGGFGCVYKGFLHG----------------GQVVAVKQLRVGSRQG-----------------EREFRAEVEIISRVH--HRHLVSLVGYCI
. .   .|.|.|| |||.  |                 |...|.||... . .                  . ..  |..| .. .  | . |   |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ADA-------QRLLVYDFVPNGTLE---HHLHGEGR---------TVMDWPTRLKIAAGFARG-LAYLHEDCKI
 .        .  ..  ....|.|.   .| .| |.         .... .   .|.    .| |.|||.  .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII

Kinase PERK_b-1.AA TK 543-561 21 0.021417 2.98 In-house 468-486 (486) Show / Hide
Range on Protein: 543-561
Range on HMM: 468-486/486
Sequence Identity: 21% (4 aa)

CVRHSASERPRMAEVVPAL
| .. ...||...... .|
CWHYDPEDRPTFSQLHEQL

Kinase PERK_b-1.AA MLK 548-561 28 0.309438 0.2 In-house 278-291 (291) Show / Hide
Range on Protein: 548-561
Range on HMM: 278-291/291
Sequence Identity: 28% (4 aa)

ASERPRMAEVVPAL
...|| ....|. |
PHKRPSFRQIVQHL

Kinase PERK_b-1.AA Pkinase_Tyr 543-561 26 3.362372 1.3 Pfam 252-270 (270) Show / Hide
Range on Protein: 543-561
Range on HMM: 252-270/270
Sequence Identity: 26% (5 aa)

CVRHSASERPRMAEVVPAL
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CWHYDPEDRPTFSEIHEQL