Gene MLK-p1_c (S.moellendorffii)

MLK-p1_c

Species: S.moellendorffii
Alias: MLK-p1_c
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_c.AA Protein None 779 None Fasta, JSON
MLK-p1_c.NA RNA None 2340 None Fasta, JSON
MLK-p1_c.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_c.AA Dicty4 513-769 45 6.9e-118 394.66 In-house 1-277 (277) Show / Hide 
Range on Protein: 513-769
Range on HMM: 1-277/277
Sequence Identity: 45% (126 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKIL--LDQDATQELLSELTREIVILRRLRHPNIVLFMGAVT----KPPHLSIVTEYLPRGTLFRLLHT----P
..  .|.|.||||.|... | |..||||.|  . |.. ...|.|. .|. |.  .|||||.||||| |    .|. ..|||||.|.|.|..|||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

KAREILDEKRRLR---MALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR-FKSKTFLSS--QTGAGTPEWMAPEVLRDEPSKEKSDV
. .  ||  ...|   ||.|.|||.|.|| . | |.|||||| |||||| ..|||||||||. .|  . ..    | .||| ||||||.. .|  ||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVVLWELVTLQKPWT--GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDA--LKK
|||| ||||..| | |    .   ||.|.||.  . |. ||... |. ..||. || .||. ||||. || .  |  
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_c.AA DRK 513-769 43 3.5e-104 352.42 In-house 1-258 (258) Show / Hide 
Range on Protein: 513-769
Range on HMM: 1-258/258
Sequence Identity: 43% (114 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDAT-QELLSELTREIVILRRLRHPNIVLFMGAVTKPPHLSIVTEYLPRGTLFRLLHTPKAREILDEK
 .   | | |..| | .  | || |||| |        ..|.|. ||| .. .||||||..|||. . ||   |..||.||| | . || ..    .|  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE--MDWP

RRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR----FKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGVVLWELV
....|..|.|.|..||| . | |.|||||| |||||    ||| |||||      |...|    |  ||| | ||||||...  || |||||..||||.|
LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKF--AMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

TLQKPWTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDALKK
| | |  |   .||| .|   | |. .| .. ||  .|.  ||  ||  |||.  ..  |  
TRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_c.AA TKL 519-767 31 1.5e-103 350.31 In-house 1-364 (364) Show / Hide 
Range on Protein: 519-767
Range on HMM: 1-364/364
Sequence Identity: 31% (118 aa)

LGGGSFGTVHLADWQG----------TDVAVKILLDQD-------------------------ATQELLSELTREIVILRRLRHPNIVLFMGAVTKPPH-
.| |.||.|. . |.|          .|||||..  ..                          .. .  .. .||....||||||||.|||... ||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LSIVTEYLPRGTLFRLLHTPKAREILDEKRRLRMALDVARGVNYLHRSK------PAIVHRDLKSPNLLVDKYLT-------------
            | ||.|| |.|.|. .||           .|.|.|||.|||.|||| ..      |.|.||||||.|.|||. .|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKVCDFGLSRFKSKTFLSSQTG-------------------AGTPEWMAPEVLRDE----------------PSKEKSDVYSFGVVLWELVTLQKPWTG
 .|.||||||||.|... .. |.                    ||| ||||||||..                .  ||.||||||.||||..| ..|. .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LTAMQVV---------AAVAFNGRRLQIP------------SNVNPKMRALIESCWANDPELRPSFASIIDAL
.  |...         . |. .|.|. ||            ... | |. |.. ||. ||| ||||  |.. |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-p1_c.AA MLK 513-767 36 6e-96 325.06 In-house 1-291 (291) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-291/291
Sequence Identity: 36% (107 aa)

LVLKERLGGGSFGTVHLADWQGTD-----VAVKILL----DQDATQELLSELTREIVILRRLRHPN----IVLFMGAVTKPPH-LSIVTEYLPRGTLFRL
. ..| .| |||| |... |...|     ||||.      |   | .   .. .|. .||.|.|||    |. |.|. ..||. . ||.||.. | |...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHT-PKARE----------ILDEKRRLRMALDVARGVNYLHRSKP-AIVHRDLKSPNLLVD------KYLTVKVCDFGLSRFKSKTFLSSQTG-AGTPEW
||. ..  .          . |    .. ||..|||..|||  .| .|.||||||.|.|.|      ...|.|.||||.||.....  .  .. |||. |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEVL---RDEPSKEKSDVYSFGVVLWELVTLQKPWT-GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
|||||.   | |.  ||.||.|.||||||..| . |   .. .|.. . || || |. |||. .. .  |.. ||  ||. ||||..|.  |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_c.AA TKL-Unique 515-767 37 4.4e-91 308.91 In-house 1-290 (290) Show / Hide 
Range on Protein: 515-767
Range on HMM: 1-290/290
Sequence Identity: 37% (110 aa)

LKERLGGGSFGTVHLADWQGTDVAVKILL-DQDATQELLSELTREIVILRRLR-HPNIVLFMGAVT----KPPHLSIVTEYLPRGTLFRLLHT-------
  . .|.|..|.|  . | |..||.|..    |   |.. |. .|. .. .|. |||||..||. .    .||...||.||.|.|.|  .||.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-PKAREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKY-----LTVKVCDFGLSRFKSKT---FLS------SQTGAGTPEWMAPEVLR
 ..  . |. ..|..||.|.|.| .|||...| | ||||||.|.|||       . .|.||||||.|.||    ...       ||  |.. ||||||||
NNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

D--EPSKEKSDVYSFGVVLWELVTLQK------PWTGLTAMQVVAAVAF--NGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
.  .   |||||||||.||||..| .       |  |..  |. ..|..   . |. ||.. ..  | ||. ||. ||. |||| .||  |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_c.AA LRRK 513-769 28 1.5e-79 270.64 In-house 1-351 (351) Show / Hide 
Range on Protein: 513-769
Range on HMM: 1-351/351
Sequence Identity: 28% (100 aa)

LVLKERLGGGSFG-TVHLADWQG----------------------------TDVAVKILLDQ---------DATQ-----------------------EL
|.  | .| |.|| .|. |.|.|                            ..||.|...           . .                        . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LSELTREIVILRRLRHPNIVLFMGAVTKPPHLSIVTEYLPRGTLFRLLHTPKAREI------LDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLL
..|. .|..|...|.|||||  .|   .|  | .|.||.| |.| ..|| .|  ..      ..   .|. ||..|.|..|||...| |.|||||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---D---------KYLTVKVCDFGLSR-FKSKTFLS--SQTGAGTPEWMAPEVLRDE---PSKEKSDVYSFGVVLWELVTLQ-KPWTGLT-A-----MQ
.   .            ..|..|||.|| |  ..|..    .  |.| |||||..|..      ||.|.||||..||||.|.|  |  ...       | 
LWSSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

VVAAVAFNGRRLQIPSN-VNP-----KMRALIESCWANDPELRPSFASIIDALKK
 .     .|.|  ||..  .|      . .||..||..||. ||.| .|.. |. 
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-p1_c.AA Shk 513-767 41 1.5e-74 253.97 In-house 1-264 (269) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-264/269
Sequence Identity: 41% (111 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDATQELLSELTREIVILRRLRHPNIVLFMGAVT-KPPHLSIVTEYLPRGTLFRLLHTPKAREILDE-
 .  . ||.||||.|  .   | .||||... |   .  ...   |  |  ...||||.||||| | .|  ..||||  |.| |  |||   . ..  . 
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLH---DQMVKKPF

---KRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR-FKSKTFLSS-QTGA-GTPEWMAPEVLRDEPSKEKSDVYSFGVVLW
   || .||..| | |.| || | . |.|||||. |||||. ..|||||||.|   |  . |.  | || ||| ||||||.   |  ||.|||||| .||
ILYKRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILW

ELVTLQKPWT--GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDA--L
|. | | |         . ..|.     |  ||    .  . ||. ||  .|. ||||. || .  |
EILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRIL
Kinase MLK-p1_c.AA Pkinase_Tyr 513-767 34 3e-73 248.71 Pfam 1-270 (270) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-270/270
Sequence Identity: 34% (93 aa)

LVLKERLGGGSFGTVHLADWQ------GTDVAVKILLDQDATQEL--LSELTREIVILRRL-RHPNIVLFMGAVT--KPP-HLSIVTEYLPRGTLFRLLH
... . || |.||.|... |       ...||||.|  ..|..|   . .. ||. |.. | .||||| ..|..|  . | .. ||.|| | | |   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TP-KAREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFK-SKTFL-SSQTGAGTP-EWMAPEVLRDEPSKEKSDV
..   .. |. |. | |....|.| .||.. .  ..||||   | ||.. ..||.|||||.|   ..     ...|.  |  |||||....    .||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVVLWELVTL-QKP-WTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
.||||..||..|. ..| . |..  .|..... .|.|. .| |  ...  |. .||. ||| ||.|. |.  |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_c.AA Dicty4-Unclassified 513-767 34 7.2e-70 238.43 In-house 1-263 (263) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-263/263
Sequence Identity: 34% (93 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKIL-LDQDATQ-ELLSELTREIVILRRLRHPNIVLFMGAVTKP----PHLSIVTEYLPRGTLFRLLH---TPK
.     .| | |  ||   | | |||||..   ..    |.. .  .|. ||  . ||| |   |.   |      . ||.| ...|.|| . |     .
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

AREI-LDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGVV
 . | ||.   ...|.|.|.|  .||     ..|||.|| |.|.||   .|. |||.||  . .|    | |||| | .||.|. |    ||||||....
QQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNF-NMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LWELVTLQKPWTGLT-AMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
|.||.|   |. .    | .   |.  . | .||.|. . .. ||  || |||  ||..  ||. |
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_c.AA TK 513-767 18 1.3e-68 228.86 In-house 1-486 (486) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LVLKERLGGGSFG---TVHLA------DWQG---------------------TDVAVKILL---DQDATQELLSELT------------REIVILR--RL
..| . || | ||   .|...      .|.|                     |.||||.|    ......... |..            .|. ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVLFMGAVTKP------------PHLSIVTEYLPRGT----LFRLLHTPKA---------------------------------------------
.||||| . |..|..            ... ||.|| | |     |   |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------REILDEKRRLRMALDVARGVNYLHRSKP----AIVHRDLKSPNLLVDKYLT-----------VKVCDFGLSR
                            ...|. ...| |....|.|  |||. .      .|||||   | ||.. ..           .|..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

FKS---------KTFLSSQTGAGTPE-------------------------WMAPEVLRDEPSKEK---------SDVYSFGVVLWELVTLQ-KPWTG-L
 .|         ..   .... ||.                          |||||.|.|    |.         |||.||||..||..|.  .|. | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TA---------MQVVAAVAFN-----------GRRLQIP--SNVN--------------PKMRALIESCWANDPELRPSFASIIDAL
.           .|.  .              |.|.. |   .                . .  |. .||. ||| ||.|. . ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-p1_c.AA TyrKc 513-767 31 2.5e-66 227.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-280/280
Sequence Identity: 31% (93 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDATQELLSELTREIVILRRL--RHPNIVLFMGAVTKP-------PHLSIVTEYLPRGTLFRLLHTPK
..|.. || | ||.|... |  ..|||| | .       . .. ||. |...|  .||||| . |..|..       . | ||.|| | | |   |. ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

AREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKT--------FLSSQTGAGTPE-----WMAPEVLRDEPS
 .  |  |  | .....|.| .|||.    ..||||   | ||.. .|||..||||||.              ..... |.       |||||....   
PK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

KEKSDVYSFGVVLWELVTL-QKPWTG-----LTAMQVVAAVAFNGRRLQIPSN--------VNPKMRALIESCWANDPELRPSFASIIDAL
 .||||.||||..||. |. |.|. |     ... .|.. |  .|.|. .| |          ..|  ....||. ||| ||.|. |.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_c.AA Pkinase 513-767 27 4.3e-66 230.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

LVLKERLGGGSFGTVHLADWQGTD--VAVKILLDQDATQELLSELTR--EIVILRRLRHPNIVLFMGAVTKPPHLSIVTEYLPRG----TLFRLLHTPKA
.......| ||||.| .. ..||   |||||.  ...  . . ...|  || |..||.||||| . .... ..|. .|.||.. |     ||....| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

REIL--DEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTV----KVCDFGLSRFK-SKTFLSSQTGAGTPEWMAPEVLR-DEPSKEKSDV
.  .  .|.   .... ..||..|.|.    |.|||||. |.|.|.  ..    |.|||||....        .| .|||..|||||.| ...   |.|.
HGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVVLWELVTLQKPWTGL------TAMQVVAAVAFNGRRLQIP-------------------SNVNPKMRALIESCWANDPELRPSFASIIDA--L
.|.|..|.|... . |. |       . ||... .     . ..|                    |... .. .|..|.. ||. ||... |     .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-p1_c.AA S_TKc 513-775 28 8.5e-62 212.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 513-775
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

LVLKERLGGGSFGTVHLADWQG--TDVAVKILLDQDATQELLSELTREIVILRRLRHPNIVLFMGAVTKPPHLSIVTEYLPR--GTLFRLLHTPKA---R
  . . .| |.||.|... . .    ||.||.            . ||| ||.. .||||| . ..     || .|.||..   |.||....  .    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGVVLWE
  ..| .  ...  ......|.|. .  |.|||||  |.|.|.  ..|.|||||.|.         |  |||..||||||    .|.|.|..|.|..|.|
FPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LVTLQKPWTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIID-ALKKFQEPLF
... . |.     ||..  .              | .. .|. |.  ||| ||.   .    ..  . | |
MLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-p1_c.AA TK-Unique 513-767 29 8.6e-61 208.27 In-house 1-294 (294) Show / Hide 
Range on Protein: 513-767
Range on HMM: 1-294/294
Sequence Identity: 29% (87 aa)

LVLKERLGGGSFGTVHLADWQG-------TDVAVKILLDQDATQELLSELTREIVILRRLR-HPNIVLFMGAVTKPP-HLSIVTEYLPRGTLFRLLH--T
|......| |.||.|. ..  |       .....  .|  .||..  .....|| ... |  ||||| ..|. ||.     |. ||.|.|.|  .|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PKAREI---------------------LDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR--FKSKTFLSSQT-GAGTP
|..|.                      ...|. .. | ..|.| .||.. .  |||||| . | |.  ....|.||||..|   . .   .... |    
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

EWMAPEVLR--DEPS-KEKSDVYSFGVVLWELVTL-QKPWTGLTAMQVVAAVAFNGRRLQIPSNV-NPKMRALIESCWANDPELRPSFASIIDAL
 |||||.|.  ...   .||||.||||..||..|| . | .|. . ... ..  .| |.. |... .. |. |..|||  .|| ||||..|.. |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR-DGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL