Gene MLK-p1_k (S.moellendorffii)

MLK-p1_k

Species: S.moellendorffii
Alias: MLK-p1_k
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_k.AA Protein None 783 None Fasta, JSON
MLK-p1_k.NA RNA None 2352 None Fasta, JSON
MLK-p1_k.kin_dom Protein Kinase Domain None 71 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_k.AA Dicty4 664-733 52 7.4e-29 93.51 In-house 134-206 (277) Show / Hide 
Range on Protein: 664-733
Range on HMM: 134-206/277
Sequence Identity: 52% (38 aa)

NIIHRDLKSANCLVDKHWCVKICDFGLSR-LTTGTPIQE--TTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
.||||||||.| ||||.| ||.||||||.   ...  .   .||.||| ||||| ....|   | | .| | |
VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIV
Kinase MLK-p1_k.AA TKL 663-733 33 4.9e-28 98.03 In-house 159-278 (364) Show / Hide 
Range on Protein: 663-733
Range on HMM: 159-278/364
Sequence Identity: 33% (40 aa)

MNIIHRDLKSANCLVDKHWC--------------VKICDFGLSRLTTGTPI-------------------QETTAAGTPEWMAPELLRNE----------
..||||||||.|.|||..|               .|||||||||  ...                     .  |  ||| |||||.||..          
PPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGID

------PVSYKCDIFSLGVV
      . | |||..| |.|
EFCKGFEYSEKCDVYSFGIV
Kinase MLK-p1_k.AA LISK 663-733 33 4.4e-27 84.86 In-house 120-228 (296) Show / Hide 
Range on Protein: 663-733
Range on HMM: 120-228/296
Sequence Identity: 33% (37 aa)

MNIIHRDLKSANCLVDKH----WCVKICDFGLSRLTTGTP----------------------------------IQETTAAGTPEWMAPELLRNEPVSYK
|||||||||| ||||..     | .|.||||. |. . ..                                   .  |  |||.||||| |. .  ...
MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTICGTPYWMAPEMLLGQSYDES

CDIFSLGVV
||.|| |.|
CDVFSFGIV
Kinase MLK-p1_k.AA Dicty4-Unclassified 655-733 44 1.5e-24 80.98 In-house 120-197 (263) Show / Hide 
Range on Protein: 655-733
Range on HMM: 120-197/263
Sequence Identity: 44% (35 aa)

RGMMCVQRMNIIHRDLKSANCLVDKHWCVKICDFGLSRLTTGTPIQETTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
.||      |.||||.||.| |.|||  .|| |||.|| .  .    || |||| | .|| |. |    | |..| ...
QGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN-FNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM
Kinase MLK-p1_k.AA Pkinase 662-733 40 4.2e-24 86.3 Pfam 126-201 (293) Show / Hide 
Range on Protein: 662-733
Range on HMM: 126-201/293
Sequence Identity: 40% (32 aa)

RMNIIHRDLKSANCLVDKHWCV----KICDFGLSRL--TTGTPIQETTAAGTPEWMAPELLR-NEPVSYKCDIFSLGVV
.|.|||||||..|.|.|..  .    |||||||...  .   .   || .|||..||||..| ... ..|.|..|.|..
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI
Kinase MLK-p1_k.AA LZK 665-733 53 7.1e-24 77.31 In-house 108-176 (241) Show / Hide 
Range on Protein: 665-733
Range on HMM: 108-176/241
Sequence Identity: 53% (37 aa)

IIHRDLKSANCLVDKHWCVKICDFGLSRLTTGTPIQETTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
|||||||| | |. .   ||||||| |.            .||  |||||. ||||.| | ||.| |||
IIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVV
Kinase MLK-p1_k.AA Shk 664-733 49 1.7e-23 81.12 In-house 123-195 (269) Show / Hide 
Range on Protein: 664-733
Range on HMM: 123-195/269
Sequence Identity: 49% (36 aa)

NIIHRDLKSANCLVDKHWCVKICDFGLSR-LTTGTPIQE--TTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
||||||||.|| |||. | ||.||||.|    ...  .     |.||| ||||| . | |   | | .| | .
NIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGII
Kinase MLK-p1_k.AA MLK 661-733 45 7.9e-23 76.11 In-house 144-225 (291) Show / Hide 
Range on Protein: 661-733
Range on HMM: 144-225/291
Sequence Identity: 45% (38 aa)

QRMNIIHRDLKSANCLVD------KHWCVKICDFGLSRLTTGTPIQ-ETTAAGTPEWMAPELL---RNEPVSYKCDIFSLGVV
... |||||||| | |.|      .|  .||||||.||  . .  .  . .|||. ||||| .   |.|..| |||..| |||
APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV
Kinase MLK-p1_k.AA DRK 665-733 48 6.4e-22 71.05 In-house 121-191 (258) Show / Hide 
Range on Protein: 665-733
Range on HMM: 121-191/258
Sequence Identity: 48% (36 aa)

IIHRDLKSANCLVDKHWCVKICDFGLSR-----LTTGTPIQETTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
|||||||| | ||| || ||. |||||      .  ..     |. ||| | ||| |||..   | |..| ..|
IIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAM---TMCGTPCWTAPEVLRNQRYTEKADVYSFAIV
Kinase MLK-p1_k.AA Dicty5 663-733 49 1.9e-21 70.54 In-house 123-192 (260) Show / Hide 
Range on Protein: 663-733
Range on HMM: 123-192/260
Sequence Identity: 49% (35 aa)

MNIIHRDLKSANCLVDKHWCVKICDFGLSRLTTGTPIQETTAAGTPEWMAPELLRNEPVSYKCDIFSLGVV
|||||||||| | |. . | .|| ||| ||       . |.  ||. |||.||    |   |||..| |.|
MNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIV
Kinase MLK-p1_k.AA TKL-Unique 665-733 43 5.1e-21 70.98 In-house 133-217 (290) Show / Hide 
Range on Protein: 665-733
Range on HMM: 133-217/290
Sequence Identity: 43% (37 aa)

IIHRDLKSANCLVDKH-----WCVKICDFGLSRLTTGT---PIQET------TAAGTPEWMAPELLRN--EPVSYKCDIFSLGVV
|||||||| | ||| .     | .||||||||.. .     .. |       |  |.. |||||.||.  .  | |.|..| |.|
IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV
Kinase MLK-p1_k.AA Pkinase_Tyr 662-733 39 5.1e-13 44.71 Pfam 129-203 (270) Show / Hide 
Range on Protein: 662-733
Range on HMM: 129-203/270
Sequence Identity: 39% (30 aa)

RMNIIHRDLKSANCLVDKHWCVKICDFGLSRLTTGTPIQETTAAG----TPEWMAPELLRNEPVSYKCDIFSLGVV
..|.|||||   ||||..  .||||||||.|. . .    ....|       ||||| ...   . | |. | ||.
SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL
S_TKc MLK-p1_k.AA S_TKc 575-779 19 6.9e-13 12.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 575-779
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

LRIGIRIGIGNFKRVTFSPSLI--------HLVHGSMHESSSPVNGYRIHAYGLTLSPHPYERTRKEAKLAK-------------------------KT-
 .|.  || | | .|                .                             |..|.| .. |                          . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGD

-ENATRYLQRR-----------------RDLFRGMMCVQRMNIIHRDLKSANCLVDKHWCVKICDFGLSRLTTGTPIQETTAAGTPEWMAPELLRNEPVS
  .  .|...|                 . .....    ...||||||| .| |.|.  ..|||||||.|.        ||  |||..||||.|   . .
LGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYG

Y-KCDIFSLGVV-------------HEVSVKRSRLEIPQGLLGKLIADCWQENPQERPSYDEILT-----RLHECE
. |||. |.|..             ...  |. .   .. ..  .|  |.| .|..||.  |.|.     ..|.  
KCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-p1_k.AA Dicty4 752-777 46 1.3e-10 31.82 In-house 250-277 (277) Show / Hide 
Range on Protein: 752-777
Range on HMM: 250-277/277
Sequence Identity: 46% (13 aa)

KLIADCWQENPQERPSYDEILTR--LHE
.||..|| ..|| |||  ||. |  | .
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_k.AA TKL-Unique 736-775 37 2.7e-10 32.71 In-house 246-290 (290) Show / Hide 
Range on Protein: 736-775
Range on HMM: 246-290/290
Sequence Identity: 37% (17 aa)

VSV--KRSRLEIPQ---GLLGKLIADCWQENPQERPSYDEILTRL
| .  ...|..||.     . .|| .||  .|..||| |||..||
VHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_k.AA DRK 752-777 53 2.8e-10 31.07 In-house 233-258 (258) Show / Hide 
Range on Protein: 752-777
Range on HMM: 233-258/258
Sequence Identity: 53% (14 aa)

KLIADCWQENPQERPSYDEILTRLHE
.|. ||| |.|| ||| .|.| ||  
QLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_k.AA TKL 736-775 34 8.7e-10 31.43 In-house 310-364 (364) Show / Hide 
Range on Protein: 736-775
Range on HMM: 310-364/364
Sequence Identity: 34% (19 aa)

VSVKRSRLEIP------------QGL---LGKLIADCWQENPQERPSYDEILTRL
|..|. |..||                  . ||. |||...|..||| .||| ||
VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
TyrKc MLK-p1_k.AA TyrKc 575-775 18 4e-09 -75.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 575-775
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

LRIGIRIGIGNFKRV------------------------------TF--S-PSLIHLVHGSMHE-----SSSPVNGYRIHAYGLTLSPHPYERTRKEAKL
.. |  .| |.| .|                               .  . | .. |.   ...     .. |.  . .  |    . . | | ...   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL--MIVMEYMPHGDLKDYLRKHRPK--

AKKTENATRYLQRRRDLF---RGMMCVQRMNIIHRDLKSANCLVDKHWCVKICDFGLSRLTTGT-PI----QETTAAG--TPE------WMAPELLRNEP
           .     .   .||    ..|.|||||   ||||..  .|||.||||||  .         .  ....           ||||| ..   
-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

VSYKCDIFSLGV-------------------------VHEVSVKRSRLEIPQG-----------LLGKLIADCWQENPQERPSYDEILTRL
 . | |..| ||                         |.|   .. |...|.             . ... .||.|.| .||.  ||  ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_k.AA MLK 750-775 38 6.6e-09 27.16 In-house 266-291 (291) Show / Hide 
Range on Protein: 750-775
Range on HMM: 266-291/291
Sequence Identity: 38% (10 aa)

LGKLIADCWQENPQERPSYDEILTRL
. ||. .||...| .||| ..|.. |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_k.AA Dicty4-Unclassified 752-775 41 4.9e-08 23.58 In-house 240-263 (263) Show / Hide 
Range on Protein: 752-775
Range on HMM: 240-263/263
Sequence Identity: 41% (10 aa)

KLIADCWQENPQERPSYDEILTRL
||| .|| . |. ||....|  .|
KLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_k.AA Dicty5 752-779 39 5.6e-07 20.04 In-house 233-260 (260) Show / Hide 
Range on Protein: 752-779
Range on HMM: 233-260/260
Sequence Identity: 39% (11 aa)

KLIADCWQENPQERPSYDEILTRLHECE
.||  |||. |. |||. ||.  .    
NLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLK-p1_k.AA Shk 750-780 45 7e-06 17.42 In-house 237-269 (269) Show / Hide 
Range on Protein: 750-780
Range on HMM: 237-269/269
Sequence Identity: 45% (15 aa)

LGKLIADCWQENPQERPSYDEILTR--LHECEF
| .||. ||  ||| |||  ||. |  | .   
LKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase MLK-p1_k.AA Pkinase_Tyr 752-775 37 6.6e-05 17.24 Pfam 247-270 (270) Show / Hide 
Range on Protein: 752-775
Range on HMM: 247-270/270
Sequence Identity: 37% (9 aa)

KLIADCWQENPQERPSYDEILTRL
.|. .||...|..||.  ||. .|
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_k.AA LZK 753-775 39 0.000323 10.03 In-house 219-241 (241) Show / Hide 
Range on Protein: 753-775
Range on HMM: 219-241/241
Sequence Identity: 39% (9 aa)

LIADCWQENPQERPSYDEILTRL
|.  ||.  |  |||.  ||  .
LMKQCWSQKPRNRPSFRQILMHW
Kinase MLK-p1_k.AA LISK 761-775 46 0.000845 8.0 In-house 282-296 (296) Show / Hide 
Range on Protein: 761-775
Range on HMM: 282-296/296
Sequence Identity: 46% (7 aa)

NPQERPSYDEILTRL
.| .||| .||...|
DPKNRPSFKEIVQWL
Kinase MLK-p1_k.AA Pkinase 752-775 26 0.024594 9.34 Pfam 268-293 (293) Show / Hide 
Range on Protein: 752-775
Range on HMM: 268-293/293
Sequence Identity: 26% (7 aa)

KLIADCWQENPQERPSYDEILTR--L
..| .|.. .|..||. ..||    .
DFIKWCLCKDPKKRPTAEQILQHPWF