Gene MLK-Un_p-2 (S.moellendorffii)

MLK-Un_p-2

Species: S.moellendorffii
Alias: MLK-Un_p-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_p-2.AA Protein None 318 None Fasta, JSON
MLK-Un_p-2.NA RNA None 957 None Fasta, JSON
MLK-Un_p-2.kin_dom Protein Kinase Domain None 171 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_p-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_p-2.AA TKL 75-305 21 2.7e-25 88.03 In-house 70-364 (364) Show / Hide 
Range on Protein: 75-305
Range on HMM: 70-364/364
Sequence Identity: 21% (65 aa)

EKELAILKRLSES-HVNILQFFGTYVDGKT-------------KYAVMERPGKEISTLDEFIHNKPELKDGHWSLKKNFALEIAMGLQYAHA--------
..|   .. .|   | ||.|| |   ...               . |||    .  .| ...|         |... ..||.|| |..| |.        
FFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYC--PGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTK

VGVVHKNLRSPNIFIDDS------------QDLRPKIFGF----------NQGRI--------EALKSDKRPQSKEQV---RWKAPEMLPQA--------
 ...| .| |.||..|.              | ..||  |          |. ..        | .. . | ..  |.   || |||.| ..        
PPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE-HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVG

--NRAIRRPEYSYACDIFSLGVVMWEIVTWSFPFEQIKGVRGVLE---ARARRGMTLDFSALPPGDR----------SPALQSFVQISMDCMEEDSGKRP
     ..  ||| .||..| |.|.|||.|   |.....    ..         .  ...  .|. ..          .....|. .. .||...|  |||
IDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP

NVDEVVERL
. .|...||
SFQEILKRL
Kinase MLK-Un_p-2.AA TKL-Unique 75-246 22 1.7e-17 58.4 In-house 43-237 (290) Show / Hide 
Range on Protein: 75-246
Range on HMM: 43-237/290
Sequence Identity: 22% (46 aa)

EKELAILKRLSESHVNILQFFGTYV----DGKTKYAVMERPGKEISTLDEFIH-------NKPELKDGHWSLKKNFALEIAMGLQYAHAVG--VVHKNLR
|.|. ..|.| . | ||....|. .    . .  . |||   .. ..|.. .|       | .. ..  .... ..|. || |. | |  .  . | .|.
ENEVNWMKKL-HYHPNIVHYMGYCMDHQVYPPNMCIVMEY--CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLK

SPNIFIDDS---QDLRPKIFGFNQGRIEA--LKSDKR-------PQSKEQVRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTWSF------PF
|.|. .|       .. || .|.  .. .  .|. ..       .  .   || |||.| . .       ||  .|..| |.|.|||.|.        |.
SSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-----CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY

EQI
. .
QGM
Kinase MLK-Un_p-2.AA TK-Unique 138-238 29 1.4e-15 50.26 In-house 135-234 (294) Show / Hide 
Range on Protein: 138-238
Range on HMM: 135-234/294
Sequence Identity: 29% (31 aa)

NFALEIAMGLQYAHA--VGVVHKNLRSPNIFIDDSQDLRPKIFGF---NQGRIEALKSDKRPQSKEQVRWKAPEMLPQANRAIRRPEYSYACDIFSLGVV
.|| .||.|..| .    ..||..| . |... .  |.. || .|     .. .   | .. |.. ..|| ||| |  .    ... ...  |. |.||.
HFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVL

MWEIVT
||||.|
MWEIFT
Kinase MLK-Un_p-2.AA TK 118-305 12 2.4e-14 43.73 In-house 146-486 (486) Show / Hide 
Range on Protein: 118-305
Range on HMM: 146-486/486
Sequence Identity: 12% (44 aa)

LDEFIHNKPELKDGHWSLKKN------------------------------------------------------------------------FALEIAM
|... ..... .  . . . |                                                                        ... || 
LRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIAC

GLQYAHAV------GVVHKNLRSPNIFIDDSQD---------LRPKIFGFN--------QGRIEALKSDKRPQS--------------------------
|..| |.       ..|| .|   |. ....           .  ||  |           |    ..| . .|                          
GMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGG

KEQVRWKAPEMLPQANRAIR--RPEYSYACDIFSLGVVMWEIVTWS-FPFEQIKGV--------RGVLEARARRGMTLDFS--------ALPPGDRSPAL
|  .|| ||| |             .. . |..|.||.||||.|    |.                 .  . ||| .| .          ...     . 
KLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCP

--------------QSFVQISMDCMEEDSGKRPNVDEVVERL
              . . .. ..| ..|  .||. ....|.|
DWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_p-2.AA RAF 140-307 23 2.1e-13 39.54 In-house 109-282 (282) Show / Hide 
Range on Protein: 140-307
Range on HMM: 109-282/282
Sequence Identity: 23% (42 aa)

ALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKIFGFNQGRIEALKSDKRPQSKEQ----VRWKAPEMLP------QANRAIRRPE-YSYACDIFS
.. .. |. | ||  ..|  |.| ||| ..  |.. ||  |   ... . | .. |  ||    . | |||         . .  ..    ||   |..|
SRQVCQGMDYLHAKNIIHRDLKSNNIFLHE--DMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYS

LGVVMWEIVTWSFPF-EQIKGVRGVLEARARRGMTLDFSALPPGDRSPALQSFVQISMDCMEEDSGKRPNVDEVVERLSQ
 |.||.|..| . |.  .|.    ..    |  .  | |..    |. . ..  .   ||.. .  .||   ....|.  
FGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKV----RQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase MLK-Un_p-2.AA MLK 200-305 26 3e-13 42.44 In-house 197-291 (291) Show / Hide 
Range on Protein: 200-305
Range on HMM: 197-291/291
Sequence Identity: 26% (28 aa)

VRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTWSFPFE-QIKGVRGVLEARARRGMTLDFSALPPGDRSPALQSFVQISMDCMEEDSGKRPNV
..| |||.. |    .|   || .||..| |||.||..|   |..  ... .   .. |  | ..   ..|..    .  .. .  ..|...|..|||. 
YAWMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWV-AYNGLRP---PIPST----CPEHWKKLMKQCWNQDPHKRPSF

DEVVERL
...|. |
RQIVQHL
S_TKc MLK-Un_p-2.AA S_TKc 45-309 18 2.1e-12 4.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-309
Range on HMM: 1-231/231
Sequence Identity: 18% (53 aa)

YDEHTL----------CATLEQPGSSSATRVLLLYSEDLGEKELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKEISTLDEFIHNKPE------L
|. . .          ...    |   |  ..     .  ..|..|||.    | || .......| .  | |||  .    .| ..|....       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KDGHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKIFGFNQGRIEALKSDKRPQSKEQV---RWKAPEMLPQANRAIRRPEYSY-AC
   |    . .. .|. .|.| |  |..|  |   ||..|.    . ||  |   |.           . ..    . |||.|           |.. .|
PE-H---ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------TTFCGTPWYMAPEVL----------GYGKCKC

DIFSLGVVMWEIVTWSFPFEQIKGVRGVLEARARRGMTLDFSALPPGDRSPALQSFVQISMDCMEEDSGKRPNVDEVVE-----RLSQLV
|. |.|....| ..   ||.        ...  .. .            || . .|.   . |.. |  ||| . |. .     .. . .
DWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG------------SPEAKDFI---RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc MLK-Un_p-2.AA TyrKc 67-305 18 3.1e-10 -57.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 67-305
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

LLYSEDLGE-----------------------------KELAILKRLSESHVNILQFFGTYVDG-------KTKYAVMERPGKEISTLDEFIHNKPELKD
.   . |||                             .|. |...|  .| ||....|  ...       .  . |||   .  . |....... .   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GD-LKDYLRKHRPK--

GHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDSQDLRPKI-------FGFNQ---GRIEALKSDKRP----QSK--EQVRWKAPEMLPQANRA
  .. . .|.. || | .| |  ...|  |   |. ... .  . ||       .. .    |   . |. .|.    ..|    .|| ||| .      
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI------

IRRPEYSYACDIFSLGVVMWEIVTWSFPFEQI-----KGVRGVLEARARRGMTLDFSALPPGDRSP-----ALQSFVQISMDCMEEDSGKRPNVDEVVER
 .  ... . |..| ||.|||| |   .         .  . |.| . ..|. ..  . .     |     . .   ||  .| .||  .||.  |..|.
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIE-YVKQGYRMPQPPNDY----PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase MLK-Un_p-2.AA Dicty4-Unclassified 117-168 32 2.8e-08 24.43 In-house 88-143 (263) Show / Hide 
Range on Protein: 117-168
Range on HMM: 88-143/263
Sequence Identity: 32% (18 aa)

TLDEFIHNKPELKDGHWSLKK----NFALEIAMGLQYAHAVGVVHKNLRSPNIFID
.| | || ||  ..   .|       .|..|| |.|. | . ..|  ..| || .|
NLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMD
Kinase MLK-Un_p-2.AA LRRK 118-167 36 2.8e-07 21.78 In-house 142-199 (351) Show / Hide 
Range on Protein: 118-167
Range on HMM: 142-199/351
Sequence Identity: 36% (21 aa)

LDEFIHNKPELK------DGHWSLKKNFALEIAMGLQYAHAVG--VVHKNLRSPNIFI
|..|.||| . .      .  |.||   ||.|| |..| |     ..| .|.||||..
LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL
Kinase MLK-Un_p-2.AA UTK 200-239 40 3.2e-07 20.76 In-house 203-236 (296) Show / Hide 
Range on Protein: 200-239
Range on HMM: 203-236/296
Sequence Identity: 40% (16 aa)

VRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTW
.|| ||| | ..        .. . |..|.|||.|||.||
IRWMAPEALTHHT------RFTTKSDVWSFGVVCWEIWTW
Kinase MLK-Un_p-2.AA LISK 75-174 24 5.9e-07 18.42 In-house 44-141 (296) Show / Hide 
Range on Protein: 75-174
Range on HMM: 44-141/296
Sequence Identity: 24% (25 aa)

EKELAILKRLSESHVNILQFFGTYVD-GKTKYAVMERPGKEIS--TLDEFIHNKPE-LKDGHWSLKKNFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDS
..|....|.|  .| ||.||.| ..   .  ..| |     |.  .| ........  ..  |... ..|| || |. | |. ...|  | | |. ....
LREVQMMKNL--RHPNIVQFMGVCYHNDGQLHIVTEY----INGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVREN

QDLR
 . .
DNNQ
Kinase MLK-Un_p-2.AA Pkinase 201-305 17 8.7e-07 25.08 Pfam 176-293 (293) Show / Hide 
Range on Protein: 201-305
Range on HMM: 176-293/293
Sequence Identity: 17% (22 aa)

RWKAPEMLPQANRAIR-RPEYSYACDIFSLGVVMWEIVTWSFPFEQI----KGVRGVLEARARRGMTLDFSALPPGDRS-----------------PALQ
.. |||        || ...|....|..|.|....| ..  .|| .     . ..     . ..|  |.|.   . ..|                 ....
WYMAPEV-------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

SFVQISMDCMEEDSGKRPNVDEVVER--L
.|.    .| . |  |||. .....   .
DFIK---WCLCKDPKKRPTAEQILQHPWF
Kinase MLK-Un_p-2.AA Pkinase 77-157 27 4e-06 22.64 Pfam 50-131 (293) Show / Hide 
Range on Protein: 77-157
Range on HMM: 50-131/293
Sequence Identity: 27% (23 aa)

ELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKE--ISTLDEFIH--NKPELKDGHWSLKKNFALEIAMGLQYAHAVGVVH
|..|.|||.  | ||....... |..  | |||  ..      | ..|.  ..  .  . .   |.....|. ||.| |. |..|
EIQIMKRLN--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIH
Kinase MLK-Un_p-2.AA LISK 219-238 50 3.4e-05 12.61 In-house 215-234 (296) Show / Hide 
Range on Protein: 219-238
Range on HMM: 215-234/296
Sequence Identity: 50% (10 aa)

EYSYACDIFSLGVVMWEIVT
.|...||.|| |.|. ||.|
SYDESCDVFSFGIVLCEIIT
Kinase MLK-Un_p-2.AA TKL-Unique 286-305 40 0.000349 10.86 In-house 271-290 (290) Show / Hide 
Range on Protein: 286-305
Range on HMM: 271-290/290
Sequence Identity: 40% (8 aa)

DCMEEDSGKRPNVDEVVERL
.|   |. .||..||...||
QCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_p-2.AA LRRK 285-307 43 0.000361 10.63 In-house 329-351 (351) Show / Hide 
Range on Protein: 285-307
Range on HMM: 329-351/351
Sequence Identity: 43% (10 aa)

MDCMEEDSGKRPNVDEVVERLSQ
..| ..|  |||   ..|.||||
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_p-2.AA LRRK 225-249 30 0.000498 10.13 In-house 264-289 (351) Show / Hide 
Range on Protein: 225-249
Range on HMM: 264-289/351
Sequence Identity: 30% (8 aa)

DIFSLGVVMWEIVTWS-FPFEQIKGV
|..| |...||..| . .||......
DCYSFGMILWELLTRQHHPFDEHDFF
Kinase MLK-Un_p-2.AA Pkinase_Tyr 214-238 40 0.001498 12.65 Pfam 185-209 (270) Show / Hide 
Range on Protein: 214-238
Range on HMM: 185-209/270
Sequence Identity: 40% (10 aa)

AIRRPEYSYACDIFSLGVVMWEIVT
.|.  ... . |. | ||.||||.|
CINYGKFTTKSDVWSFGVLMWEIFT
Kinase MLK-Un_p-2.AA Dicty4-Unclassified 286-305 30 0.001515 7.97 In-house 244-263 (263) Show / Hide 
Range on Protein: 286-305
Range on HMM: 244-263/263
Sequence Identity: 30% (6 aa)

DCMEEDSGKRPNVDEVVERL
.|. .|  |||  ......|
WCWHNDPNKRPTMNQIIQYL
Kinase MLK-Un_p-2.AA UTK 77-174 23 0.004274 6.44 In-house 59-165 (296) Show / Hide 
Range on Protein: 77-174
Range on HMM: 59-165/296
Sequence Identity: 23% (26 aa)

ELAILKRLSESHVNILQFFGTYVDGKTKYAVMERPGKEISTLDEFIH-NKPELK-DGHWSLKKN---FALEIAMGLQYAHAVGVVHKNLRSPNIFIDDS-
||...|...  |.|.|.. |. ....  . |.|    | . |. .   ..|..  ..||  .     .|. || |.|| |  |.|| .|   |...... 
ELQMMKQFH-WHPNVLRLVGVCTQEEPWMIVTEY--MENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHR

------QDLR
      .. .
MMWHCMMVCK
Kinase MLK-Un_p-2.AA LISK 279-305 33 0.006078 5.17 In-house 270-296 (296) Show / Hide 
Range on Protein: 279-305
Range on HMM: 270-296/296
Sequence Identity: 33% (9 aa)

SFVQISMDCMEEDSGKRPNVDEVVERL
.|... .|| . |  .||. .|.|..|
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase MLK-Un_p-2.AA UTK 282-305 20 0.012353 4.84 In-house 273-296 (296) Show / Hide 
Range on Protein: 282-305
Range on HMM: 273-296/296
Sequence Identity: 20% (5 aa)

QISMDCMEEDSGKRPNVDEVVERL
.. ..|.. |  .||. ...|...
RLMHRCWHYDPQERPDFEDLVQQM
Kinase MLK-Un_p-2.AA MLK 138-177 34 0.029672 3.78 In-house 128-174 (291) Show / Hide 
Range on Protein: 138-177
Range on HMM: 128-174/291
Sequence Identity: 34% (16 aa)

NFALEIAMGLQYAHAVG---VVHKNLRSPNIFIDD----SQDLRPKI
|.|| .| |..| |.     ..|  | |.|| ||.     ...  ||
NWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKI
Kinase MLK-Un_p-2.AA TK-Unique 287-305 26 0.031528 3.63 In-house 276-294 (294) Show / Hide 
Range on Protein: 287-305
Range on HMM: 276-294/294
Sequence Identity: 26% (5 aa)

CMEEDSGKRPNVDEVVERL
|  ..  .||. .... ||
CWQWEPEERPSFRQIKHRL
Kinase MLK-Un_p-2.AA Dicty4-Unclassified 200-246 23 0.06529 2.29 In-house 172-211 (263) Show / Hide 
Range on Protein: 200-246
Range on HMM: 172-211/263
Sequence Identity: 23% (11 aa)

VRWKAPEMLPQANRAIRRPEYSYACDIFSLGVVMWEIVTWSFPFEQI
..| .|| |       .   |  . |..| .....| .|   |.  |
PKWESPECL-------MHESYNQKSDVYSYAMMLYELATGDEPYQEI
Kinase MLK-Un_p-2.AA Pkinase_Tyr 285-305 33 0.411456 4.39 Pfam 250-270 (270) Show / Hide 
Range on Protein: 285-305
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

MDCMEEDSGKRPNVDEVVERL
..|...|  .||   |..|.|
KQCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_p-2.AA Pkinase_Tyr 138-170 21 0.881078 3.27 Pfam 115-147 (270) Show / Hide 
Range on Protein: 138-170
Range on HMM: 115-147/270
Sequence Identity: 21% (7 aa)

NFALEIAMGLQYAHAVGVVHKNLRSPNIFIDDS
.....||.|..| .. . .|  |.  |. ....
QMCWQIAKGMEYLESKNCIHRDLAARNCLVTEN