MLK-Un_f-2

Species: S.moellendorffii
Alias: MLK-Un_f-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_f-2.AA Protein None 460 None Fasta, JSON
MLK-Un_f-2.NA RNA None 1383 None Fasta, JSON
MLK-Un_f-2.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_f-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank MLK-Un_f-2.AA Ank 74-106 48 1e-09 39.34 Pfam 1-33 (33) Show / Hide
Range on Protein: 74-106
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

DSRTALHVAACEGKKETVELLIAEGADVNARDR
| .|.||.|.. | .| |..|.  ||||||.|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank MLK-Un_f-2.AA Ank 46-73 35 3.171666 5.07 Pfam 6-33 (33) Show / Hide
Range on Protein: 46-73
Range on HMM: 6-33/33
Sequence Identity: 35% (10 aa)

LLWSASLGDVAGVRALLGKGMDVNSTDF
| . .. |..  |. ||..| ||| .| 
LHLACRCGHTEVVKMLLQHGADVNAQDD

Kinase MLK-Un_f-2.AA TKL 189-433 23 3.2e-65 222.97 In-house 12-364 (364) Show / Hide
Range on Protein: 189-433
Range on HMM: 12-364/364
Sequence Identity: 23% (84 aa)

GKWRG----------TKVFVKVISIDTKTGDDK------------------------LKEFINELSLALMLRHPNVVQFLGAVTQSIP------------
|||||          . | ||.....    ..|                         .....|. . ..|||||.|||.|..... .            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-VMLVMEHLPKGDLQSYMKKKGKPLKPKKALKFALDIARGLNYVHEFKP-----EPVIHSNLKPSNLLRDKAGH--------------LKITDFAFTKYA
  ..|||  |.|.| .|.        . . ...|||||||.|| |  .|      |.|| .||..|.| |. ..              .||.|| . .  
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

FNDRQFVPDSGTIF-----------LLMSG---RYMAPELYRCE----------------DYDSKVDVFSFALIVQEMMEGVPPFPKLG----------E
... .    . |.            . . .   |.||||. | .                .|. |.||.||...  |.. . .|. ...          |
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

EEVAKSYADGKRPPFK---------IKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEV
|. .. . .|.||| .          .. . |...|.|...||. ||.||||| .| |. 
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase MLK-Un_f-2.AA TKL-Unique 189-433 28 3e-53 183.21 In-house 16-290 (290) Show / Hide
Range on Protein: 189-433
Range on HMM: 16-290/290
Sequence Identity: 28% (80 aa)

GKWRGTKVFVKVISIDTKTGDDKLKEFINELSLALMLR-HPNVVQFLGAVT----QSIPVMLVMEHLPKGDLQSYMK---------KKGKPLKPKKALKF
|||||..| .|....  .   ....||.||...  .|. |||.|.. |. .    . .   .||| .| | | ..           .. ..| ... .|.
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

ALDIARGLNYVHEFKPEPVIHSNLKPSNLLRDKA-----GHLKITDFAFTKYAFND-RQFVP---DSGTIFLLMSGRYMAPELYRC--EDYDSKVDVFSF
|.|||.|..| |  .|  .|| .||.||.| | .        || || . | . .. . ..     ..    . | |.||||. |   ..|. |.||.||
AIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSF

ALIVQEMMEGVP------PFPKLGEEEVAKSYAD---GKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEV
. .. |. ..        |. ..  |....  ..   ..|||    |   |. ..|||..|||.|| .|||| .| .. 
GIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPI---PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase MLK-Un_f-2.AA LRRK 189-435 24 3.6e-39 136.23 In-house 19-351 (351) Show / Hide
Range on Protein: 189-435
Range on HMM: 19-351/351
Sequence Identity: 24% (85 aa)

GKWRG----------------------------TKVFVKVISID--TKTGDD------------------------------KLKEFINELSLALMLRHP
.||||                            ..| .|.. .|  | .  |                              .. || .|...   |.||
AKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNHP

NVVQFLGAVTQSIPVMLVMEHLPKGDLQSYMKKKGK--------PLKPKKALKFALDIARGLNYVHEFKPEPVIHSNLKPSN-LL-RDKAG---------
|.|. .|   .  | ..||| .| |||......| .         ...   || ||.||.|..| | ..| |.|| .||. | || . ...         
NIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAH

-HLKITDFAFTKYAFNDRQFVPDSGTIFLLMSGRYMAPELYR---CEDYDSKVDVFSFALIVQEMMEGV-PPFPKLG-------EEEVAKSYADGKRPPF
 . || ||  .   |   | .. ... ...   ..||||  |    | |. |||..||..|  | . .  .||  .        .|.. .   .| ||..
VCAKIADFGISR-MF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTI

K---IKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEVEK
.    .|. ..  ..|||..||. ||.|||.| .| |  . 
PQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase MLK-Un_f-2.AA TK 189-433 16 8.8e-37 120.29 In-house 21-486 (486) Show / Hide
Range on Protein: 189-433
Range on HMM: 21-486/486
Sequence Identity: 16% (78 aa)

GKWRG---------------------------TKVFVKVISIDTKTGDD-KLKEFIN----------ELSLALMLR-----HPNVVQFLGAVTQS-----
|.|||                           |.| ||..  .. . .. .. |...          |.. . |..     |||.|...|..||.     
GEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPC

-------IPVMLVMEHLPKGD----LQSYMKKKGKP----------------------------------------------------------------
        |.|.|||. |.||    |..| .|. ..                                                                
FEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQM

-----------LKPKKALKFALDIARGLNYVHEFKPEPV----IHSNLKPSNLLRDKAGH-----------LKITDFA--------FTKYAFNDRQFVPD
           | ..  | ....||.|. | |. . |      .| .|   | | .. ..            ||.||          ...  .|   . .
AWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRK

S-GTIFLLMSG---------------------RYMAPELYRCED---------YDSKVDVFSFALIVQEMME-G-VPPFPKLGE---------EEVAKSY
| ..  ..|                       |.||||  .            . .| ||.||   . |..  | .|. . .           .|| .  
SSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYL

ADGKRPPFK------------IKPRYYP--------------EGLKDLIEECWHDDPRKRPSFRTICKEV
 .| |. ..             .| . |              | . ||. .||| ||..||.|... .. 
RRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase MLK-Un_f-2.AA TKL-ciliate2 190-434 32 1.1e-33 109.38 In-house 19-273 (273) Show / Hide
Range on Protein: 190-434
Range on HMM: 19-273/273
Sequence Identity: 32% (86 aa)

KWRGTKVFVKVISIDTKTGDDKLKEFINELSLALMLRHPNVVQFLGAVTQSIPVMLVMEHLPKGDLQSYMKKKGKPLKPKKALKFALDIARGLNYVHEFK
||| . | ||   .|    ......|.||      |||||.| |||| |..    ..||   .| | | .. .  .|      . |||||||  |.|  .
KWREIVVAVKKFKMDHDN-QQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSN

PEPVIHSNLK--------------------PSNLLRDKAGHLKITDFAFTKYAFNDRQFVPDSGTIFLLMSGRYMAPELYRCEDYDSKVDVFSFALIVQE
| |.||  ||                      |.| |     |.||| .|.   .|       ||        .||||  .   |  | ||||...|. |
P-PIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNKIGTY------QWMAPEVIKAFYYTEKADVFSYSIILWE

MMEGVPPFPKLGEEEVA-KSYADGKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEVE
.    ||.     . || |   .  ||     |.  |  . ||.. || ..   ||||  | ||.|
IASREPPYRNKKGDVVAEKVMCNNLRP---TIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE

S_TKc MLK-Un_f-2.AA S_TKc 166-431 23 1.4e-33 118.77 SMART 1-220 (231) Show / Hide
Range on Protein: 166-431
Range on HMM: 1-220/231
Sequence Identity: 23% (66 aa)

EIDREEL------SVLKCVAFGWQDSFTIGKWRGTKVFVKVISIDTKTGDDKLKEFINELSLALMLRHPNVVQFLGAVTQSIPVMLVMEHLPK--GDLQS
    ...      .| ||.  .           | .| .|.|.          . ...|...  . .|||.|.....      . .|||...   ||| .
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD

YMKKKGKP-----LKPKKALKFALDIARGLNYVHEFKPEPVIHSNLKPSNLLRDKAGHLKITDFAFTKYAFNDRQFVPDSGTIFLLMSGRYMAPELYRCE
|.||.|..     . .  | ...  |...|.| |. .   .||  |||.|.| |.  |.||.|| . .                .  .  |||||.    
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---

DYDS-KVDVFSFALIVQEMMEGVPPFPKLGEEEVAKSYADGKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICK
 |.  |.|. |.  |. ||. | ||||     .... .   .           .. .||.|. |.. ||.|||.   . .
GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ

Kinase MLK-Un_f-2.AA Dicty4-Unclassified 189-433 29 9.9e-32 105.92 In-house 18-263 (263) Show / Hide
Range on Protein: 189-433
Range on HMM: 18-263/263
Sequence Identity: 29% (76 aa)

GKWRGTKVFVKVI-SIDTKTGDDKLKEFINELSLALMLRHPNVVQFLGAVTQSIP------VMLVMEHLPKGDLQSYMK----KKGKPLKPKK--ALKFA
| |.|  | || . .   |  .. ...|  |  .   . ||| |.  |.     |       . ||| ..|| |          . .|.|      .|.|
GNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN--PRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYA

LDIARGLNYVHEFKPEPVIHSNLKPSNLLRDKAGHLKITDFAFTKYAFNDRQFVPDSGTIFLLMSGRYMAPELYRCEDYDSKVDVFSFALIVQEMMEGVP
.|||.|. . |      .||  .| ||.| ||    || ||       .        ||       .  .||  . | | .| ||.|.|..  |.. |  
FDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTP------KWESPECLMHESYNQKSDVYSYAMMLYELATGDE

PFPKLG-EEEVAKSYADGKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEV
|.       ..| | .| |  | || |   .  .| ||  |||.||.|||..  | .  
PYQEIQSIMNAARSVCDKKLRP-KI-PDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase MLK-Un_f-2.AA STE 193-425 17 2.3e-31 108.06 In-house 39-347 (359) Show / Hide
Range on Protein: 193-425
Range on HMM: 39-347/359
Sequence Identity: 17% (58 aa)

GTKVFVKVISIDTKTG--------------DDKLKEFINELSLALMLR--HPNVVQFLGAVTQSIP-------VMLVMEHLPKGDLQSYMKKKGKPLKP-
|. . .|........               .........|...   ..  |||.|...|.  .  .       . ..||... | | . .|.|....|| 
GEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPL

------------KKALKFALDIARG-LNYVHEFKPEPVIHSNLKPSNLLRDKAGHLKITDFAFTKYAFN-----------------DRQFVPDSGTIFLL
            .   ... .| .| |.| |. .   .||  .||.| |       |..|| . .   .                 . .   . ||    
NHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---

MSGRYMAPELYRCED------YDSKVDVFSFALIVQEMMEGVPPFPKLGEEEVAKSYADG---------------KRPPFKIK----------------P
    .||||  ....      || |.|. |. . . || .| ||. ..   ..    ...               . ||.. .                |
----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYP

RYYPEGLKDLIEECWHDDPRKRPS
. . . .|| |. |   ||.|||.
HKWSPEFKDFINKCLQKDPNKRPT

TyrKc MLK-Un_f-2.AA TyrKc 166-433 25 6e-27 96.77 SMART 1-280 (280) Show / Hide
Range on Protein: 166-433
Range on HMM: 1-280/280
Sequence Identity: 25% (78 aa)

EIDREEL------SVLKCVAFGWQDSFTIGKWRGTKVFVKVISIDTKTGDDKLKEFINELSLALML--RHPNVVQFLGAVTQS-------IPVMLVMEHL
    ..|       | |...              ..| ||..  |.      ...|..|...  .|  .|||.|...|..||.        |.|.|||. 
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

PKGDLQSYMKKKGKPLKPKKALKFALDIARGLNYVHEFKPEPVIHSNLKPSNLLRDKAGHLKITDFAFTKYAFND-------RQFVPDS--GTIFLLMSG
|.|||..| .|... |..|. |.|...||.| .| |.    ..||  |   | | .. .. ||.||  ...  .|          .. .  |. . ..  
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT-MLPI

RYMAPELYRCEDYDSKVDVFSFALIVQEMME-GVPPFPK-----LGEEEVAKSYADGKRPPFKIKPRY--------YPEGLKDLIEECWHDDPRKRPSFR
| ||||  .   . .| ||.||     |..  | .| |      .  .|| .   .|.|.|   .| .         |. . .....||| || .||.|.
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP---QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

TICKEV
.|... 
EIHECF

Kinase MLK-Un_f-2.AA Dicty4 189-316 35 1.3e-26 85.94 In-house 18-158 (277) Show / Hide
Range on Protein: 189-316
Range on HMM: 18-158/277
Sequence Identity: 35% (51 aa)

GKWRGTKVFVKVI-SIDTKTGDDKLKEFINELSLALMLRHPNVVQFLGAVT--QSIP--VMLVMEHLPKGDLQSYMKK------KGKPLK---PKKALKF
|.|||..| ||.  .  ..   . |.|| .| ..   .||||...|.|| |   |.|  .. |.| .|||.| |   .      . ..|     |.|.. 
GTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRM

ALDIARGLNYVHEFKPEPVIHSNLKPSNLLRDKAGHLKITDF
|.|.|||.|. |.  |  .||  ||..||| ||    |..||
AFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDF

Kinase MLK-Un_f-2.AA Pkinase_Tyr 189-284 29 6.6e-26 88.36 Pfam 18-126 (270) Show / Hide
Range on Protein: 189-284
Range on HMM: 18-126/270
Sequence Identity: 29% (33 aa)

GKWR------GTKVFVKVISIDTKTGDDK--LKEFINELSLALML-RHPNVVQFLGAVT-QSIP--VMLVMEHLPKGDLQSYMKKK---GKPLKPKKALK
|.|.      ...| ||..    .. ..   ...|..|...   | .|||.|...|..| |. |  ...|||. |.||| .| .|.   ..||..|  |.
GTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQ

FALDIARGLNY
....||.|..|
MCWQIAKGMEY

Kinase MLK-Un_f-2.AA MLK 189-316 27 1.9e-25 85.28 In-house 18-177 (291) Show / Hide
Range on Protein: 189-316
Range on HMM: 18-177/291
Sequence Identity: 27% (45 aa)

GKWRGTK-----VFVKVISIDT----KTG--DDKLKEFINELSLALMLRHPN----VVQFLGAVTQSIP-VMLVMEHLPKGDLQSYM---KKKGK-----
|.||..      | || . ...    .|.  ..........|.   .|.|||    ..||.|. .|. . . .||| ...| | ..    ..|.      
GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLR---ILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHN

-----PLKPKKALKFALDIARGLNYVHEFKPEPVIHSNLKPSNLLRD------KAGHLKITDF
       ..  |...||..|||..| |. .| |.||  ||..|.| |      . |.|||.||
QKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF

Pkinase MLK-Un_f-2.AA Pkinase 188-316 27 3.2e-24 86.74 Pfam 17-156 (293) Show / Hide
Range on Protein: 188-316
Range on HMM: 17-156/293
Sequence Identity: 27% (40 aa)

IGKWRGTK--VFVKVISIDTKTGDDKLKEFIN--ELSLALMLRHPNVVQFLGAVTQSIPVMLVMEHLPKG----DLQSYMK-KKGKPL--KPKKALKFAL
.....||   | ||.|. . .. ..|... ..  |... ..|.|||.|....... .  . .|||....|    || .|.. ......   .. . ....
KCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY

DIARGLNYVHEFKPEPVIHSNLKPSNLLRDKAGHL----KITDF
 |.|||.| |.     .||  |||.|.| |. ||.    ||.||
QILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDF

Kinase MLK-Un_f-2.AA Fer 194-295 31 7.8e-21 67.78 In-house 33-134 (283) Show / Hide
Range on Protein: 194-295
Range on HMM: 33-134/283
Sequence Identity: 31% (33 aa)

TKVFVKVISI-DTKTGDDKLKEFINELSLALM-LRHPNVVQFLGAVTQSIPVMLVMEHLPKGDLQSYMKKKGKP-LKPKKALKFALDIARGLNYVHEFKP
.|| |||     ........||| .|  . .. . |||||.| |  ..  |.|.|||  . |.|.||.||...  .. .. .......|.|..| |. . 
NKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKN-

EPVIH
  .||
--CIH

Kinase MLK-Un_f-2.AA Pkinase 342-433 26 1e-19 70.77 Pfam 176-293 (293) Show / Hide
Range on Protein: 342-433
Range on HMM: 176-293/293
Sequence Identity: 26% (32 aa)

RYMAPELYR-CEDYDSKVDVFSFALIVQEMMEGVPPFPKL----GEEEVAKSYADGKRPPFKIKPRYY--------------------PEGLKDLIEECW
.|||||. | ...|..|||..|. .|. ||. | ||||      .  .  . ..  ..||..    .                     .| .||.|. |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

HDDPRKRPSFRTICKE--V
. || |||... |..   .
CKDPKKRPTAEQILQHPWF

Kinase MLK-Un_f-2.AA Dicty4 343-435 31 1.4e-19 62.13 In-house 183-277 (277) Show / Hide
Range on Protein: 343-435
Range on HMM: 183-277/277
Sequence Identity: 31% (31 aa)

YMAPELYRCEDYDSKVDVFSFALIVQEMMEGVPPFPKLGEE--EVAKSYAD-GKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKE--VEK
.||||  . . |..|.||.||...  |.  .  |..|.. .  ... . .. . |||    | . |  .|.||..||. || .||||  | ..   | 
WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPI---PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase MLK-Un_f-2.AA MLK 342-433 35 1.1e-18 61.57 In-house 198-291 (291) Show / Hide
Range on Protein: 342-433
Range on HMM: 198-291/291
Sequence Identity: 35% (34 aa)

RYMAPELY---RCEDYDSKVDVFSFALIVQEMMEGVPPFP-KLG-EEEVAKSYADGKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEV
..||||     ||| |. |.||.|....  ||. .  |.   .   .  ..  . |.|||  .     ||..| |...||..||.|||||| | .. 
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase MLK-Un_f-2.AA Pkinase_Tyr 342-433 35 2.6e-11 38.93 Pfam 179-270 (270) Show / Hide
Range on Protein: 342-433
Range on HMM: 179-270/270
Sequence Identity: 35% (34 aa)

RYMAPE--LYRCEDYDSKVDVFSFALIVQEMME-GVPP-FPKLGEEEVAKSY-ADGKRPPFKIKPRYYPEGLKDLIEECWHDDPRKRPSFRTICKEV
. ||||   |.   . .| || ||     |..  |  | .| .  ||| .    || | |    |.. |. . ||. .||| || .||.|. |  . 
KWMAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC---PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase MLK-Un_f-2.AA Fer 342-434 25 4.7e-11 34.0 In-house 183-283 (283) Show / Hide
Range on Protein: 342-434
Range on HMM: 183-283/283
Sequence Identity: 25% (27 aa)

RYMAPELYRCEDYDSKVDVFSFALIVQEMME-GVPPFPK------LGEE--EVAKSYAD-GKRPPFKIKPRYYPEGLKDLIE-ECWHDDPRKRPSFRTIC
|..|||  .   | .| ||.||     | .. |  |.|       ...   .  | ... |...|.   |   |. .. ...  ||. || .||.. .||
RWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPM---PNHMPPEIMQIMMKQCWQKDPEDRPTMKEIC

KEVE
....
QKLK