Gene MLK-Un_k-1 (S.moellendorffii)

MLK-Un_k-1

Species: S.moellendorffii
Alias: MLK-Un_k-1
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_k-1.AA Protein None 424 None Fasta, JSON
MLK-Un_k-1.NA RNA None 1275 None Fasta, JSON
MLK-Un_k-1.kin_dom Protein Kinase Domain None 273 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_k-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank MLK-Un_k-1.AA Ank 45-77 45 2.7e-11 45.01 Pfam 1-33 (33) Show / Hide 
Range on Protein: 45-77
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DGRTALHIAALHGGADAARLLLAAGANVNATDR
||.|.||.|...|... ...|| .||.|||.|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Kinase MLK-Un_k-1.AA TKL 137-387 25 2.9e-85 289.57 In-house 1-364 (364) Show / Hide 
Range on Protein: 137-387
Range on HMM: 1-364/364
Sequence Identity: 25% (95 aa)

IGKGSFGEIRKVVWRG----------TPVAAKTILP---SLCNDRMVV---------------------EDFRYEVQLLVKLRHPNIVQFLGAVTKKPP-
||.|.|||. | .|||          ..|| |..     ..... .                       . ...|. .. .|||||||||.|...  |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LMLITEFLPKGDLHRVLREKGGLHSSVAINFALDIARGMAYLHR-GP-----NVIIHRDLKPRNILMDEGSE--------------LK
            |....|. |.|.|. .|        .. ...||||||||.|||  .|       |||||||..||| ||  .              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VGDFGLSKLIRGQNPHDFY---------------KLTGETGSYRYMAPEVFKHD----------------KYDKSVDVFSFGMILYEMLEGNAPFFHMEP
..|||||. . . .                    ..  . |..|.|||||.. .                .|....||.|||..|.|.| .  |.... .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

YSAA---------STVAD-GERPSFK-----------AKGYTAEMKELIENCWQDSAALRPSFPTIIERL
..           . |.| |.||  .            .    .||.|.. ||.  .  |||| .|..||
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_k-1.AA Dicty4 131-389 36 8.9e-78 258.98 In-house 1-277 (277) Show / Hide 
Range on Protein: 131-389
Range on HMM: 1-277/277
Sequence Identity: 36% (101 aa)

LRRSTLIGKGSFGEIRKVVWRGTPVAAKTILPSLCND--RMVVEDFRYEVQLLVKLRHPNIVQFLGAVT----KKPPLMLITEFLPKGDLHRVLRE----
. .  .||||||||  |  |||. || | .|...  .      ..|| || .. |.|||||..|.|| |    ... ..  ||..|||.|...|.     
INIEQRIGKGSFGEVYKGTWRGKEVAVK-KLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

---KGGLHSSVAIN---FALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDFYKLTGETGSYRYMAPEVFKHDKYDKSV
   .  | ..  .     |.|.||||..||    ||||||||. |.|.|.    ||.|||||....    | . ....  |.  .|||||  |. |. ..
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKD-NQMTACGTPCWMAPEVMMHQPYNEKA

DVFSFGMILYEMLEGNAPFF--HMEPYSAASTVAD-GERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIER--LER
||.|||..|.|.| . .|..  ||..  ..  |.. ..||.  . .  .  |.||. ||  .   ||||. ||.|  || 
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWC-PPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-Un_k-1.AA MLK 131-387 32 1.6e-75 257.19 In-house 1-291 (291) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-291/291
Sequence Identity: 32% (97 aa)

LRRSTLIGKGSFGEIRKVVWRGTP-----VAAKTILPSLCNDRMV----VEDFRYEVQLLVKLRHPN----IVQFLGAVTKKPP-LMLITEFLPKGDLHR
.. .. ||.||||.  | .||..      || | .  .   |  .     .||. |. .| .|.|||    |.||.|. .. |. . ...|....| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLREK--------------GGLHSSVAINFALDIARGMAYLHR-GPNVIIHRDLKPRNILMDE------GSELKVGDFGLSKLIRGQNPHDFYKL----T
||...              .    ..|.|.||..||||.|||   |  |||||||..||| ||      .  ||. |||.|        .|...     .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS--------RDWHQMCTNMM

GETGSYRYMAPEVF---KHDKYDKSVDVFSFGMILYEMLEGNAPFF-HMEPYSAASTVADGE-RPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIER
.  |.|..|||||.   ...||....||.|.|..|.||| .  |.  |..|  .|  ||  . ||    ..  . .|.|...||.. .. ||||  |.. 
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPI-PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH

L
|
L
Kinase MLK-Un_k-1.AA TKL-Unique 133-387 32 6.8e-71 241.84 In-house 1-290 (290) Show / Hide 
Range on Protein: 133-387
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

RSTLIGKGSFGEIRKVVWRGTPVAAKTILP-SLCNDRMVVEDFRYEVQLLVKLR-HPNIVQFLGAVTK---KPP-LMLITEFLPKGDLHRVLR-------
 . .|| |..|.. |..|||.||| |.. | .. . .| ...|. || .. ||. |||||.. |. ..   .|| . ...|..| | |. ||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEM-MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---EKGGLHSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEG-----SELKVGDFGLSKLIRGQNPHDFYKL-----TGETGSYRYMAPEVFK
   ..  |  .. ...|.|||.|| |||.    |||||||..|.| |..        |. ||||||.    |   .  .     ... ||.|.|||||..
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

H--DKYDKSVDVFSFGMILYEMLEGNA------PFFHMEPYSAASTVAD---GERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIERL
   ..|....||.|||..|.|....        |. .|.... ...|..   . ||         | ..||. || .    |||| .||.||
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPI-PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_k-1.AA Pkinase 131-387 26 1.6e-70 245.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LRRSTLIGKGSFGEIRKVVWRGTP--VAAKTILPSLCNDRMVVEDFR-YEVQLLVKLRHPNIVQFLGAVTKKPPLMLITEFLPKG----DLHRVLR--EK
...   ||.||||. .| ...||.  || |.|  .  .. . ....|  |.|.. .|.|||||....... |. . ...|....|    ||.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--HSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSEL----KVGDFGLSKLIRGQNPHDFYKLTGETGSYRYMAPEVFK-HDKYDKSV
|..     ....... |.||..|.|.  . |||||||| |||.|.  ..    |..||||.|...    .  . .|. .|...|||||| . . .|...|
GCFYFSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DVFSFGMILYEMLEGNAPFFHM------EPYSAASTVADGERPSFKAKGYT-------------------AEMKELIENCWQDSAALRPSFPTIIER--L
|..|.| |||||| |. || .       ...     . ... ..   . ..                    |.|..|..|..   . ||... | .   .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-Un_k-1.AA TyrKc 131-387 30 3e-67 230.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-280/280
Sequence Identity: 30% (89 aa)

LRRSTLIGKGSFGEIRKVVWRGTPVAAKTILPSLCNDRMVVEDFRYEVQLLVKL--RHPNIVQFLGAVTKK-------PPLMLITEFLPKGDLHRVLREK
..    .| | |||..| .|. ..|| |.. ..       .|||. | ... ||  .|||||...|..|..       .|||...|. |.|||.  ||..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GG-LHSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQ----NPHDFYKLT---GET--GSYRYMAPEVFKHDKYD
.. |  .  ..|...||.||.|||.    .|||||  ||.| .|.   |..|||||. |         .| |. .   |.     .| ||||.... |. 
RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDVFSFGMILYEMLE-GNAPFFH-----MEPYSAASTVADGERPSFKAKGY-------TAEMKELIENCWQDSAALRPSFPTIIERL
   ||.|||  ..|..  |  |        |... .   | .|.|.   . .|       ..|| .... ||.  .. ||.| .|.|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-Un_k-1.AA Pkinase_Tyr 131-387 30 1e-64 219.81 Pfam 1-270 (270) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-270/270
Sequence Identity: 30% (85 aa)

LRRSTLIGKGSFGEIRKVVWR------GTPVAAKTILPSLCNDRMV--VEDFRYEVQLLVKL-RHPNIVQFLGAVT-KKPP--LMLITEFLPKGDLHRVL
..    .|.|.|||..| .|.      ..||| |.. .    .      |||  |.... .| .|||||...|..| .. |  .....|. |.|||.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RE----KGGLHSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDFY--KLTGETGSYRYMAPEVFKHDKYDK
|.    |. |  .  ......||.||.||.. .  .|||||  ||.| .|.   |..||||...|    . | |  | .|     . ||||.... |.  
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

SVDVFSFGMILYEMLE-GNAP-FFHMEPYSAASTV-ADGERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIERL
  || |||  ..|..  |  | .  | ..     .  ||.|     .. ..|. .|.  ||.  .. ||.|  |.|.|
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_k-1.AA S_TKc 131-390 28 2.3e-59 204.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 131-390
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

LRRSTLIGKGSFGEIRKVVWRG--TPVAAKTILPSLCNDRMVVEDFRYEVQLLVKLRHPNIVQFLGAVTKKPPLMLITEFLPK--GDLHRVLREKGG---
 .   .||||.||. .|.....    || | |           |..| |.|.| | .|||||.....      | ...|...   |||.......|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LHSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDFYKLTGETGSYRYMAPEVFKHDKYDK-SVDVFSF
   ..  .|  ..  |.....|.|.  . |||||||| |||.||  ..|..||||....           |   |.  ||||||.   .|.| ..|. |.
RFPFPE-HARFYMYQICCALEYCHS--HGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GMILYEMLEGNAPFFHMEPYSAASTVADGERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIE------RLERL
| |||||| |  ||   ...     .             . |.|..|..|.|   . ||.   . .        . .
GCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_k-1.AA TK 131-387 17 4e-59 196.53 In-house 1-486 (486) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-486/486
Sequence Identity: 17% (85 aa)

LRRSTLIGKGSFG---EIRKVVWRG---------------------------TPVAAKTILPSLCNDRMVVED--------------FRYEVQLLV--KL
..    .|.| ||   |..|  |||                           |||| |.. .   .. .  .|              .  | ...   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVQFLGAVTKK------------PPLMLITEFLPKGD----LHRVLREKGG---------------------------------------------
.|||||...|..|..            .|.|...|. |.||    |.  ||.. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LHSSVAIN-------------------FALDIARGMAYLHRGPN----VIIHRDLKPRNILMDEGSE-----------LKVGDFGLSK-
           |. .  ..                   ....||.||.|||. .      ..||||  ||.| .|.              |..|||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LIRGQNPHDFYKLTG---------------ETGSYRY----------MAPEVFK---------HDKYDKSVDVFSFGMILYEMLE-GNAPFFH-ME
    | |  ...| |  ..               ..  ||           ||||...         . |.    ||.|||  ..|..  | .|.   | 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

P---------YSAASTVADG--------------ERPSFKAKGYT-------------AEMKELIENCWQDSAALRPSFPTIIERL
                . .|               |.   .                 .|. .|.  ||.  .. ||.| .. |.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_k-1.AA HH498 129-387 32 7.7e-58 181.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 129-387
Range on HMM: 1-284/284
Sequence Identity: 32% (95 aa)

IDLRRSTLIGKGSFGEIRKVVWRGTPVAAK--TILPSLCNDR---MVVEDFRYEVQLLVKLRHPNIVQFLGAVTKKP-PLMLITEFLPKGDLHRVL----
|   ..  || ||||.. |. ||.  || |   .   .|       .|  |  || ....| ||. |||..|    |  . ..|..   | | ..|    
IEFHEK--IGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

-----------REK-----GGLHSSVAINFALDIARGMAYLHR-GPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDFYKLTGETGSYRYMA
            .|       | |   |  ..|.|.|| |||   .  ||||||   |||..|    .| ||| |  .  .  ||   .|   |  |.||
IGGAGANNNNHNQKNNYRIMDLQSKMTI--SVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFV--CDMHD-DNMTKQPGNLRWMA

PEVFK-HDKYDKSVDVFSFGMILYEMLEGNAPFFHMEPYSAASTVADGE-RPSFKAK---GYTAEMKELIENCWQDSAALRPSFPTIIERL
||||.   ||.. |||||..|...||. .  || | .|  ||  .|  . ||           .    ||  ||.     ||.|  |.  |
PEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase MLK-Un_k-1.AA DRK 137-389 34 4.1e-54 181.67 In-house 7-258 (258) Show / Hide 
Range on Protein: 137-389
Range on HMM: 7-258/258
Sequence Identity: 34% (89 aa)

IGKGSFGEIRKVVWRGTPVAAKTILPSLCNDRMVVEDFRYEVQLLVKLRHPNIVQFLGAVTKKPPLMLITEFLPKGDLHRVLR-EKGGLHSSVAINFALD
||.|..||.    |||| || |       ||   . .|. |. |. .||||||.||.|. .  |    ..|..|.| | ..|  |.  .  .  .  ..|
IGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFD

IARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDFYK-LTGETGSYRYMAPEVFKHDKYDKSVDVFSFGMILYEMLEGNAPFF
.|.|| |||    .|||||||  | | ||    || |||||   .    | | .   | ..     ||||   . |    ||.||. .| |..    |.|
CAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPC---WTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYF

HMEPYSAASTVAD-GERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIERLER
 | .      |   |.||   . .  .    |.  ||      |||.. ..|||| 
GMPTFQVVFSVGRHGMRPPMPQWC-PPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-Un_k-1.AA CZAK 131-338 37 6.3e-52 178.84 In-house 1-227 (279) Show / Hide 
Range on Protein: 131-338
Range on HMM: 1-227/279
Sequence Identity: 37% (86 aa)

LRRSTLIGKGSFGEIRKVVWRGTPVAAKTILPSLCNDRMV---VEDFRYEVQLLVKLRHPNIVQFLGAVTKKP--PLMLITEFLPKGDLHRVLREKGGLH
|     ||.| |||..| .|||. || | |      .       . |  ||  . ||.|||.|||||| .         ..|.   | | | | ..  .|
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

SS---VAINFALDIARGMAYLHR--GPNVIIHRDLKPRNILMDEGSE-------------LKVGDFGLSKLIRGQNPHDFYKLTGETGSYRYMAPEVFKH
     .. | |.|||||| |||    || |.||||  |||| |.                 |. |||||.. . |        |   |.  .||||.|| 
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQP----FEMTQTMGCLCWMAPECFKG

DKYDKSVDVFSFGMILYEMLEGNAPFFHMEP
. |   |||.||||||.... .  |   |.|
ENYTEKVDVYSFGMILWCIITCDQPYQNMQP
Kinase MLK-Un_k-1.AA Dicty4-Unclassified 131-387 32 9.8e-52 175.45 In-house 1-263 (263) Show / Hide 
Range on Protein: 131-387
Range on HMM: 1-263/263
Sequence Identity: 32% (89 aa)

LRRSTLIGKGSFGEIRKVVWRGTPVAAKTILPSLCNDR-MVVEDFRYEVQLLVKLRHPNIVQFLGAVTKKPP------LMLITEFLPKGDLHRVLR----
..    |||| | .. | .|.|  || | .       |  ...||. || .|  . ||| |.  |.     |      .. ..||..|| |  |      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN--PRSHKSTMCIVMEFMHKGNLFEVIHSKPS

EKG---GLHSSVAINFALDIARGMAYLHRGPNVIIHRDLKPRNILMDEGSELKVGDFGLSKLIRGQNPHDF-YKLTGETGSYRYMAPEVFKHDKYDKSVD
|.     | . . | .|.|||.||..||     .||||.|  |||||     |..|||.|  |      || . .|   |  .  .||. .|  |    |
EQQQPIKLDDTLIIKYAFDIAQGMQHLHT--RNFIHRDIKSSNILMDKHFNIKIADFGISRVI------DFNFNMTTIAGTPKWESPECLMHESYNQKSD

VFSFGMILYEMLEGNAPFFHME-PYSAASTVAD-GERPSFKAKGYTAEMKELIENCWQDSAALRPSFPTIIERL
|.|..|.|||.. |. |.     .  ||  |.| . ||          .| ||  || ..   ||..  ||..|
VYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKI-PDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-Un_k-1.AA LRRK 174-389 30 3.2e-48 166.54 In-house 104-351 (351) Show / Hide 
Range on Protein: 174-389
Range on HMM: 104-351/351
Sequence Identity: 30% (78 aa)

FRYEVQLLVKLRHPNIVQFLGAVTKKPPLMLITEFLPKGDLHRVLR--EKGG-------LHSSVAINFALDIARGMAYLHRGPNV--IIHRDLKPRNILM
|| || .. .|.|||||. .|   .  ||....|..| |||...|.  .. |       .  .. .  ||.||.||.|||.  .   |||||||. |||.
FRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSPNILL

---D---------EGSELKVGDFGLSK--LIRGQNPHDFYK--LTGETGSYRYMAPEVFKHD---KYDKSVDVFSFGMILYEMLEGN-APFFHME-----
   .         .    |..|||.|    .       |..  . | .|  ..||||. . .    |.  ||..||||||.| | .   || ...     
WSSPQNHSPNYPNAHVCAKIADFGISRMFQC-------FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHM

--PYSAASTVADGERPSFK---AKG--YTAEMKELIENCWQDSAALRPSFPTIIERLER
   .     . .| ||...    ..  .  ....||. |||     ||.| .|..||. 
QWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_k-1.AA CZAK 364-387 50 3e-06 18.65 In-house 256-279 (279) Show / Hide 
Range on Protein: 364-387
Range on HMM: 256-279/279
Sequence Identity: 50% (12 aa)

ELIENCWQDSAALRPSFPTIIERL
|||| ||  .  .||||  |.. |
ELIEMCWNKNPDERPSFKQILQHL
Kinase MLK-Un_k-1.AA LRRK 131-163 32 5e-06 17.18 In-house 1-34 (351) Show / Hide 
Range on Protein: 131-163
Range on HMM: 1-34/351
Sequence Identity: 32% (11 aa)

LRRSTLIGKGSFG-EIRKVVWRGTPVAAKTILPS
|..  .||.|.|| .. .  ||| ||........
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQK