Gene MLK-Un_z (S.moellendorffii)

MLK-Un_z

Species: S.moellendorffii
Alias: MLK-Un_z
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_z.AA Protein None 1365 None Fasta, JSON
MLK-Un_z.NA RNA None 4098 None Fasta, JSON
MLK-Un_z.kin_dom Protein Kinase Domain None 191 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_z.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_z.AA TKL 48-233 21 1.3e-31 111.14 In-house 1-283 (364) Show / Hide 
Range on Protein: 48-233
Range on HMM: 1-283/364
Sequence Identity: 21% (64 aa)

CGAGSYGSVRLGVYRG----------QAVAVKSYNRGV-SESSI-------------------------RREVEVMRSLKG--ESRVVQFLGRVQT----
 | |..| |  |..||          . |||| ...   .|...                          .|.|......      .|||.| ..     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GLDDDRCIVMELAYNLS-LRALLDASGQSLSGRLKVVIARDLCGGLCSLHG--------RGIAHEDVKSDNVLLDFGLR--------------
       | . . |||||.. . | |  |.          ... .|.| . |.. ||         ..|.| | ||.|.|.|  ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKLCDFGTARQMGDND---------------------FGEVLGTPAFMAPEKRAAP-------------PGSMYHRLASDIYSLGLVLQELL
.|.||||..| |  .                       . . |||..||||                  .|. |   ..|.|| |.|| |.|
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSE-KCDVYSFGIVLWEIL
Kinase MLK-Un_z.AA S_TKc 42-265 23 5e-28 100.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 42-265
Range on HMM: 1-231/231
Sequence Identity: 23% (61 aa)

DSREVECGAGSYGSVRLGVYRG--QAVAVKSYNRGVSESSIRREVEVMRSLKGESRVVQFLGRVQTGLDDDRCIVMELAYN--LSLRALLDASGQS----
     . | |..|.|.... ..  . ||.|  .      .||||......  .   .|....  |.   |. ..|||.. .   .|. ...  |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSGRLKVVIARDLCGGLCSLHGRGIAHEDVKSDNVLLDFGLRAKLCDFGTARQMGDNDFGEVLGTPAFMAPEKRAAPPGSMYHRLASDIYSLGLVLQEL
 ..      ... .| .|  .| .|| | |.| .|.|||   . |.|||| |||.       . ||| .||||         | . ..|..|.| .| |.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEM

LG-------------------DVEIVIQCLASCPLERPSCDEVLD----ALDHLYS
|                      ... .||   | .||.. |.|     .  | . 
LCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_z.AA CAMK 47-205 16 6.2e-27 83.23 In-house 1-290 (425) Show / Hide 
Range on Protein: 47-205
Range on HMM: 1-290/425
Sequence Identity: 16% (48 aa)

ECGAGSYGSVRLGVYR-G-------------QAVAVKSYN------------------------------RGVSESSIRREVEVMRSLKG------ESRV
. | ||.| |.|.. .               | ||.| ..                              |.... ..|||.|.|..|.|         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQFLGRVQTGL-----------------DDDRCIVM---ELAYNL----SLRALLDASGQ--------------SLSGRLKVVIARDLCGGLCSLHGRGI
....   ...                  |.. ..||   |.. .      |   . . |.               .. |    . | .| ..  .| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHEDVKSDNVLLD--FG---------------LRAKLCDFGTARQMGDND-------------------------FGEVLGTPAFMA-PE
.| | | .|.|||  ..                  |..||| |... ...                         . .. |||..|| ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase MLK-Un_z.AA Pkinase 49-233 25 3.8e-24 86.46 Pfam 8-206 (293) Show / Hide 
Range on Protein: 49-233
Range on HMM: 8-206/293
Sequence Identity: 25% (53 aa)

GAGSYGSVRLGVYRGQA--VAVKSYNRGVSESSIRR------EVEVMRSLKGESRVVQFLGRVQTGLDDDRCIVMELAYNL----SLRALLD-ASGQSL-
|.||.|.|.... .|    ||||  ..   .|. ..      |...|..|. .  .|.... ...  .|. ..|||.. .     .| ...   .. .. 
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-SGRLKVVIARDLCGGLCSLHGRGIAHEDVKSDNVLLDFGLRA----KLCDFGTAR---QMGDNDFGEVLGTPAFMAPEKRAAPPGSMYHRLASDIYSLG
 | .    ... .. ||  .| .|| | |.|..|.|.|         |.|||| |.      .  .  . ||| .||||      |. |.  ..|..|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKVDMWSCG

LVLQELL
..| |.|
CILYEML
Kinase MLK-Un_z.AA MLK 41-233 26 4.1e-24 80.62 In-house 1-230 (291) Show / Hide 
Range on Protein: 41-233
Range on HMM: 1-230/291
Sequence Identity: 26% (63 aa)

IDSREVECGAGSYGSVRLGVYRGQA-----VAVKSYN--------RGVSESSIRREVEVMRSLKGES---RVVQFLGR-VQTGLDDDRCIVMELAYNLSL
|.  |. .|.||.|.| .|..|..      |||| ..         . .   ...|..  | |. .     ..||.|   |..   . ||||| . . ||
IQFHEW-IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSL

RALL-DASGQSL------------SGRLKVVIARDLCGGLCSLHGRG---IAHEDVKSDNVLLDF------GLRAKLCDFGTARQMGDNDFG---EVLGT
  .| .|....             .  ... .| .   |.  ||      | | | || |.|.|       .. .| |||||.| . ...        ||
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGT

PAFMAPEKRAAPPGSMYHRLASDIYSLGLVLQELL
.|.|||| .   ....| . ..|..| |.|| |.|
YAWMAPEVIQQFRCEKYSE-KCDVWSWGVVLWEML
Kinase MLK-Un_z.AA STE 49-233 21 3.1e-23 78.99 In-house 8-262 (359) Show / Hide 
Range on Protein: 49-233
Range on HMM: 8-262/359
Sequence Identity: 21% (56 aa)

GAGSYGSVRLGVYR-----------------GQAVAVKSYNRGVS-------------------ESSIRREVEVMRSLKG-ESRVVQFLGRVQTGL----
| |..|.| .....                 |. .|.|  |   .                   . .| .|...|. ..     .|...|    .     
GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK

-DDDRCIVMELAYNLSLRALLD---ASGQSLS----------GRLKVVIARDLCGG-LCSLHGRGIAHEDVKSDNVLLDFGLRAKLCDFGTARQMGDN--
 ||. .|.||.  . ||. ...     |..|.            .  .|.|... | |  ||  .| | |.|..|.||     .||||||.. |. |.  
NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMA

------------DFG----EVLGTPAFMAPEKRAAPPGSMY---HRLASDIYSLGLVLQELL
            . .     . ||| .||||      .. .   .   .||.|||... |..
NIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA
Kinase MLK-Un_z.AA TKL-Unique 49-233 27 1.6e-19 65.65 In-house 6-222 (290) Show / Hide 
Range on Protein: 49-233
Range on HMM: 6-222/290
Sequence Identity: 27% (60 aa)

GAGSYGSVRLGVYRGQAVAVKSYNR--GVSESSIR---REVEVMRSLKGESRVVQFLGRVQ--TGLDDDRCIVMELAYNLSLRALLD---------ASGQ
|.|.||.|  |..||  ||.|. .   ..| ....   .|| .|  |.    .|.. |     .    ..|||||     ||. .|.         ..  
GEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNC

SLSGRLKVVIARDLCGGLCSLHGRG--IAHEDVKSDNVLLDFG-----LRAKLCDFGTAR---QMGDNDFG--------EVLGTPAFMAPEKRAAPPGSM
 |.  ..| .|.|  .|.. || ..  |.| | || |.|.| .     ...|.||||...   .. .. ..        ...|..  ||||    .  ..
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQ

YHRLASDIYSLGLVLQELL
| .  ||.|| | || |..
YSE-KSDVYSFGIVLWEIA
Kinase MLK-Un_z.AA CAMKL 49-205 24 4.4e-18 54.15 In-house 8-203 (297) Show / Hide 
Range on Protein: 49-205
Range on HMM: 8-203/297
Sequence Identity: 24% (48 aa)

GAGSYGSVRLGVYR---GQAVAVKSYN------RGVSESS-----------IRREVEVMRSLKGESR---VVQFLGRVQTGLD----DDRCIVMELAYNL
| ||.| |.|.. .   |. ||.| ..      . ....            ||||.. |..|.  ..   .....  ..|       .. ..|||.. . 
GKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGG

S--LRALLDASGQSLSGRLKVVIARDLCGGLCS----LHGRGIAHEDVKSDNVLLD-FGL-RAKLCDFGTARQMGD-----ND-FGEVLGTPAFMAPE
.  |   ... |    ||..   || .   ..|    .| .||.| | | .|.|||  |   .|..||| . .. .     .. . .  |.|..||||
EMDLFDYIVKHGHRR-GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPE
Kinase MLK-Un_z.AA TK-Unique 49-229 23 2.2e-17 56.61 In-house 8-229 (294) Show / Hide 
Range on Protein: 49-229
Range on HMM: 8-229/294
Sequence Identity: 23% (53 aa)

GAGSYGSVRLGVYRG--------QAVAVKSYNRGVSESS---IRREVEVMRSLKGESRVVQFLGRVQTGLDDDRCIVMELAYNLSLRALLDASGQS----
| |..| |  | ..|        . ||||  ...... .     .| ..|..|.    .||.||  ..   .. .|.|| ... .|. .|  ...     
GEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTCRPAMRQH

---------------------LSGRLKVVIARDLCGGLCSLHG--RGIAHEDVKSDNVLLDFGLRAKLCDFGTAR--------QMGDNDFGEVLGTPAFM
                     .| .. . .| ... |.  |..  ..| | |. . ||||  ....|.|||| ||        .| .  .   .   . |
QTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI---RWM

APE--KRAAPPGSMYHRLASDIYSLGLVL
|||  |..   . |||.  ||..|.| ..
APESLKCY---HGMYHTTKSDVWSFGVLM
Kinase MLK-Un_z.AA TK 42-205 12 1.2e-15 48.17 In-house 1-355 (486) Show / Hide 
Range on Protein: 42-205
Range on HMM: 1-355/486
Sequence Identity: 12% (45 aa)

DSREVECGAGSYG---SVRLGVYRG---------------------------QAVAVKSYNRGVSESSIR----------------REVEVMRSLKG---
   . . |.| .|    |..| .||                           . ||||    | ..|. .                .|.|.|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-ESRVVQFLG---RVQT-------GLDDDRCIVMELAYN----LSLRALLDASGQS--------------------------------------------
    .|...|   ....        ..   .||||.. .     |||  | ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSGRLKVVIARDLCGGLCSLHGR------GIAHEDVKSDNVLLDFGLR-----------AKLCDFG---
                               |. . .. ...... |.  || .      .. | |.   |.|.. ...           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TARQMGDNDFGEVLGTPAF----------------------------MAPE
      || ....|   . ...                              ||||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE
Kinase MLK-Un_z.AA Ciliate-E2 142-233 21 1.2e-14 46.63 In-house 165-290 (365) Show / Hide 
Range on Protein: 142-233
Range on HMM: 165-290/365
Sequence Identity: 21% (29 aa)

IARDLCGGLCSLHGRG-IAHEDVKSDNVLLDFGLRAKLCDFGTARQMGDN--------------DFGE--------------------VLGTPAFMAPEK
... .. .| .|| .. | | | | .|.|.      |..|||....  |.              . .                     ..||| .|||| 
YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

RAAPP-----GSMYHRLASDIYSLGLVLQELL
    .     .. ..  ..||.||| .| |.|
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEML
Kinase MLK-Un_z.AA LISK 123-205 26 3e-13 39.2 In-house 84-209 (296) Show / Hide 
Range on Protein: 123-205
Range on HMM: 84-209/296
Sequence Identity: 26% (33 aa)

LRALLDASGQ---SLSGRLKVVIARDLCGGLCSLHGRGIAHEDVKSDNVLLD-F---GLRAKLCDFGTARQMGDNDFG----------------------
|. .|.....    |. ...| ||.|   |.  || ..| | | || |.|.. .   . |.|.|||| || | . . .                      
LHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKR

--------------EVLGTPAFMAPE
               . ||| .||||
KIPKKCMNQRKRRMTICGTPYWMAPE
Kinase MLK-Un_z.AA TyrKc 42-260 18 8e-13 -15.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 42-260
Range on HMM: 1-280/280
Sequence Identity: 18% (51 aa)

DSREVECGAGSYGSVRLGVYRGQAVAVKSYNRGVSESSIRREVEVMRSL-KGESRVVQFLGRVQTG-----LDDDRCIVMELAYNLSLRALLDASGQSLS
 . . . | | .| |..|... . ||||. . .  .  ..|| ..|..| .    .|...| . ..      ..  .||||.. . .|.  | ...  |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

GRLKVVIARDLCGGLCSLHGRGIAHEDVKSDNVLLDFGLRAKLCDFGTARQMGDN-------DFGEVL---GTP-----AFMAPEKR-------------
 . .. .. . . |   || ... | |    |.|.. ....| .||| .|  .|        |   .    |.        ||||               
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

------------AAPPGS-----MYHRLASDIYSLGLVLQELLG------------DVEIVIQCLASCPLERPSCDEVLDAL
            . |.       |  . .      |  .                   .|  || .  | .||.  |. . .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-Un_z.AA Pkinase_Tyr 49-191 24 3.1e-12 42.07 Pfam 8-164 (270) Show / Hide 
Range on Protein: 49-191
Range on HMM: 8-164/270
Sequence Identity: 24% (39 aa)

GAGSYGSVRLGVYR------GQAVAVKSYNRGVSESS-----IRREVEVMRSLKGESRVVQFLGRVQTGLDDD--RCIVMELAYNLSLRALLDAS---GQ
|.|..|.|..|...      .. ||||. . | ...        ||...|..|     .|...| .    ..    .||||.. . .|.  | .    .|
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

SLSGRLKVVIARDLCGGLCSLHGRGIAHEDVKSDNVLLDFGLRAKLCDFGTARQMGDND
.|.   .. .... . |.  |. ... | |.   |.|.. .. .| |||| || .  ||
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YND
Kinase MLK-Un_z.AA LISK 47-90 30 6.4e-07 18.31 In-house 1-53 (296) Show / Hide 
Range on Protein: 47-90
Range on HMM: 1-53/296
Sequence Identity: 30% (16 aa)

ECGAGSYGSVRLGVYR--GQAVAVKSYN-------RGVSESSIRREVEVMRSL
| | |..|.|  | .|  || .|.|          .   .  . |||..|..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNL
Kinase MLK-Un_z.AA TKL 237-260 33 0.000566 10.21 In-house 341-364 (364) Show / Hide 
Range on Protein: 237-260
Range on HMM: 341-364/364
Sequence Identity: 33% (8 aa)

EIVIQCLASCPLERPSCDEVLDAL
..  .| .. | .|||..|.|. |
KLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_z.AA TKL-Unique 241-260 45 0.009733 5.7 In-house 271-290 (290) Show / Hide 
Range on Protein: 241-260
Range on HMM: 271-290/290
Sequence Identity: 45% (9 aa)

QCLASCPLERPSCDEVLDAL
|| .. | .||| ||..  |
QCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_z.AA TK 241-260 30 0.019751 3.1 In-house 467-486 (486) Show / Hide 
Range on Protein: 241-260
Range on HMM: 467-486/486
Sequence Identity: 30% (6 aa)

QCLASCPLERPSCDEVLDAL
|| .  | .||. ......|
QCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_z.AA TK-Unique 237-260 29 0.023439 4.08 In-house 271-294 (294) Show / Hide 
Range on Protein: 237-260
Range on HMM: 271-294/294
Sequence Identity: 29% (7 aa)

EIVIQCLASCPLERPSCDEVLDAL
.. ..|. . | ||||...... |
NLMKSCWQWEPEERPSFRQIKHRL
Kinase MLK-Un_z.AA MLK 241-260 35 0.063017 2.63 In-house 272-291 (291) Show / Hide 
Range on Protein: 241-260
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

QCLASCPLERPSCDEVLDAL
||  ..| .||| ....  |
QCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_z.AA Pkinase 237-260 23 0.968105 3.7 Pfam 268-293 (293) Show / Hide 
Range on Protein: 237-260
Range on HMM: 268-293/293
Sequence Identity: 23% (6 aa)

EIVIQCLASCPLERPSCDEVLDA--L
...  ||. .| .||.....|    .
DFIKWCLCKDPKKRPTAEQILQHPWF
Sel1 MLK-Un_z.AA Sel1 335-363 24 0.015393 11.57 Pfam 1-36 (43) Show / Hide 
Range on Protein: 335-363
Range on HMM: 1-36/43
Sequence Identity: 24% (9 aa)

AVAKLFLG--IMNFHGY--G-CQR-N-WEA-ALELFK
. | . ||   | .||.  | . . .  |  |.....
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQ
Sel1 MLK-Un_z.AA Sel1 459-495 20 2.915794 4.01 Pfam 1-43 (43) Show / Hide 
Range on Protein: 459-495
Range on HMM: 1-43/43
Sequence Identity: 20% (9 aa)

AHAQALLALFYMAVNP---G-YRE-L-PAK-EMEFLERSVEGGS
. ||  |...||  .    |  ..   ..|  ....... | |.
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH
Sel1 MLK-Un_z.AA Sel1 693-710 42 0.00321 13.83 Pfam 23-43 (43) Show / Hide 
Range on Protein: 693-710
Range on HMM: 23-43/43
Sequence Identity: 42% (9 aa)

Q-D-ERK-AMEWWRAAAEAGD
| |  .| |..|.. |||.|.
QDDDYEKEAFYWYQKAAEQGH
Sel1 MLK-Un_z.AA Sel1 743-772 20 0.555652 6.4 Pfam 1-43 (43) Show / Hide 
Range on Protein: 743-772
Range on HMM: 1-43/43
Sequence Identity: 20% (9 aa)

DTAMLQLA--I---CG---G-VGR---ERK--LQLLQRAVDLGN
  |...|.       |   | | .    .|  ....|.| ..|.
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH
Sel1 MLK-Un_z.AA Sel1 773-800 20 6.609511 2.83 Pfam 1-32 (43) Show / Hide 
Range on Protein: 773-800
Range on HMM: 1-32/43
Sequence Identity: 20% (7 aa)

SLAMVELAGMLR--YRGDLAG-AEK-L-LKQ-AL
. |. .|. |..  |.|.. |  ..   ... |.
P-AQYNLG-MYYMYYHGQFGGCVPQDDDYEKEAF
Sel1 MLK-Un_z.AA Sel1 723-742 18 12.336542 1.93 Pfam 23-43 (43) Show / Hide 
Range on Protein: 723-742
Range on HMM: 23-43/43
Sequence Identity: 18% (4 aa)

Q-NGDNDM-AVRLWEQGVSAGN
| . | .  |......   .|.
QDD-DYEKEAFYWYQKAAEQGH
Sel1 MLK-Un_z.AA Sel1 870-905 20 1.233765 5.25 Pfam 1-43 (43) Show / Hide 
Range on Protein: 870-905
Range on HMM: 1-43/43
Sequence Identity: 20% (9 aa)

AESLFNMGMLV--ASRT--G-LKQ-V-SMQ-AYNFFAMAAEKKR
. . .|.||.         |  .|     . |. .. .|||.  
P-AQYNLGMYYMYYHGQFGGCVPQDDDYEKEAFYWYQKAAEQGH
Kinase MLK-Un_z.AA TKL-Unique 1212-1299 26 1.5e-09 29.99 In-house 126-218 (290) Show / Hide 
Range on Protein: 1212-1299
Range on HMM: 126-218/290
Sequence Identity: 26% (25 aa)

LHRCH--IVHESISSNNILIVAQQQAASLQVKLAGFLLARLAD-PLEMSERERSGNDPHYELRKRIYQAPERIAG--GRYSFECDIYSMGVVM
||.|   | |  . | |.|..     | ...|...| |.....  ..|. .| .|     ..   .. ||| . .    ||  .|.|| |.|.
LHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL
Kinase MLK-Un_z.AA TKL 1203-1302 19 8.8e-08 24.12 In-house 139-282 (364) Show / Hide 
Range on Protein: 1203-1302
Range on HMM: 139-282/364
Sequence Identity: 19% (28 aa)

LSLAAAVADLHRCH--------IVHESISSNNILIVAQ---------QQAASLQVKLAGFLLARLADPLEMSERE-----------RSGNDPHYELRKRI
|. | ... || ..        |.|  . |.|||.              .|   .|.. | |.|  .. . ...            ....  . .     
LDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPR

YQAPERIAGG----------------RYSFECDIYSMGVVMAEL
. ||| . |                  ||  ||.||.|.|. |.
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase MLK-Un_z.AA Ciliate-E2 1212-1299 21 4e-07 20.47 In-house 176-286 (365) Show / Hide 
Range on Protein: 1212-1299
Range on HMM: 176-286/365
Sequence Identity: 21% (26 aa)

LHRCH-IVHESISSNNILIVAQQQAASLQVKLAGFLLARLADPL--------EMSERERSGNDPHYELR----------------KRIYQAPERIAGGR-
||  . |.|  |  .|||.          .|.. | |.. .|.         .. .    .|| .   .                   |.||| . |.  
LHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

--------YSFECDIYSMGVVM
        |...|||.|.||..
DNQQKQKGYDYKCDIWSLGVIL
Kinase MLK-Un_z.AA Pkinase 1275-1302 37 7.5e-05 18.24 Pfam 177-205 (293) Show / Hide 
Range on Protein: 1275-1302
Range on HMM: 177-205/293
Sequence Identity: 37% (11 aa)

YQAPERIA-GGRYSFECDIYSMGVVMAEL
| ||| |  |  |. ..|..|.|....|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEM
Kinase MLK-Un_z.AA STE 1275-1306 34 0.000127 12.38 In-house 228-265 (359) Show / Hide 
Range on Protein: 1275-1306
Range on HMM: 228-265/359
Sequence Identity: 34% (13 aa)

YQAPERIAGGR------YSFECDIYSMGVVMAELKLGK
. |||.| ...      |.. |||.| | .. |.  ||
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase MLK-Un_z.AA CAMK 1275-1299 27 0.000198 9.4 In-house 285-324 (425) Show / Hide 
Range on Protein: 1275-1299
Range on HMM: 285-324/425
Sequence Identity: 27% (11 aa)

YQA-PERIAGGR--------------YSFECDIYSMGVVM
| | || . | .              |...||. |.||..
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase MLK-Un_z.AA TK 1212-1302 16 0.000287 9.37 In-house 250-387 (486) Show / Hide 
Range on Protein: 1212-1302
Range on HMM: 250-387/486
Sequence Identity: 16% (23 aa)

LHRC------HIVHESISSNNILIVAQQQAA------SLQVKLAGFLLAR-----LADPLEMSERERSGNDPHYEL------------------RKRI--
||..      ..||  .   |.|.  . . .       ...|.| | |.|     ||  .. ..  .. ...   .                  . ..  
LHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPI

-YQAPERIA---------GGRYSFECDIYSMGVVMAEL
 . ||| ..          |... . |..| ||.| |.
RWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase MLK-Un_z.AA LISK 1277-1302 42 0.000592 8.51 In-house 207-232 (296) Show / Hide 
Range on Protein: 1277-1302
Range on HMM: 207-232/296
Sequence Identity: 42% (11 aa)

APERIAGGRYSFECDIYSMGVVMAEL
||| . |  |.  ||..| |.|. |.
APEMLLGQSYDESCDVFSFGIVLCEI
Kinase MLK-Un_z.AA CAMKL 1275-1299 39 0.001213 7.33 In-house 199-226 (297) Show / Hide 
Range on Protein: 1275-1299
Range on HMM: 199-226/297
Sequence Identity: 39% (11 aa)

YQAPERIAG--GRYS-FECDIYSMGVVM
|.||| ..|   .|  .. || |.||..
YMAPEIFQGNNKPYDGPKVDIWSCGVIL
Kinase MLK-Un_z.AA MLK 1277-1299 46 0.088007 2.12 In-house 201-226 (291) Show / Hide 
Range on Protein: 1277-1299
Range on HMM: 201-226/291
Sequence Identity: 46% (12 aa)

APERI---AGGRYSFECDIYSMGVVM
||| |    ...||  ||..| |||.
APEVIQQFRCEKYSEKCDVWSWGVVL
Kinase MLK-Un_z.AA STE 1212-1245 38 0.305326 0.29 In-house 168-191 (359) Show / Hide 
Range on Protein: 1212-1245
Range on HMM: 168-191/359
Sequence Identity: 38% (13 aa)

LHRCHIVHESISSNNILIVAQQQAASLQVKLAGF
||. ||.|  | . |||.          |||. |
LHSHHIIHRDIKPANILL----------VKLCDF
Kinase MLK-Un_z.AA Pkinase_Tyr 1277-1302 42 0.828784 3.36 Pfam 182-207 (270) Show / Hide 
Range on Protein: 1277-1302
Range on HMM: 182-207/270
Sequence Identity: 42% (11 aa)

APERIAGGRYSFECDIYSMGVVMAEL
||| |. |... . |..| ||.| |.
APECINYGKFTTKSDVWSFGVLMWEI
Kinase MLK-Un_z.AA TKL 1343-1364 40 0.000592 10.14 In-house 343-364 (364) Show / Hide 
Range on Protein: 1343-1364
Range on HMM: 343-364/364
Sequence Identity: 40% (9 aa)

IRECMDNDASNRPFAQEVYDRL
. .|.| |...|| .||. .||
MQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_z.AA TK 1337-1364 17 0.01785 3.25 In-house 459-486 (486) Show / Hide 
Range on Protein: 1337-1364
Range on HMM: 459-486/486
Sequence Identity: 17% (5 aa)

DDVAACIRECMDNDASNRPFAQEVYDRL
....  ...| . |.. ||  ......|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_z.AA TKL-Unique 1343-1364 40 0.019402 4.63 In-house 269-290 (290) Show / Hide 
Range on Protein: 1343-1364
Range on HMM: 269-290/290
Sequence Identity: 40% (9 aa)

IRECMDNDASNRPFAQEVYDRL
|..| . | |.||  .|.. ||
IQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_z.AA MLK 1343-1364 22 0.247678 0.54 In-house 270-291 (291) Show / Hide 
Range on Protein: 1343-1364
Range on HMM: 270-291/291
Sequence Identity: 22% (5 aa)

IRECMDNDASNRPFAQEVYDRL
. .|.. |...||  ...   |
MKQCWNQDPHKRPSFRQIVQHL
Pkinase_Tyr MLK-Un_z.AA Pkinase_Tyr 1336-1364 24 0.554931 3.95 Pfam 242-270 (270) Show / Hide 
Range on Protein: 1336-1364
Range on HMM: 242-270/270
Sequence Identity: 24% (7 aa)

TDDVAACIRECMDNDASNRPFAQEVYDRL
.|..   ...|.. |...||  .|.. .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL