Gene MLKx_o (S.moellendorffii)

MLKx_o

Species: S.moellendorffii
Alias: MLKx_o
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_o.AA Protein None 612 None Fasta, JSON
MLKx_o.NA RNA None 1842 None Fasta, JSON
MLKx_o.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of MLKx_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_o.AA TKL 124-363 22 3.8e-40 139.68 In-house 9-364 (364) Show / Hide 
Range on Protein: 124-363
Range on HMM: 9-364/364
Sequence Identity: 22% (80 aa)

VQKGNWLG----------QAVAVKKCGDG------------------------------FRYCREAGVFQHFQPSHPNVIQVLG--ESEVP---------
| ||.| |          . |||||                                  || ..|  . .. . .|||..| .|   .. .         
VYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVG

ETKEKLLVMEEK-NSDLKRYFHSSGPITQLQAVDFLIQIAGAMVYLHG--------KGVCYRDLKLENIMIDVQY-------------LELTLADFGHSK
....  .|||   . .|  |.|        | ... ..|| .| |||         ... .|||| .||..|  .               . ..||| |.
PWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSR

PRFDPLGDNTC-------------------PVGTVSYMAPEVLAGITSGQDP----------GYGFSVDVFSFGIACSEIVSGQPLELTVPLTR------
  .   ..|                     ..||  .|||||| | .  ..            |  ..||.||||   ||..... .   |         
FMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP

--EERIERLRRGERPSLP------------ESCHQKLKKLITQCWDFSPKNRPTFEVIYEKL
  |. . .  .|.|| .|            ..| . .|||...|||  |..||.|. | ..|
FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_o.AA Pkinase 147-363 23 6.4e-35 124.55 Pfam 47-293 (293) Show / Hide 
Range on Protein: 147-363
Range on HMM: 47-293/293
Sequence Identity: 23% (62 aa)

R--EAGVFQHFQPSHPNVIQVLGESEVPETKEKLLVMEEKNS-----DLKRYFH--SSGPI--TQLQAVDFLIQIAGAMVYLHGKGVCYRDLKLENIMID
|  |. . ....  |||... ..  |    ..  .|||  .      ||..| .  ..|..  .  .. ... ||. .. |.| .|...||||.|||.||
RLSEIQIMKRLN--HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

VQYLEL----TLADFGHSKPR-FDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFGIACSEIVSGQPLELTVPLTRE------ERIERLRR
 .  ..     ..||| .|     . . .| ..||  ||||||.       ...|| .||..|.|. . | ..|.      |   .      . .....|
-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR-----PPFPGHCWHDNHDQMQMICR

GERPSLPESCH-----------------------QKLKKLITQCWDFSPKNRPTFEVIYEK--L
  .| |....                        . .|..|. |... || |||.| | .   .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc MLKx_o.AA S_TKc 111-365 23 3.6e-30 107.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-365
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LLSGIVLGD-ANSLVQKGNWLG--QAVAVKKCGDGFRYCREAGVFQHFQPSHPNVIQVLGESEVPETKEKLLVMEEKNS---DLKRYFHSSGP------I
   . ..|  | . | |. . .  . ||.|.     . .||  . ..    |||... ..  .    ..  .|||  .    ||..| .. |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TQLQAVDFLIQIAGAMVYLHGKGVCYRDLKLENIMIDVQYLELTLADFGHSKPRFDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGF-SVDVFSFGIA
.  .|  .. ||. |. |.| .|...|||| |||..|    .. ..||| ..         |  .||  |||||||         |||. ..|. |.|. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCI

CSEIVSGQPLELTVPLTREERIERLRRGERPSLPESCHQKLKKLITQCWDFSPKNRPTFEVIYE-------KLWE
  | ..|.|.      . .. .....            . .| .| .|... |..|||   . .         | 
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_o.AA TK 144-363 17 1.2e-29 95.97 In-house 84-486 (486) Show / Hide 
Range on Protein: 144-363
Range on HMM: 84-486/486
Sequence Identity: 17% (69 aa)

RYCREAGVFQHFQ---PSHPNVIQVLGESEVPET----------KEKLLVMEE-KNSD----LKRYFHSSGP----------------------------
....|| . . ..     |||... .| .  .|.          .  ..|||  .. |    |. | ... |                            
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD

----------------------------ITQLQAVD-------------------FLIQIAGAMVYLHGK------GVCYRDLKLENIMIDVQYL-----
                            .|. . ..                   .  ||| .| ||| |      ..  |||   |.... ..      
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHF

-----ELTLADFGHSKP------RFDPLGDNTCPVGTVS----------------------------YMAPEVLA-GITSGQ--DPGYGFSVDVFSFGIA
        .|||| |.       | .. .|. . ... .                            .||||.|. .. | .  .  .    ||.|||. 
DGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVL

CSEIVS-G-QPLELTVPL-------TREERIERLRRG--------------ERPSLPESCH--------------QKLKKLITQCWDFSPKNRPTFEVIY
. ||.. | .|    ..        . .| .|.||||               |.  |. |.              . .  |..|||.. |. ||||. ..
MWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLH

EKL
|.|
EQL
Kinase MLKx_o.AA LRRK 208-365 28 2.6e-26 90.1 In-house 171-351 (351) Show / Hide 
Range on Protein: 208-365
Range on HMM: 171-351/351
Sequence Identity: 28% (53 aa)

IQIAGAMVYLHGKG--VCYRDLKLENIMI-DV----------QYLELTLADFGHSKPRFDPLGD--NTCPVGTVSYMAPEVLAG---ITSGQDPGYGFSV
.||| .| ||| .   ...|||| .|| .             .    ..|||| |   | ...       ||.  .||||.. .   ..      |   |
LQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEE------YTEKV

DVFSFGIACSEIVSGQ--PLELTV-P--LTREERIER-LRRGERPSLPES-CHQ-----KLKKLITQCWDFSPKNRPTFEVIYEKLWE
|..|||.   |....|  | .  . .  .  .|.||    .| ||..|.. |..      ...||..||.  ||.||.|. | ..| .
DCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_o.AA CAMK 158-296 23 2.4e-25 78.03 In-house 96-322 (425) Show / Hide 
Range on Protein: 158-296
Range on HMM: 96-322/425
Sequence Identity: 23% (53 aa)

SHPNVIQVLGESEVPE---------TKEK---------LLVME--EKNS------DLKRYFHSSGP---------------ITQLQAVDFLIQIAGAMVY
.|||.|. .   | |.         | .|          .|||  |  |      ||  |  . |.               .|  .|  .  ||. |. |
DHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY

LHGKGVCYRDLKLENIMIDVQY----------------LELTLADFGHSKPRFDPLGDNTC-----------------------PVGTVSYMA-PEVLAG
.| .... ||||.|||..|  .                  . ..||| ..  ..  ....|                       ..|| .||| |||| |
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------ITSGQDPGYGFSVDVFSFGI
        .|... |.||...|. | |.
KGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase MLKx_o.AA Ciliate-E2 184-357 19 8.6e-25 82.02 In-house 126-357 (365) Show / Hide 
Range on Protein: 184-357
Range on HMM: 126-357/365
Sequence Identity: 19% (50 aa)

KNSDLKRYFH---SSGPITQLQAVDFLIQIAG---------------AMVYLHGKG-VCYRDLKLENIMIDVQYLELTLADFGHSK--------------
||...|| ..     ...|  .. ..  ||.                |. ||| |. ...||.|.|||..      . ..||| ||              
KNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQ

--PRFDPLGDNTCPVG----------------TVSYMAPEVLAGITSG---QDPGYGFSVDVFSFGIACSEIVSGQPLELTVPLTREERIERLRRGERPS
     .  .|..   |                |  |||||.| |   .   .  ||....|..|.|.   | ..|.|             ..       .
CKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKID

LP------------------ESCHQKLKKLITQ----CWDFSPKNRPT-FE
.|                  ... |. | || .    . .  |..|.| .|
FPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
Kinase MLKx_o.AA TKL-Unique 197-363 27 6.5e-23 77.76 In-house 106-290 (290) Show / Hide 
Range on Protein: 197-363
Range on HMM: 106-290/290
Sequence Identity: 27% (52 aa)

PITQLQAVDFLIQIAGAMVYLHGKG--VCYRDLKLENIMIDVQY----LELTLADFGHSKPRFDPLGDNTC---------PVGTVSYMAPEVLAGITSGQ
... .| |.. |.||..| ||| ..  .  ||||  |. .|       .   ..||| || .   .  ..          ..|.  .|||||| .     
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---

DPGYGFSVDVFSFGIACSEIVSGQP--------LELTVPLTREERIERLRRGERPSLPESCHQKLKKLITQCWDFSPKNRPTFEVIYEKL
   |  ..||.||||   ||....          ...    .|   ..  .. || .|..| . ...||.|||.  | .||.|. |...|
-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_o.AA RSK 207-296 34 2.9e-22 78.41 In-house 110-200 (278) Show / Hide 
Range on Protein: 207-296
Range on HMM: 110-200/278
Sequence Identity: 34% (32 aa)

LIQIAGAMVYLHGKGVCYRDLKLENIMIDV--QYLELTLADFGHSKP-RFDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFGI
. .|. |. .|| .|. .||||.|||. |   .  .. | ||| .|  | |  .    ...|. |||||.|.     |. |.. ..|..|.|.
MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACDWWSLGV
Kinase MLKx_o.AA Ciliate-E2-Unclassified 179-306 22 2.7e-21 70.65 In-house 98-268 (352) Show / Hide 
Range on Protein: 179-306
Range on HMM: 98-268/352
Sequence Identity: 22% (39 aa)

LVMEEKNSDLKRYFHSS------------------GPITQLQAV-----DFLIQIAGAMVYLHGKG-VCYRDLKLENIMIDVQYL--ELTLADFGHSK--
.|||  .    ......                    .|  ||.     ... ||  .  ||| |. ...||.|.|||..| .    .. ..||| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

-----------PRFDPLGDNTC--PVGTVSYM----APEVLAG-ITSGQDPGYGFSVDVFSFGIACSEIVSGQP
           .... . .. .   .|| .||    ||||| |   ...     ...|..|.|. . |.. |..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGYY
Kinase MLKx_o.AA MLK 124-296 25 1.2e-18 61.46 In-house 15-224 (291) Show / Hide 
Range on Protein: 124-296
Range on HMM: 15-224/291
Sequence Identity: 25% (56 aa)

VQKGNWLGQA-----VAVKKCG--------------DGFRYCREAGVFQHFQPS-HPNVIQVLGESEVPETKEKLLVME-EKNSDLKRYFHSS-------
| ||.| ..      ||||..               |  . ||.. ...|  |  ||..||..| .  |. .. ..|||   .. | .. |.        
VWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSH--PNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYNVLHGARSKWMDA

-------GPITQLQAVDFLIQIAGAMVYLHGKG---VCYRDLKLENIMIDV-----QYLELTLADFGHSKPRFDPLGD-NTCPVGTVSYMAPEVLAGITS
       . ..  .|...  |.| .| ||| .    .  ||||  ||.||      ... |  .||| |.   .   .  ..  ||. .|||||.  . .
NHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRC

GQDPGYGFSVDVFSFGI
..   |  ..||.|.|.
EK---YSEKCDVWSWGV
Kinase MLKx_o.AA Pkinase_Tyr 269-363 35 7.5e-18 61.09 Pfam 181-270 (270) Show / Hide 
Range on Protein: 269-363
Range on HMM: 181-270/270
Sequence Identity: 35% (35 aa)

MAPEVLAGITSGQDPGYGFSVDVFSFGIACSEIVS-G-QPLELT-VPLTREERIERL-RRGERPSLPESCHQKLKKLITQCWDFSPKNRPTFEVIYEKL
||||...         .    || |||. . ||.. | ||   |   .. || .|.. ..|.|   || |.... .|..|||.. |..||||. |.|.|
MAPECINYGK------FTTKSDVWSFGVLMWEIFTYGEQP---TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc MLKx_o.AA TyrKc 111-363 26 6.9e-17 50.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-363
Range on HMM: 1-280/280
Sequence Identity: 26% (75 aa)

LLSGIVLGD-ANSLVQKGNWLGQAVAVKKCGDG--FRYCREAGVFQHFQPSHPNVIQVLGESEVP-----ETKEKLLVME-EKNSDLKRYFHSSGP-ITQ
.  | .||  |   | || |  . ||||.. ..     .||| .  .. ..|||... .|    .     . .  ..|||  .. ||| | ....| .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

LQAVDFLIQIAGAMVYLHGKGVCYRDLKLENIMIDVQYLELTLADFGHSKPRFDP--------LGDN----TCP-VGTVSYMAPEVLAGITSGQDPGYGF
 . ..| .|||  | ||| |..  |||   |.... ..     .||| |.   |           .      .  .  .  ||||..      ..  . .
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKFTT

SVDVFSFGIACSEIVS-GQPLELTV---PLTREERIERLRRGERPSLPES--------CHQKLKKLITQCWDFSPKNRPTFEVIYEKL
  ||.|||. . || . ||.    .   ... .| ||....|.|.  |..        |.... ....|||.. |..||||. |.|..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_o.AA Dicty5 197-296 35 9.2e-13 40.25 In-house 100-191 (260) Show / Hide 
Range on Protein: 197-296
Range on HMM: 100-191/260
Sequence Identity: 35% (36 aa)

PITQLQAVDFLIQIAGAMVYLHGKGVCYRDLKLENIMIDVQYLELTLADFGHSKPR-FDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFG
||   | . . | || .| .|| ...  ||||  |. |    ..  . ||| |  |  |     |  |||  .||.|.  | .      |   .||.|||
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLIT-ENWKIKIIDFGTS--RFVDNRYHMTMHVGTQCWMACELFNGQP------YHQKCDVYSFG

I
|
I
Kinase MLKx_o.AA MLK 325-363 43 7.8e-12 37.46 In-house 253-291 (291) Show / Hide 
Range on Protein: 325-363
Range on HMM: 253-291/291
Sequence Identity: 43% (17 aa)

GERPSLPESCHQKLKKLITQCWDFSPKNRPTFEVIYEKL
|.|| .| .|   .|||..|||.  |..||.|  | ..|
GLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_o.AA Dicty5 325-367 39 3.2e-10 31.37 In-house 218-260 (260) Show / Hide 
Range on Protein: 325-367
Range on HMM: 218-260/260
Sequence Identity: 39% (17 aa)

GERPSLPESCHQKLKKLITQCWDFSPKNRPTFEVIYEKLWEIK
|||| .|  |     .||  ||   |.|||.|  | . .  | 
GERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLKx_o.AA Pkinase_Tyr 124-221 26 0.020521 8.8 Pfam 15-131 (270) Show / Hide 
Range on Protein: 124-221
Range on HMM: 15-131/270
Sequence Identity: 26% (32 aa)

VQKGNWL------GQAVAVKKC--GDGFRY------CREAGVFQHFQPSHPNVIQVLGESEVPETKEK---LLVME-EKNSDLKRYFHS----SGPITQL
| || |       .. ||||..  |   .        ||| .  .. ..|||... .|     . .|    ..|||  .. ||. | ..     .|.|  
VYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL-GHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMK

QAVDFLIQIAGAMVYLHGKG
. ... .||| .| ||. |.
DLLQMCWQIAKGMEYLESKN