Gene MLKx_p (S.moellendorffii)

MLKx_p

Species: S.moellendorffii
Alias: MLKx_p
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_p.AA Protein None 707 None Fasta, JSON
MLKx_p.NA RNA None 2124 None Fasta, JSON
MLKx_p.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of MLKx_p.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_p.AA TKL 219-458 21 6.1e-38 132.38 In-house 9-364 (364) Show / Hide 
Range on Protein: 219-458
Range on HMM: 9-364/364
Sequence Identity: 21% (78 aa)

VQKGNWLG----------QAVAVKKCGDG------------------------------FRYCREAGVFQHFQPSHPNVIQVLG--ESEVP---------
| ||.| |          . |||||                                  || ..|  . .. . .|||..| .|   .. .         
VYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVG

ETKEKLLVME--EKDSDLKRYFHSSGPITQLQAVDFLIQIAGAMVYLHGKD--------VCYRDLKLENIMIDVKY-------------LELTLADFGHS
....  .|||  .. | | ..          | ... ..|| .| ||| ..        . .|||| .||..| ..               . ..||| |
PWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS

KPRFDPLGDNTC-------------------PVGTVSYMAPEVLAGITSGQDP----------GYGFSVDVFSFGIACSEIVSGQPLELTVPLTR-----
.  .   ..|                     ..||  .|||||| | .  ..            |  ..||.||||   ||..... .   |        
RFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD

---EERIERLRRGERPSLP------------ESCHQKLKQLITQCWDFSPKNRPTFEVIYEKL
   |. . .  .|.|| .|            ..| . .|.|...|||  |..||.|. | ..|
PFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_p.AA Pkinase 242-458 23 3.6e-34 121.91 Pfam 47-293 (293) Show / Hide 
Range on Protein: 242-458
Range on HMM: 47-293/293
Sequence Identity: 23% (61 aa)

R--EAGVFQHFQPSHPNVIQVLGESEVPETKEKLLVMEEKDS-----DLKRYFH--SSGPI--TQLQAVDFLIQIAGAMVYLHGKDVCYRDLKLENIMID
|  |. . ....  |||... ..  |    ..  .|||  .      ||..| .  ..|..  .  .. ... ||. .. |.| . ...||||.|||.||
RLSEIQIMKRLN--HPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

VKYLEL----TLADFGHSKPR-FDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFGIACSEIVSGQPLELTVPLTRE------ERIERLRR
 .  ..     ..||| .|     . . .| ..||  ||||||.       ...|| .||..|.|. . | ..|.      |   .      . .....|
-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR-----PPFPGHCWHDNHDQMQMICR

GERPSLPESCH-----------------------QKLKQLITQCWDFSPKNRPTFEVIYEK--L
  .| |....                        . .|..|. |... || |||.| | .   .
IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc MLKx_p.AA S_TKc 206-460 23 3.1e-30 107.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 206-460
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

LLSGIVLGD-ANSLVQKGNWLG--QAVAVKKCGDGFRYCREAGVFQHFQPSHPNVIQVLGESEVPETKEKLLVMEEKDS---DLKRYFHSSGP------I
   . ..|  | . | |. . .  . ||.|.     . .||  . ..    |||... ..  .    ..  .|||  |    ||..| .. |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK---HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TQLQAVDFLIQIAGAMVYLHGKDVCYRDLKLENIMIDVKYLELTLADFGHSKPRFDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGF-SVDVFSFGIA
.  .|  .. ||. |. |.| . ...|||| |||..|    .. ..||| ..         |  .||  |||||||         |||. ..|. |.|. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCI

CSEIVSGQPLELTVPLTREERIERLRRGERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYE-------KLWE
  | ..|.|.      . .. .....            . .|..| .|... |..|||   . .         | 
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_p.AA TK 239-458 17 1.1e-28 92.62 In-house 84-486 (486) Show / Hide 
Range on Protein: 239-458
Range on HMM: 84-486/486
Sequence Identity: 17% (69 aa)

RYCREAGVFQHFQ---PSHPNVIQVLGESEVPET----------KEKLLVMEEKD-SD----LKRYFHSSGP----------------------------
....|| . . ..     |||... .| .  .|.          .  ..|||  .  |    |. | ... |                            
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD

----------------------------ITQLQAVD-------------------FLIQIAGAMVYLHGKDV------CYRDLKLENIMIDVKYL-----
                            .|. . ..                   .  ||| .| ||| | .        |||   |.... ..      
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHF

-----ELTLADFGHSKP------RFDPLGDNTCPVGTVS----------------------------YMAPEVLA-GITSGQ--DPGYGFSVDVFSFGIA
        .|||| |.       | .. .|. . ... .                            .||||.|. .. | .  .  .    ||.|||. 
DGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVL

CSEIVS-G-QPLELTVPL-------TREERIERLRRG--------------ERPSLPESCH--------------QKLKQLITQCWDFSPKNRPTFEVIY
. ||.. | .|    ..        . .| .|.||||               |.  |. |.              . . .|..|||.. |. ||||. ..
MWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLH

EKL
|.|
EQL
Kinase MLKx_p.AA LRRK 303-460 28 5.7e-27 92.45 In-house 171-351 (351) Show / Hide 
Range on Protein: 303-460
Range on HMM: 171-351/351
Sequence Identity: 28% (53 aa)

IQIAGAMVYLHGKD--VCYRDLKLENIMI-DVK----------YLELTLADFGHSKPRFDPLGD--NTCPVGTVSYMAPEVLAG---ITSGQDPGYGFSV
.||| .| ||| ..  ...|||| .|| .   .              ..|||| |   | ...       ||.  .||||.. .   ..      |   |
LQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEE------YTEKV

DVFSFGIACSEIVSGQ--PLELTV-P--LTREERIER-LRRGERPSLPES-CHQ-----KLKQLITQCWDFSPKNRPTFEVIYEKLWE
|..|||.   |....|  | .  . .  .  .|.||    .| ||..|.. |..      ...||..||.  ||.||.|. | ..| .
DCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_p.AA CAMK 253-391 21 1.5e-24 75.37 In-house 96-322 (425) Show / Hide 
Range on Protein: 253-391
Range on HMM: 96-322/425
Sequence Identity: 21% (50 aa)

SHPNVIQVLGESEVPE---------TKEK---------LLVM------EEKDS--DLKRYFHSSGP---------------ITQLQAVDFLIQIAGAMVY
.|||.|. .   | |.         | .|          .||      .  .   ||  |  . |.               .|  .|  .  ||. |. |
DHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY

LHGKDVCYRDLKLENIMIDVKY----------------LELTLADFGHSKPRFDPLGDNTC-----------------------PVGTVSYMA-PEVLAG
.| .... ||||.|||..| ..                  . ..||| ..  ..  ....|                       ..|| .||| |||| |
CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

--------ITSGQDPGYGFSVDVFSFGI
        .|... |.||...|. | |.
KGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase MLKx_p.AA Ciliate-E2 289-452 19 1.9e-24 80.79 In-house 139-357 (365) Show / Hide 
Range on Protein: 289-452
Range on HMM: 139-357/365
Sequence Identity: 19% (46 aa)

SSGPITQLQAVDFLIQIAG---------------AMVYLHGKD-VCYRDLKLENIMIDVKYLELTLADFGHSK----------------PRFDPLGDNTC
  ...|  .. ..  ||.                |. ||| |  ...||.|.|||..      . ..||| ||                   .  .|.. 
D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSR

PVG----------------TVSYMAPEVLAGITSG---QDPGYGFSVDVFSFGIACSEIVSGQPLELTVPLTREERIERLRRGERPSLP-----------
  |                |  |||||.| |   .   .  ||....|..|.|.   | ..|.|             ..       ..|           
TPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCI

-------ESCHQKLKQLITQ----CWDFSPKNRPT-FE
       ... |. |.|| .    . .  |..|.| .|
QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
Kinase MLKx_p.AA TKL-Unique 292-458 27 5.6e-22 74.41 In-house 106-290 (290) Show / Hide 
Range on Protein: 292-458
Range on HMM: 106-290/290
Sequence Identity: 27% (52 aa)

PITQLQAVDFLIQIAGAMVYLHGKD--VCYRDLKLENIMIDVKY----LELTLADFGHSKPRFDPLGDNTC---------PVGTVSYMAPEVLAGITSGQ
... .| |.. |.||..| ||| ..  .  ||||  |. .| .     .   ..||| || .   .  ..          ..|.  .|||||| .     
KLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---

DPGYGFSVDVFSFGIACSEIVSGQP--------LELTVPLTREERIERLRRGERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYEKL
   |  ..||.||||   ||....          ...    .|   ..  .. || .|..| . .. ||.|||.  | .||.|. |...|
-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_p.AA RSK 302-391 33 9.1e-22 76.58 In-house 110-200 (278) Show / Hide 
Range on Protein: 302-391
Range on HMM: 110-200/278
Sequence Identity: 33% (31 aa)

LIQIAGAMVYLHGKDVCYRDLKLENIMIDV--KYLELTLADFGHSKP-RFDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFGI
. .|. |. .|| ... .||||.|||. |      .. | ||| .|  | |  .    ...|. |||||.|.     |. |.. ..|..|.|.
MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACDWWSLGV
Kinase MLKx_p.AA MLK 219-391 26 7.8e-19 62.06 In-house 15-224 (291) Show / Hide 
Range on Protein: 219-391
Range on HMM: 15-224/291
Sequence Identity: 26% (58 aa)

VQKGNWLGQA-----VAVKKCG--------------DGFRYCREAGVFQHFQPS-HPNVIQVLGESEVPETKEKLLVME--EKDSDLKRYFHSS------
| ||.| ..      ||||..               |  . ||.. ...|  |  ||..||..| .  |. .. ..|||  |. | | .. |.       
VWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSH--PNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGS-LYNVLHGARSKWMD

--------GPITQLQAVDFLIQIAGAMVYLHGKD---VCYRDLKLENIMIDV-----KYLELTLADFGHSKPRFDPLGD-NTCPVGTVSYMAPEVLAGIT
        . ..  .|...  |.| .| ||| ..   .  ||||  ||.||      ... |  .||| |.   .   .  ..  ||. .|||||.  . 
ANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFR

SGQDPGYGFSVDVFSFGI
...   |  ..||.|.|.
CEK---YSEKCDVWSWGV
Kinase MLKx_p.AA Pkinase_Tyr 364-458 35 4e-18 62.01 Pfam 181-270 (270) Show / Hide 
Range on Protein: 364-458
Range on HMM: 181-270/270
Sequence Identity: 35% (35 aa)

MAPEVLAGITSGQDPGYGFSVDVFSFGIACSEIVS-G-QPLELT-VPLTREERIERL-RRGERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYEKL
||||...         .    || |||. . ||.. | ||   |   .. || .|.. ..|.|   || |.... .|..|||.. |..||||. |.|.|
MAPECINYGK------FTTKSDVWSFGVLMWEIFTYGEQP---TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc MLKx_p.AA TyrKc 206-458 26 1.1e-16 46.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 206-458
Range on HMM: 1-280/280
Sequence Identity: 26% (76 aa)

LLSGIVLGD-ANSLVQKGNWLGQAVAVKKCGDG--FRYCREAGVFQHFQPSHPNVIQVLGESEVP-----ETKEKLLVME--EKDSDLKRYFHSSGP-IT
.  | .||  |   | || |  . ||||.. ..     .||| .  .. ..|||... .|    .     . .  ..|||  ..  ||| | ....| ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPKLC

QLQAVDFLIQIAGAMVYLHGKDVCYRDLKLENIMIDVKYLELTLADFGHSKPRFDP--------LGDN----TCP-VGTVSYMAPEVLAGITSGQDPGYG
  . ..| .|||  | ||| | .  |||   |.... ..     .||| |.   |           .      .  .  .  ||||..      ..  . 
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKFT

FSVDVFSFGIACSEIVS-GQPLELTV---PLTREERIERLRRGERPSLPES--------CHQKLKQLITQCWDFSPKNRPTFEVIYEKL
.  ||.|||. . || . ||.    .   ... .| ||....|.|.  |..        |.... |...|||.. |..||||. |.|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_p.AA Dicty4 418-460 37 1.2e-14 45.45 In-house 233-277 (277) Show / Hide 
Range on Protein: 418-460
Range on HMM: 233-277/277
Sequence Identity: 37% (17 aa)

RRGERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYEK--LWE
. ..||..| .|  ..|.||. ||| .|..||.|| | ..  | .
NKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_p.AA Dicty5 292-391 35 1.1e-12 39.97 In-house 100-191 (260) Show / Hide 
Range on Protein: 292-391
Range on HMM: 100-191/260
Sequence Identity: 35% (36 aa)

PITQLQAVDFLIQIAGAMVYLHGKDVCYRDLKLENIMIDVKYLELTLADFGHSKPR-FDPLGDNTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFG
||   | . . | || .| .|| . .  ||||  |. |  . ..  . ||| |  |  |     |  |||  .||.|.  | .      |   .||.|||
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLIT-ENWKIKIIDFGTS--RFVDNRYHMTMHVGTQCWMACELFNGQP------YHQKCDVYSFG

I
|
I
Kinase MLKx_p.AA MLK 420-458 41 1e-11 37.01 In-house 253-291 (291) Show / Hide 
Range on Protein: 420-458
Range on HMM: 253-291/291
Sequence Identity: 41% (16 aa)

GERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYEKL
|.|| .| .|   .|.|..|||.  |..||.|  | ..|
GLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_p.AA Dicty5 420-462 39 1.3e-09 29.22 In-house 218-260 (260) Show / Hide 
Range on Protein: 420-462
Range on HMM: 218-260/260
Sequence Identity: 39% (17 aa)

GERPSLPESCHQKLKQLITQCWDFSPKNRPTFEVIYEKLWEIK
|||| .|  |      ||  ||   |.|||.|  | . .  | 
GERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLKx_p.AA Dicty4 309-391 32 3e-09 27.16 In-house 125-205 (277) Show / Hide 
Range on Protein: 309-391
Range on HMM: 125-205/277
Sequence Identity: 32% (29 aa)

MVYLHGKD--VCYRDLKLENIMIDVKYLELTLADFGHSK--PRFDPLGD-NTCPVGTVSYMAPEVLAGITSGQDPGYGFSVDVFSFGI
| .||. .  .  ||||  |...| | .    .||| |.   .   ..|  . ..||. .|||||...       .|  ..||.||||
MNWLHCCNPVIIHRDLKSHNLLVD-KNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ------PYNEKADVYSFGI
Kinase MLKx_p.AA Pkinase_Tyr 282-315 31 0.044546 7.66 Pfam 93-130 (270) Show / Hide 
Range on Protein: 282-315
Range on HMM: 93-130/270
Sequence Identity: 31% (12 aa)

DLKRYFHS----SGPITQLQAVDFLIQIAGAMVYLHGK
||. | ..     .|.|  . ... .||| .| ||. |
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK
Kinase MLKx_p.AA Dicty4 221-233 69 0.063111 2.41 In-house 17-29 (277) Show / Hide 
Range on Protein: 221-233
Range on HMM: 17-29/277
Sequence Identity: 69% (9 aa)

KGNWLGQAVAVKK
||.| |..|||||
KGTWRGKEVAVKK