Gene WAKL_b (S.moellendorffii)

WAKL_b

Species: S.moellendorffii
Alias: WAKL_b
External Links:
Annotation:

Classification

Group: TKL
Family: WAKL

Sequence

Name Sequence Type Origin Length Description Download
WAKL_b.AA Protein None 983 None Fasta, JSON
WAKL_b.NA RNA None 2952 None Fasta, JSON
WAKL_b.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of WAKL_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WAKL_b.AA TKL 63-300 16 1.5e-19 67.02 In-house 1-282 (364) Show / Hide 
Range on Protein: 63-300
Range on HMM: 1-282/364
Sequence Identity: 16% (54 aa)

IDGGNFGKIFKGTLMESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGEVELDEVVEV----------------------LREACN
|  | ||...||...   | ..     |                   | .  .|||||. . .. ...  .                        .|   
IGSGGFGEVYKGKWRGWGG-KC-----P-------------------SDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEE

VRVLQG--TRNVVHVYGVTRNSDLNG-----------VCIVMELVEGPHGD-LSRFLKSRGPGLEELPSWWKTKLEIFMEVVVGVKTCHRNG--------
....      |.|. .|.  ... ..            |||||...|  |. |....             |  .. . ...  |.   | ..        
IMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPG--GSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPP

VYHGDLKGRNVLLDSFCT--------------PKLVDFGFSFRVRDVDY--------------------LNSLGGSLFWISPEVSDALDDPEG----FKL
. | ||| .|.|.|.  |              .|. |||.| ..                         ... .|.. | .||| .  .. .     .. 
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-

IVDNPFPS---DVYSLGMLWIEM
.  .   |   |||| |... |.
FCKGFEYSEKCDVYSFGIVLWEI
Kinase WAKL_b.AA Pkinase 115-300 22 5.3e-18 64.72 Pfam 26-205 (293) Show / Hide 
Range on Protein: 115-300
Range on HMM: 26-205/293
Sequence Identity: 22% (45 aa)

TVAVKKIDTGEVELDEVVEVLR--EACNVRVLQGTRNVVHVYGVTRNSDLNGVCIVMELVEGPHG----DLSRFLK-SRGPGL--EELPSWWKTKLEIFM
.||||.|.  . . .. .. .|  |..  . | .  |.|  |.. ..   . ...|||..||  |    ||..... .|. ..  .|          .. 
IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEG--GLYVMDLFDYISTWRHGCFYFSEWEC-----KFYMY

EVVVGVKTCHRNGVYHGDLKGRNVLLDSFCTP----KLVDFGFSFR--VRDVDYLNSLGGSLFWISPEVSDALDDPEGFKLI--VDNPFPSDVYSLGMLW
... |.. ||..|. | |||  |.|.|. ...    |. |||..          .... |......|||           .    . . ..|..|.| . 
QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-----------IRGGQYYGPKVDMWSCGCIL

IEM
.||
YEM
S_TKc WAKL_b.AA S_TKc 57-376 17 4.8e-16 58.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-376
Range on HMM: 1-231/231
Sequence Identity: 17% (60 aa)

LDSVGSIDGGNFGKIFKGTLMESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGEVELDEVVEVLREACNVRVLQGTRNVVHVYGV
 . .  |  | ||| .|..  .                                     ||.|.|.           ..||    .   .  |.|. |.|
YEILRKIGKGAFGKVYKCRHKK---------------------------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDV

TRNSDLNGVCIVMELVEGPHGDLSRFLKSRGPG-----LEELPSWWKTKLEIFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRVRDV
 ..   . ...|||...|  ||| ...|.||..     . |   .      .. ... ... ||..|. | |||  |.|||.  . |. |||.. ..   
FQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR-----FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---

DYLNSLGGSLFWISPEVSDALDDPEGFKLIVDNPF-PSDVYSLGMLWIEMSWDGFIPDGPEKRDEIKEIIDNKRFPGCPVTLEIPPGLKQPVIEPVFDEL
   ... |......|||                 . ..|..|.| . .||   |  |       ........ .                       .|.
---TTFCGTPWYMAPEVL-------------GYGKCKCDWWSCGCILYEM-LCGYPPFP-----QMQMMFKKIG----------------------SPEA

FAMVDGCCQ-DRTNRFSLEQCLE-------HAHA
  ....|.| | ..| .  ..|.       |   
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase WAKL_b.AA CAMKL 116-268 23 6.5e-15 43.89 In-house 28-204 (297) Show / Hide 
Range on Protein: 116-268
Range on HMM: 28-204/297
Sequence Identity: 23% (44 aa)

VAVKKIDTGEVELDEVVE-------------VLREACNVRVLQGTR---NVVHVYGVTRNSDL----NGVCIVMELVEGPHGD--LSRFLKSRGPGLEEL
||.| ||     .|....             . ||..  . |. ..   |... | |  ...     . ...|||...|  |.  |  .....| .    
VAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSG--GEMDLFDYIVKHGHRR---

PSWWKTKLE------IFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFC--TPKLVDFGFSFRVRD-----VDYLNSLGGSLFWISPEV
      ...      .|  .| .|. ||..|. | |.|  |.|||.    . |..|||||   |.      . |.   ||.   .||.
-----GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEI
Kinase WAKL_b.AA NuaK 203-268 39 8.3e-15 34.83 In-house 104-169 (252) Show / Hide 
Range on Protein: 203-268
Range on HMM: 104-169/252
Sequence Identity: 39% (26 aa)

IFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRVRDVDYLNSLGGSLFWISPEV
.|  .|  |  ||.... | |||  |.|||  |  |  ||| |    | . |.   ||  . |||.
FFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEI
Kinase WAKL_b.AA CAMK 62-268 15 3.1e-14 41.58 In-house 1-291 (425) Show / Hide 
Range on Protein: 62-268
Range on HMM: 1-291/425
Sequence Identity: 15% (50 aa)

SIDGGNFGKIFKGTLMESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKM------------ITVAVKKIDTGEVELDE-------------------
 .  |.||| .                                 .. | .                ||.| ||.  .  ..                   
TLGRGSFGKVK---------------------------------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRY

-------VVEVLREACNVRVLQG------TRNVVHVYGVTRNS----------DLNG--------VCIVM---ELVEGP--HGDLSRFLKSRGPGLEELP
         .|.|| .  . |||       .|... | |  ..            .         ...||   |...|     ||  .....|.. ||  
CWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-

SWWK-------TKL------EIFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSF-----------------CTPKLVDFGFS--FRVRDVDY---------
            ..       .|  .. .|. || ... | |||  |.|||.                  .. |..||||.  |.  . ..         
---DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE

-------------LNSLGGSLFWIS-PEV
             ..   |..  .. |||
MHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase WAKL_b.AA MSN 203-300 37 2.4e-12 36.84 In-house 109-202 (265) Show / Hide 
Range on Protein: 203-300
Range on HMM: 109-202/265
Sequence Identity: 37% (37 aa)

IFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRV-RDVDYLNSLGGSLFWISPEVSDALDDPEGFKLIVDNPFPSDVYSLGMLWIEM
|  |.. |.   | . | | |.||.||||      |||||| |  . | |   |.  |  .|. ||| .  ..|.      |  . ||..|.|.  |||
ICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD---ATYD--YRSDLWSVGITAIEM
Kinase WAKL_b.AA TyrKc 57-374 20 2.1e-11 -38.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-374
Range on HMM: 1-280/280
Sequence Identity: 20% (70 aa)

LDSVGSIDGGNFGKIFKGTLMESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGEVELDEVVEVLREACNVRVL-QGTRNVVHVYG
.     .  |.||...|||.                                     |.||||..  .      . . .|||   . |     |.|  ||
ITLGKKLGEGAFGEVYKGTWK------------------------------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYG

VTRNS-----DLNGVCIVMELVEGPHGDLSRFLKSRGPGLEELPSWWKTKLEIFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRVRD
| . .         ..||||....  |||  .|....|    |.  .|..|..   .  |    |.... | ||  ||.|...  | |  ||| |  . |
VCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKHRPK---LC--MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYD

V-------DYLNS----LG---GSLFWISPEVSDALDDPEGFKLIVDNPFPSDVYSLGMLWIEMSWDGFIPDGP-----EKRDEIKEIIDNKRFPGCPVT
        ||  .     |     . | .||.         .. .    . |||.| | .  |.  .|  |         . .|. | ... . . .|  
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--------NYGKFT--TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPN

LEIPPGLKQPVIEP-----VFDELFAMVDGCCQD-RTNRFSLEQCLEHA
 .           |       ||.. .   |..    .| . ... |  
DY-----------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase WAKL_b.AA STE20 215-268 31 4.6e-11 36.96 In-house 134-193 (288) Show / Hide 
Range on Protein: 215-268
Range on HMM: 134-193/288
Sequence Identity: 31% (19 aa)

HRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRVRD-----VD-YLNSLGGSLFWISPEV
|.|.. | |.|. |.||..    ||.|||..  . .      .   |.. |. .| .|||
HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEV
Kinase WAKL_b.AA MARK 165-268 29 5.8e-11 32.25 In-house 77-176 (262) Show / Hide 
Range on Protein: 165-268
Range on HMM: 77-176/262
Sequence Identity: 29% (32 aa)

VCIVMELVEGPHGDLSRFLKSR--GPGLEELPSWWKTKLEIFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFC--TPKLVDFGFSFRVRDVDYLNSLGGS
....||...|  |.|  ..|..  |.  ||.         ||  .| .|. ||.... | |.|  |.|.|.      |. ||||| ..     ||.  |.
IYLIMEYASG--GELYDYIKAHPNGRLHEEEA------RRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGT

LFWISPEV
.   .||.
PPYMAPEI
Kinase WAKL_b.AA GIN4 149-268 31 9.5e-11 30.12 In-house 95-205 (293) Show / Hide 
Range on Protein: 149-268
Range on HMM: 95-205/293
Sequence Identity: 31% (38 aa)

NVVHVYGVTRNSDLNGVCIVMELVEGPHGDLSRFLKSRGPGLEELPSWWKTKLEIFMEVVVGVKTCHRNGVYHGDLKGRNVLLDSFCT-PKLVDFGFSFR
||. .| |  .   | . .|.| .|.  |.|  .| ..||    ||   .  ...|  ...||  ||  .. | |||  |.|||..    |. |||    
NVMRLYDVWETN--NDLYLVLEYAEK--GELFNYLVDHGP----LPE--REAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAAL

VRDVDYLNSLGGSLFWISPEV
  | . |.   ||  . .||.
ETDNKLLETSCGSPHYAAPEI
Kinase WAKL_b.AA Ciliate-E2 57-245 16 1.3e-10 32.69 In-house 1-203 (365) Show / Hide 
Range on Protein: 57-245
Range on HMM: 1-203/365
Sequence Identity: 16% (39 aa)

LDSVGSIDGGNFGKIFKGTL--------------------MESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGE-VELDEVVEVL
 . .  |  ||||...|..                     |.                                 |.  .|.| .   .  ..  .  ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQ------------------------------EKVKIKIYAMKIMKKNQIEQIKQEIHIM

REAC------NVRVLQGTR---NVVHVYGVTRNSDLNGVCIVMELVEGPHGDLSRFLKSR-GPGLEELP----SWWKTKLEIFMEVVV------------
||        | . .. .    |..  | .  . | | . .|||...|  |||  ..|..    ..|..      .|  ..|. ...             
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIAC

---GVKTCHRNG-VYHGDLKGRNVLLDSFCTPKLVDFGFS
   ... .| .. . | |.|  |.|.     .|..|||.|
IILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS
Kinase WAKL_b.AA STE 215-268 26 2.2e-10 32.97 In-house 169-233 (359) Show / Hide 
Range on Protein: 215-268
Range on HMM: 169-233/359
Sequence Identity: 26% (19 aa)

HRNGVYHGDLKGRNVLLDSFCTPKLVDFGFSFRVRD-----------------VDYLNSLGGSLFWISPEV
|.... | |.|. |.||      ||.|||.. .. |                 .   |.. |.  | .|||
HSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEV
Pkinase_Tyr WAKL_b.AA Pkinase_Tyr 55-190 22 7.1e-07 23.91 Pfam 1-108 (270) Show / Hide 
Range on Protein: 55-190
Range on HMM: 1-108/270
Sequence Identity: 22% (32 aa)

LKLDSVGSIDGGNFGKIFKGTLMESHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGEVELDE--VVEVLREACNVRVLQGTRNVVH
.... .  .  |.||...|||.                               |.... |.||||..       ..    . .|||   . |    |.| 
ITFGKK--LGEGAFGEVYKGTWKG-----------------------------DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVR

VYGVTR-NSDLNGVCIVMELVEGPHGDLSRFLKSR---GPGL
 |||    .. | ..||||...  ||||  .|...   .. |
LYGVCTDQGEPNQIYIVMEYMP--HGDLLDYLRKHREDKQPL
Kinase WAKL_b.AA STE 57-174 14 0.000152 12.11 In-house 1-121 (359) Show / Hide 
Range on Protein: 57-174
Range on HMM: 1-121/359
Sequence Identity: 14% (21 aa)

LDSVGSIDGGNFGKIFKGTLME---SHGERFELSRGPWVNAKRHQTPSRSILKGDHSEKMITVAVKKIDTGEVE---------------LDEVVEVLREA
.. .. |  |.||. .|.  ..    | .  |..                       |.   .|.|...  . .                .|. ..|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVEN--------------------NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEI

CNVRVLQG-TRNVVHVYGVTRNSD-----LNGVCIVMELVEG
   . ..    |.|. ||   . .      . ..|.||...|
KIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDG
Ank WAKL_b.AA Ank 437-447 63 2.275763 5.59 Pfam 1-11 (33) Show / Hide 
Range on Protein: 437-447
Range on HMM: 1-11/33
Sequence Identity: 63% (7 aa)

DGNTLLHLFCK
||.| ||| |.
DGFTPLHLACR
Ank WAKL_b.AA Ank 541-569 24 4.958372 4.37 Pfam 5-33 (33) Show / Hide 
Range on Protein: 541-569
Range on HMM: 5-33/33
Sequence Identity: 24% (7 aa)

PLHRMAHQGNTKLMRILLDYVQQPDYVNV
|||  .. |.|. .. ||..   .. .. 
PLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank WAKL_b.AA Ank 574-598 32 20.185534 2.17 Pfam 1-25 (33) Show / Hide 
Range on Protein: 574-598
Range on HMM: 1-25/33
Sequence Identity: 32% (8 aa)

EFHTPLSYAIEGDKVGAVMFLLERG
.  ||| .|.. . .  | .||..|
DGFTPLHLACRCGHTEVVKMLLQHG
Ank WAKL_b.AA Ank 685-718 26 15.739421 2.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 685-718
Range on HMM: 1-33/33
Sequence Identity: 26% (9 aa)

YGVEPFSHACSRDGDWSVFQLLISHWKDPARHDR
.|  |   ||... . .| ..|..|  |.  .|.
DGFTPLHLACRCG-HTEVVKMLLQHGADVNAQDD
Ank WAKL_b.AA Ank 900-929 40 0.000123 20.98 Pfam 4-33 (33) Show / Hide 
Range on Protein: 900-929
Range on HMM: 4-33/33
Sequence Identity: 40% (12 aa)

TPLLQAVASQDSEMVELLLRAGARPNAGTS
|||  |. . . |.|..|| .|| .|| . 
TPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank WAKL_b.AA Ank 930-961 31 0.001099 17.55 Pfam 2-33 (33) Show / Hide 
Range on Protein: 930-961
Range on HMM: 2-33/33
Sequence Identity: 31% (10 aa)

GETAMDIAARCGNQRIVRLLIRYNFDTGMRDK
|.|.  .|.|||. ..|..|. .. |  ..|.
GFTPLHLACRCGHTEVVKMLLQHGADVNAQDD