Gene LmjF21.0853 (L.major)

LmjF21.0853

Species: L.major
Alias: LmjF21.0853, LmajK112
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF21.0853.AA Protein None 2301 None Fasta, JSON
LmjF21.0853.kin_dom Protein Kinase Domain None 490 None Fasta, JSON

Protein domain

Protein domains of LmjF21.0853.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF21.0853.AA NEK 326-437 42 4e-44 152.92 In-house 122-247 (286) Show / Hide 
Range on Protein: 326-437
Range on HMM: 122-247/286
Sequence Identity: 42% (54 aa)

QCLDALAYLHAL-----CIVHRDIKPSNIYLSKRDG---TVKIGDFGVSKLLQSAEPFTLT-FVGTPFYLCPELCMGDPYSFGADIWALGVVLYELYCL-
| . || |.|        |.||||||.|| |.|..    .|||||||.||.|..   .  | .|||| |..||.| . ||.. .|||.||.||||. .| 
QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLK

-KLPFTSD--NVLAQIYVITEG-KYD
 | || ..  | .. .. |..| .|.
PKHPFEAWDMNMPSLYMKIMKGPQYP
Kinase LmjF21.0853.AA NEK8 326-436 42 9.9e-43 119.74 In-house 127-240 (278) Show / Hide 
Range on Protein: 326-436
Range on HMM: 127-240/278
Sequence Identity: 42% (49 aa)

QCLDALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQSA-EPFT-LTFVGTPFYLCPELCMGDPYSFGADIWALGVVLYELYCLKLPFTSDN
| . |....|   |.|||.|. || . .. . ||||||| || . .     |  | |||| |. ||.| | || .  |.|||| ||||. |||  |  .|
QMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASN

VLAQIYVITEG-KY
 .| .  |. . .|
LPALVWKIMQCRAY
Kinase LmjF21.0853.AA Pkinase 322-501 27 1.4e-41 148.07 Pfam 112-293 (293) Show / Hide 
Range on Protein: 322-501
Range on HMM: 112-293/293
Sequence Identity: 27% (52 aa)

DIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRDGTV----KIGDFGVSKLL-QSAEPFTLTFVGTPFYLCPELCM-GDPYSFGADIWALGVVLYELYCL
....| | .|.|.|.  |.|||.||.|| .. ..|..    ||.|||..|..     . . ||.|||.|. ||... | .|.  .|.|..|..|||..| 
FYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCG

KLPFTSD----NVLAQIYVITEGKYDTAALSTPHAFAESQQAVLETLYGPSFLRSERLLHSLVVSMVGKMLQVDPAERPSAEELLAGVFG
..|| ..    | . |...| . ..     . |    .|    . . . .  ..   ....   . . ..|..||..||.||..|   . 
RPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF21.0853.AA NEK1 330-436 39 2.2e-38 130.77 In-house 116-238 (276) Show / Hide 
Range on Protein: 330-436
Range on HMM: 116-238/276
Sequence Identity: 39% (49 aa)

ALAYLHALCIVHRDIKPSNIYLS-KRDG---------------TVKIGDFGVSKLLQSAEPFTLTFVGTPFYLCPELCMGDPYSFGADIWALGVVLYELY
|| . |   | |||||..|| |.  ..|               .||.||||....|..   .  | .||| || ||.|   ||    |||.||.||||| 
ALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELC

CLKLPFTSDNVLAQIYVITEGKY
 ||.|| . |  . .  |..| |
TLKHPFEANNWKNLVLKICQGTY
Kinase LmjF21.0853.AA CAMK 328-437 24 1.9e-36 114.45 In-house 189-365 (425) Show / Hide 
Range on Protein: 328-437
Range on HMM: 189-365/425
Sequence Identity: 24% (44 aa)

LDALAYLHALCIVHRDIKPSNIYLSKRD----------------GTVKIGDFGVSKLLQSAE-----------------------PFTLTFVGTPFYLC-
..|..|.| . |||||.|| || |....                ...|| ||| .. ... |                       .   ||.||| | . 
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA

PELCMG--------------DPYSFGADIWALGVVLYELYCLKLPFTSDN------------VLAQIY-VITEGKYD
||.  |              ..|.. .|.|..||.|| . | ..|| .|.             . ...  |..||||
PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYD
Kinase LmjF21.0853.AA Ciliate-E2 120-496 14 6.7e-35 117.23 In-house 109-360 (365) Show / Hide 
Range on Protein: 120-496
Range on HMM: 109-360/365
Sequence Identity: 14% (66 aa)

LCLVTEYMDGGDLAALLR---QYSGQGLSSTKGVCEATSLRTLDTAAAARKRGRPSAAVTDGAAAGADQGEASEGDWVSRSRLHRQRLVTTLRAAPRPPM
. ||.|| .||||  ...   . ... ..                                                                       
IYLVMEYCQGGDLFDYIKNNKKKRNHEIE-----------------------------------------------------------------------

STSATTATKATVMRWDGLNASADQTWMSDASAAAMPTTPLGATDVEAADGAARGSRNGIQMHTAAASNAAVGSAATGAPHLASVPLEPQLPPLPNQLWVE
                                                                                                .   
--------------------------------------------------------------------------------------------K-D-KYFT

SFLITDIAKQCLD---------------ALAYLHALC-IVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQS----------AEPFTLTF-----------
 . | .| || |.               || |||    |.||||||.|| .      .|| ||| || ..           .. ..  .           
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

-----------VGTPFYLCPELCMGDP---------YSFGADIWALGVVLYELYCLKLPFTSDNVLAQIYVITEGKYDTAALSTPHAFAESQQAVLE-TL
           .||| |..||  .| .         |.. .|||.|||.|||. . |.||                               ||  ..  .
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------------------QQQIKQCKI

YGPSFLRSERLLHSLV--------------VSMVGK----MLQVDPAERPS-AEELL
  |..   .. .  ..                .  |    |||.|| .|.. .|..|
DFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase LmjF21.0853.AA ULK 120-419 14 5e-34 116.2 In-house 95-256 (329) Show / Hide 
Range on Protein: 120-419
Range on HMM: 95-256/329
Sequence Identity: 14% (47 aa)

LCLVTEYMDGGDLAALLRQYSG----QGLSSTKGVCEATSLRTLDTAAAARKRGRPSAAVTDGAAAGADQGEASEGDWVSRSRLHRQRLVTTLRAAPRPP
. ...|| .||||  .. .. .    . .                                                                       
IYIIMEYCNGGDLEQYIKKNKKLPEDT-E-----------------------------------------------------------------------

MSTSATTATKATVMRWDGLNASADQTWMSDASAAAMPTTPLGATDVEAADGAARGSRNGIQMHTAAASNAAVGSAATGAPHLASVPLEPQLPPLPNQLWV
                                                                                               ..   
-----------------------------------------------------------------------------------------------EKKRL

ESFLITDIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRD-----------GTVKIGDFGVSKLLQSA---EPFTLTFV------GTPFYLCPELCMGD-
.   .  . || | .. .||   |.||||||.|| ... .           |..||.||| .| ...    .  ..|.|      ||| | .|.. .|  
SEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQG

---PYS-FGADIWALGVVLYELYCLKLPF
   ||. . .||| ||...||.   | ||
EQKPYYDYKCDIWSLGCIFYEMLYGKPPF
S_TKc LmjF21.0853.AA S_TKc 11-500 12 1.3e-33 118.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-500
Range on HMM: 1-231/231
Sequence Identity: 12% (66 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEEVLMVMSEVSLLKNVGHPNIITYYDSFLYDDDESALSRKGGATLVPQADGDDIAA
|. .|.||.|.||.||.|....       ..||.| ..                                                              
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------------------------------------------------------------

AGAGFRSQWLCLVTEYMDGGDLAALLRQYSGQGLSSTKGVCEATSLRTLDTAAAARKRGRPSAAVTDGAAAGADQGEASEGDWVSRSRLHRQRLVTTLRA
                                                                                                    
----------------------------------------------------------------------------------------------------

APRPPMSTSATTATKATVMRWDGLNASADQTWMSDASAAAMPTTPLGATDVEAADGAARGSRNGIQMHTAAASNAAVGSAATGAPHLASVPLEP---QLP
                                                .  | .     .  | .... .  .         .  ..    ..     | 
----------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLF

PLPNQLW-------VESFLITDIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQSAEPFTLTFVGTPFYLCPELCMGDPYSF-G
 .  .              .  ...| ..||.|.| . |.|||.||.|| |..   ..||.|||....|        ||.|||.|. ||..   .|..  
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCK

ADIWALGVVLYELYCLKLPFTSDNVLAQIYVITEGKYDTAALSTPHAFAESQQAVLETLYGPSFLRSERLLHSLVVSMVGKMLQVDPAERPSAEELLA--
.|.|..|..|||..| . ||   .. . . .|                                        . . ... |.||.||..||.| |.|.  
CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

------GVF
        |
WDIKCHPWF
Kinase LmjF21.0853.AA ULK 120-419 14 1.8e-33 116.18 In-house 92-252 (324) Show / Hide 
Range on Protein: 120-419
Range on HMM: 92-252/324
Sequence Identity: 14% (46 aa)

LCLVTEYMDGGDLAALLRQYSG---QGLSSTKGVCEATSLRTLDTAAAARKRGRPSAAVTDGAAAGADQGEASEGDWVSRSRLHRQRLVTTLRAAPRPPM
.....|| .||||  .. .. .   . .                                                                        
IYIIMEYCNGGDLEQYIKKNKKLPET-E------------------------------------------------------------------------

STSATTATKATVMRWDGLNASADQTWMSDASAAAMPTTPLGATDVEAADGAARGSRNGIQMHTAAASNAAVGSAATGAPHLASVPLEPQLPPLPNQLWVE
                                                                                              ..   .
----------------------------------------------------------------------------------------------EKKRLS

SFLITDIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRD-----------GTVKIGDFGVSKLLQ---SAEPFTLTFV------GTPFYLCPELCMGD--
   .  . || . .. .||   |.||||||.|| ... .           |..||.||| .| ..    ..  . |.|      ||| | .|.. .|   
EQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGE

--PYS-FGADIWALGVVLYELYCLKLPF
  ||. . .||| ||...||.   | ||
QKPYYDYKCDIWSLGCIFYEMLYGKYPF
Kinase LmjF21.0853.AA CAMKL 325-424 39 1e-31 98.4 In-house 134-241 (297) Show / Hide 
Range on Protein: 325-424
Range on HMM: 134-241/297
Sequence Identity: 39% (43 aa)

KQCLDALAYLHALCIVHRDIKPSNIYLSKRDG-TVKIGDFGVSKLLQS----AEPFTLTFVGTPFYLCPELCMG--DPYS-FGADIWALGVVLYELYCLK
.| ..|..|.| ..|||||||| || |....  ..|| ||| | . .      . .  || |.| | .||.. |  .||  . .|||..||.|| . | .
RQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGY

LPFTSDNV
|||  |..
LPFDDDTY
Kinase LmjF21.0853.AA STE 323-419 34 6e-31 106.56 In-house 156-268 (359) Show / Hide 
Range on Protein: 323-419
Range on HMM: 156-268/359
Sequence Identity: 34% (41 aa)

IAKQCLDA-LAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQS----------------AEPFTLTFVGTPFYLCPELCMG------DPYSFG
|..|.| . |.||| . |.||||||.|| |      ||. ||||.. |..                    . |||||| .  ||  ..      ..|.. 
ICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

ADIWALGVVLYELYCLKLPF
.||| || .. |. . | |.
CDIWSLGCTIIEMATGKPPW
Kinase LmjF21.0853.AA STE20 323-412 40 1.4e-25 90.61 In-house 122-220 (288) Show / Hide 
Range on Protein: 323-412
Range on HMM: 122-220/288
Sequence Identity: 40% (40 aa)

IAKQCLDALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQS----AEPFT-LTFVGTPFYLCPELCMG-----DPYSFGADIWALGVVLYEL
| ...| .|.|||.  |.|||||  || |.. || ||. ||||.  |..    .. |.  ||||||... ||. ..      .| . .|||.||  . |.
ICREVLQGLDYLHSNHIIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEM
Kinase LmjF21.0853.AA NEK8 11-85 36 6.1e-22 59.32 In-house 1-72 (278) Show / Hide 
Range on Protein: 11-85
Range on HMM: 1-72/278
Sequence Identity: 36% (27 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEEVLMVMSEVSLLKNVGHPNIITYYDSFLYD
| .|||.|.| || . |.  .| .|    . |  | . .  .  .|  | ..|...|. . ||||| |||.|. |
YERIRVVGRGAFGICWLYRRKEDQS---HHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMED
Pkinase LmjF21.0853.AA Pkinase 11-141 23 5.7e-20 71.69 Pfam 1-101 (293) Show / Hide 
Range on Protein: 11-141
Range on HMM: 1-101/293
Sequence Identity: 23% (32 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSL-GALCDEEVLMVM-SEVSLLKNVGHPNIITYYDSFLYDDDESALSRKGGATLVPQADGDDI
|. .|.||.|.||.||.|..          .|||| ... .. .....  .  ||....|...||||...||.| .                        
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------------------------

AAAGAGFRSQWLCLVTEYMDGG----DLAALLR-QYSG
        ......|.||..||    ||..... ...|
--------KDHIYMVMEYCEGGLYVMDLFDYISTWRHG
Kinase LmjF21.0853.AA STE 11-141 19 6.7e-20 67.04 In-house 1-133 (359) Show / Hide 
Range on Protein: 11-141
Range on HMM: 1-133/359
Sequence Identity: 19% (31 aa)

YRPIRVIGQGGFGTVYLCVDTEP----ASPMY------EQEVAVKAVSL-----------GALCD------EEVLMVMSEVSLLKNVG--HPNIITYYDS
.. |..||.|.|||||.... ..     .          . .|.| ..|               .      ||.  .. |....|.    ||||..||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FLYDDDESALSRKGGATLVPQADGDDIAAAGAGFRSQ--WLCLVTEYMDGGDLAALLRQYSG
.......                            ..  .|... |||||| |  ..... |
YFKEGHN---------------------------HKNDDELWICMEYMDGGSLDDIIKHKYG
Kinase LmjF21.0853.AA NEK 11-89 33 3.9e-17 57.21 In-house 1-80 (286) Show / Hide 
Range on Protein: 11-89
Range on HMM: 1-80/286
Sequence Identity: 33% (27 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEEVLMVM-SEVSLLKNVGHPNIITYYDSFLYDDDES
|. |..|||| ||.||.. ...  .   |. .. | ...| . ..|  . . .|| .||   ||||..|||||. .....
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNC
Kinase LmjF21.0853.AA STE20 11-88 35 1.1e-15 54.05 In-house 1-82 (288) Show / Hide 
Range on Protein: 11-88
Range on HMM: 1-82/288
Sequence Identity: 35% (30 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMY-EQEVAVKAVSLGALCD--EEVLMVMSEVSLLKNVGHPNIITYYDSFLYD---DDE
|  ...||||..|.||..  ..  .  |  |.||.| ..|    .  .|. ... |.| .|.  ||||..||.|.|.|   |||
YELLEKIGQGSYGKVYKA--YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDE
Kinase LmjF21.0853.AA CAMKL 11-145 16 1.2e-15 46.32 In-house 1-125 (297) Show / Hide 
Range on Protein: 11-145
Range on HMM: 1-125/297
Sequence Identity: 16% (27 aa)

YRPIRVIGQGGFGTVYLCVD-TEPASPMYEQEVAVKAVSLGALC-DEEVLM------------VMSEVSLLKNVG---HPNIITYYDSF---LYDDDESA
|| ....|.|.||.| |...   .     ...||.| .    .. |. ...            .  |....| .    |||||  |. .    .      
YRIGKTLGKGSFGKVKLATHIRTT-----GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH------

LSRKGGATLVPQADGDDIAAAGAGFRSQW-----LCLVTEYMDGGD--LAALLRQYSGQG--LS
                                  ..||.|| .||.  |   ...  . .  ..
----------------------------DIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMP
Kinase LmjF21.0853.AA CAMK 16-132 15 1.2e-14 42.92 In-house 1-147 (425) Show / Hide 
Range on Protein: 16-132
Range on HMM: 1-147/425
Sequence Identity: 15% (28 aa)

VIGQGGFGTVYLCVDTEPA--------SPMYEQEVAVKAVSLGALCD-------------------------EEVLM-VMSEVSLLKNVG-------HPN
..|.|.||.|.||....          .    |.||.| ..   | |                         .. .  |..|....|..        |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IITYYDSFL-------YDDDESALSRKGGATLVPQADGDDIAAAGAGFRSQW------------LCLVT---EYMDGGDL
||  |. .                                        ..              ...|.   ||..||.|
IIKLYEVYEDPHYFKNT-------------------------------ND-YETSKQVFTKDKHMYMVMEIMEYCSGGEL
Kinase LmjF21.0853.AA TyrKc 11-499 12 1.1e-13 -1.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-499
Range on HMM: 1-280/280
Sequence Identity: 12% (63 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEEVLMVMSEVSLLKNV--GHPNIITYYDSFLYDDDESALSRKGGATLVPQADGDDI
 . ....| | ||.||... .        ..|||| .  .|     . . |.| ......   ||||.  |                |. . ..      
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----------------GVCTQQGRN----

AAAGAGF-RSQWLCLVTEYMDGGDLAALLRQYSGQGLSSTKGVCEATSLRTLDTAAAARKRGRPSAAVTDGAAAGADQGEASEGDWVSRSRLHRQRLVTT
      |  .. |..|.|||..|||   || . ..                                                                 
------FMYIEPLMIVMEYMPHGDLKDYLRKHRPK-----------------------------------------------------------------

LRAAPRPPMSTSATTATKATVMRWDGLNASADQTWMSDASAAAMPTTPLGATDVEAADGAARGSRNGIQMHTAAASNAAVGSAATGAPHLASVPLEPQLP
                                                                                                    
----------------------------------------------------------------------------------------------------

PLPNQLWVESFLITDIAKQCLDALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQSA-------EPFTLTF-VGTP-----FYLCPELCMGD
       .      ... |  .  .|||  ...|||.   |. ....  ||||.||| |. . .        .  . .   |.        . ||  .  
-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYSFGADIWALGVVLYELYCL-KLPFTS-----DNVLAQIYVITEGKYDTAALS----TPHAFAESQQAVLETLYGPSFLRSERLLHSLVVSMVGKMLQV
 ...  |.|. ||...|.. . . |         .    |  . .|..     .                        |       .. . ..  .  . 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------F----VCCPDEMYQIMKQCWHE

DPAERPSAEELLAGV
||..||. .|.    
DPEDRPTFSEIHECF
Kinase LmjF21.0853.AA NEK1 11-82 31 9.3e-11 33.71 In-house 1-67 (276) Show / Hide 
Range on Protein: 11-82
Range on HMM: 1-67/276
Sequence Identity: 31% (23 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEEVLMVMSEVSLLKNVGHPNIITYYDSF
|  |..||.| || ..|  ..|       |. . |  ..    ..|   .| || .|..  ||||..|..||
YHYIKQIGEGSFGKAWLVKHKE-----DGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESF
Kinase LmjF21.0853.AA ULK 11-80 23 4.8e-09 28.29 In-house 1-82 (324) Show / Hide 
Range on Protein: 11-80
Range on HMM: 1-82/324
Sequence Identity: 23% (20 aa)

YRPIRVIGQGGFG-TVYLC--VDTEPASPMYEQEVAVKAVSLGALCDEEVL--------MVMSEVSLLKNVG---HPN--IITYYD
|  ....|.| || .||    ..|.       | ||.| ...  . . . .        . ..|....|      |||  |. .||
YCLNHCLGKGSFGVKVYKGRNKKTNT----QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD
Kinase LmjF21.0853.AA Ciliate-E2 11-82 20 6.3e-09 26.77 In-house 1-101 (365) Show / Hide 
Range on Protein: 11-82
Range on HMM: 1-101/365
Sequence Identity: 20% (22 aa)

YRPIRVIGQGGFGTVYLCVD------------------TEPASPMYEQEVAVKAVSLGALCDEEVLMVMSEVSLLK----------------NVGHPNII
|  |..||||.||.||.| .                  ..    | . .|..| . .  .   .. ....| ....                .. |||||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQ----M-QEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNII

TYYDSF
 .|..|
KMYECF
Kinase LmjF21.0853.AA ULK 11-82 22 6.6e-09 27.31 In-house 1-87 (329) Show / Hide 
Range on Protein: 11-82
Range on HMM: 1-87/329
Sequence Identity: 22% (20 aa)

YRPIRVIGQGGFGTVYLC--VDTEPASPMYEQEVAVKAVSLGALCDEEVL--------MVMSEVSLLKNVG--------HPNIITYYDSF
|  ....|.| ||.||    ..|.  .    . ||.| ...  .  .. .        ....|. ..|           ||||. .|| |
YCLNHCLGKGSFGKVYKGRNKKTK--D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWF
Kinase LmjF21.0853.AA Pkinase_Tyr 11-79 26 5.3e-07 24.35 Pfam 1-70 (270) Show / Hide 
Range on Protein: 11-79
Range on HMM: 1-70/270
Sequence Identity: 26% (19 aa)

YRPIRVIGQGGFGTVYLCVDTEPASPMYEQEVAVKAVSLGALCDEE---VLMVMSEVSLLKNV-GHPNIITYY
 . ....|.| ||.||... .       ...|||| .     ...|     . |.|....|.   ||||. .|
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLK--EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase LmjF21.0853.AA NEK 476-501 38 1.8e-05 15.67 In-house 261-286 (286) Show / Hide 
Range on Protein: 476-501
Range on HMM: 261-286/286
Sequence Identity: 38% (10 aa)

SMVGKMLQVDPAERPSAEELLAGVFG
... .|||.|| .|||....|.  | 
NLISQMLQKDPEQRPSCNQILEMPFI
Kinase LmjF21.0853.AA NEK1 476-501 34 4.5e-05 13.73 In-house 251-276 (276) Show / Hide 
Range on Protein: 476-501
Range on HMM: 251-276/276
Sequence Identity: 34% (9 aa)

SMVGKMLQVDPAERPSAEELLAGVFG
| | .|....|  |||.  .|  .| 
SLVSQMFKRNPRHRPSVNQILERPFI
Kinase LmjF21.0853.AA NEK8 476-497 45 0.000104 9.23 In-house 253-274 (278) Show / Hide 
Range on Protein: 476-497
Range on HMM: 253-274/278
Sequence Identity: 45% (10 aa)

SMVGKMLQVDPAERPSAEELLA
..|   ||.||. |||| ...|
MLVHNCLQQDPEQRPSASQIMA
Kinase LmjF21.0853.AA STE20 477-496 55 0.000156 12.82 In-house 264-283 (288) Show / Hide 
Range on Protein: 477-496
Range on HMM: 264-283/288
Sequence Identity: 55% (11 aa)

MVGKMLQVDPAERPSAEELL
.| |.||.||..||.|..||
FVDKCLQKDPEKRPTASQLL
Kinase LmjF21.0853.AA CAMK 480-497 55 0.000237 9.14 In-house 404-421 (425) Show / Hide 
Range on Protein: 480-497
Range on HMM: 404-421/425
Sequence Identity: 55% (10 aa)

KMLQVDPAERPSAEELLA
||||||| .|...|. |.
KMLQVDPEKRMTIEQCLN
Kinase LmjF21.0853.AA CAMKL 480-496 47 0.000717 8.07 In-house 276-292 (297) Show / Hide 
Range on Protein: 480-496
Range on HMM: 276-292/297
Sequence Identity: 47% (8 aa)

KMLQVDPAERPSAEELL
|||||.| .||......
KMLQVNPEKRPTIHQIM
Kinase LmjF21.0853.AA STE 480-496 58 0.002609 7.69 In-house 336-352 (359) Show / Hide 
Range on Protein: 480-496
Range on HMM: 336-352/359
Sequence Identity: 58% (10 aa)

KMLQVDPAERPSAEELL
| || || .||.|..||
KCLQKDPNKRPTASQLL
Kinase LmjF21.0853.AA Pkinase_Tyr 329-373 26 0.004567 11.01 Pfam 122-165 (270) Show / Hide 
Range on Protein: 329-373
Range on HMM: 122-165/270
Sequence Identity: 26% (12 aa)

DALAYLHALCIVHRDIKPSNIYLSKRDGTVKIGDFGVSKLLQSAE
....||..  ..|||.   |. ... ...|||.||| ...... .
KGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDD
Kinase LmjF21.0853.AA NEK 120-143 35 0.014298 5.34 In-house 81-108 (286) Show / Hide 
Range on Protein: 120-143
Range on HMM: 81-108/286
Sequence Identity: 35% (10 aa)

LCLVTEYMD-GGDLAAL---LRQYSGQG
|| | || . ||||. .   . .. ..|
LCIVMEYCEGGGDLYQKIKSIKKQKQKG
Kinase LmjF21.0853.AA Pkinase_Tyr 120-145 39 0.042475 7.73 Pfam 82-109 (270) Show / Hide 
Range on Protein: 120-145
Range on HMM: 82-109/270
Sequence Identity: 39% (11 aa)

LCLVTEYMDGGDLAALLRQY--SGQGLS
...|.||| .|||   ||.   ..| |.
IYIVMEYMPHGDLLDYLRKHREDKQPLT
Kinase LmjF21.0853.AA Pkinase_Tyr 396-415 25 0.136772 6.01 Pfam 191-210 (270) Show / Hide 
Range on Protein: 396-415
Range on HMM: 191-210/270
Sequence Identity: 25% (5 aa)

YSFGADIWALGVVLYELYCL
..   |.|. ||...|.. .
FTTKSDVWSFGVLMWEIFTY