LmjF28.3000

Species: L.major
Alias: LmajK116, LmjF28.3000
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF28.3000.AA Protein None 387 None Fasta, JSON
LmjF28.3000.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of LmjF28.3000.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF28.3000.AA S_TKc 13-270 24 3.4e-59 203.89 SMART 1-231 (231) Show / Hide
Range on Protein: 13-270
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

LRFVGFLGCGAFGDAYVVRDAS-DTCFVVKRSKSLVKQSGFLEEYLGMMNLCSLNVVTSHDAWIDHESRVCILMDYCDA--GDLGDYLKKGYP------L
 ...  .| ||||  | .|. . .  . .|. |       .. |   ...    |.|. .|.. |  ..... |.|||   ||| ||.||  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKRLSRCGARVVSRVGTPLYLAPEIISGYAYTS-KADIWSMGLV
|| .. ....|....|...|... .|||.|||||.|..         . |..|||. ..|        . .||| |.|||..    |.  |.|.|| | .
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VYRLMVNNSPFRVTSVDTHTRCVLRLSPPHPSTLSGYSRALGDCVMAMLSRNWKRRPNAEALLR-------CDLF
.| ...   ||.    .  .  ...            |. . | .. .| .. ..|| |  .|.          |
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Pkinase LmjF28.3000.AA Pkinase 13-270 24 3.4e-49 174.57 Pfam 1-293 (293) Show / Hide
Range on Protein: 13-270
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

LRFVGFLGCGAFGDAYVVRDASDTC-FVVKRSKSLVKQSGFLE------EYLGMMNLCSLNVVTSHDAWIDHESRVCILMDYCDAG----DLGDYLK--K
..... .| |.||  |  .. .. . ..||. |   . |....      |   | .|.. |.|. .|.. | ...... |.||. |    || ||..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

GYPL--PEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVA----KLGDFGSVKRL-SRCGARVVSRVGTPLYLAPEIIS-GYAYT
. ..  .|.|. ... |.| ||...|... .|||.|||||....        ..     |..|||. | .    .    ...||| |.|||.|  |  |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN-------GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

SKADIWSMGLVVYRLMVNNSPFRVT------SVDTHTRCVLR--LSPPHPSTLSGY----------------SRALGDCVMAMLSRNWKRRPNAEALLRC
.|.|.||.|...| ..  . ||.        . .   . ...  |. . | . |..                |... | .  .| .. |.||.|| .|  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

DLF
. |
PWF

Kinase LmjF28.3000.AA NEK 66-207 34 3.7e-44 153.02 In-house 65-218 (286) Show / Hide
Range on Protein: 66-207
Range on HMM: 65-218/286
Sequence Identity: 34% (54 aa)

NVVTSHDAWIDHES-RVCILMDYCD-AGDLGDY---LKKGY----PLPEEEVLSIVAQLLLGLDHIHKR-----NRVHRDIKPENIFLSSARTGGGRWPV
|.|. .|..|.... . || |.||.  ||| .    .||.     ...||... . .|..|.|...|.|     . .|||||| ||||.. ...    ..
NIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY---HN

AKLGDFGSVKRLSRCGARVVS-RVGTPLYLAPEIISGYAYTSKADIWSMGLVVYRLM
.|.||||  | |..      .  |||| |..||....  |..|.|||| | |.| ..
VKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMC

Kinase LmjF28.3000.AA Ciliate-E2 66-270 20 1.5e-43 147.4 In-house 93-365 (365) Show / Hide
Range on Protein: 66-270
Range on HMM: 93-365/365
Sequence Identity: 20% (61 aa)

NVVTSHDAWID-HESRVCILMDYCDAGDLGDYLK------------KGYPLPEEEVLSIVAQLLL---------------GLDHIHKRN-RVHRDIKPEN
|..  ......  .. . . |.||. ||| ||.|            .  .. |.|.. | .|.|                .| ..|..|  .||||||||
NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

IFLSSARTGGGRWPVAKLGDFGSVKRL----------SRCGARVVSR----------------------VGTPLYLAPEIIS---------GYAYTSKAD
|..             |. |||  |..          ..|.     .                      .||| |.||||..         .  |. |.|
ILF------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

IWSMGLVVYRLMVNNSPFRVTSVDTHTRCVLRLSPPHPS-----------TLSGYSRALGDCVMA----MLSRNWKRRPN-AEALLRCDLF
|||.| . |... .. ||     . .  | .....|..                 |    |        || .. . |.. .| .|    |
IWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase LmjF28.3000.AA STE 13-270 20 5.4e-42 145.84 In-house 1-359 (359) Show / Hide
Range on Protein: 13-270
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

LRFVGFLGCGAFGDAYVVRDA----------------SDTCFVVKRSK----------------SLV---KQSGFLEEYLGMMNLC--SLNVVTSHDAWI
.......| ||||  |  ..                 . . . .|. .                . .   ..  .|.|   |...   . |.|. ... .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DH------ESRVCILMDYCDAGDLGDYLKKGY--------------PLPEEEVLSIVAQLLLG-LDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKL
.       .. ..| | |.|.| | | .|. |              ..||...  |. |.| | |...|. ...|||||| ||.|            .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKL

GDFGSVKRLSRCGA----------------RVVSRVGTPLYLAPEIISG------YAYTSKADIWSMGLVV------YRLMVNNSPFRV-TSVDTHTRCV
 |||  ..|.  .|                .  . |||| . |||.|..        |. |.|||| |...         . . .|.|.     . ....
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

L---------RLSPPHPSTLS----------------GYSRALGDCVMAMLSRNWKRRPNAEALLR--CDLF
            .|| |..||                 .|  . | .   | .. . ||.|. ||.     .
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase LmjF28.3000.AA CAMK 18-270 16 1.8e-39 124.37 In-house 1-425 (425) Show / Hide
Range on Protein: 18-270
Range on HMM: 1-425/425
Sequence Identity: 16% (69 aa)

FLGCGAFGDAYVVRDASDTC-------------FVVKR-SKS-----------------------------LVKQSGFLEEYLGMMN-------LCSLNV
 || |.||  . ... ..|.             . .|  .|.                              ...  .. |.  |..       |   |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTSHDAWIDH------------------ESRVCILM---DYCDAG----DLGDYLKKG---------------YPLPEEEVLSIVAQLLLGLDHIHKRNR
.  .... |.                  ...... |   .||. |    || ||...                  ..|.|.  .. |.. .....|..| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPENIFLSSARTGGGRWP-----------VAKLGDFGSVKRLSR-----------------------CGARVVSRVGTPLYLA-PEIISG-----
||||.||||| |..  ..  . .             |. |||  ... .                        |     ..||| | | ||...|     
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------YAYTSKADIWSMGLVVYRLMVNNSPFRVTSVD-----------------THTRCVLRLSPPHPSTLS-----------------GYSRALG
           |. |.|.||.| . | . .  .||.  . .                   ...  .  ||. |..|                   |    
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DCVMAMLSRNWKRRPNAEALLRCDLF
| .  || .. ..|...|  |.   .
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase LmjF28.3000.AA NEK1 83-207 38 1.7e-34 117.15 In-house 77-215 (276) Show / Hide
Range on Protein: 83-207
Range on HMM: 77-215/276
Sequence Identity: 38% (54 aa)

ILMDYCDAGDLGDYLK----KGYPLPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTG----------GGRWPVAKLGDFGSVKRLSRCGA
| |.|||.|||    .    || . .| . ..   |. |.| |||.|.  |||||. ||||.. . |              |..||||||. . |.   .
IVMEYCDGGDLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTME

RVVSRVGTPLYLAPEIISGYAYTSKADIWSMGLVVYRLM
     .||| || |||.    |. | |||| | | | |.
YACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELC

Kinase LmjF28.3000.AA ULK 85-214 31 2.9e-34 117.05 In-house 99-257 (329) Show / Hide
Range on Protein: 85-214
Range on HMM: 99-257/329
Sequence Identity: 31% (51 aa)

MDYCDAGDLGDYLKKGYP----------LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSS-----ARTGGGRW----PVAKLGDFGSVKRLSR
|.||. ||| .|.||  .          |.|.|....  |.| |. ..||.| .||||||.|| ..       ..         .|.|..|||  | .. 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK----KVHPNGVLKIADFGFAKHVDN

C---GARVVSRV------GTPLYLAPEIIS----GYAYT-SKADIWSMGLVVYRLMVNNSPFR
     .  .. |      ||||| ||.|..    .  |. .|.||||.| . | . ..  ||.
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY

Kinase LmjF28.3000.AA CAMKL 75-270 26 2.4e-33 103.69 In-house 84-297 (297) Show / Hide
Range on Protein: 75-270
Range on HMM: 84-297/297
Sequence Identity: 26% (59 aa)

IDHESR------VCILMDYCDAGD--LGDYLK-KGY---PLPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKR
|. ..       ... | ||. |.  | ||.. .|.   ..||.|   .  |.. .....|... |||||||||| |..         ..|. |||    
IETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-----NIKIIDFGFSNM

LSRC----GARVVSRVGTPLYLAPEIISG--YAYT-SKADIWSMGLVVYRLMVNNSPFRVTSVD---------THTRCVLRLSPPHPSTLSGYSRALGDC
  .|    |     . |.| | ||||..|    |   |.||||.| . | ... . ||.  ..           .   ..   ||... .|   | |   
YRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDL---

VMAMLSRNWKRRPNAEALLRCDLF
   || .| ..||... ...   .
IRKMLQVNPEKRPTIHQIMNHPWM

Kinase LmjF28.3000.AA ULK 85-204 31 3.3e-33 115.2 In-house 96-243 (324) Show / Hide
Range on Protein: 85-204
Range on HMM: 96-243/324
Sequence Identity: 31% (48 aa)

MDYCDAGDLGDYLKKGYP---------LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSS-----ARTGGGRW----PVAKLGDFGSVKRLSRC
|.||. ||| .|.||  .         |.|.|....  |.. |. ..||.| .||||||.|| ..       ..         .|.|..|||  | .   
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK----KVHPNGVLKIADFGFAKHVDNN

G---ARVVSRV------GTPLYLAPEIIS----GYAYT-SKADIWSMGLVVY
.       . |      ||||| ||.|..    .  |. .|.||||.| . |
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY

Kinase LmjF28.3000.AA Ciliate-E2-Unclassified 85-213 28 1.6e-32 110.17 In-house 100-270 (352) Show / Hide
Range on Protein: 85-213
Range on HMM: 100-270/352
Sequence Identity: 28% (49 aa)

MDYCDAGDLGDYLKK-----------------GYPLPEEEVL-----SIVAQLLLGLDHIHKRN-RVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVK
|.||. ||| .|.||                 .  ..|....      . ||.|.||...|. |  .|||||||||....           |. |||. |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----NYYIKIIDFGISK

RLSRC---------------GARVVSRVGTPLYL----APEIISGYAYT----SKADIWSMGLVVYRLMVNNSPF
..  .                 .  ...||| |.    |||.. |  |      |.||||.| . | .. .. ||
KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

Kinase LmjF28.3000.AA STE7-Unclassified 66-202 31 5.5e-26 88.58 In-house 66-214 (301) Show / Hide
Range on Protein: 66-202
Range on HMM: 66-214/301
Sequence Identity: 31% (49 aa)

NVVTSHDAWIDHES--RVCILMDYCDAGDLG---DYLKKGY--------PLPEEEVLSIVAQLLLGLDHIHKRN-RVHRDIKPENIFLSSARTGGGRWPV
..|. ..| .. ..   . |.| | | |.|    | .||.|        ..||  . .|. |.. ||...|..   .||||||.|| ..|   |      
YIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNS--KG-----Q

AKLGDFGSVKRLSRCGARVVSRVGTPLYLAPEIISGY-----AYTSKADIWSMGLV
.|. |||  ..|      ... ||.  | .||.|.|      .|. | |||| ||.
VKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLT

Kinase LmjF28.3000.AA TyrKc 13-270 20 7.6e-13 -14.96 SMART 1-280 (280) Show / Hide
Range on Protein: 13-270
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

LRFVGFLGCGAFGD---AYVVRDASDTCFV-VKRSKSLVKQSGFLEEYLGMMNL--CSLNVVTSHDAWIDHE------SRVCILMDYCDAGDLGDYLKKG
...   ||.||||    .           | ||  |.   .  |..|   |..|     |.|  . . ....        ..|.| |.. ||| |||.| 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

YP-LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKRLSRC------GARVVSRV--GTP--L---YLAPEIIS
 | |. .. ||.  |   | ...|..| .|||.   |. ... .       ..| .|||  . .         .   ...   |.   |    .||| | 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GYAYTSKADIWSMGLVVYRLMVNNSPFR-------VTSVDTHTRCVLRLSPPHPST----LSGYSRALGDCVMAMLS---RNWKRRPNAEALLRCDLF
 . .|.| |.|| | . . .. .  .         ..  . . .   .  .| |       .   ..  .  . |..   .. . ||. ...  ...|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase LmjF28.3000.AA Pkinase_Tyr 76-132 31 2e-06 22.38 Pfam 75-137 (270) Show / Hide
Range on Protein: 76-132
Range on HMM: 75-137/270
Sequence Identity: 31% (20 aa)

DHESR--VCILMDYCDAGDLGDYLKK----GYPLPEEEVLSIVAQLLLGLDHIHKRNRVHRDI
|..    ..| | |.  ||| |||.|    . ||. .. |.. .|   |... . .| .|||.
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase LmjF28.3000.AA Pkinase_Tyr 180-198 47 0.085558 6.7 Pfam 181-199 (270) Show / Hide
Range on Protein: 180-198
Range on HMM: 181-199/270
Sequence Identity: 47% (9 aa)

LAPEIISGYAYTSKADIWS
.||| |. . .|.| |.||
MAPECINYGKFTTKSDVWS

Kinase LmjF28.3000.AA STE7-Unclassified 13-31 26 0.20425 0.88 In-house 1-19 (301) Show / Hide
Range on Protein: 13-31
Range on HMM: 1-19/301
Sequence Identity: 26% (5 aa)

LRFVGFLGCGAFGDAYVVR
|.... || |..| .. ..
LERLKYLGHGMHGTVVKCL

Kinase LmjF28.3000.AA NEK1 237-270 29 0.28914 0.35 In-house 243-276 (276) Show / Hide
Range on Protein: 237-270
Range on HMM: 243-276/276
Sequence Identity: 29% (10 aa)

SGYSRALGDCVMAMLSRNWKRRPNAEALLRCDLF
. ||. |   |  |..|| . || . ..|     
PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI