Gene LmjF20.1340 (L.major)

LmjF20.1340

Species: L.major
Alias: LmajK135, LmjF20.1340
External Links:
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF20.1340.AA Protein None 377 None Fasta, JSON
LmjF20.1340.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of LmjF20.1340.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF20.1340.AA Pkinase 45-279 21 5.8e-27 96.42 Pfam 1-222 (293) Show / Hide 
Range on Protein: 45-279
Range on HMM: 1-222/293
Sequence Identity: 21% (56 aa)

IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDFSLEQYAV
. . ...|.||||.| .....       . |||.|..|.|     .    .   .|... .| . .|..| .|  . |  .. | . |.  .  |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLN-HPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMD

HC-------GFRF--PPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVN---VFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGV-EEVEQELKR
 .       . .|  ..  . ... | .|.....|..|..|||.||.|. ..   . |.                  .|.| |||||. . .   . .. 
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLAKQFDY-NNS-MTT

CVGTPHYMAPETFSHLC-DCDVPAACDVWSLGVTLFRLATGVFPVFDQ------D
 .|||.|||||    .  . . . ..|.||.|..|. ...| .|  ..      |
FCGTPWYMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHD
Kinase LmjF20.1340.AA S_TKc 46-359 18 1.2e-25 92.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-359
Range on HMM: 1-231/231
Sequence Identity: 18% (64 aa)

WTPQR-LGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDF---SLEQ
..  | .| |.||.| ... ..     |. |.|.|.              . . ||......    |..| .|  . |   . . . |.  |    .| .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFD

YAVHCGFR-----FPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQELKRCVGTP
| ...| .     ||.    ....| ..|....|..|..|||.||.|  ..                       . | |||||. .       . ..|||
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL-------TTFCGTP

HYMAPETFSHLCDCDVPA-ACDVWSLGVTLFRLATGVFPVFDQDVTASWPPASASSARLGVPACDHRGRALSSGAPRRGDCGRIDACRESTPPPNYGKRS
.||||| .           .||.||.|..|. ...|  |   |. .                                                     |
WYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------------------------------S

TAAA-------GHRRDSRAGAAERLV---P---HPPN
  |            . | .| | |        ||  
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF20.1340.AA CAMK 165-274 23 3.7e-25 77.41 In-house 191-333 (425) Show / Hide 
Range on Protein: 165-274
Range on HMM: 191-333/425
Sequence Identity: 23% (37 aa)

AVAHLHRRGVVHRDVKPDNFVVN-------------VFDTVGGAGAGGDGDCGEARPPF-VRILDFGLACGVEEVE-----------------------Q
||...| ...|||| ||.|  ..             .||                   . . | |||.|. ... |                       |
AVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD----------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ

ELKRCVGTPHYMA-PETFSHLC-----------DCDVPAACDVWSLGVTLFRLATGVFP
 .| ..|||.||| || ..                 .. .||.||.|| |. . .| .|
KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP
Kinase LmjF20.1340.AA AGC 158-279 17 9.7e-25 59.51 In-house 151-309 (395) Show / Hide 
Range on Protein: 158-279
Range on HMM: 151-309/395
Sequence Identity: 17% (33 aa)

MCAQ-------CARAVAHLHR-RGVVHRD-VKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVE-------------------------
..|.        . |. .||. .|..||| .||.| . .                       ... ||||.. .                          
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-------------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKS

-------------------------EVEQELKRCVG--TPHYMAPETFSHLCDCDVPAACDVWS--LGVTLFRLATGVFPVFDQD
                         . ..  .  .|  ||.||||| .          ||| ||  ||. .. . ||  | ....
NMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWWSFGLGCLMYEMLTGYPPFYGDN
Kinase LmjF20.1340.AA CAMK-Unique 159-274 26 5e-22 69.32 In-house 163-292 (363) Show / Hide 
Range on Protein: 159-274
Range on HMM: 163-292/363
Sequence Identity: 26% (36 aa)

CAQCARAVAHLHRRGVVHRDVKPDNFVVNVF--DTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE--LKRCVGTPHYMAP-------------
... . |||..|  ..|||| |..| .|.    |        .| .  . .  .. ..||||.| ..... .  ..  .||| ||||             
MQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN----HHRDFPYDWSN-WHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTR

-ETFS-HLCDCDVPAACDVWSLGVTLFRLATGVFP
 |.   .  |. .  | | |||||... ...|  |
DEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP
Kinase LmjF20.1340.AA CAMKL 165-274 29 2.5e-20 61.44 In-house 139-235 (297) Show / Hide 
Range on Protein: 165-274
Range on HMM: 139-235/297
Sequence Identity: 29% (34 aa)

AVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV----EQELKRCVGTPHYMAPETFSHLCDCDVPAACDVWS
||...|..|.|||| ||.|  .   .                    . | |||..   ...    .| || . |.|.||||| |.   .     . |.||
AVNYCHSHGIVHRDIKPENILLDENGNN-----------------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWS

LGVTLFRLATGVFP
.||.|. . .| .|
CGVILYAMVCGYLP
Kinase LmjF20.1340.AA Ciliate-E2 165-274 22 1e-18 60.89 In-house 172-295 (365) Show / Hide 
Range on Protein: 165-274
Range on HMM: 172-295/365
Sequence Identity: 22% (33 aa)

AVAHLHRRG-VVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE-------------------------------LKRC
|. .|| .. ..||| ||.| ..                        . | ||||.  . . .|.                                ...
ALEYLHSKNNIIHRDIKPENILF------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTI

VGTPHYMAPETFSHLC------DCDVPAACDVWSLGVTLFRLATGVFP
.|||.||||| ..           .   .||.|||||.|... .| .|
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase LmjF20.1340.AA STE 158-287 24 2.2e-18 61.6 In-house 156-281 (359) Show / Hide 
Range on Protein: 158-287
Range on HMM: 156-281/359
Sequence Identity: 24% (37 aa)

MCAQCARA-VAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEE----------------VEQELKRCVGTPHYMA
.| |. ..  ..||. ...|||.||.|  .                        | . |||..  ...                  |. . .|||| .||
ICRQILKGLLYYLHSHHIIHRDIKPANILL------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMA

PETFSH-----LCDCDVPAACDVWSLGVTLFRLATGVFPVFD-QDVTASWPPA
||  .        ..|.   ||.|||| |.  .|||  | .| ..  | .. .
PEVIQQNGQGRDKGYDT--KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP
Kinase LmjF20.1340.AA TKL 155-279 18 6.4e-16 53.81 In-house 134-293 (364) Show / Hide 
Range on Protein: 155-279
Range on HMM: 134-293/364
Sequence Identity: 18% (32 aa)

LLSMCAQCARAVAHLHR--------RGVVHRDVKPDNFVVNVFDT------VGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQ-------------
..... ..||....||         ....||| |..|  |.   |      .            .. . .. | ||||.  ... ..             
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY-----------NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE

------ELKRCVGTPHYMAPETFSHLCD-------------CDVPAACDVWSLGVTLFRLATGVFPVFDQD
       . ...||| .|||| .    .              .   .|||.| |. |. ..|.  | .|..
HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
Kinase LmjF20.1340.AA CAMKK 215-271 28 4.1e-15 43.98 In-house 242-322 (396) Show / Hide 
Range on Protein: 215-271
Range on HMM: 242-322/396
Sequence Identity: 28% (23 aa)

DFGLACGVEEVEQELKR-----------CVGTPHYMAPETFSHLCD--------------CDVPAACDVWSLGVTLFRLATG
||| .. .|. .|.|..           ..|||..|||| .|   .              .. . |.|.|.|||||. . .|
DFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGK-AADIWALGVTLYCFVFG
Kinase LmjF20.1340.AA CAMKK-Unclassified 213-274 26 5.2e-15 45.05 In-house 245-332 (392) Show / Hide 
Range on Protein: 213-274
Range on HMM: 245-332/392
Sequence Identity: 26% (23 aa)

ILDFGLACGVEEVEQE-LKRCVGTPHYMAPETFSHLCDCDVPAA-------------------------CDVWSLGVTLFRLATGVFP
| |||..  .|  .|. || . ||...|||| .|   .   . .                         .|.||||||.. ....  |
IADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLP
Kinase LmjF20.1340.AA RSK 211-274 32 1.7e-09 31.24 In-house 146-211 (278) Show / Hide 
Range on Protein: 211-274
Range on HMM: 146-211/278
Sequence Identity: 32% (22 aa)

VRILDFGLACG-VEEVEQELKRCVGTPHYMAPETFS---HLCDCDVPAACDVWSLGVTLFRLATGVFP
... |||...  . . .| ..  ..| .|||||      . .  |  .|||.||||| .. . ||  |
IKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD--KACDWWSLGVLMYEMLTGCPP
Kinase LmjF20.1340.AA TyrKc 45-376 15 1.1e-07 -98.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-376
Range on HMM: 1-280/280
Sequence Identity: 15% (60 aa)

IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAG-VSPHVVPMYKPWFDCREGVIALP------------
|   . || | ||.| ..         .. ||| .   .       .|  .   ||  . .. |   |..| .|        ||.  .            
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFM---REARIMCKLGGHHPNIVRLY--------GVCTQQGRNFMYIEPLMI

----MDAGDFS--LEQYAVHCGFRFPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV
    |. ||    |  .  .    ...  |||.| | |.  ..||.....|||    |  |.                       |.| ||||.  ... 
VMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDD

-----EQELKRC---VGTP-----HYMAPETFSHLCDCDVPAACDVWSLGVTLFRLATGVFPVFDQDVTASWPPASASSARLGVPACDHRGRALS----S
     ... .|     |.        ||||.. . . .    . |||| ||... . |   .    ..     . |.. ..  | . . . .  .    |
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTT--KSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMS

GAPRRGDCGRIDACRESTPPPNYGKRSTAAAGHRRDSRAGAAERLVPHPPNACVSPGCDGCCVR-----------RSAY
                                              .. | .  .     |. .           ..  
---------------------------------------------FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF20.1340.AA RSK 160-183 54 3.7e-07 22.61 In-house 111-134 (278) Show / Hide 
Range on Protein: 160-183
Range on HMM: 111-134/278
Sequence Identity: 54% (13 aa)

AQCARAVAHLHRRGVVHRDVKPDN
|. . || ||| .|..||| ||.|
AEIVLAVEHLHQQGIIHRDLKPEN
Kinase LmjF20.1340.AA CAMKK-Unclassified 161-183 20 0.000119 10.73 In-house 186-229 (392) Show / Hide 
Range on Protein: 161-183
Range on HMM: 186-229/392
Sequence Identity: 20% (9 aa)

QCARAVAHLHRRG---------------------VVHRDVKPDN
||. ..  .| ..                     ..||| ||.|
QCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQN
Kinase LmjF20.1340.AA Pkinase_Tyr 149-179 32 0.000172 15.83 Pfam 107-137 (270) Show / Hide 
Range on Protein: 149-179
Range on HMM: 107-137/270
Sequence Identity: 32% (10 aa)

RFPPLALLSMCAQCARAVAHLHRRGVVHRDV
....  ||.||.| |.. ..|.... .|||.
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase LmjF20.1340.AA CAMKK 169-183 22 0.001072 7.11 In-house 192-226 (396) Show / Hide 
Range on Protein: 169-183
Range on HMM: 192-226/396
Sequence Identity: 22% (8 aa)

LH-RRG-------------------VVHRDVKPDN
||  ..                   ..||| ||.|
LHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQN
Kinase LmjF20.1340.AA STE 46-83 25 0.003599 7.19 In-house 1-51 (359) Show / Hide 
Range on Protein: 46-83
Range on HMM: 1-51/359
Sequence Identity: 25% (13 aa)

WTP-QRLGAGSFGTVTLAYRH------EGDAV------WRKTAVKRISLRK
|.  ...| |.|||| .|..|      . . |       .  |.|...|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLEN
Kinase LmjF20.1340.AA CAMK 50-64 53 0.019475 2.86 In-house 1-15 (425) Show / Hide 
Range on Protein: 50-64
Range on HMM: 1-15/425
Sequence Identity: 53% (8 aa)

RLGAGSFGTVTLAYR
 || ||||.| |...
TLGRGSFGKVKLCIH
Kinase LmjF20.1340.AA CAMKL 44-62 52 0.108542 1.0 In-house 1-18 (297) Show / Hide 
Range on Protein: 44-62
Range on HMM: 1-18/297
Sequence Identity: 52% (10 aa)

YIWTPQRLGAGSFGTVTLA
|.  .  || ||||.| ||
YRIGK-TLGKGSFGKVKLA
Kinase LmjF20.1340.AA TKL 51-80 27 0.144895 1.42 In-house 1-35 (364) Show / Hide 
Range on Protein: 51-80
Range on HMM: 1-35/364
Sequence Identity: 27% (10 aa)

LGAGSFGTVTLA-YRHEGDAVW-----RKTAVKRIS
.| |.||.|  . .| .|  .      .  |||...
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFK
Kinase LmjF20.1340.AA Pkinase_Tyr 255-266 50 5.992044 0.45 Pfam 194-205 (270) Show / Hide 
Range on Protein: 255-266
Range on HMM: 194-205/270
Sequence Identity: 50% (6 aa)

ACDVWSLGVTLF
. |||| ||...
KSDVWSFGVLMW