Gene LmjF14.0020 (L.major)
LmjF14.0020
Species: L.major
Alias: LmjF14.0020, LmajK167
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF14.0020.AA | Protein | None | 938 | None | Fasta, JSON |
| LmjF14.0020.kin_dom | Protein Kinase Domain | None | 302 | None | Fasta, JSON |
Protein domains of LmjF14.0020.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_rbd | LmjF14.0020.AA | PI3K_rbd | 109-151 | 32 | 2.2e-09 | 37.12 | Pfam | 73-115 (115) | Show / Hide |
Range on Protein: 109-151 Range on HMM: 73-115/115 Sequence Identity: 32% (14 aa) FVFRVKGRSEYIYGSQPLINYCYIRDCVSKRAEIDLVVEPKEA .|..| ||.||..|. ||... ||| |.. .....|.. ... YVLKVCGRDEYLHGDHPLCQFEYIRNCIMWGRCPHLTLMECCS |
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| PI3K_rbd | LmjF14.0020.AA | PI3K_rbd | 22-151 | 14 | 5.1e-05 | 15.29 | SMART | 1-116 (116) | Show / Hide |
Range on Protein: 22-151 Range on HMM: 1-116/116 Sequence Identity: 14% (19 aa) SLPQVFSVPPLQTAQMYLLMQMWPRNAETGDGSISMCLWYLHCAGSRCSTRRTFPCNTVADDAIRLTVSSVRG---FANMRGKSDGTAL-IFVFRVKGRS . . . .... |.. .. ... . . . |..|| . .... .. . .. . | ...|.| . ....| ||. MSRKCPEHIWMKTINNKIIIVVHWEKR-----------------VCNWQQTKTMDCN-PNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRD EYIYGSQPLINYCYIRDCVSKRAEIDLVVEPKEA ||. . ||... ||| |.. ......|. ... EYLHPDHPLGQFEYIRNCIMWGRCPHFVLMECCK |
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| PI3Ka | LmjF14.0020.AA | PI3Ka | 414-599 | 29 | 3.3e-38 | 134.15 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 414-599 Range on HMM: 1-232/232 Sequence Identity: 29% (68 aa) HLINNE--VEQLRPLQLALM-YDPLVYLTSDDKTILWKYR-EMLLSLPKAMV-----KEMSAVSWLMPFGVYEARCL*RRW--SPLAAFDALELLDAHYA . . |..| .....| |.|. ||...| .||.| . | . |||. | ...|.| . | .| .| .| |. . |||||||.... DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP D---LVVREQAVEYIDKMPNYELRGCILQLV*VLKYE--------------------------PYHDSALARFLLGRSLRSNHVFARYVFRYLAAEV--- | .||. ||. . .|...|| .|||| .|||| |||||.|.|||| |.|.. .. . . || .|. DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH ---KNLTICERHGLLLEELVKWS-PHRSNYARQ .. .|.| |.||| ... . |.. . .. CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | LmjF14.0020.AA | PI3Ka | 432-588 | 34 | 1e-35 | 124.41 | Pfam | 20-200 (211) | Show / Hide |
Range on Protein: 432-588 Range on HMM: 20-200/211 Sequence Identity: 34% (63 aa) YDPLVYLTSDDKTILWKYREMLL-SLPKAMV------KEMS-AVSWLMPFGVYEARCL*RR--WSPLAAFDALELLDAHYAD--LVVREQAVEYIDK-MP ||||. ||...| .||.| .. . |||. | .. | | . | .| .| . | |. . |||||||. ..| ||. ||. ... |. YDPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMS NYELRGCILQLV*VLKYE----PYHDSALARFLLGRSLRSNHVFARYVFRYLAAEV------KNLTI-CERHGLLLEELVK ..|| .|||| .|||| |.|||.|.|||| |.... ... | |...|. .. .. |.| |.||| ... DDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCR |
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| PI3Kc | LmjF14.0020.AA | PI3Kc | 683-938 | 27 | 5.2e-63 | 216.55 | SMART | 4-336 (336) | Show / Hide |
Range on Protein: 683-938
Range on HMM: 4-336/336
Sequence Identity: 27% (92 aa)
FKPGDDLSQVLLTLQLLEFTDNLWKAS----GLDLHLIPYGCISTGEGVGMMEVVSNSGTIAKIT-----------------------------------
||.|||| | ...|... ...|. ..|||. ||.||.||.. ||.|.|.|. |...|
FKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYMMIW
--------------------SHEGGAQAAFNVDPVINWLRVFSHDR-GEVERCLWNVVRSVAGYTAATYALGIGDRHNDNIMLR-QDGTLFHNDFGHFLG
..|| ..|.... .|.. . | .. . .| .||.||| .|| ||||||||||||| ..| .|| ||||..|
HQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFG
NFKKFGIK----RETACFIFTPMYLHAMGGS--SSPIFKYFVDVACRTCNALRRNSSALMMRFMLVLSTGI-PERQTL-EDIEWLRAVLLPS-RTDEEAS
...|. ||.. |..|......|||. |. |.||.. .||. .|.|..| ..| | . ....| |. . .||. ||. . .. .||||.
HGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAA
EHY------KNLNHALSNFRTLLSDYIH-IMMH
.. | ..| .. . | . . .| ....
QYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | LmjF14.0020.AA | PI3_PI4_kinase | 683-891 | 25 | 1.3e-46 | 166.01 | Pfam | 6-300 (300) | Show / Hide |
Range on Protein: 683-891 Range on HMM: 6-300/300 Sequence Identity: 25% (76 aa) FKPGDDLS--QVLLTLQLL-----------------------EFTDNLWKASGLDLH----LIPYGCISTGEGVGMMEVVSNSGTIAKITSHEG--GAQA || |||| | ...|.. .. ...|| |.|. . || ||.||.. ||.|.| |. |...| . . .. . FKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHK AFNV---------------------------------DPVINWLRVFSHDR-GEVERCLWNVVRSVAGYTAATYALGIGDRHNDNIML---RQDGTLFHN .|| . .|.. . | .| .. | |||.||. ..| ||.|||||||||. . .| ||| HFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHI DFGHFLG-NFKKFGIKRETACFIFTP------MYLHAMGG----SSSPIFKYFVDVACRTCNALRRNSSALMMRF-------MLVLSTGIPERQT ||||... |...|.|. | .|. .. ||||| |. . | |. ... .||||.. ..|. . . . .|.|. DFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | LmjF14.0020.AA | FRAP | 778-817 | 53 | 3.6e-08 | 26.27 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 778-817 Range on HMM: 139-179/251 Sequence Identity: 53% (22 aa) NVVRSVAGYTAATYALGIGDRHNDNIML-RQDGTLFHNDFG | || | | | ||.|||| |||| |. | . | ||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | LmjF14.0020.AA | ATR | 778-878 | 25 | 4e-06 | 16.32 | In-house | 166-267 (267) | Show / Hide |
Range on Protein: 778-878 Range on HMM: 166-267/267 Sequence Identity: 25% (26 aa) NVVRSVAGYTAATYALGIGDRHNDNIMLRQ-DGTLFHNDFGHFLGNFKKFGIKRETACFIFTPMYLHAMGG-SSSPIFKYFVDVACRTCNALRRNSSALM | .|| | .. | .|.|||| |||.. . | . | |. . ..| . |. | | .|| . .|. . | .. | . ... NYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVW MRF | DCF |
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| Kinase | LmjF14.0020.AA | PIKK | 781-818 | 46 | 1.6e-05 | 16.51 | In-house | 191-229 (290) | Show / Hide |
Range on Protein: 781-818 Range on HMM: 191-229/290 Sequence Identity: 46% (18 aa) RSVAGYTAATYALGIGDRHNDNIMLRQD-GTLFHNDFGH ||.| . |.||.|||| .|||. .. | . | |||. RSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | LmjF14.0020.AA | ATM | 781-817 | 47 | 0.000127 | 10.25 | In-house | 142-179 (304) | Show / Hide |
Range on Protein: 781-817 Range on HMM: 142-179/304 Sequence Identity: 47% (18 aa) RSVAGYTAATYALGIGDRHNDNIML-RQDGTLFHNDFG |||| | ||.|||| ||.. | | | | | RSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG |
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