Gene LmjF02.0120 (L.major)
LmjF02.0120
Species: L.major
Alias: LmajK172, LmjF02.0120
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF02.0120.AA | Protein | None | 4905 | None | Fasta, JSON |
| LmjF02.0120.kin_dom | Protein Kinase Domain | None | 336 | None | Fasta, JSON |
Protein domains of LmjF02.0120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | LmjF02.0120.AA | ATM | 4567-4817 | 43 | 7e-79 | 251.62 | In-house | 1-250 (304) | Show / Hide |
Range on Protein: 4567-4817 Range on HMM: 1-250/304 Sequence Identity: 43% (111 aa) RQLLKAGDDLRQDALIEQVFATANRLFRRRSAT--RPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYLTGRYTGKEEVPGAHERYFPGEPNTRECR---I ||| | ||||||| . ||| | | | | | | | |. .|||. .|.| | ||| ...| |. ||| || | . | . RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFL----INNED--GAHKRYRPNDFSAFQCQKKMM QLQNAPQSSKCQVLLSLYEKFTPALHYFFLEEYLSAQVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHIDLGIAFDQNKLLPVPELV | | | . | | || .| .| .| .. .||||| |||||| .||||||. |||. ||.||||||.||.| |.|| || | EVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETV PFRLTRNMIDGLGVRGTEGSLRPCAEAAMHLLRGKRELIRTILSSIMHDPLARWAI |||||| ..||.|. | || | | | | .| | . || .. ||| | . PFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM |
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| Kinase | LmjF02.0120.AA | PIKK | 4561-4807 | 30 | 4.7e-73 | 249.0 | In-house | 26-290 (290) | Show / Hide |
Range on Protein: 4561-4807
Range on HMM: 26-290/290
Sequence Identity: 30% (82 aa)
SDGTVVRQLLKAGDDLRQDALIEQVFATANRLFRRR--SATRPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYLTGRYTGK--EEVPGAHERYFP-----
.|| ..|.| ..|||||. ..|.| |...... . .| |.|||....|. . |...||... .|.| .. .. .| .. ..| .| .
HDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCMYRD
-------GEPNTRECRIQLQNAPQSSKCQVLLSLYEK-FTPALHYFFLEEYLSAQVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHI
. . . .| .|.. | .|. . .. . . ....|.. .... | .| . .|||.| ...||| |||||| .||.. . |.|.|||
WLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHI
DLGIAFD-QNKLLPVPELVPFRLTRNMIDGLGVRGTEGSLRPCAEAAMHLLRGKRELIRTILSSI
|.| .| . . |||||.|||||||||....|. |.|| .| | |..|...| .|| . |..
DFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
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| Kinase | LmjF02.0120.AA | PI3Kc | 4567-4869 | 21 | 1e-54 | 189.02 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 4567-4869 Range on HMM: 1-336/336 Sequence Identity: 21% (75 aa) RQLLKAGDDLRQDALIEQVFATANRLFRRR--SATRPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYLTGRYTGKE----------------EVPGAHER . ..|.|||||||... |.| . |.. .. .. |.|..|.. ..|. | |...|| .. .| . . ... | | . AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM YFPGEPNTREC--RIQLQNAPQSSKCQVLLSLYE-KFTPALHYFFLEEYLSAQ-VWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHID | ... .. .| . |.. .. .... . ...| |. .|.| . .. .|.... .||||.|. ..|.| |.|||| .||.|.. | ...||| Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID LGIAFDQNKLLPVP-----ELVPFRLTRNMIDGLG----VRGTEGSLRPCAEAAMHLLRGKRELIRTILSSIMHDPL-ARWAIGSPTHANHIMGAGAGDM .| .|.. ...|.. |.||||||..|... | . | .| | |.. |. ..| ..|| .... ..||. | . .. . .. . FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLD -PQESNTRQPA----PVRTHGSS-ADAARTLARIDAKLRGY . . .| . .. ...| . .. .. ....| HLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | LmjF02.0120.AA | ATR | 4536-4807 | 28 | 9.1e-47 | 157.16 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 4536-4807 Range on HMM: 2-267/267 Sequence Identity: 28% (78 aa) RVMRYRDYFTTPGGVNVPKVLQCELSDGTVVRQLLKAGDDLRQDALIEQVFATANRLFRR--RSATRPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYLT . . | . || . ||| . | ||||.| .. |.. |. .. | ...||....|| ..|. ||. |. | |. YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD GRYTGKEEVPGAHERYFPGEPNTRECRIQLQNAPQSSKCQVL-LSLYEKFTPALHYFFLEEYLSAQVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNIL . |. .. | | .. . .. | .|. | . | | .|. .. .| | .. . || |. ..||| .|||||| .||| KLWKEKKQYMQFYQ--------LRQCMDKKSRE-EWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNIL LHKGTAEVVHIDLGIAFDQNKLLPVPELVPFRLTRNMIDGLGVRGTEGSLRPCAEAAMHLLRGKRELIRTILSSI . | . |.||.| . | . . . |||.||||||.||. |.| .|.| | | | ..| .|. | .. IDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | LmjF02.0120.AA | PI3_PI4_kinase | 4681-4817 | 28 | 1.2e-37 | 136.16 | Pfam | 140-300 (300) | Show / Hide |
Range on Protein: 4681-4817 Range on HMM: 140-300/300 Sequence Identity: 28% (46 aa) KFTPALHYFFLEEYLSA-QVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILL--HKGTAEVVHIDLGIAFD--QNKLLPVPELVPFRLTR------NM ...|.|. .|.. . .| | .. ..|.||.| ..|.| |.|||| .||.. .|.| ...||| |..|. . | ...||.||||.|. .| TPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPM IDGL------GVRGTEGSLRPCAEAAMHLLRGKRELIRTIL-------SSIMHDPLARWAI .... .. | .| .| . . |. .|| .|. . | . .||.| .| VHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | LmjF02.0120.AA | FRAP | 4696-4817 | 37 | 5.5e-28 | 99.29 | In-house | 129-251 (251) | Show / Hide |
Range on Protein: 4696-4817 Range on HMM: 129-251/251 Sequence Identity: 37% (47 aa) SAQVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHIDLG----IAFDQNKLLPVPELVPFRLTRNMIDGLGVRGTEGSLRPCAEAAMH . .| .| .||| | |..|| |||||| ||.| . | .|||| | .| |. ||..|||||| .. . . | || | | | NSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKF---PEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMK LLRGKRELIRTILSSIMHDPLARWAI .| ..| . .| ||| | . VIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | LmjF02.0120.AA | SMG1 | 4705-4759 | 54 | 3.3e-19 | 60.13 | In-house | 188-242 (242) | Show / Hide |
Range on Protein: 4705-4759 Range on HMM: 188-242/242 Sequence Identity: 54% (30 aa) QTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHIDLGIAFDQNKLLPVPE | . || | |.||| .||||||. |.|. | |||||| | |.. | | ||| QSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
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| Kinase | LmjF02.0120.AA | DNAPK | 4716-4817 | 31 | 1.1e-15 | 53.44 | In-house | 199-301 (301) | Show / Hide |
Range on Protein: 4716-4817 Range on HMM: 199-301/301 Sequence Identity: 31% (32 aa) IVGYTVGLGDRHINNILLHKGTAEVVHIDLGIAFD-QNKLLPVPELVPFRLTRNMIDGLGVRGTEGSLRPCAEAAMHLLRGKRELIRTILSSIMHDPLAR | .. | |||| || . . ... || | .| |||||| |||||| | . . | .. .| .| .| . ||. ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD WAI | WKN |
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| Kinase | LmjF02.0120.AA | PI3_PI4_kinase | 4565-4628 | 18 | 3.1e-13 | 50.63 | Pfam | 1-91 (300) | Show / Hide |
Range on Protein: 4565-4628 Range on HMM: 1-91/300 Sequence Identity: 18% (17 aa) VVRQLLKAGDDLR--QDALIEQVF-----------------------ATANRLFRRRSATRP--LQIRTFTIVPLAPTAGILQWVEHTIPL .....| ||||| ||....| . . |.. . ....| .|.... ..|..| |...||... .. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTF |
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| Kinase | LmjF02.0120.AA | DNAPK | 4569-4632 | 37 | 6.1e-10 | 32.19 | In-house | 36-101 (301) | Show / Hide |
Range on Protein: 4569-4632 Range on HMM: 36-101/301 Sequence Identity: 37% (25 aa) LLKAGDDLRQDALIEQVFATANRLFRRRSA--TRPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYL . | . ||||| ||| | | | .. | || ||. |.|. | . ||. | | . | CYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
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| Kinase | LmjF02.0120.AA | FRAP | 4569-4624 | 37 | 7.7e-08 | 25.03 | In-house | 5-62 (251) | Show / Hide |
Range on Protein: 4569-4624 Range on HMM: 5-62/251 Sequence Identity: 37% (22 aa) LLKAGDDLRQDALIEQVFATANRLFRRRSAT--RPLQIRTFTIVPLAPTAGILQWVEH ||| .|.||| . | |. ||| . | . | |. . |.|| .|.. ||.| LLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH |
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| Kinase | LmjF02.0120.AA | SMG1 | 4544-4628 | 31 | 0.005753 | 5.49 | In-house | 1-87 (242) | Show / Hide |
Range on Protein: 4544-4628 Range on HMM: 1-87/242 Sequence Identity: 31% (27 aa) FTTPGGVNVPKVLQCELSDGTVVRQLLKAGDDLRQDALIEQVFATANRLFR--RRSATRPLQIRTFTIVPLAPTAGILQWVEHTIPL | || | ||| | | .|| | | | . | .| | | | . . || .|..|||. || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL |
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| FATC | LmjF02.0120.AA | FATC | 4873-4905 | 36 | 6.2e-09 | 31.64 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 4873-4905 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) DMLSVPTHVRKLMEDAQRVESLAVMFPGWSQWV |||. .|..| ..| .| |..|..||. |. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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