LmjF20.1120

Species: L.major
Alias: LmjF20.1120, LmajK174
External Links:
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
LmjF20.1120.AA Protein None 3279 None Fasta, JSON
LmjF20.1120.kin_dom Protein Kinase Domain None 314 None Fasta, JSON

Protein domain

Protein domains of LmjF20.1120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT LmjF20.1120.AA FAT 2266-2626 16 2.1e-15 51.81 Pfam 1-408 (408) Show / Hide
Range on Protein: 2266-2626
Range on HMM: 1-408/408
Sequence Identity: 16% (76 aa)

ARCGATAAWLLGRWDD--VQHLAERLS--------------MSEQHTTALRLFFLNGVAL---KSAITEHSSAAYENLRHMITQSKLVIDESLRT-LLPL
|. .| ||| || ||.   ..  . .               .. . .|  | ||    .|   .. .. . .|..      | .     |. ..  |  .
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDE-PTWDRSFFQAILCLYKHHNQFDTY-EAHR-----YIDKARQLLDTEWTACLPGE

SYTHAYESLTMLQHFTEMEEMIDYC-HCRST---------KGRQQIYERWNNRFRSLNPDSLQPSLLSLMLHSLVLS--------------TGEMADMIL
||  .|  .  .|  .|.|| | |.  | ..           . .. . |..| .    . .      |.....|.|              . | ..|..
SYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWI

HFCE-TRQASHPQLAEWAMSWLR---------HGSFSGRSSNLCSPSVASPASPGPVEGITVTTLSSADKNPKVAVGFITHLWSQGKRQAAVESMEMFLR
 | .  | . ..||.| ... |.         |.                                     | . .    ..|..|..| | . .. |. 
KFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP----------------------------------RAPPQWTYAYLKYMWATGQQQEAFQHLREFTS

-DCGRD-----------------------LEENNATCYG-DAQLRLGTWKQEL---HADSFWERGFRDEELGHFHKAIRAVPSSYE-AWHSWGLMNYRIQ
     |                       ||. ..  ..  . ...| | ..|     .. |...  || |.....|.   |..|. |||.|.|.| .. 
CHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVF

QRDHNLSP-------EDQRTFVEAAHQGFVGAICRCKDSSEALPAVMRLLQ
| . . .        ... ..|  | ..|  .|  ..  |...    |||.
QHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQG-SNSRQDTLRLLW

Kinase LmjF20.1120.AA FRAP 2927-3180 42 1.7e-89 303.59 In-house 2-251 (251) Show / Hide
Range on Protein: 2927-3180
Range on HMM: 2-251/251
Sequence Identity: 42% (109 aa)

YTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISS--SAYIHRFPVIPISSNVGLLGWVENANTINNTICNYRSNISNVRTHQESSVLRAYVGSFGNWDK
| . ||| |||| ||||||| |..| ||     .      | |. .||.| | ||.|||..  |.   | .||    ..|   |    . .  .. ..|.
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKY-HIRYNIE---YNIMDRMCNDYDH

LSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETI
| |... ||  ..|.    |  |  . .| .    | |..||| .| |||||||.||.|||||||. ||..   .|||||||||| |.|   |  .|| |
LPLMNKVEIFRYIMNNTKGE--DLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKI

PFRLTRMLTNAMEVFGVDGVFR-ASATRTQTTLHKNRDSIMALLSAFVHDPIVQYKG
||||||||.||||. |..| .| ....  .  .  ...|.|| | ||| ||.  .. 
PFRLTRMLVNAMEACGIEGNYRNTCELVMK-VIREHKESVMAVLEAFVYDPLFYWRL

Kinase LmjF20.1120.AA PIKK 3050-3170 44 5.7e-57 195.58 In-house 170-290 (290) Show / Hide
Range on Protein: 3050-3170
Range on HMM: 170-290/290
Sequence Identity: 44% (54 aa)

RAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASA
.. |... ..|.|..||...| |.|.|.||||.|||||||. ||.| |..|.|||||||..| ..  |   ||..||||||...|||...||.||||.. 
KWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCC

TRTQTTLHKNRDSIMALLSAF
  .   . ..|...|... .|
EHVMMCMRQHRETLMTVCEVF

Kinase LmjF20.1120.AA PI3_PI4_kinase 2926-3180 21 2.5e-51 181.63 Pfam 1-300 (300) Show / Hide
Range on Protein: 2926-3180
Range on HMM: 1-300/300
Sequence Identity: 21% (68 aa)

LYTYCLKGNEDIR--MDERVMQLL-----------------------GMVNVLLSHTRISSS--AYIHRFPVIPISSNVGLLGWVENANTINNTICNYR-
 | . .||..| |   |.|.||..                       ...| ...  . .      .. . .|| ... |...||.|. |... ...|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

---------SNISNVRTHQESSVLRAYVGSFGNWDKLSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTA-EQWLDRRTAFTVSLATMSMVGYVLGLGD
         ... ... ...   |              ..|..|.  | |..     ..  .  |    .| | |...|. |. |.| |..|.|.||.||
KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEV--FEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGD

RHLGNILI--SMSSGKIVHIDFGDSFD-VGRLRHVLPETIPFRLTR------MLTNAM------EVFGVDGVFRASATRTQTTLHKNRDSIMALL-----
||..||..   ...|...|||||..|. .   .   ||..|||.|.      .. .||      ...| .| || .  ..   | .. ...|.||     
RHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVM

--SAFVHDPIVQYKG
  ...|||...  . 
RGECMVHDGLPMWRS

Kinase LmjF20.1120.AA PI3Kc 2928-3231 17 1.6e-49 171.72 SMART 1-336 (336) Show / Hide
Range on Protein: 2928-3231
Range on HMM: 1-336/336
Sequence Identity: 17% (67 aa)

TYCLKGNEDIRMDERVMQLLGMVNVLLSHT----RISSSAYIHRFPVIPISSNVGLLGWVENANTINNTICNYRSNIS----------------------
   .|...| | |.|.||.....| ...      |   . .. .. .||.... |...|| |. |. .  ..|. . .                      
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRR--DLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNM

------------------------------NVRTHQESSVLRAYVGSFGNWDKLSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTAEQWLDRRTAFTV
                              ..  ... . .   .  |.. .                                    | | ..|. || 
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN------------------------------------EDWWEARDNFTR

SLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLP----ETIPFRLTRMLTNAME----VFGVDGVFRASATRTQTTLHKNRDSI
|.| ..||.|.||.||||..||.. | .|...|||||. |. |..... .    |. |||||... ..|.    . |..| ||  . |. . . |....|
SCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLI

MALLSAFVHDPI-VQYKGK--MKNIMEKSRSPQ-DIAERIRNKLRGT-EMAIDHSK-VNIFNTTQDSCRRPDLL
|.|....|.|||  . ...  ...  ...  ..    | ....   | . .....     .......  .   .
MNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase LmjF20.1120.AA ATR 3059-3170 37 5.7e-33 109.39 In-house 157-267 (267) Show / Hide
Range on Protein: 3059-3170
Range on HMM: 157-267/267
Sequence Identity: 37% (42 aa)

AEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASATRTQTTLHK
..||   | ..  | | ..||||..||||||  ||||    | .||.|.   |  |.   | ||..|||||. . ..|  .. .|.||     .   . .
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

NRDSIMALLSAF
.|| ||... .|
HRDDIMSVWDCF

Kinase LmjF20.1120.AA ATM 3062-3175 42 1.4e-32 101.17 In-house 133-245 (304) Show / Hide
Range on Protein: 3062-3175
Range on HMM: 133-245/304
Sequence Identity: 42% (49 aa)

WLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASATRTQTTLHKNRD
| ..| |.| | || |.|||.|||||||  ||||   |  .|||| |  |. |..    |||.|||||| .   | . ||.||||    .|   .    .
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SIMALLSAFVHDPI
 .. .    . ||.
TLLTIVEVLLYDPL

Kinase LmjF20.1120.AA PIKK 2897-2998 32 1.4e-28 101.23 In-house 1-104 (290) Show / Hide
Range on Protein: 2897-2998
Range on HMM: 1-104/290
Sequence Identity: 32% (34 aa)

TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHT-RISSSAY-IHRFPVIPISSNVGLLGWVENANTINNTIC
 |...   . |...|..|..| . |.||  | |..|| ||.| |.|||||....| .|    . .. .. | .. ||| |.. ||..||.|. |.   . 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NYRS
....
QWCQ

Kinase LmjF20.1120.AA DNAPK 3050-3180 32 1.3e-23 82.65 In-house 171-301 (301) Show / Hide
Range on Protein: 3050-3180
Range on HMM: 171-301/301
Sequence Identity: 32% (42 aa)

RAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASA
||.   . | | .|  |  |  . |     ...|| ||||| | .. |. | |. |||| ||    .    ||  ||||||  .| |   .. |... . 
RAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIM

TRTQTTLHKNRDSIMALLSAFVHDPIVQYKG
      . | |   .     |. || .  | 
IHSMMAFRKDRNILTNFCDVFINDPSFDWKN

Kinase LmjF20.1120.AA SMG1 3052-3107 48 1.1e-16 51.64 In-house 173-228 (242) Show / Hide
Range on Protein: 3052-3107
Range on HMM: 173-228/242
Sequence Identity: 48% (27 aa)

MWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDF
.|    | . |     ..  | | ||||||..||||||| |.|| |  | .||||.
LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase LmjF20.1120.AA SMG1 2905-2986 34 2.9e-14 43.53 In-house 1-84 (242) Show / Hide
Range on Protein: 2905-2986
Range on HMM: 1-84/242
Sequence Identity: 34% (29 aa)

LDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISSSAYIH--RFPVIPISSNVGLLGWVENA
. ..| | .|...   ||||  | |  || ||. .|||.|| | .|| .            |   . | |.    ||. ||. |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA

Kinase LmjF20.1120.AA DNAPK 2897-2988 32 2.8e-12 40.82 In-house 3-96 (301) Show / Hide
Range on Protein: 2897-2988
Range on HMM: 3-96/301
Sequence Identity: 32% (31 aa)

TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLG-MVNVLLSHTRISSSAYIHR-FPVIPISSNVGLLGWVENANT
 || |  .  |. | .||.|| . | |     .| || || |.| |. ||   | |..      .. .   | . .||  .  ||. ||.|  .
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVV

Kinase LmjF20.1120.AA ATR 2897-2989 28 4.7e-12 36.92 In-house 2-96 (267) Show / Hide
Range on Protein: 2897-2989
Range on HMM: 2-96/267
Sequence Identity: 28% (27 aa)

TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISSSAYIH--RFPVIPISSNVGLLGWVENANTI
 || |   .... | ..|..| | |||| .|    |  .|.| | | |.   ..| ..     .    .|   . |||. .. ... ||.|  |.
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL

FATC LmjF20.1120.AA FATC 3247-3279 45 7.1e-14 47.48 Pfam 1-33 (33) Show / Hide
Range on Protein: 3247-3279
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

LAMTPEEQVSFLIDEATRIDNYTTMYFGWGPLW
. ...|.||. ||.||| ..|.  || || | |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW