Gene LmjF04.0440 (L.major)

LmjF04.0440

Species: L.major
Alias: LmajK191, LmjF04.0440
External Links:
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF04.0440.AA Protein None 1367 None Fasta, JSON
LmjF04.0440.kin_dom Protein Kinase Domain None 465 None Fasta, JSON

Protein domain

Protein domains of LmjF04.0440.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF04.0440.AA STE 887-1351 15 4e-60 206.07 In-house 1-359 (359) Show / Hide 
Range on Protein: 887-1351
Range on HMM: 1-359/359
Sequence Identity: 15% (87 aa)

WRMRGYIGRGTSGVVYEGVLED-----CKQTP---------VAVKVLEVGVPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQ
|.  . ||.|..|.|| ..  .     ...           .|.|....    . | .                                     . . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-E---------------------------------NQ-EN-Q-E

------EALLVLLREVEMMEKLH--HDNIVTCLRCQV---TPVQDRYLELHQQQQQQQQCRDGGSNNGEGLSGTAAAGRDSEEVGKRRHDSAGRHYVGNG
      | .  .|.|...| |..  |.|||... | .   ..                                                          
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN----------------------------------------------------------

KAAVCDGVFSASQSPQRNAAPRIPVQVEIVMELCNRGTISSVVRR--SPGGQLP----------VRVARRYLRDVLKG-LAYLHRNNFIHRDVKGDNVLI
                         .. |.||... |........  ..|..|.            . ....|..||| |.|||... ||||.|..|.|.
--------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL

SAADVAKLADFGCSRRIVLT----------NNVHGAADSEGGTSSIATTRTAATDSRFTTMAEYQWFDTTG-VAQTMVGTPMFMAPEIIQASGPPCMTTP
     .||.|||.. ... .          ..                                   .|..   .|.|||| .||||.||  | .     
-----VKLCDFGVCGQLTDSMANIQSNNIIDC----------------------------------IETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---

TASSPASSTFEGNDGGHGSSSKATPPPAPVGYTASADIWSFGCLVLE-VFGRTPWPA-SGGNAYHLMKQIEQSVA---------DLPPGVPDGTP-----
                              ||....||||.||...| . |. ||   .   |. .. .   ...         . ||  || .      
----------------------------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMI

--------------AELLDLLRCCFHRDPHRRSTARALLR--APWM
               |. | .. |. .||. | ||  ||.   |. 
SYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LmjF04.0440.AA S_TKc 887-1351 14 1.1e-46 162.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 887-1351
Range on HMM: 1-231/231
Sequence Identity: 14% (68 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEVGVPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVLLREVEMME
...   ||.|. |.|| ..  .  .  ||.|..                                                                   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------------------------------------------------------------

KLHHDNIVTCLRCQVTPVQDRYLELHQQQQQQQQCRDGGSNNGEGLSGTAAAGRDSEEVGKRRHDSAGRHYVGNGKAAVCDGVFSASQSPQRNAAPRIPV
                                                                    |  .   |   .. .     . |         
-----------------------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-------D

QVEIVMELCNR--GTISSVVRRSPG----GQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFGCSRRIVLTNNVHGAADSEGG
 . .|||.|.   |.  .. .. ..     ..|  .||.|.. ....|.|.|....||||.| .|.|..   . |..||| .|..               
HLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------

TSSIATTRTAATDSRFTTMAEYQWFDTTGVAQTMVGTPMFMAPEIIQASGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGYTA-SADIWSFG
                                |..||| .||||..                                         ||.  ..|.||.|
-------------------------------TTFCGTPWYMAPEVL-----------------------------------------GYGKCKCDWWSCG

CLVLEVFG-RTPWPASGGNAYHLMKQIEQSVADLPPGVPDGTPAELLDLLRCCFHRDPHRRSTARALLR-------APWM
|.. | .  ..|.|    . . ..|.|               . |..|..| |...|| .| ||  .|.        ||.
CILYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF04.0440.AA STE11 1088-1284 26 5.6e-37 129.17 In-house 88-230 (303) Show / Hide 
Range on Protein: 1088-1284
Range on HMM: 88-230/303
Sequence Identity: 26% (57 aa)

VEIVMELCNRGTISSVVR-RSPGGQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISA-ADVAKLADFGCSRRIVLTNN--------------V
| | || |  |..||. | .   . ..  | |.| ...|.||.||| .. ||||.||.|.|. .   | |||||||..|..  ..              .
VNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSM

HGAADSEGGTSSIATTRTAATDSRFTTMAEYQWFDTTGVAQTMVGTPMFMAPEIIQ--ASGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGY
 |   .                                   .|.||||.||||.|    ..                                     ||
TGTPYN-----------------------------------SMMGTPMWMAPEVIKQEGRD-------------------------------------GY

TASADIWSFGCLVLE
...|||||.|| |.|
GRKADIWSLGCTVIE
Kinase LmjF04.0440.AA CAMK 978-1351 15 3.4e-32 100.48 In-house 78-425 (425) Show / Hide 
Range on Protein: 978-1351
Range on HMM: 78-425/425
Sequence Identity: 15% (75 aa)

LLREVEMMEK-------LHHDNIVTCLRCQVTPVQ------------------DRYLELHQQQQQQQQCRDGGSNNGEGLSGTAAAGRDSEEVGKRRHDS
..||.|.| |       |.| ||. ..    .| .                  . |. .                                         
VRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME----------------------------------------

AGRHYVGNGKAAVCDGVFSASQSPQRNAAPRIPVQVEIVMELCNRG----TISSVVRRSPG-------------GQLPVRVARRYLRDVLKGLAYLHRNN
                                      .||.|  |     . . ... ..             | .. | |||| | .. ...|.| .|
--------------------------------------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

FIHRDVKGDNVLISAAD-----------------VAKLADFGCSRRI--------------------VLTNNVHGAADSEGGTSSIATTRTAATDSRFTT
 .||| | .|.|..  .                   |..||| ....                    .                                
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW--------------------------------

MAEYQWFDTTG----VAQTMVGTPMFMA-PEIIQASGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGYTASADIWSFGCL--VLEVFGRTPW
        ||.      .|..||| .|| ||... .|   |.   | .                          .|. ..|.|| |..  .. . |. |.
--------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ-N-A-T---------------------DEEKPYYGPKCDMWSCGVILYIM-LCGYPPF

PAS-----------GGNAYHLMKQIEQSVADLPPGVPDGTP--------------------AELLDLLRCCFHRDPHRRSTARALLRAPWM
 ..           | | | |...| .   | ||   ....                    .|  ||.|..  .|| .| |.   |. |||
YGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LmjF04.0440.AA TKL 1090-1342 18 2.1e-26 92.1 In-house 115-357 (364) Show / Hide 
Range on Protein: 1090-1342
Range on HMM: 115-357/364
Sequence Identity: 18% (56 aa)

IVMELCNRGTISSVVRRSPGGQLPVRVARRYLRDVLKGLAYLHRNN--------FIHRDVKGDNVLISAADV--------------AKLADFGCSRRIVL
||||.| .|.  ...           .  |  .|. .|..||| .|         |||| | .|.|.                   .|..||| ||..  
IVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ

TNNVHGAADSEGGTSSIATTRTAATDSRFTTMAEYQWFDTTGVAQTM--VGTPMFMAPEIIQ-------ASGPPCMTTPTASSPASSTFEGNDGGHGSSS
..|    . ...   |.                |      ..  .||  .||| .||||...       ..|                            
SGNMNDTMTTMME--SA----------------E---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI---------------------------

KATPPPAPV----GYTASADIWSFGCLVLEVFGRTPWPAS-GGNAYHL------MKQIEQSVADLPPGVP------------DGTPAELLDLLRCCFHRD
      ...     |. ..|..||| .  |.. | . | .  ..  ..      . ..  ..  |.| .|            . .| .. .|. .| . |
------DEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHD

PHRRSTA
|. | ..
PEKRPSF
Kinase LmjF04.0440.AA STE11-Unclassified 1116-1226 30 4.5e-23 78.66 In-house 108-207 (308) Show / Hide 
Range on Protein: 1116-1226
Range on HMM: 108-207/308
Sequence Identity: 30% (37 aa)

VARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFGCSR-------RIVLTNNVHGAADSEGGTSSIATTRTAATDSRFTTMAEYQWF-DT
|.. | ...|.|||||| .. ||||.||.|.|| .  ..||.||||..       |.|  | .  .                          . | . . 
VIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFD----------------------HYKICQHINSQ

TGVAQTMVGTPM---FMAPEII
 .  ..| |||.    ||||.|
QNHCKSMQGTPYQPFWMAPEVI
Kinase LmjF04.0440.AA Pkinase 1209-1351 18 2.6e-22 79.98 Pfam 167-293 (293) Show / Hide 
Range on Protein: 1209-1351
Range on HMM: 167-293/293
Sequence Identity: 18% (31 aa)

GVAQTMVGTPMFMAPEIIQASGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGYTASADIWSFGCLVLEVFG-RTPWPAS----GGNAYHLMK
. ..| .||| .||||.|.                                        .|. ..|.||.||.. |..  |.|.| .    . . .....
S-MTTFCGTPWYMAPEVIR-------------------------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC

QIEQSVADLPPGVPDGTP-----------------AELLDLLRCCFHRDPHRRSTARALLRAPWM
.| .   . .   ..  .                  |..|....|...||..| ||. .|  ||.
RIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF04.0440.AA Pkinase 1090-1182 25 5.4e-22 78.85 Pfam 77-175 (293) Show / Hide 
Range on Protein: 1090-1182
Range on HMM: 77-175/293
Sequence Identity: 25% (26 aa)

IVMELCNRG----TISSVVRRSPGGQL--PVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVA----KLADFGCSRRIVLTNNVHGAADSEG
.|||.|. |      ....... .| .  . .....|.. .|.||.|.|....||||.| .|.||.  ..     |..|||... .   .   . ...  
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFC

GTS
||.
GTP
Kinase LmjF04.0440.AA MEKK15 1088-1167 40 1e-20 71.86 In-house 76-153 (264) Show / Hide 
Range on Protein: 1088-1167
Range on HMM: 76-153/264
Sequence Identity: 40% (32 aa)

VEIVMELCNRGTISSVVRRSPGGQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFGCSRRIVL
|.| |.    | |||.. |   | |.  |  .| . .|.| .||| |. .|||.|| ||.. .  . || |||| .|. .
VNIFMQFVPGGSISSIINRF--GPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCW
Kinase LmjF04.0440.AA Dicty2 1119-1160 53 2e-19 64.44 In-house 107-151 (264) Show / Hide 
Range on Protein: 1119-1160
Range on HMM: 107-151/264
Sequence Identity: 53% (24 aa)

RYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADV---AKLADFG
.|.. |||||.||||.  |||| |..| ||. . .   .||||||
IYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFG
Kinase LmjF04.0440.AA Ciliate-E2-Unclassified 1090-1165 27 5.2e-18 59.09 In-house 206-305 (352) Show / Hide 
Range on Protein: 1090-1165
Range on HMM: 206-305/352
Sequence Identity: 27% (27 aa)

IVMELCNRGTISSVVRRSPG---------------GQLPVRVAR-----RYLRDVLKGLAYLHRNN-FIHRDVKGDNVLISAAD---VAKLADFGCSRRI
||||.|. |. .   . ...                ... . |.     .|.. .|.|| |||..| .|||| | .|.|..        |..||| |...
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
Kinase LmjF04.0440.AA TK 41-1165 3 6.4e-18 55.94 In-house 82-309 (486) Show / Hide 
Range on Protein: 41-1165
Range on HMM: 82-309/486
Sequence Identity: 3% (38 aa)

GCETSHSAAPKTAGVEGGRINSVSGSGAQPRQHYRRARSIHITLRKTRSGSRPVNAQRDSSIGVSRDLGVATGVAEGRTPNTRQRHGSFGSASGALGDAV
|                                                                                                   
G---------------------------------------------------------------------------------------------------

SPTSTATVTGTPTGAGGAAASSPFTFPVVSGCVSPKLTPRHHDAMSASLTVTAGGAHRAPLFDDVANSNNNPNSCGSSRIMNSSSYTPYILHTHGRSGDG
                                                                                                    
----------------------------------------------------------------------------------------------------

TASDSTTAAAAPAINMQTTGAAATNVGSSSSSMVGGAGGSSSSVGPSSGSCVPTVHGVGYFNTFVKAIHPSDMKQALLPPNMRDRAVVLGMKHGDQAAEA
                                                                                                    
----------------------------------------------------------------------------------------------------

MAAHRRPFSSGAISRRSSSFSGNHGRVHHHPSVSRAQAVSQRSHASGYSGGLRSSSMSGCHTAAGIYNGKNSSHRHATATHGLQDCAPPYPDSASVALHP
                                                                                                    
----------------------------------------------------------------------------------------------------

QPHQQQQPGHPPTPAWRGHLSSMPTVNLGTSPRLSPSAVPAAASDQQDQHRRHYRARSYTVGGRVRSSSSSSGGGAVVVATAADATTPNASGRVGYVDSA
                                                                                                    
----------------------------------------------------------------------------------------------------

PSPSPNRSVSLASSSPTAAAPVFGAVATTAAGQCSRTSTLIHHPSLSREGSSVETTMTAITATLPPASPLPAYTESRASSAVTGTMTPRTPRPANAAIEA
                                                                                                    
----------------------------------------------------------------------------------------------------

AAAGISSAQRGIRLIEHPSHGASSGQQRSVSSDIVNGLDDSVDSVRCGSVPSASNTSAANMMGSASGTLDRYNYGGATAASRQGGTAVFATSHRYARDSV
                                                                                                    
----------------------------------------------------------------------------------------------------

ASEDKTDDEGRRHRGPLRRYSTTLTNTTTEDEDEPQQQLAQPSTLELLRGNHLRRESGAGGGGGNVNVAAVLSRARAARASATGAAAAGATNRDGSPTTA
                                                                                                    
----------------------------------------------------------------------------------------------------

IERWRAQEQQRKRDEERQQQRQRQRQRLSARQWREAFHRLQEKRVRWRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEVGVPIPVDLDTSGDDNDGQS
                                                                                                    
----------------------------------------------------------------------------------------------------

SRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVLLREVEMMEKLH-----HDNIVTCLRCQVTPVQDRYLELHQQQQQQQQCRDGGSNNGEGLSGT
                                   .  |.|.|.|....     |.||| .. . . ..  . .|                         
-----------------------------------EDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFE-------------------------

AAAGRDSEEVGKRRHDSAGRHYVGNGKAAVCDGVFSASQSPQRNAAPRIPVQVE-----IVMELCNRGT----ISSVVRRSPGG----------------
                                                . | |.     ||||... |       .  |.....                
------------------------------------------------V-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYP

--------------------------------------QLPVRVARR-------------------YLRDVLKGLAYLHRN------NFIHRDVKGDNVL
                                      .|. .   .                   . ... .|..|||..      ||.|||.   |.|
PSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCL

ISAADV-----------AKLADFG--------CSRRI
..  .|           .|.||||         .|.|
VGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDI
Kinase LmjF04.0440.AA STE20 1090-1160 38 2e-17 60.51 In-house 85-162 (288) Show / Hide 
Range on Protein: 1090-1160
Range on HMM: 85-162/288
Sequence Identity: 38% (30 aa)

IVMELCNRGTISSVVRRSP--GG-----QLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFG
||||.|. |... .....   |.      .        .|.||.||.|||.|. ||||.|.||.|..    .||||||
IVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFG
Kinase LmjF04.0440.AA STE11-Unclassified 1268-1351 32 6.3e-14 45.8 In-house 214-308 (308) Show / Hide 
Range on Protein: 1268-1351
Range on HMM: 214-308/308
Sequence Identity: 32% (32 aa)

GYTASADIWSFGCLVLEVF-GRTPWPASGGNAYH--LMKQIEQSV-ADLPPGVPDGTP-----------AELLDLLRCCFHRDPHRRSTARALLRAPWM
|.....||||.||.|.| . |. ||.    |     .|. |   | .. .|  |  .            .|. |.|| || .||. | ||. ||  |. 
GHCRKSDIWSLGCTVIEMATGKHPWS----NCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTANQLLQHPFI
Kinase LmjF04.0440.AA Pkinase_Tyr 1090-1165 32 1.5e-12 43.15 Pfam 84-161 (270) Show / Hide 
Range on Protein: 1090-1165
Range on HMM: 84-161/270
Sequence Identity: 32% (25 aa)

IVMELCNRGTISSVVRRS--PGGQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFGCSRRI
||||..  |   .  |.   ....|..     . ... ||..||...|.||||.   |.|..   |.| .||| .| |
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LmjF04.0440.AA TK 1269-1349 21 9.2e-12 34.93 In-house 371-486 (486) Show / Hide 
Range on Protein: 1269-1349
Range on HMM: 371-486/486
Sequence Identity: 21% (25 aa)

YTASADIWSFGCLVLEVF--GRTPWPASGGN--------AYHLMKQIEQS-----------VADLPPGVPDGTP--------------AELLDLLRCCFH
.|   |.||||.|. |.|  |..|..    |           .|.....               ...  |.. |              .|. ||...|.|
FTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWH

RDPHRRSTARALLRAP
.|| .| | ..|... 
YDPEDRPTFSQLHEQL
Kinase LmjF04.0440.AA TyrKc 887-1349 11 2.7e-11 -40.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 887-1349
Range on HMM: 1-280/280
Sequence Identity: 11% (59 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEVGVPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVLLREVEMME
 ..   .|.|  |.||.|..     ..||||.|  .                                                    .  ..|| ..| 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---------------------------------------------------REDFMREARIMC

KL--HHDNIVTCLRCQV---------TPVQ-----------DRYLELHQQQQQQQQCRDGGSNNGEGLSGTAAAGRDSEEVGKRRHDSAGRHYVGNGKAA
||  ||.||| .. . .          |.            . ||  |. .                                                 
KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-------------------------------------------------

VCDGVFSASQSPQRNAAPRIPVQVEIVMELCNRGTISSVVRRSPGGQLPVRVARRYLRDVLKGLAYLHRNNFIHRDVKGDNVLISAADVAKLADFGCSRR
                                               |...    .  .. .| .|||..|.||||    |.|...  ..| .||| || 
-----------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD

IVLT------NNVHGAADSEGGTS----------SIATTRTAATDSRFT----------------TMAEYQWFDT----TGVAQTMVGTPMFMAPEIIQA
|           .  .. ..|| .          .|        ...||                |  .  . .        .. .      . ... . 
IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPN

----SGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGYTASADIWSFGCLVLEVFGRTPWPASGGNAYHLMKQIEQSVADLPPGVPDGTPAEL
    |                                                                                         . |.|.
DYPMS--------------------------------------------------------------------------------------F-VCCPDEM

LDLLRCCFHRDPHRRSTARALLRAP
 .. ..| |.||. | | ... .  
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF04.0440.AA Dicty2 1268-1351 36 2.3e-10 32.46 In-house 183-264 (264) Show / Hide 
Range on Protein: 1268-1351
Range on HMM: 183-264/264
Sequence Identity: 36% (31 aa)

G--YTASADIWSFGCLVLEVFGRTPWPASGGNAYHLMKQIEQSVADLPPGVPDGTPAELLDLLRCCFHRDPHRRSTARALLRAPWM
|   . . |||| || ..| .  .| | ...|  | |  .   | |  |  |..  .|..| |  || .||  |.||  ||  || 
GNHCCTACDIWSLGCTIIELLTGNP-PYWDLNPMHAMFRM---VQDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase LmjF04.0440.AA Ciliate-E2-Unclassified 1211-1351 17 1.9e-09 28.94 In-house 219-352 (352) Show / Hide 
Range on Protein: 1211-1351
Range on HMM: 219-352/352
Sequence Identity: 17% (30 aa)

AQTMVGTPMFM----APEIIQASGPPCMTTPTASSPASSTFEGNDGGHGSSSKATPPPAPVGYTASADIWSFGCLVLE-VFGRTPWPASGGNAYH-----
..|..|||..|    |||..|  ..  ..                                    ..||||.|..  | .||. | ..   . .      
MWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----------------------------------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQ

---------LMKQIEQSVADLPPGVP----DGTPAELLDLLR----CCFHRDPHRRSTARALLRAPWM
         | ..| |   . |.  .    .. . |  |...    ...  .|  | |.  .|  ||.
WINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase LmjF04.0440.AA MEKK15 1268-1351 34 4.1e-08 25.53 In-house 183-264 (264) Show / Hide 
Range on Protein: 1268-1351
Range on HMM: 183-264/264
Sequence Identity: 34% (29 aa)

GYTASADIWSFGCLVLEVFGRTPWPASGGNAYHLMKQIEQSVADLPPGVPDGTPAELLDLLRCCFHRDPHRRSTARALLRAPWM
||   .|||| || | |.  | | |    .    |  |  .  |. | .|.    .  .  | |  || | |.||  ||. |..
GYGRKSDIWSIGCTVFEMATRKP-PWADMDRMAAMFYIG-AHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase LmjF04.0440.AA STE20 887-995 15 2.5e-07 23.15 In-house 1-68 (288) Show / Hide 
Range on Protein: 887-995
Range on HMM: 1-68/288
Sequence Identity: 15% (18 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTP------VAVKVLEVGVPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVLLR
. .   ||.|..|.|| .    .|.|       ||.|....  . .                                            | . .  .. 
YELLEKIGQGSYGKVYKA---YHKPTGEYCNQRVAIKKMNLEKCDNE-------------------------------------------Q-DEWEDIQK

EVEMMEKLHHDNIVT
|. .| ...| |||.
EISIMKQCKHPNIVK
Kinase LmjF04.0440.AA TKL 893-997 18 4.9e-07 21.38 In-house 55-145 (364) Show / Hide 
Range on Protein: 893-997
Range on HMM: 55-145/364
Sequence Identity: 18% (22 aa)

IGRGTSGVVYEGVLED-------CKQTPVAVKVLEVGVPIPVDL------DTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACM---SPSQQEALL
||.|..|.|| |..          . ..||||.. .      ..      | .. ..                            . |   .| .. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENND-NN-NY---------------------------SD-MQLNDPEASWFRF

VLLREVEMMEKLHHDNIVTCL
 . .|. || .|.|.||| ..
FEEEEIMMMSRLRHPNIVQFM
Kinase LmjF04.0440.AA STE11 1321-1351 41 2e-05 15.87 In-house 268-303 (303) Show / Hide 
Range on Protein: 1321-1351
Range on HMM: 268-303/303
Sequence Identity: 41% (15 aa)

P-----AELLDLLRCCFHRDPHRRSTARALLRAPWM
|     .|. | || || .||. | ||. ||. |. 
PISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase LmjF04.0440.AA STE20 1207-1230 43 2.4e-05 15.83 In-house 174-203 (288) Show / Hide 
Range on Protein: 1207-1230
Range on HMM: 174-203/288
Sequence Identity: 43% (13 aa)

TTG-VAQTMVGTPMFMAPEIIQA-----SG
| .   .|.|||| .||||.||      .|
TMQFKRNTFVGTPYWMAPEVIQCMEGPDKG
Kinase LmjF04.0440.AA CAMK 892-920 20 0.000162 9.68 In-house 267-306 (425) Show / Hide 
Range on Protein: 892-920
Range on HMM: 267-306/425
Sequence Identity: 20% (8 aa)

YIGRGTSGVVYEGVLEDCKQ-----------TPVAVKVLE
 .|||. |.|....    ..           . ||.|...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID
Kinase LmjF04.0440.AA STE11-Unclassified 887-995 17 0.000194 11.71 In-house 1-69 (308) Show / Hide 
Range on Protein: 887-995
Range on HMM: 1-69/308
Sequence Identity: 17% (20 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEV-GVPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVL-----LR
|  .  ||.|. | || ..  .  .  .||| .|. .  .                                             |||...         
WQKGEFIGKGSFGQVYKCMNCNTGEF-MAVKQIEIHDYNS---------------------------------------------QQEDMQKEMIQSIQK

EVEMMEKLHHDNIVT
|.. ...|.|.|||.
EMKVLKQLNHKNIVQ
Kinase LmjF04.0440.AA Pkinase 887-1003 14 0.000362 15.82 Pfam 1-72 (293) Show / Hide 
Range on Protein: 887-1003
Range on HMM: 1-72/293
Sequence Identity: 14% (18 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEVGVPIPVD------LDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLVLLR
..  . ||.|..|.||...  .  .  ||||....    .        |                                                  .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL--------------------------------------------------S

EVEMMEKLHHDNIVTCLRCQVTP
|...| .|.|.|||.....  ..
EIQIMKRLNHPNIVRLYDWFEDK
Kinase LmjF04.0440.AA Dicty2 1213-1230 72 0.000518 10.05 In-house 166-183 (264) Show / Hide 
Range on Protein: 1213-1230
Range on HMM: 166-183/264
Sequence Identity: 72% (13 aa)

TMVGTPMFMAPEIIQASG
| ||||  ||||.|| ||
TVVGTPYWMAPEVIQMSG
Kinase LmjF04.0440.AA STE11 887-994 16 0.000535 10.68 In-house 1-73 (303) Show / Hide 
Range on Protein: 887-994
Range on HMM: 1-73/303
Sequence Identity: 16% (20 aa)

WRMRGYIGRGTSGVVYEGVLEDCKQTPVAVKVLEV----G-VPIPVDLDTSGDDNDGQSSRQARYTENSGAPTSAADAAAADAACMSPSQQEALLV----
|. .  ||.|. |.|| ..  |  .  .|||  |.                                                    . |.. .      
WQKGEIIGKGAFGTVYKCMNVDTGEL-MAVKQIEIQNNNQMK---------------------------------------------EDQEKEYQSHKMH

--LLREVEMMEKLHHDNIV
  .  |...|..|.| |||
KAIQEEIKLMKHLNHKNIV
Kinase LmjF04.0440.AA STE20 1323-1351 37 0.00196 8.76 In-house 260-288 (288) Show / Hide 
Range on Protein: 1323-1351
Range on HMM: 260-288/288
Sequence Identity: 37% (11 aa)

ELLDLLRCCFHRDPHRRSTARALLRAPWM
|. |..  |  .||. | ||  ||. |. 
EFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase LmjF04.0440.AA MEKK15 1210-1230 47 0.005854 6.61 In-house 163-183 (264) Show / Hide 
Range on Protein: 1210-1230
Range on HMM: 163-183/264
Sequence Identity: 47% (10 aa)

VAQTMVGTPMFMAPEIIQASG
. . | ||| .||||.|. .|
MLKSMRGTPYWMAPEVIMETG
Kinase LmjF04.0440.AA Pkinase_Tyr 880-919 30 0.015424 9.22 Pfam 1-36 (270) Show / Hide 
Range on Protein: 880-919
Range on HMM: 1-36/270
Sequence Identity: 30% (13 aa)

LQEKRVRWRMRGYIGRGTSGVVYEGVLE---DCKQTPVAVKVL
..  ..       .|.|  |.||.|..    | ...|||||.|
ITFGKK-------LGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase LmjF04.0440.AA Pkinase_Tyr 1269-1347 30 0.01767 9.02 Pfam 191-268 (270) Show / Hide 
Range on Protein: 1269-1347
Range on HMM: 191-268/270
Sequence Identity: 30% (25 aa)

YTASADIWSFGCLVLEVF--GRTP-WPASGGNAYHLMKQI-EQSVADLPPGVPDGTPAELLDLLRCCFHRDPHRRSTARALLR
.|   |.|||| |  |.|  |..| .|      . ....| |.         |...|.|. ||.. | | || .| | .....
FTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYED---GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHE
Kinase LmjF04.0440.AA STE20 1268-1279 58 0.060996 3.24 In-house 203-214 (288) Show / Hide 
Range on Protein: 1268-1279
Range on HMM: 203-214/288
Sequence Identity: 58% (7 aa)

GYTASADIWSFG
||.  .||||.|
GYDYKCDIWSLG
Kinase LmjF04.0440.AA Pkinase_Tyr 978-997 42 0.094744 6.55 Pfam 50-70 (270) Show / Hide 
Range on Protein: 978-997
Range on HMM: 50-70/270
Sequence Identity: 42% (9 aa)

LLREVEMMEKL-HHDNIVTCL
..||...| .| ||.||| ..
FMREAKIMKQLGHHPNIVRLY