Gene LmjF08.0660 (L.major)

LmjF08.0660

Species: L.major
Alias: LmajK196, LmjF08.0660
External Links:
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF08.0660.AA Protein None 1284 None Fasta, JSON
LmjF08.0660.kin_dom Protein Kinase Domain None 297 None Fasta, JSON

Protein domain

Protein domains of LmjF08.0660.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF08.0660.AA S_TKc 972-1272 14 2.3e-11 -10.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 972-1272
Range on HMM: 1-231/231
Sequence Identity: 14% (48 aa)

CRILALGSAGAIASVNYIMYRE-VHPVVAKAIRDAPPGPISDALRCATPVCGPTAQQDAAIKRLIARHQELRHPNILAPLAFSQSVEGGVVLIWEFCPG-
 .|| .   || ..|     ..  . |  | |.                           |.| |. ... .||||   . . |.  . . .. |.|.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGD

-GTLRQLLARYPQ------VKSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNGHCRLV-----GQFADHALEREIFHFKPSC----YLSPAMA
 |.|.... ...           . ...  |...|| ..|..|. |  |  .|...|.  |  .       |.            .  |    |..| . 
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL

AGALPTP-SCDMFCYGLLAMEAVTQQPCWRWATAAEYRGHRDSKPPSAKELADLMATGGQRFADAVVQGRVVLNLEQLDAGPITEHHNDIMISVCRRLLS
     .. .||.   | .  | .. .| ..   .. ..  .                                               . ...  |..| 
---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------------------------------SPEAKDFIRKCLQ

LDPASRPTAAQLRE-----ENKTVL
 ||. |||| .. .      .   .
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF08.0660.AA TKL 1041-1268 13 1.3e-10 34.45 In-house 82-364 (364) Show / Hide 
Range on Protein: 1041-1268
Range on HMM: 82-364/364
Sequence Identity: 13% (43 aa)

LRHPNILAPLAFSQSVEGG------------VVLIWEFCPGGT-LRQLLARYPQVKSITFACFGLQMLSALSHLHE--------RGVAHGRLNLDNVMVD
||||||.  ...... ..|              .. |.||||. | .|.          .  . |.. .....||         ....|  |. .|..||
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD

SNGH----------CRLVGQFADHALEREIFHFK---------------------------PSCYLSPAMAAGA----------------LPTPSCDMFC
.|..             .   .|  | |.... .                             ....| .  |.                  ...||.. 
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

YGLLAMEAVTQQPCWRWATAAEYRGHRDSKPPSAKELADLMATGGQRFADAVVQ-------GRVVLNLEQLDAGPITEH------HNDI---MISVCRRL
.|..  | .| ..                               .. . . ..|         |... ...   || ..       .|.   |.. . . 
FGIVLWEILTRCR----------------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDC

LSLDPASRPTAAQLREEN
 . || .||.. .. .. 
WDHDPEKRPSFQEILKRL
Kinase LmjF08.0660.AA AGC 1093-1127 32 3.8e-10 20.92 In-house 161-197 (395) Show / Hide 
Range on Protein: 1093-1127
Range on HMM: 161-197/395
Sequence Identity: 32% (12 aa)

QMLSALSHLHE-RGVAHGR-LNLDNVMVDSNGHCRLV
....|| .||. .|. |   | ..|.. |..||..|.
CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT
Kinase LmjF08.0660.AA TK 1037-1126 11 1.2e-09 27.76 In-house 96-292 (486) Show / Hide 
Range on Protein: 1037-1126
Range on HMM: 96-292/486
Sequence Identity: 11% (22 aa)

RHQELRHPNILAPLA-FSQSVE----------GGVVLIWEFCPGGT----LRQLLARYP-----------------------------------------
.|. ..||||.  ..  .|...          . . .. |..|.|     ||. | . .                                         
CHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCP

-----------------------------------QVKSITFACFGLQMLSALSHLHER------GVAHGRLNLDNVMVDSNGH-----------CRL
                                   |.   .   . .|  .....||..      .. |. |   |..|..|..           |..
EEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI
Kinase LmjF08.0660.AA TK-Unique 1026-1124 19 1.5e-09 29.24 In-house 45-172 (294) Show / Hide 
Range on Protein: 1026-1124
Range on HMM: 45-172/294
Sequence Identity: 19% (25 aa)

QQDAAIKRLIARHQELR-HPNILAPLAFSQSVEGGVVLIWEFCPGGTLRQLLA--RYPQVKS---------------------IT---FACFGLQMLSAL
..... .. |. ..||  ||||.  |  ... .. . .|.|.||.|.|. .|   |.... .                     |.   .. |. |  ...
TDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGM

SHLHE--RGVAHGRLNLDNVMVDSNGHC
..|..  ... |..|   ||.. ... |
EYLASQRKKIVHRDLCARNVLLTEDKVC
Kinase LmjF08.0660.AA Pkinase 1038-1126 22 2e-09 34.4 Pfam 54-153 (293) Show / Hide 
Range on Protein: 1038-1126
Range on HMM: 54-153/293
Sequence Identity: 22% (23 aa)

HQELRHPNILAPLAFSQSVEGGVVLIWEFCPGG----TLRQLLA--RYPQV--KSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNGHC----R
...|.||||.  . . .. .. . .. |.|.||     |  ..   |.  .     .  .. .|.|..| ..|..|. |  | ..|...|.|||.    .
MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK

L
.
I
Kinase LmjF08.0660.AA NKF4 1065-1118 34 1e-08 23.82 In-house 115-169 (336) Show / Hide 
Range on Protein: 1065-1118
Range on HMM: 115-169/336
Sequence Identity: 34% (19 aa)

EFCPGGTLRQ-LLARYPQVKSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMV
.|| || . | || | |..   |.  | .|. .|. |||  ...|  |  .|...
DFCDGGDMNQYLLSRHPRLNDDTYKSFMMQLAQAMAHLHKNHIIHRDLKPYNIII
Kinase LmjF08.0660.AA UTK 1039-1126 19 2.3e-08 24.76 In-house 64-166 (296) Show / Hide 
Range on Protein: 1039-1126
Range on HMM: 64-166/296
Sequence Identity: 19% (20 aa)

QELR-HPNILAPLAFSQSVEGGVVLIWEFCPGGTLRQLLARYPQ--------VKSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNG-------
. .. |||.|  ..  .. |..  ...|....| ||..| | ..        ... .  |. ..  .....||..|. |. |   |. |....       
KQFHWHPNVLRLVG-VCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMM

HCRL
 |..
VCKI
Kinase LmjF08.0660.AA Slob 1090-1128 42 4.6e-08 23.61 In-house 141-180 (268) Show / Hide 
Range on Protein: 1090-1128
Range on HMM: 141-180/268
Sequence Identity: 42% (17 aa)

FGLQMLSALSHLHERGVAHGRLNLDNVMVDS-NGHCRLVG
.. | | ||  ||..| ..| |.. |||.|  |. |||..
YCRQILEALIFLHSKGFPYGHLHSGNVMIDDSNDCCRLSD
Kinase LmjF08.0660.AA Eta 1094-1126 45 1.3e-07 21.89 In-house 109-141 (261) Show / Hide 
Range on Protein: 1094-1126
Range on HMM: 109-141/261
Sequence Identity: 45% (15 aa)

MLSALSHLHERGVAHGRLNLDNVMVDSNGHCRL
. .||  ||..||    | |||...| .|||.|
VTCALMFLHQHGVIYRDLKLDNILLDHEGHCKL
Kinase LmjF08.0660.AA MEKK15 1041-1127 31 1.4e-07 23.6 In-house 58-143 (264) Show / Hide 
Range on Protein: 1041-1127
Range on HMM: 58-143/264
Sequence Identity: 31% (28 aa)

LRHPNILAPLAFSQSVEGGVVLIW-EFCPGGTLRQLLARYPQVKSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNGHCRLV
|.| || | |    ..|  || |. .| ||| .  ...|.  .  . |  .  |.|     |||  | |  .   |||. . |  .|.
LKHKNIVAYLGV--CLEDNVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLI
Kinase LmjF08.0660.AA PKC 1095-1127 42 2.5e-07 19.61 In-house 110-142 (262) Show / Hide 
Range on Protein: 1095-1127
Range on HMM: 110-142/262
Sequence Identity: 42% (14 aa)

LSALSHLHERGVAHGRLNLDNVMVDSNGHCRLV
..||  |||.|.    | ||||..|. ||....
ICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIA
TyrKc LmjF08.0660.AA TyrKc 971-1268 15 7e-06 -127.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 971-1268
Range on HMM: 1-280/280
Sequence Identity: 15% (54 aa)

TCRILALGSAGAIASVNYIMYREVHPVVAKAIRDAPPGPISDALRCATPVCGPTAQQDAAIKRLIARHQEL--RHPNILAPLAFSQSVE------GGVVL
   .  ||. ||   |   ...   .|  | ...                        ... | .    .|  .||||.. ..   . .      . . .
ITLGKKLGE-GAFGEVYKGTWK--IQVAVKMLKEDA---------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI

IWEFCPGGTLRQLLARYPQ-VKSITFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNGHCRLVGQFADHALEREIF----------HFKP----SCY
. |..|.| |.. | ..   ..  ..  | .|  .  ..||.... |  |   |..|..|....     .|  | |.|             ..    .. 
VMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKI----SDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-------LSPAMAAGALPTPSCDMFCYGLLAMEAVT--QQPCWR-------WATAAEY--RGHRDSKPPS----AKELADLMATGGQRFADAVVQGRVVL
       ..|        |.  | . .| .  |  |  ||| .        .. . ||  .|.|  .||.    .                         
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------

NLEQLDAGPITEHHNDIMISVCRRLLSLDPASRPTAAQLREEN
            .  | | .. ..    ||..||| ....|. 
---------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF08.0660.AA TK 1227-1268 17 0.004268 5.37 In-house 414-486 (486) Show / Hide 
Range on Protein: 1227-1268
Range on HMM: 414-486/486
Sequence Identity: 17% (13 aa)

LEQLDAG-----------------PITEHHN--------------DIMISVCRRLLSLDPASRPTAAQLREEN
.|.| .|                 |  .|                ...  ....  ..||. ||| .||.|. 
MEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LmjF08.0660.AA Pkinase 1243-1266 33 0.193808 6.17 Pfam 266-289 (293) Show / Hide 
Range on Protein: 1243-1266
Range on HMM: 266-289/293
Sequence Identity: 33% (8 aa)

MISVCRRLLSLDPASRPTAAQLRE
........| .||..||||.|. .
CKDFIKWCLCKDPKKRPTAEQILQ