Gene LmjF31.1840 (L.major)

LmjF31.1840

Species: L.major
Alias: LmjF31.1840, LmajK210
External Links:
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF31.1840.AA Protein None 1358 None Fasta, JSON
LmjF31.1840.kin_dom Protein Kinase Domain None 294 None Fasta, JSON

Protein domain

Protein domains of LmjF31.1840.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF31.1840.AA TKL 1105-1208 20 6e-14 46.62 In-house 63-195 (364) Show / Hide 
Range on Protein: 1105-1208
Range on HMM: 63-195/364
Sequence Identity: 20% (29 aa)

PSPEQEAFMKATLLKHQH-LRHPNIVSLIGYSHSLEGG------------VVLIWEFSPGGTLRELLNRYGRLPAITTIRFGLHALSALSFLHENN----
| .... | .   ... . |||||||...||. . ..|              .. |. |||.|...|.         ..|. | . .....|| .|    
PEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWC

----IAHGNLNLDTVMVDSDGS--------------CRL
    |.| .|. . ..||...               | .
TKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
Kinase LmjF31.1840.AA STE11 1120-1190 27 2.8e-12 40.97 In-house 64-139 (303) Show / Hide 
Range on Protein: 1120-1190
Range on HMM: 64-139/303
Sequence Identity: 27% (21 aa)

HQHLRHPNIVSLIGYSHS--LEGGVVLIWEFSPGGTLRELLN-RYGR--LPAITTIRFGLHALSALSFLHENNIAH
..||.|.|||  .| ...   ...|  . |. |||.|...|. ..|.  ..  .. ..    |..|..||...| |
MKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIH
Kinase LmjF31.1840.AA MEKK15 1123-1225 31 7.8e-12 39.21 In-house 58-160 (264) Show / Hide 
Range on Protein: 1123-1225
Range on HMM: 58-160/264
Sequence Identity: 31% (33 aa)

LRHPNIVSLIGYSHSLEGGVVLIW-EFSPGGTLRELLNRYGRLPAITTIRFGLHALSALSFLHENNIAHGNLNLDTVMVDSDGSCRLVGLYTHERLPFA-
|.| |||. .|   .||  || |. .| ||| .  ..||.| |. .   ..    |    .||||.. |  .    ||. . |  .|.      || .. 
LKHKNIVAYLGV--CLEDNVVNIFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQG

LPQTH
. .||
INRTH
Kinase LmjF31.1840.AA TK 1108-1208 11 8.1e-11 31.71 In-house 71-292 (486) Show / Hide 
Range on Protein: 1108-1208
Range on HMM: 71-292/486
Sequence Identity: 11% (25 aa)

EQEAFMK-----------ATLLKHQH---LRHPNIVSLIGYSHSLE-----------GGVVLIWEFSPGGT----LRELLNRYGR---------------
.....|.           |  .|  .   ..|||||.|.|...  |           . . .. |. |.|     ||. | .  .               
FFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNK

-------------------------------------------------------------LPAITTIRFGLHALSALSFLHEN------NIAHGNLNLD
                                                             |.  . . . . . .....||..      |. |..|   
YPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAAR

TVMVDSDGS-----------CRL
 ..|....            |..
NCLVGENNVCKWHFDGCGPVCKI
S_TKc LmjF31.1840.AA S_TKc 1054-1346 16 9.5e-11 -19.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 1054-1346
Range on HMM: 1-231/231
Sequence Identity: 16% (51 aa)

GMRMALGSAGFIASVSFSPFRD-LHPVVAKAIRDAPPGPMSDALRSATPVCGPSPEQEAFMKATLLKHQHLRHPNIVSLIGYSHSLEGGVVLIWEFSPG-
   . .   |  ..|     ..  . |  | |.                       . .     .||.   .||||| |... ..  . . .. |. .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGD

-GTLRELLNRYGR------LPAITTIRFGLHALSALSFLHENNIAHGNLNLDTVMVDSDGSCRLV--GLYTHERLPFALPQT-HYISPLMATGALPTP-A
 |.|.... ..||      .|  .. ..    ..|| ..|...| |  |  . ...|.     .   || ..      .  | .|..| .      .. .
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCK

CDVFCYGLGALEGLTRQPCWRWTTKEDGEPYGAASELLDLMKDGGHAFCDAVVQGRVVANAEAFDTPLFAEKYSELARSTLRSCLSHAPSERPTAVEVRN
||.   |    | |...| ..              ..  ..|  |                            |. |.. .| ||   |..|||| |. .
CDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-----IVKILL
          .
DEWDIKCHPWF
Kinase LmjF31.1840.AA Pkinase 1120-1190 22 1.3e-10 38.61 Pfam 54-131 (293) Show / Hide 
Range on Protein: 1120-1190
Range on HMM: 54-131/293
Sequence Identity: 22% (18 aa)

HQHLRHPNIVSLIGYSHSLEGGVVLIWEFSPGG----TLRELLN--RYGRL--PAITTIRFGLHALSALSFLHENNIAH
...|.||||| |... .. .. . .. |. .||     | ...   |.|..  .  . ... .  |..| ..|...| |
MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase LmjF31.1840.AA UTK 1079-1208 17 2.7e-09 27.95 In-house 14-166 (296) Show / Hide 
Range on Protein: 1079-1208
Range on HMM: 14-166/296
Sequence Identity: 17% (27 aa)

VVAKAIRDAPPGPMSDALRSATPVCGPSPEQEAFMK--ATLLKHQ-------HLR-HPNIVSLIGYSHSLEGGVVLIWEFSPGGTLRELLNRYGR----L
.| || .. ....| .... | .|| ..   . ..   .......       ... |||.. |.|. .. |..  ...|. ..| || .| | ..     
EVHKARFTQCSEHMYEMDV-AVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGV-CTQEEPWMIVTEYMENGDLRSYLRRHRPTPPAC

PAITTIR----FGLHALSALSFLHENNIAHGNLNLDTVMVDSDG-------SCRL
|.. | .    . ..  .....||. .. |..|    . |....       .|..
PHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKI
Kinase LmjF31.1840.AA NuaK 1123-1204 24 1.6e-08 17.95 In-house 56-136 (252) Show / Hide 
Range on Protein: 1123-1204
Range on HMM: 56-136/252
Sequence Identity: 24% (20 aa)

LRHPNIVSLIGYSHSLEGGVVLIWEFSPGGTLRELLNRYGRLPAITTIRFGLHALSALSFLHENNIAHGNLNLDTVMVDSDG
| ||.|..      . .  .|.. |.. || | . . . ..||   . .|     ||. . | ..|.|  | |  .. | ..
LNHPHIIHIYEVFENKD-KIVIVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNC
Kinase LmjF31.1840.AA ULK 1122-1190 26 1.7e-08 26.37 In-house 69-149 (324) Show / Hide 
Range on Protein: 1122-1190
Range on HMM: 69-149/324
Sequence Identity: 26% (22 aa)

HLRHPN--IVSLIGYSHSLEG-GVVLIWEFSPGGTLRELLNRYGRLPAIT----------TIRFGLHALSALSFLHENNIAH
.|.|||  || |. .. .     . .| |. .||.|.........||  |          .| |  . .... .||..|| |
ELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIH
Kinase LmjF31.1840.AA STE 1120-1190 20 5.2e-08 24.51 In-house 82-175 (359) Show / Hide 
Range on Protein: 1120-1190
Range on HMM: 82-175/359
Sequence Identity: 20% (19 aa)

HQHLR--HPNIVSLIGYS------HSLEGGVVLIWEFSPGGTLRELLNRY--------------GRLPAITTIRFGLHALSA-LSFLHENNIAH
.....  |||||  .|.       |. .. . .. |. .||.|.......              .|.|    ...    | . |..||...| |
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH
Kinase LmjF31.1840.AA STE11-Unclassified 1121-1190 30 8.9e-08 23.71 In-house 60-130 (308) Show / Hide 
Range on Protein: 1121-1190
Range on HMM: 60-130/308
Sequence Identity: 30% (22 aa)

QHLRHPNIVSLIGYS-HSLEGGVVLIWEFSPGGTLRELLNRYGRLPAITTIRFGLHALSALSFLHENNIAH
..|.|.|||. .| . |  |... .. |  ||| ....||.||..   ..  .    |. |..||...| |
KQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIH
TyrKc LmjF31.1840.AA TyrKc 1057-1342 15 1e-06 -114.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 1057-1342
Range on HMM: 1-280/280
Sequence Identity: 15% (52 aa)

MALGS---AGFIASVSFSPFRDLHPVVAKAIRDAPPGPMSDALRSATPVCGPSPEQEAFMK-ATLLKHQHL--RHPNIVSLIGYSHSLE------GGVVL
  ||     |.   |     .   .|  | ...                      .|.||. | ...  .|  .||||| |.|.  . .      . . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------------------REDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI

IWEFSPGGTLRELLNRYGR-LPAITTIRFGLHALSALSFLHENNIAHGNLNLDTVMVDSDG---------SCRL-VG--------LYT-----HER--LP
. |. |.| |.. | .... |.  . . | . . .  ..||..|. |  |    ..|....         |  .  .         |.     ...  ||
VMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

FALPQTHYISPLMATGALPTPACDVFCYGLGALEGLTR-QPCWRW-----TTKEDGEPYGAASELLDLMKD----GGHAFCDAVVQGRVVANAEAFDTPL
         .|        |.. ||. .|    | .|. |. .        . ..   |  . . .. ...                             
IR-----WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------

FAEKYSELARSTLRSCLSHAPSERPTAVEVRNIV
| .  .|. .   ..|  . |..|||  |.. . 
FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF31.1840.AA TK-Unique 1124-1193 19 4e-06 17.43 In-house 62-159 (294) Show / Hide 
Range on Protein: 1124-1193
Range on HMM: 62-159/294
Sequence Identity: 19% (19 aa)

RHPNIVSLIGYSHSLEGGVVLIWEFSPGGTLRELLNRYGRL-----------------PAITT---IR------FGLHALSALSFLHE--NNIAHGNL
.|||||...|.. . .. . .|.|. |.|.|. .| . ..                  |..     |       |.    .....|..   .| |..|
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDL
Kinase LmjF31.1840.AA Pkinase_Tyr 1122-1193 22 0.00015 16.03 Pfam 59-137 (270) Show / Hide 
Range on Protein: 1122-1193
Range on HMM: 59-137/270
Sequence Identity: 22% (18 aa)

HL-RHPNIVSLIGYSHSLEGG--VVLIWEFSPGGTLRELLNRY----GRLPAITTIRFGLHALSALSFLHENNIAHGNL
.| .|||||.|.|   . ..   . .. |. |.| |.. | .     ..|.  . . . .   .....|...|. |  |
QLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase LmjF31.1840.AA TK 1321-1342 22 0.001836 6.62 In-house 465-486 (486) Show / Hide 
Range on Protein: 1321-1342
Range on HMM: 465-486/486
Sequence Identity: 22% (5 aa)

LRSCLSHAPSERPTAVEVRNIV
...| .. |..|||  ....  
MQQCWHYDPEDRPTFSQLHEQL
Kinase LmjF31.1840.AA TK-Unique 1321-1342 27 0.009631 5.43 In-house 273-294 (294) Show / Hide 
Range on Protein: 1321-1342
Range on HMM: 273-294/294
Sequence Identity: 27% (6 aa)

LRSCLSHAPSERPTAVEVRNIV
..||... |.|||.  ..... 
MKSCWQWEPEERPSFRQIKHRL
Kinase LmjF31.1840.AA MEKK15 1307-1344 39 0.0101 5.74 In-house 227-264 (264) Show / Hide 
Range on Protein: 1307-1344
Range on HMM: 227-264/264
Sequence Identity: 39% (15 aa)

PLFAEKYSELARSTLRSCLSHAPSERPTAVEVRNIVKI
|   .|.|| ||   | ||     |||||...     |
PQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase LmjF31.1840.AA TKL 1318-1342 24 0.016134 4.9 In-house 340-364 (364) Show / Hide 
Range on Protein: 1318-1342
Range on HMM: 340-364/364
Sequence Identity: 24% (6 aa)

RSTLRSCLSHAPSERPTAVEVRNIV
.. .  | .| |..||.. |.  . 
KKLMQDCWDHDPEKRPSFQEILKRL
Kinase LmjF31.1840.AA STE11 1321-1337 52 0.022533 4.74 In-house 280-296 (303) Show / Hide 
Range on Protein: 1321-1337
Range on HMM: 280-296/303
Sequence Identity: 52% (9 aa)

LRSCLSHAPSERPTAVE
|| |. | |..|||| .
LRHCFEHDPKKRPTANQ
Kinase LmjF31.1840.AA STE 1311-1337 33 0.027332 4.04 In-house 324-350 (359) Show / Hide 
Range on Protein: 1311-1337
Range on HMM: 324-350/359
Sequence Identity: 33% (9 aa)

EKYSELARSTLRSCLSHAPSERPTAVE
.|.|.  .  .. ||   |..|||| .
HKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase LmjF31.1840.AA Pkinase 1314-1342 29 0.2082 6.06 Pfam 263-293 (293) Show / Hide 
Range on Protein: 1314-1342
Range on HMM: 263-293/293
Sequence Identity: 29% (9 aa)

SELARSTLRSCLSHAPSERPTAVEVRNI--V
|| ... ...||   |..|||| .. .   .
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF31.1840.AA UTK 1321-1342 22 0.216946 0.52 In-house 275-296 (296) Show / Hide 
Range on Protein: 1321-1342
Range on HMM: 275-296/296
Sequence Identity: 22% (5 aa)

LRSCLSHAPSERPTAVEVRNIV
...|    |.|||......  .
MHRCWHYDPQERPDFEDLVQQM
Kinase LmjF31.1840.AA Pkinase_Tyr 1321-1342 27 1.044307 3.02 Pfam 249-270 (270) Show / Hide 
Range on Protein: 1321-1342
Range on HMM: 249-270/270
Sequence Identity: 27% (6 aa)

LRSCLSHAPSERPTAVEVRNIV
...|  . |..|||  |.... 
MKQCWHYDPEDRPTFSEIHEQL