Gene 88712.m00283 (T.vaginalis)
88712.m00283
Species: T.vaginalis
Alias: TvagK0072, 88712.m00283
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 88712.m00283.AA | Protein | None | 231 | None | Fasta, JSON |
| 88712.m00283.kin_dom | Protein Kinase Domain | None | 191 | None | Fasta, JSON |
Protein domains of 88712.m00283.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 88712.m00283.AA | CAMKL | 2-192 | 32 | 1.4e-81 | 260.14 | In-house | 86-297 (297) | Show / Hide |
Range on Protein: 2-192 Range on HMM: 86-297/297 Sequence Identity: 32% (70 aa) DNEN------IYIFIELCNGGD--LNDIVQDVEG----LTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDD--AKLTDFGLCKQQR-G--- . |. ||.. |.| ||. | | .. .. ..|.||..|| ||..|..|.|..|..||| |.||||.. ... .|..|||.. ..| . TPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFG -NDPTLTTCGTLVYAAPEIIRE--EPYNGMKADIWSAGIVLYAMIAAHFPWIVPDD---LPPDILMKETAKQIAEGDISLPDGISDQLQNLLGNMLNVDP .. | ||.. |.||||. .||.| |.||||.|..||||. ..|. ... .| .. . . . . . .| ....|. ||.|.| PGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNP EERPTADEILQHPWF |.|||...|..|||. EKRPTIHQIMNHPWM |
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| Kinase | 88712.m00283.AA | CAMK | 2-192 | 24 | 8e-79 | 253.46 | In-house | 128-425 (425) | Show / Hide |
Range on Protein: 2-192
Range on HMM: 128-425/425
Sequence Identity: 24% (73 aa)
DNENIYIFI---ELCNGG----DLNDIVQDVEG---------------LTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDD-----------
.....|.. |.| || || | ... .. .||.||..||.||..|. |.|.....||| |.||||.....
KDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEI
------DAKLTDFGLCKQQRG------------------------NDPTLTTCGTLVYAA-PEIIRE-------------EPYNGMKADIWSAGIVLYAM
. |..|||. .. .. ... | |||. |.| ||... .|| | |.|.||.|..||.|
FDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM
IAAHFPWIVP---DDLPPD----ILMKETAKQIAEGDISLP----------------DGISDQ--------LQNLLGNMLNVDPEERPTADEILQHPWF
..|. . ... | ..|. ..| .|. . | |.|||. ..|. .||.||||.|.|....|.|||.
LCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 88712.m00283.AA | MARK | 2-192 | 38 | 3.4e-70 | 228.67 | In-house | 72-262 (262) | Show / Hide |
Range on Protein: 2-192 Range on HMM: 72-262/262 Sequence Identity: 38% (76 aa) DNEN-IYIFIELCNGGDLNDIVQDV--EGLTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDD--DAKLTDFGLCKQQRGNDPTLTTCGTLVY .... ||. |.. ||.| | .. . |.|.||...|.||. |..| |. ...||| |.||||| . ..|..|||.. . . | |||. | TEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPY AAPEIIREEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPDIL--MKETAKQIAEGDISLPDGISDQLQNLLGNMLNVDPEERPTADEILQHPWF .||||. .||.| |.|||| |.|||.|. .||. . .|| |.| |. . |. .|....||. .|.|.||||||..||..|||. MAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD-------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 88712.m00283.AA | Ciliate-E2 | 1-192 | 26 | 1.3e-65 | 224.18 | In-house | 104-365 (365) | Show / Hide |
Range on Protein: 1-192
Range on HMM: 104-365/365
Sequence Identity: 26% (76 aa)
MDNENIYIFIELCNGGDLNDIVQ------------DVEGLTEDEAKHYFHQIID---------------ALSYIHKLG-VAHRDVKLENILITTDDDAKL
.|..|||. |.|.|||| |. . | . .|| |.|... ||.. || |.|. . . ||| |.||||. |.
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKI
TDFGLCK------------QQRGNDPTLT---------------------TCGTLVYAAPEIIREEPYNG--------MKADIWSAGIVLYAMIAAHFPW
.||||.| ||... . .|||. | ||||.. ..|.. |.||||.|..|| |. .|.
IDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
IVPDDLPPDILMKETAKQIAEGDISLP------------------DGISDQLQNLLGN----MLNVDPEERPT-ADEILQHPWF
.|| ...|..| . .|.. ..|. . ||..|||.|.| ...||.||||
---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 88712.m00283.AA | Pkinase | 1-192 | 32 | 2e-63 | 221.8 | Pfam | 70-293 (293) | Show / Hide |
Range on Protein: 1-192 Range on HMM: 70-293/293 Sequence Identity: 32% (73 aa) MDNENIYIFIELCNGG----DLNDIVQ--DVEGL--TEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDDA----KLTDFGLCKQ--QRGNDP .|. .||. |.|.|| || |... . .. .|.|.|.|. ||. .| |.|. |. |||.|.||||| ... |..||||.|| | EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS- TLTTCGTLVYAAPEIIREEPYNGMKADIWSAGIVLYAMIAAHFPWIVPD-DLPPDILMKETAKQIAEGDISLPDGIS---------------------DQ . | |||. |.|||.||. .| | |.|.||.|..|| |. ..|. . . .. . ... ..| ..... . . . MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE LQNLLGNMLNVDPEERPTADEILQHPWF .. .. ..|..||..||||..||||||| CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 88712.m00283.AA | AMPK | 3-192 | 36 | 1.6e-61 | 181.41 | In-house | 72-254 (254) | Show / Hide |
Range on Protein: 3-192 Range on HMM: 72-254/254 Sequence Identity: 36% (70 aa) NENIYIFIELCNGGDLNDIVQDVEGLTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDDAKLTDFGLCKQQRGNDPTLTTCGTLVYAAPEII .. |....| ||.| | . . |.|.||. .| ||| ...|.|.....||| |.||.|. . |. |||| . .. | || |||||.| PTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMI REEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPDILMKETAKQIAEGDISLPDGISDQLQNLLGNMLNVDPEERPTADEILQHPWF .|.| . |||| |..||||. . | || | | | .|. ..|. .|.. ..|. .||.|||..| | ..| .|||| SGKLYCGPEVDIWSCGVILYAMLCGYLPF---DDENTPTLY----KKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | 88712.m00283.AA | Ciliate-E2-Unclassified | 2-192 | 26 | 2.9e-60 | 206.54 | In-house | 92-352 (352) | Show / Hide |
Range on Protein: 2-192 Range on HMM: 92-352/352 Sequence Identity: 26% (70 aa) DNENIYIFIELCNGGDLNDIVQDVEG-----------------LTEDEAK-----HYFHQIIDALSYIHKLG-VAHRDVKLENILITTDD---DAKLTDF | .|||| |.|.|||| .. .. .. .|| .|| .|| ||...|.|.|. . . ||| |.||||.. . |..|| DKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF GLCK---QQRGNDPT--------------LTTCGTLVYA----APEIIREEPYNGM---KADIWSAGIVLYAMIAAHFPWIVPDDLPPD----------- |..| |....| | |.|||. | |||..... |... |.|||| |..||.|. .| ... . GISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY --ILMKETAKQIAEGDISLP----DGISDQLQNLLG----NMLNVDPEERPTADEILQHPWF .| .. ... . . . . ...|.. .... ||...|..|.|...||.|||| RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 88712.m00283.AA | RSK | 2-192 | 33 | 5.8e-57 | 195.55 | In-house | 72-278 (278) | Show / Hide |
Range on Protein: 2-192 Range on HMM: 72-278/278 Sequence Identity: 33% (72 aa) DNENIYIFIELCNGGDLNDIVQDVEG---LTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITT---DDDAKLTDFGLCKQ--QRGNDPTLTTCGT ... .|. |.|.||.| . | . ..||||. |. .|. |....|..|. ||| |.|||| . . ||||||.||| . | .| | |.| TEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYT LVYAAPEIIR---EEP-YNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPDILMKETAKQIAEGD--ISLP--DGISDQLQNLLGNMLNVDPEERPT--- . |.|||... . . . .|.|| |...| | . . | |.| ||. |.| .|. ..| . .|. ..|. || .||. |.. IEYMAPEMLKRANQQGGH-DKACDWWSLGVLMYEMLTGCPPFQGPND----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGP --ADEILQHPWF |.||.||||| QDAEEIKQHPWF |
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| Kinase | 88712.m00283.AA | TSSK | 6-192 | 32 | 2.2e-53 | 173.57 | In-house | 92-289 (289) | Show / Hide |
Range on Protein: 6-192 Range on HMM: 92-289/289 Sequence Identity: 32% (66 aa) IYIFIELCNGGDLNDIVQDV------EGLTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDDAKLTDFGLCKQQRGNDPT-----LTT-CGT ||.. |.. .||| . .|.. .|.|..|. |.|...|. |.| ..|.|||.|.|||| .. |||||| . . .|| ..| || IYMVMEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGS LVYAAPEIIREEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDD--LPPDILMKETAKQIAEGDISLPDGISDQLQNLLGNMLNVDPEERPTADEILQHPW ||||||.| ||.....|.|| |..||.| .. | || . ..... . . .... .||.. ..|. || .| .||...||. |.| YAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPF---DDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCW F M |
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| Kinase | 88712.m00283.AA | ULK | 2-192 | 29 | 3.7e-52 | 179.61 | In-house | 90-329 (329) | Show / Hide |
Range on Protein: 2-192 Range on HMM: 90-329/329 Sequence Identity: 29% (70 aa) DNE-NIYIFIELCNGGDLNDIVQDVEG----------LTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTD----DD--------AKLTDFGLC .|. ||||. |.|||||| .. . . |.|.||...|.||. .. ..|| .. ||| |..||||. . |. .|..|||.. SNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA KQ-QRG---NDPTLTTC------GTLVYAAPEIIR----EEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPD--ILMKETAK------QIAEGDIS |. . . .. ..|. || | ||.|. ..||. |.|||| |...| |. |. . . . |..|. . || . KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQ LPDG-----ISDQLQNLLGNMLNVDPEERPTADEILQHPWF |. ||.....|. || .|...| . .|...|||| FPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 88712.m00283.AA | ULK | 3-192 | 28 | 7.9e-52 | 178.51 | In-house | 88-324 (324) | Show / Hide |
Range on Protein: 3-192
Range on HMM: 88-324/324
Sequence Identity: 28% (68 aa)
NE-NIYIFIELCNGGDLNDIVQDVEG---------LTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDD------------AKLTDFGLCKQ
|. ||||. |.|||||| .. . . |.|.||...|.||. .. ..|| .. ||| |..||||. .. .|..|||..|.
NHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH
-Q---RGNDPTLTTC------GTLVYAAPEIIR----EEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPDILMKETAKQ-------IAEGDISLPD
. . . |.. || | ||.|. ..||. |.|||| |...| |. |. . . .. ... .. | | |.
VDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPK
-----GISDQLQNLLGNMLNVDPEERPTADEILQHPWF
||.....|. || .|...| . .||..||||
PPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | 88712.m00283.AA | S_TKc | 1-192 | 28 | 2e-44 | 154.84 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-192
Range on HMM: 19-231/231
Sequence Identity: 28% (69 aa)
MDNE--------------------------------------NIYIFIELCNG--GDLNDIVQDVEG------LTEDEAKHYFHQIIDALSYIHKLGVAH
... ..|.. |.|.| ||| |. .. . ..| .|..|..||..|| |.|..|. |
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH
RDVKLENILITTDDDAKLTDFGLCKQQRGNDPTLTTCGTLVYAAPEIIREEPYNGMKADIWSAGIVLYAMIAAHFPWIVPDDLPPDILMKETAKQIAEGD
||.| ||||... |..||||..| | |||. | |||.. .|.. |.|.|| |..|| |.. |. |... |.|
RDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---
ISLPDGISDQLQNLLGNMLNVDPEERPTADEILQ-------HPWF
|... ... ..|..|||.|||| |.|| ||||
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 88712.m00283.AA | TyrKc | 1-192 | 16 | 2.6e-08 | -88.23 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-192
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)
MDN--------------------------------------------------------------------ENIYIFIELCNGGDLNDIVQDVEG-LTED
| ..| |.. .|||.| .. .. |. .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
EAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDDAKLTDFGLCKQQRGN------DPTLTT----CGT--LVYA--APEIIREEPYNGMKADIWSA
. .. .|| . .|.|. .. ||| |.|.. . .| .||||.. . . .. .| | . ||| |.. .. | |.||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF
GIVLYAMIA-AHFPWIVPDDLPPDILMKETAKQIAEG-DISLPDG--------ISDQLQNLLGNMLNVDPEERPTADEILQHPWF
|.... . |. . .. .| ... .| |. .| . .. . |||.||| || | |
GVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 88712.m00283.AA | Pkinase_Tyr | 3-79 | 30 | 8e-06 | 20.33 | Pfam | 80-159 (270) | Show / Hide |
Range on Protein: 3-79 Range on HMM: 80-159/270 Sequence Identity: 30% (25 aa) NENIYIFIELCNGGDLNDIVQD----VEGLTEDEAKHYFHQIIDALSYIHKLGVAHRDVKLENILITTDDDAKLTDFGLCK | .||| |.. .||| | .. . || . .. .|| ....| . . |||. |.|.| . .| .||||.. N-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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