Gene 95940.m00256 (T.vaginalis)

95940.m00256

Species: T.vaginalis
Alias: TvagK0641, 95940.m00256
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
95940.m00256.AA Protein None 2268 None Fasta, JSON
95940.m00256.kin_dom Protein Kinase Domain None 130 None Fasta, JSON

Protein domain

Protein domains of 95940.m00256.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 95940.m00256.AA FAT 1323-1451 18 3.9e-05 17.42 Pfam 1-165 (408) Show / Hide 
Range on Protein: 1323-1451
Range on HMM: 1-165/408
Sequence Identity: 18% (31 aa)

APYFAEASMHLQKWDD--IKQIRDYTN------------EDSL-----KNILVNALFSL--HEKNYE--EVDGLIEKGLSLIASKPIS-FWSQYQQLQDE
||. |||. .|..||.  ...  . ..            |||      .  . .|. .|  | ....  |.  .|.|. .|   .  .   .   .    
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

IVLNAQKLVELHELAEYI---KET--------PENKEKFENVWIQRHLTM-PRDFALWNDLIENR
..   | |.||.|...|.    ..        ||. .   . | .| . .  |..  | ... .|
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWR
Kinase 95940.m00256.AA PIKK 1902-2176 38 2.8e-87 296.27 In-house 1-290 (290) Show / Hide 
Range on Protein: 1902-2176
Range on HMM: 1-290/290
Sequence Identity: 38% (112 aa)

RIKFFFEQVMVYTSKQQPKSISVMGDDGKVYQYLLKGHEDLRLDERIMQFFSTVNSLIKTS---FAKSTVIKTMVVMPLSKLNGLVQWVNGADTLKSIVE
||.|. . | | ..|| || |. .| ||| | ||.|||||||.|.|.||.|. .| .  .      .   | |  | |.|   ||..||....||| |  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

QYRN--LIDPQNESAVRDDL----------EEYKMAGELGCYNYNNMLTIQKMAVLKKIFETTPDTDIANFLWLQSKDAEHWMRIRTTFAVSCAVNSAIG
|..    |   .|.  . ..            ||  ..  | .|.     .| .|. .. . ||  . ....|. . |.| | . |. .. | || .  |
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPEVVPFRLTRMLVKAMGIAGTGGTFRSTFVDYMTVLRENWRVLILVLAVF
|..|||||||.|||||. ||. .|||||.|||.||.|   || |||||||..| |||. |. | ||.. .. | ..|..   |. |. ||
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 95940.m00256.AA FRAP 1932-2180 41 9.4e-80 271.26 In-house 2-245 (251) Show / Hide 
Range on Protein: 1932-2180
Range on HMM: 2-245/251
Sequence Identity: 41% (105 aa)

YQYLLKGHEDLRLDERIMQFFSTVNSLIK---TSFAKSTVIKTMVVMPLSKLNGLVQWVNGADTLKSIVEQYRNLIDPQNESAVRDDLEEYKMAGELGCY
| .|||||||.| |||.|| |  .| |..   ..  |   |.   ..|||   ||. ||.  |||. .. .||.    .           |..  .  | 
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE-------YNIM-DRMCN

NYNNMLTIQKMAVLKKIFETTPDTDIANFLWLQSKDAEHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPE
.|. .  ..|  . . | . |   |..  ||| |   | |.  || .  | |. | .||..|||||||||||..| |||..||||||||||||.|  .||
DYDHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPE

VVPFRLTRMLVKAMGIAGTGGTFRSTFVDYMTVLRENWRVLILVLAVFVHEP
 .||||||||| || ..|  |..| |    | |.||.   .. ||  ||  |
KIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDP
Kinase 95940.m00256.AA PI3Kc 1933-2250 19 1.3e-58 201.92 SMART 1-336 (336) Show / Hide 
Range on Protein: 1933-2250
Range on HMM: 1-336/336
Sequence Identity: 19% (70 aa)

QYLLKGHEDLRLDERIMQFFSTVNSLIKTS---FAKSTVIKTMVVMPLSKLNGLVQWVNGADTLKSIVEQYRN----------------LIDPQNESAVR
. ..|...||| |.|.||.|...| . ..    .  .  .... ..|...  |...||. ..|| .|   |.                 |  |. ..  .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQK-NM

DDLEEYKMAGELGCYNYNNMLTIQKMAVLKKIFETTPDTDIANFLWLQSKDA-EHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHID
  . . .  .. ..  | .|  ... ..  .    ... ......| ...|. | |   |..|. |||. . ..|. |.||||..|||.|..||...|||
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

FGDCFEVAMKRKLYP-----EVVPFRLTRMLVKAMG----IAGTGGTFRSTFVDYMTVLRENWRVLILVLAVFVHEPC-VESSDVAASDTVAKITRIGSC
||..|. . ..|. .     |.||||||...| .||    ..| .| ||.. .  ....|..  ... .....|. |   . .         .|  ... 
FGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQR

IDGGVPSVAPNSDDADTIRLRVKS----KLLGNDFGNVSMKVSDQADLLIAS
.   .          . .. ...     ||.... .   ... ......   
FRLDH-------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 95940.m00256.AA PI3_PI4_kinase 1931-2186 24 1.9e-54 191.97 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1931-2186
Range on HMM: 1-300/300
Sequence Identity: 24% (75 aa)

VYQYLLKGHEDLR--LDERIMQFF-----------------------STVNSLIKTSFAKST---VIKTMVVMPLSKLNGLVQWVNGADTLKSIVEQYR-
 |....||..|||   |.|.||..                       ...| . |   .       . .  ..|... .|...||. ..|.. |   |. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

--NLIDPQNESAVRDDLEEYKMAGELGCYNYNNMLTIQKMAVLKKIFETTPDTDIANFLWLQSKDA-EHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSN
  . .. ..|  ...... .. . .           .||  |  .    ||  .. ...| ...|| | | . |..|. |||. . ..|..|.||||..|
KCKHKHFNKEHKMWMKMWPDWWHLM----------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDN

IMI--DRNTGKMIHIDFGDCFE-VAMKRKLYPEVVPFRLTR------MLVKAM------GIAGTGGTFRSTFVDYMTVLRENWRVLILVL-------AVF
||.  |. ||...|||||.||. ..||.   || ||||.|.      ..|.||      .  |  |.||.. .. . .||.. .... .|       . .
IMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

VHEPCVESSD
|| . .. ..
VHDGLPMWRS
Kinase 95940.m00256.AA ATR 2064-2176 37 1.2e-28 94.41 In-house 156-267 (267) Show / Hide 
Range on Protein: 2064-2176
Range on HMM: 156-267/267
Sequence Identity: 37% (42 aa)

DAEHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPEVVPFRLTRMLVKAMGIAGTGGTFRSTFVDYMTVLR
|.. |   |  .  | || . .||.|||||||  ||.||. .| ..|.|.   |    . .  ||.||||||. .| .||  .| | ||   .. | ..|
DPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMR

ENWRVLILVLAVF
..   .. |.  |
DHRDDIMSVWDCF
Kinase 95940.m00256.AA ATM 2068-2180 40 6e-25 76.31 In-house 133-244 (304) Show / Hide 
Range on Protein: 2068-2180
Range on HMM: 133-244/304
Sequence Identity: 40% (46 aa)

WMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPEVVPFRLTRMLVKAMGIAGTGGTFRSTFVDYMTVLRENWR
|   |  .  | |  | .||..||||||  ||.|      ..||| |  ||   |    || ||||||| .|  ||| |  | ||      | |.|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

VLILVLAVFVHEP
 |. .  | . .|
TLLTIVEVLLYDP
Kinase 95940.m00256.AA SMG1 1910-1993 44 8e-21 65.58 In-house 1-87 (242) Show / Hide 
Range on Protein: 1910-1993
Range on HMM: 1-87/242
Sequence Identity: 44% (39 aa)

VMVYTSKQQPKSISVMGDDGKVYQYLLKGHEDLRLDERIMQFFSTVNSLIKTSFAKST---VIKTMVVMPLSKLNGLVQWVNGADTL
. .   | .|| .  .| ||| | || || ||| |||||||| | || .  |   . |     .   | ||    ||.||| ||  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
Kinase 95940.m00256.AA SMG1 2040-2128 43 3.8e-20 63.3 In-house 155-242 (242) Show / Hide 
Range on Protein: 2040-2128
Range on HMM: 155-242/242
Sequence Identity: 43% (39 aa)

AVLKKIFETTPDTDIANFLWLQSKDAEHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPE
|||  . | ||   .|  ||      . | |.   .| | || | .||.|||||||  |..||  || ..|||.  |||   | .  ||
AVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNV-PE
Kinase 95940.m00256.AA DNAPK 2066-2186 29 1.4e-17 60.4 In-house 181-301 (301) Show / Hide 
Range on Protein: 2066-2186
Range on HMM: 181-301/301
Sequence Identity: 29% (36 aa)

EHWMRIRTTFAVSCAVNSAIGYVIGLGDRHPSNIMIDRNTGKMIHIDFGDCFEVAMKRKLYPEVVPFRLTRMLVKAMGIAGTGGTFRSTFVDYMTVLREN
| ..  |  |. . ||  . ... | ||||  | |.   .|  | ||||  |  |      ||  ||||||  .  |   .  | ...  .  |  .|  
ETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKD

WRVLILVLAVFVHEPCVESSD
  .|.    ||. .| .    
RNILTNFCDVFINDPSFDWKN
Kinase 95940.m00256.AA FATC 2236-2268 45 2.6e-17 58.48 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2236-2268
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

VSMKVSDQADLLIASATSIYNLSKMFNGWCPFW
... |..|.| ||..||...||..|. ||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 95940.m00256.AA ATR 1901-1999 32 6.7e-15 46.79 In-house 1-102 (267) Show / Hide 
Range on Protein: 1901-1999
Range on HMM: 1-102/267
Sequence Identity: 32% (33 aa)

TRIKFFFEQVMVYTSKQQPKSISVMGDDGKVYQYLLKGHEDLRLDERIMQFFSTVNSLIKTSFAKSTV---IKTMVVMPLSKLNGLVQWVNGADTLKSIV
. |  | . | . .| |.|| ||. | ||| |  . | ..||| | | |.| . .| . .    .      ..|  |.||    ... |||   ||..|.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

EQ
..
DK
Kinase 95940.m00256.AA DNAPK 1901-1996 33 4.3e-12 40.13 In-house 2-100 (301) Show / Hide 
Range on Protein: 1901-1996
Range on HMM: 2-100/301
Sequence Identity: 33% (33 aa)

TRIKFFFEQVMVYTSKQQPKSISVMGDDGKVYQYLLKGHEDLRLDERIMQFFSTVNSLIKTSFA---KSTVIKTMVVMPLSKLNGLVQWVNGADTLKSI
 ||  | | | |  |   || | . | | .   .. || ||||.| || | |   |  .    .   .    .|  . |.    ||. ||.   .|| |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI
Kinase 95940.m00256.AA ATM 1933-1989 36 0.000473 8.39 In-house 1-60 (304) Show / Hide 
Range on Protein: 1933-1989
Range on HMM: 1-60/304
Sequence Identity: 36% (22 aa)

QYLLKGHEDLRLDERIMQFFSTVNSLIK--TSFAKSTV-IKTMVVMPLSKLNGLVQWVNG
  | || .||| |  . | |   | |..  |   |  . | |  |.|||.  | . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG