Gene 83714.m00208 (T.vaginalis)
83714.m00208
Species: T.vaginalis
Alias: 83714.m00208, TvagK0845
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 83714.m00208.AA | Protein | None | 1134 | None | Fasta, JSON |
| 83714.m00208.kin_dom | Protein Kinase Domain | None | 308 | None | Fasta, JSON |
Protein domains of 83714.m00208.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_C2 | 83714.m00208.AA | PI3K_C2 | 459-582 | 19 | 3.6e-13 | 49.66 | Pfam | 1-168 (168) | Show / Hide |
Range on Protein: 459-582 Range on HMM: 1-168/168 Sequence Identity: 19% (33 aa) AASIYMIRAVII--HGSNELGAPV-MTRPALGG----TSVSWNEMLTVS-LQIQQLPRSARVAITLYNYEKIGSKGS-----------AIATINIPVFNF . . ... . || . |. || |... .. ...|||..| .|...|||.|| ||.. | ...|.| .|. |.| |.. PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIW--EIYCKKKSESNMNEQNKKCPIGWCNLPLFDH -DGWYNSGVNFRSM-WNGKDTDPLITT---------------------CQCEDDDATR---IL-FEIPQY .. ..| .| | .|...| ..| ..| .. | .. . ... EKCMLRCGMHKLHMTWPSKPPCPMFPTHTPWKVPRHWRDEMNRLEKLLKKHEWGQMQRNPRCDWLDFLTF |
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| PI3K_C2 | 83714.m00208.AA | PI3K_C2 | 419-533 | 18 | 2.1e-08 | 35.19 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 419-533 Range on HMM: 1-133/133 Sequence Identity: 18% (25 aa) IILKEIEKPSFDIMGGFPHSIAKENFSIFIGGCFNIPPSLAASIYMIRAVIIHG-SNELGAPVMTRP----ALGGTS-----VSWNEMLTV-SLQIQQLP . ..... .. .. || | . ... ... . .. .|. ..| ... . || . ...|| |.. .... . ||| ||. ..|...|| VKICSLWCCNRPFVFL-PHEITIYCIHDIMLNWSQDYESSCVDLY-VECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLP RSARVAITLYNYE--KIGSK-------GSAIATIN |.|| .||.. . ...|. |.. .. RMARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF |
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| PI3Ka | 83714.m00208.AA | PI3Ka | 608-788 | 31 | 2.4e-52 | 181.12 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 608-788 Range on HMM: 1-232/232 Sequence Identity: 31% (73 aa) QQKVAV--DNLRKKVF------DPLKKLTMEEKNLIYRYRHDLY-DMSSFLP-----LVLSSIDYTVPTQAHEIAGLLQQW--EKPKPAEALSLLDSEFA . ... .. .. . .|...|| |||.||...||.. . || .|.... . .... . |..|| .. .|..|| |||..|. DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP D---QRVRAYAVECLESLSDDEIMLYMLQLVQALKYE--------------------------MYDDSPLCRFLFRRGLAEPKFLGHQLFWQLISEA--- | . ||.|||.|||..||||. .| |||||||||| | ||||||||..| |. | .||...|.| || DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH ---HISHIRRRFSSFVVNFLYGS-GIYRDELIK | .|. .|| . ...|. | . .|.| CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Ka | 83714.m00208.AA | PI3Ka | 622-788 | 36 | 6.4e-52 | 180.18 | Pfam | 21-211 (211) | Show / Hide |
Range on Protein: 622-788 Range on HMM: 21-211/211 Sequence Identity: 36% (69 aa) DPLKKLTMEEKNLIYRYRHDLY-DMSSFLP------LVLS-SIDYTVPTQAHEIAGLLQQ--WEKPKPAEALSLLDSEFAD--QRVRAYAVECLES-LSD ||| .|| |||.||...||... || |. .. . ..|. . |.. |.. .|..||.|||..|.| . ||.|||.|||| .|| DPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSD DEIMLYMLQLVQALKYE----MYDDSPLCRFLFRRGLAEPKFLGHQLFWQLISEA------HISHI-RRRFSSFVVNFLYGSGIYRDELIK ||. .|.|||||||||| ..||.| |||..|.. . .||..|| . || |.... ||.. .... | .. .|.| DELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Kc | 83714.m00208.AA | PI3Kc | 872-1133 | 30 | 7e-83 | 282.58 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 872-1133
Range on HMM: 1-336/336
Sequence Identity: 30% (101 aa)
RVLFKVGDDLRQDQLTLQVMRVMEYLWRKE----GIDLHMRCYGVLPTGFNQGFIEVVPNAITEQALQQ-------------------------------
.|.||.|||||||....|. |.| .|.|. . ||||| |...||| . |.||.|||. | .|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
---------------------EKGTFAGVWDNN---TLTDYLYKVNTTEQ-NQQLARENFMYSSAGYAVATCVLGIADRHPGNIMLQ-TDGHFLHIDFGH
.. | |. ... .| |.... .... . . ||.|| .| ||| ..| .||| |||..|||| ..|| .||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKTKLGYQ---RENAPFHFSPACANVLG--DVNGEMFKQFRKLCGDALNILRHNSKLLVTLLMLMLGTGI-PELQKA-EDIRYMTDMMFLD-KTDS
..|....|.|.. || .|| . . .| | ... ..|..||..| |....|..| |...|. .|....| |.... .||.| . ..|| ..|
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EAKIEFDK-----LTDMSLDSTRTKLNNLFHNIAVS
|| |.. | |..| |.....|||.|
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | 83714.m00208.AA | PI3_PI4_kinase | 870-1084 | 25 | 2.6e-60 | 211.49 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 870-1084 Range on HMM: 1-300/300 Sequence Identity: 25% (75 aa) PIRVLFKVGDDLR--QDQLTLQVM-----------------------RVMEYLWRKEGIDLH----MRCYGVLPTGFNQGFIEVVPNAITEQALQQEKGT ....||.||||| ||....| |.| .|.|.| |. |. | ..||| . |.||.|||. | . .. .... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV FAG-VWDN----------------------------------NTLTDYLYKVNTTE-QNQQLARENFMYSSAGYAVATCVLGIADRHPGNIML---QTDG . ..| . | ....| |... . . ||.|| .| ||..|.. .||..|||..|||. |.| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HFLHIDFGHFLGNFKTKLGYQRENAPFHFSP------ACANVLGD----VNGEMFKQFRKLCGDALNILRHNSKLLVTLL-------MLMLGTGIPELQK | ||||||.....|.| . .| ||.. . ...|. . ... ||..| .|...||... |...|| .|. .|.|.. . HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 83714.m00208.AA | FRAP | 968-1009 | 51 | 5e-08 | 25.72 | In-house | 137-179 (251) | Show / Hide |
Range on Protein: 968-1009 Range on HMM: 137-179/251 Sequence Identity: 51% (22 aa) RENFMYSSAGYAVATCVLGIADRHPGNIMLQ-TDGHFLHIDFG | |. | | .| .||. |||| ||||| | .||||| RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 83714.m00208.AA | ATR | 967-1074 | 20 | 3e-06 | 16.82 | In-house | 163-267 (267) | Show / Hide |
Range on Protein: 967-1074 Range on HMM: 163-267/267 Sequence Identity: 20% (22 aa) ARENFMYSSAGYAVATCVLGIADRHPGNIMLQT-DGHFLHIDFGHFLGNFKTKLGYQRENAPFHFSPACANVLGDVNGEMFKQFRKLCGDALNILRHNSK .|||.. | | ... ..|. ||| ||... | |.|. . .. | || . .| . . ||. | . . ..|.. SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQF--EVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRD LLVTLLMLM .. .. DIMSVWDCF |
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| Kinase | 83714.m00208.AA | PIKK | 967-1010 | 44 | 2.8e-05 | 15.57 | In-house | 185-229 (290) | Show / Hide |
Range on Protein: 967-1010 Range on HMM: 185-229/290 Sequence Identity: 44% (20 aa) ARENFMYSSAGYAVATCVLGIADRHPGNIMLQTD-GHFLHIDFGH .|||. | | .. .||. |||| |||.. . | .|||||. RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | 83714.m00208.AA | PIKK | 874-930 | 37 | 0.000489 | 11.02 | In-house | 34-94 (290) | Show / Hide |
Range on Protein: 874-930 Range on HMM: 34-94/290 Sequence Identity: 37% (23 aa) LFKVGDDLRQDQLTLQVMRVMEYLWRKE----GIDLHMRCYGVLPTGFNQGFIEVVPNAIT |.| ..|||||| ..|. ..| . .|. .||.| | | | . . | || |.|. | LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT |
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