Gene 96895.m00075 (T.vaginalis)
96895.m00075
Species: T.vaginalis
Alias: TvagK0975, 96895.m00075
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 96895.m00075.AA | Protein | None | 321 | None | Fasta, JSON |
| 96895.m00075.kin_dom | Protein Kinase Domain | None | 195 | None | Fasta, JSON |
Protein domains of 96895.m00075.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 96895.m00075.AA | CAMK | 56-255 | 15 | 3.7e-27 | 83.98 | In-house | 86-425 (425) | Show / Hide |
Range on Protein: 56-255
Range on HMM: 86-425/425
Sequence Identity: 15% (52 aa)
KS-------IKCENIVQCID---------------TAQD-----DNAFYAIY---NIPVGI----NLAEMLKSQ---------------GKLTEQQTSGI
|. .. .||..... | .. |. .| . | | ...... |..||.... .
KKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRY
IKQVLTAACYCHSQGYGLLNLCLSNVYMDKND----------------F-IEILDFSFNCQYNK------------------------DEFINEYPHSLY
..|.. | ||||.. . | . |. .|.|. . | | || | ..... .. ... ...
FRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPE
TAP-PEFFSR-------------QKFLVQLADSWSIGILTYNLISGHYPWP----------------------NIRQVE-EVPGSVIKPPP---------
.. || ... .. . .| ||.|...| . .|..|. .|.. . . | . ..|..
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD
------ILLHNSTPCTNFIQKMMMVDDACRFSITQALNHVWI
. |. | ..|.||. || |..|.|.||| |.
DISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 96895.m00075.AA | Ciliate-E2-Unclassified | 10-255 | 16 | 1.1e-18 | 61.5 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 10-255
Range on HMM: 1-352/352
Sequence Identity: 16% (57 aa)
FEIGRIVATGDQYTVFEAIGEFTT-------KPAFIKKMSREYGFK---INPMERTKSIK-------------------CENIVQCIDTAQDDNAFYAIY
..|... .| . .|.... . . . ....... . .| .| |.. ...| ...|| .... ||.. .| ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
NIPVGINLAEMLKSQGK-----------------LTEQQTS-----GIIKQVLTAACYCHSQGYGL--LNLCLSNVYMDKND---FIEILDFSF------
| .| ...|...| .||||.. ...|.| . .|.|... . .. ..|. .|.| | | ||..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------NCQYNKDEFINEYPHSLYTA----PPEFFSRQKFLV---QLADSWSIGILTYNLISGHYPWPNIRQVE---------------EVPGSVI
. |..|.. .. .... .|| . .|. .| || |.. | .. | || . . . .. .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
K----PPPILL-----HNSTPCTNFIQ----KMMMVDDACRFSITQALNHVWI
. |. | | . .||. ||. .. | .. |.||| |.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 96895.m00075.AA | CAMKL | 167-255 | 27 | 1.5e-17 | 52.44 | In-house | 200-297 (297) | Show / Hide |
Range on Protein: 167-255 Range on HMM: 200-297/297 Sequence Identity: 27% (28 aa) APPEFFSR--QKFLVQLADSWSIGILTYNLISGHYPWP----------NIRQVEEVPGSVIKPPPILLHNSTPCTNFIQKMMMVDDACRFSITQALNHVW ..|| |.. ... . .| ||.|.. |... |..|. || .. . . ||| .| | .| ..|.||..|. |..| | .|| | MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW I M |
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| Kinase | 96895.m00075.AA | MELK | 52-255 | 24 | 1.6e-17 | 56.18 | In-house | 48-254 (254) | Show / Hide |
Range on Protein: 52-255 Range on HMM: 48-254/254 Sequence Identity: 24% (52 aa) MERTKSIKCENIVQCIDTAQDDNAFYAIYNIPVGINLAEMLKSQGKLTEQQTSGIIKQVLTAACYCHSQGYGLLNLCLSNVYMDKNDFIEILDFSFNCQY |. |... ..| | . .. .. . . | .. . . .| .| |..| . .|.. | | ||||| .| |. .| . . ..|| . . MDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT --NKDEF-INEYPHSLYTAPPEFFSRQKFLVQLADSWSIGILTYNLISGHYPWP--NIRQV-EEVPGSVIKPPPILLHNSTPCTNFIQKMMMVDDACRFS .||. .. |. | || . .... || ||.||| | |. | |. |.. . . . . |. | | . ...|. || | | KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWL---SPESKQLLRHMLQVDPKKRIS ITQALNHVWI . . ||| |. MKNLLNHPWV |
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| Kinase | 96895.m00075.AA | Ciliate-E2 | 56-255 | 17 | 3.8e-15 | 48.43 | In-house | 87-365 (365) | Show / Hide |
Range on Protein: 56-255 Range on HMM: 87-365/365 Sequence Identity: 17% (50 aa) KSIKCENIVQCIDTAQ--DDNAFYAIYNIPVGINLAEMLKSQ-----------GKLTEQQTSGIIKQVLT---------------AACYCHSQG-YGLLN ..... ||...... | ||| .| . | .| . .|.. ...||.. . |.||.| | |.||.. . EQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRD LCLSNVYMDKNDFIEILDFSF--NCQYNKDEFI-----NEYPH-------------------------SLYTAPPEFFSRQKFLV--------QLADSWS . ..|. . | | || . ... . .. . ..|. ... .|| ....| .| || IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS IGILTYNLISGHYPWPNIRQVEEVPGSVIKPPP------------ILLHNSTPCTNFIQK----MMMVDDACRFS-ITQALNHVWI .|.. | ...| .|. ..| .. . . .| . . .. | | ..|.| |. .| |.. . |.||| |. LGVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 96895.m00075.AA | S_TKc | 10-255 | 21 | 4.2e-15 | 44.6 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 10-255 Range on HMM: 1-231/231 Sequence Identity: 21% (57 aa) FEIGRIVATGDQYTVFEAIGEFTTKPAFIKKMSREYGFKINPMERTKSIKCENIVQCIDTAQDDNAFYAIYNIPVG--INLAEMLKSQGK------LTEQ .||.|.. | .|. .. | . ||... .. .. |. ...|||...|. || . .| . | .| ...|..|. ..| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- QTSGIIKQVLTAACYCHSQGYGLLNLCLSNVYMDKNDFIEILDFSFNCQYNKDEFINEYPHSLYTAPPEFFSRQKFLVQLADSWSIGILTYNLISGHYPW .. ...|.. | ||||.| | .|. .|. | | || . .|. . . ... .|| . .. .| ||.|.. | ...| |. HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPF PNIRQVEEVPGSVIKPPPILLHNSTPCTNFIQKMMMVDDACRFSITQALN-------HVWI | ... .|. | .. .||.|.. .| . | .. .||. | |. P----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 96895.m00075.AA | QIK | 90-255 | 22 | 2.6e-12 | 44.17 | In-house | 87-272 (272) | Show / Hide |
Range on Protein: 90-255 Range on HMM: 87-272/272 Sequence Identity: 22% (43 aa) EMLKSQGK--------------------LTEQQTSGIIKQVLTAACYCHSQGYGLLNLCLSNVYMDKNDFIEILDFSFNCQYNKDEFINEYPHSLYTAPP . | ..|. ..|... . .|...| |||... | |. .|.| | | || | . ... . . | | | DYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAP EFFSRQKFLVQLADSWSIGILTYNLISGHYPWPNIRQ----VEEVPGSVIKPPPILLHNSTPCTNFIQKMMMVDDACRFSITQALNHVWI | | ... .| ||.|.. | |..| | .. . | .. |. . |. | .| .|. || . |..| | ..| |. EMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFM----SQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 96895.m00075.AA | MARK | 167-255 | 25 | 1.9e-11 | 33.89 | In-house | 172-262 (262) | Show / Hide |
Range on Protein: 167-255 Range on HMM: 172-262/262 Sequence Identity: 25% (23 aa) APPEFFSRQKFLVQLADSWSIGILTYNLISGHYPWP--NIRQVEEVPGSVIKPPPILLHNSTPCTNFIQKMMMVDDACRFSITQALNHVWI ..|| |.... . .| || |.. | ...|..|. .. ..| . ..| | |. | |.||....|. | .|.. ..| |. MAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 96895.m00075.AA | Pkinase | 182-255 | 18 | 3.5e-10 | 37.08 | Pfam | 193-293 (293) | Show / Hide |
Range on Protein: 182-255 Range on HMM: 193-293/293 Sequence Identity: 18% (19 aa) ADSWSIGILTYNLISGHYPWPNI----------RQVEEVPGSVIKPPPILLHNS-----------------TPCTNFIQKMMMVDDACRFSITQALNHVW .| ||.|.. | ...|. |.|. . .. .. . . | . .| .| || .. .| ..| ...|.|.| | VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW I . F |
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| Kinase | 96895.m00075.AA | CAMK1 | 230-255 | 46 | 2.1e-08 | 20.48 | In-house | 251-276 (276) | Show / Hide |
Range on Protein: 230-255 Range on HMM: 251-276/276 Sequence Identity: 46% (12 aa) NFIQKMMMVDDACRFSITQALNHVWI .|| .|. || |....|.||| || DFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | 96895.m00075.AA | CDPK | 93-121 | 37 | 5.6e-07 | 17.68 | In-house | 95-123 (271) | Show / Hide |
Range on Protein: 93-121 Range on HMM: 95-123/271 Sequence Identity: 37% (11 aa) KSQGKLTEQQTSGIIKQVLTAACYCHSQG ...|..||.....|..|.| | ||||.. IEKGHFTEKEAAYIMRQILSAVNYCHSNN |
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| Kinase | 96895.m00075.AA | Aur | 87-121 | 29 | 3e-06 | 12.01 | In-house | 85-121 (257) | Show / Hide |
Range on Protein: 87-121 Range on HMM: 85-121/257 Sequence Identity: 29% (11 aa) NLAEMLKSQ--GKLTEQQTSGIIKQVLTAACYCHSQG .| . |..| ....||.. ...|. | ||||.. ELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKN |
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| Kinase | 96895.m00075.AA | CDPK | 232-255 | 45 | 4e-06 | 14.91 | In-house | 248-271 (271) | Show / Hide |
Range on Protein: 232-255 Range on HMM: 248-271/271 Sequence Identity: 45% (11 aa) IQKMMMVDDACRFSITQALNHVWI |.|| .| |.| |||.| |. IRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | 96895.m00075.AA | CAMKL | 86-121 | 25 | 2.1e-05 | 13.02 | In-house | 108-147 (297) | Show / Hide |
Range on Protein: 86-121 Range on HMM: 108-147/297 Sequence Identity: 25% (10 aa) INLAEMLKSQ----GKLTEQQTSGIIKQVLTAACYCHSQG . | ...... |...| .. . .|.. | ||||.| MDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG |
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| Kinase | 96895.m00075.AA | Aur | 231-255 | 36 | 2.5e-05 | 9.47 | In-house | 233-257 (257) | Show / Hide |
Range on Protein: 231-255 Range on HMM: 233-257/257 Sequence Identity: 36% (9 aa) FIQKMMMVDDACRFSITQALNHVWI .|.| .| | .. |..|| || LISKILQHDPKQRMTLDQIMNHPWI |
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| Kinase | 96895.m00075.AA | Pkinase | 56-121 | 24 | 0.000208 | 16.67 | Pfam | 55-128 (293) | Show / Hide |
Range on Protein: 56-121 Range on HMM: 55-128/293 Sequence Identity: 24% (18 aa) KSIKCENIVQCIDTAQDDNAFYAIYNIPVGI----NLAEMLK--SQGKL--TEQQTSGIIKQVLTAACYCHSQG |.....|||...|. .|.. | . | |..... ..|.. .|.. ...|.| . ||||.| KRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG |
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| Kinase | 96895.m00075.AA | CAMK1 | 99-121 | 47 | 0.000631 | 7.23 | In-house | 106-128 (276) | Show / Hide |
Range on Protein: 99-121 Range on HMM: 106-128/276 Sequence Identity: 47% (11 aa) TEQQTSGIIKQVLTAACYCHSQG ||.. . |.||.| | |.||.| TEKDARHIMKQILSAVEYMHSKG |
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| Kinase | 96895.m00075.AA | Aur | 185-198 | 42 | 0.002542 | 4.06 | In-house | 185-198 (257) | Show / Hide |
Range on Protein: 185-198 Range on HMM: 185-198/257 Sequence Identity: 42% (6 aa) WSIGILTYNLISGH |..|.|.| |..|. WCLGVLCYELCHGC |
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| Kinase | 96895.m00075.AA | CAMK1 | 57-77 | 36 | 0.023573 | 2.58 | In-house | 63-84 (276) | Show / Hide |
Range on Protein: 57-77 Range on HMM: 63-84/276 Sequence Identity: 36% (8 aa) S-IKCENIVQCIDTAQDDNAFY | |...||..... ..|| || SKIDHPNIIKFYEWYESDNHFY |
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| Kinase | 96895.m00075.AA | MARK | 85-121 | 33 | 0.02724 | 3.49 | In-house | 86-124 (262) | Show / Hide |
Range on Protein: 85-121 Range on HMM: 86-124/262 Sequence Identity: 33% (13 aa) GINLAEMLKSQ--GKLTEQQTSGIIKQVLTAACYCHSQG | .| . .|.. |.|.| . | .|.. | .||||.. GGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN |
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