97241.m00123

Species: T.vaginalis
Alias: 97241.m00123, TvagK1031
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
97241.m00123.AA Protein None 395 None Fasta, JSON
97241.m00123.kin_dom Protein Kinase Domain None 179 None Fasta, JSON

Protein domain

Protein domains of 97241.m00123.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 97241.m00123.AA TKL 88-266 18 3.2e-27 95.09 In-house 118-364 (364) Show / Hide
Range on Protein: 88-266
Range on HMM: 118-364/364
Sequence Identity: 18% (47 aa)

EYPRLGTLNDAISSRDPMLEDPTNKMKIIHGIASALLYLHSNK--------ITLTNLNSSTIWIDENCE--------------PIIGDLSYSCIDGPDFM
||   |.| . .         .  .......||... ||||..        |   .|.|. | .||| .              . |.|.  |    ... 
EYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN

SNFEFDEKA--------------FV----YYSPECLANGT--------------KKVTNKADIFAFGMVLYHLLSGEPPSQ-LSSREEL---------YE
.|                      .    . .||.| . .              .. . |.|...||.||. .|....| . . .....         . 
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMM

ERYYGGRPQFG------------PNFPPMFEELISMCWESEIDQRPTAQEIIDVL
  . | ||               |..|| . .|. .||... ..||..|||.. |
VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 97241.m00123.AA LRRK 175-268 26 3.8e-24 82.33 In-house 243-351 (351) Show / Hide
Range on Protein: 175-268
Range on HMM: 243-351/351
Sequence Identity: 26% (29 aa)

FVYYSPECLAN-GTKKVTNKADIFAFGMVLYHLLSGE-PPSQLSS-------REELYEERYYGGRPQFGPN-FPP-----MFEELISMCWESEIDQRPTA
... .||.. . |..  | |.|...|||.|..||... .| .  .       .|.. ..   | || . ..  ||     |...||  ||. . ..||..
PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF

QEIIDVLSS
..|...||.
SQIVKRLSQ

Kinase 97241.m00123.AA TKL-Unique 175-266 28 1.3e-16 55.2 In-house 190-290 (290) Show / Hide
Range on Protein: 175-266
Range on HMM: 190-290/290
Sequence Identity: 28% (29 aa)

FVYYSPECLANGTKKVTNKADIFAFGMVLYHLLSGEP------PSQLSSREELYEERYY---GGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDV
| . .|| | .  .. ..|.|...||.||. .....       | |  ..|...|   |   . ||  ... |. . .|| .|| .. .|||. .|||  
FRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHR

L
|
L

Kinase 97241.m00123.AA TK 177-266 19 2.1e-13 40.52 In-house 351-486 (486) Show / Hide
Range on Protein: 177-266
Range on HMM: 351-486/486
Sequence Identity: 19% (26 aa)

YYSPECLANG-------TKKVTNKADIFAFGMVLYHLLS-G-EPPSQLSSR---------EELYE-----------------ERYYGGRPQFGPNFP---
...||||. .       ..| | | |...|| ... ... | ||.    |          .|..|                 .|.   .|.  | ..   
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------PMFEELISMCWESEIDQRPTAQEIIDVL
        .....|. .||. . ..||| ... . |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase 97241.m00123.AA MLK 189-266 26 1.5e-12 39.99 In-house 212-291 (291) Show / Hide
Range on Protein: 189-266
Range on HMM: 212-291/291
Sequence Identity: 26% (21 aa)

KVTNKADIFAFGMVLYHLLSGEPPSQ--LSSREELYEERYYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVL
|.. |.|.. .|.||. .|..| | .  ... . ...  | | ||  ....|. ...|...||...  .||. ..|.  |
KYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase 97241.m00123.AA TKL-ciliate1 175-266 28 1.6e-12 39.22 In-house 178-279 (279) Show / Hide
Range on Protein: 175-266
Range on HMM: 178-279/279
Sequence Identity: 28% (29 aa)

FVYYSPECLA---NGTKKVTNKADIFAFGMVLYHLLSGEPPS--QLSSREELYEERYYGGRPQFGP-----NFPPMFEELISMCWESEIDQRPTAQEIID
| .  || .       . .. |.||.|.| |.| | . ..|   ..|   .        |||  ||       |. | .|.  ||.    .|| ..|||.
FHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQ

VL
.|
IL

Kinase 97241.m00123.AA TKL-ciliate2 191-267 33 3.9e-11 32.83 In-house 196-273 (273) Show / Hide
Range on Protein: 191-267
Range on HMM: 196-273/273
Sequence Identity: 33% (26 aa)

TNKADIFAFGMVLYHLLSGEPPSQLSSREELYEERYYGG-RPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVLS
| |||.|.....|. . | |||    . .   |.      ||    | || | .|.  ||. . . ||. .|||  | 
TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE

Kinase 97241.m00123.AA HH498 179-266 24 4.8e-11 30.84 In-house 193-284 (284) Show / Hide
Range on Protein: 179-266
Range on HMM: 193-284/284
Sequence Identity: 24% (23 aa)

SPECLANGTKKVTNKADIFAFGMVLYHLLSGEPP-SQLSSREELYEERYYGGRPQFGPN----FPPMFEELISMCWESEIDQRPTAQEIIDVL
.||    .. | . |.|.| ..|... ....| | . .       |  |  .||  .      .|     || |||. . . ||.  .|. .|
APEVFSQCQ-KYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL

Kinase 97241.m00123.AA ARK 230-265 36 6.4e-10 32.51 In-house 245-280 (280) Show / Hide
Range on Protein: 230-265
Range on HMM: 245-280/280
Sequence Identity: 36% (13 aa)

RPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDV
||   .| |. .. ||. ||... | ||...||.  
RPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE

Kinase 97241.m00123.AA CZAK 235-266 38 3.1e-09 29.85 In-house 244-279 (279) Show / Hide
Range on Protein: 235-266
Range on HMM: 244-279/279
Sequence Identity: 38% (14 aa)

PN-FPPMFE---ELISMCWESEIDQRPTAQEIIDVL
|  ..|| .   |||.|||..  | ||.  .|.. |
PQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL

S_TKc 97241.m00123.AA S_TKc 15-272 18 4.6e-09 -43.99 SMART 1-231 (231) Show / Hide
Range on Protein: 15-272
Range on HMM: 1-231/231
Sequence Identity: 18% (50 aa)

QEKISVQSDGKYSHTKQVATGLDCFTKYYKQCDIITLKKLINDVQISTKMTHKVFGPIIGYAISPNNGLLVSREYPRL--GTLNDAISSRDP----MLED
 |.. .   | ..  ...    .      |. .    ..... .||  |  |.    ....  .  . | .  ||     |.| | | .| .       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

PTNKMKIIHGIASALLYLHSNKITLTNLNSSTIWIDENCEPIIGDLSYSCIDGPDFMSNFEFDEKAFV----YYSPECLANGTKKVTN-KADIFAFGMVL
.    .... |..|| |.||..|    |  . | .||  .  |.|   ...             . |.    | .|| |     . .  |.|. ..| .|
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCIL

YHLLSGEPPSQLSSREELYEERYYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIID---VLSSSDLI
| .|.|.|| .    .....              .| . ..|. |.. . ..|||| |.     .  .   .
YEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 97241.m00123.AA TKL-Unique 51-146 23 5.8e-08 24.35 In-house 39-148 (290) Show / Hide
Range on Protein: 51-146
Range on HMM: 39-148/290
Sequence Identity: 23% (26 aa)

LKKLINDVQISTKMT-HKVFGPIIGYAI----SPNNGLLVSREYPRLGTLNDAISS--------RDPMLEDPTNKMKIIHGIASALLYLHSNK--ITLTN
.....| | .. |   |.    ..|| .    .|.|  .|. ||  .|.|.| ..         .. .  .. ...|... ||... |||...  |. ..
MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVM-EYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRD

LNSSTIWIDEN
| || . .|.|
LKSSNFLVDNN

TyrKc 97241.m00123.AA TyrKc 12-266 18 2.4e-07 -103.85 SMART 1-280 (280) Show / Hide
Range on Protein: 12-266
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FVEQEKISVQS-----DGKYSHTKQVATGLDCFTKYYKQCDIITLKKLINDVQISTKM--THKVFGPIIGYAISPN------NGLLVSREYPRLGTLNDA
 .  .|.          |...        ...  |  | .    .. ...  .| .|    |.    ..|.....         |..  ||  .| |.| 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

ISSRDPMLEDPTNKMKIIHGIASALLYLHSNKITLTNLNSSTIWIDENCEPIIGDLSYSCIDGPD---------FMSNFEFDEKAFV---YYSPECLANG
. .. |    .  . .. . ||.   ||||...    |    . ..||    |.|   |   . |          ..  . ..|. .    ..|||.   
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--N

TKKVTNKADIFAFGMVLYHLLS-GEPPSQL-----SSREELYEERYYGGRPQFGPN--------FPPMFEELISMCWESEIDQRPTAQEIIDVL
..| | | |...|| ... ... |..|         | .|..|    |.|.   ||         |.   .....||. . ..||| .||.. .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 97241.m00123.AA Pkinase_Tyr 178-266 32 2.6e-07 25.4 Pfam 181-270 (270) Show / Hide
Range on Protein: 178-266
Range on HMM: 181-270/270
Sequence Identity: 32% (30 aa)

YSPECLANGTKKVTNKADIFAFGMVLYHLLS-GEPP--SQLSSREELYEER-YYGGRPQFGPNFPPMFEELISMCWESEIDQRPTAQEIIDVL
..|||...|    | | |. .|| ... ... || |    . | ||.||     |.|    .| |.   .|. .||. . ..||| .||.  |
MAPECINYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase 97241.m00123.AA Pkinase 177-266 18 6.2e-07 25.59 Pfam 177-293 (293) Show / Hide
Range on Protein: 177-266
Range on HMM: 177-293/293
Sequence Identity: 18% (22 aa)

YYSPECLANGTKKVTNKADIFAFGMVLYHLLSGEPPSQLS----SREELYEERYYGGRPQFGPNFP-----------------------PMFEELISMCW
| .|| .  | .. . |.|....| .|| .|.|.|| . .    .  . ..  .  ..|..  ..|                       . . ..|. |.
YMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

ESEIDQRPTAQEIIDV--L
.    .||||..|     .
CKDPKKRPTAEQILQHPWF

Kinase 97241.m00123.AA CZAK 191-214 37 0.001714 8.73 In-house 200-223 (279) Show / Hide
Range on Protein: 191-214
Range on HMM: 200-223/279
Sequence Identity: 37% (9 aa)

TNKADIFAFGMVLYHLLSGEPPSQ
| |.|.. |||.|. .. .. | |
TEKVDVYSFGMILWCIITCDQPYQ

Kinase 97241.m00123.AA LRRK 88-136 27 0.004763 6.61 In-house 135-192 (351) Show / Hide
Range on Protein: 88-136
Range on HMM: 135-192/351
Sequence Identity: 27% (16 aa)

EYPRLGTLNDAIS--SRDPM----LE-DPTNKMKIIHGIASALLYLHSNK--ITLTNL
||...|.|.. ..  ..|..     . ... | ||   ||... ||||..  |  ..|
EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDL

Kinase 97241.m00123.AA Pkinase 114-131 33 3.560533 1.7 Pfam 112-129 (293) Show / Hide
Range on Protein: 114-131
Range on HMM: 112-129/293
Sequence Identity: 33% (6 aa)

KIIHGIASALLYLHSNKI
...  |...| |.||..|
FYMYQILRGLEYCHSMGI