Gene 92477.m00232 (T.vaginalis)
92477.m00232
Species: T.vaginalis
Alias: TvagK0320, 92477.m00232
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92477.m00232.AA | Protein | None | 837 | None | Fasta, JSON |
| 92477.m00232.kin_dom | Protein Kinase Domain | None | 256 | None | Fasta, JSON |
Protein domains of 92477.m00232.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 92477.m00232.AA | TKL | 47-279 | 17 | 4.7e-41 | 142.71 | In-house | 25-364 (364) | Show / Hide |
Range on Protein: 47-279
Range on HMM: 25-364/364
Sequence Identity: 17% (62 aa)
TNRNVIIRKISKNK-------------------------ESEDKLRRFNLEVRALARCNSICVNKLIGYTIFQP--------------YSIITEYQPNKT
|.. | . |.... |.. ... |.. . |.. . ...|| . | . |..|| |. .
TGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGS
-VDTFIYSINPCRKACIIGTYQT--KIAIGIAWGLMHIHS--------KGIIHRDLCVNNILLDQDFV--------------PKIIGFGIAQFIDSLQS-
.... . ..|..|| |. . || ..|||||| .|||.|... .|| ||...|.. ..
LLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM
-------------------NTKKIDVTAYTAPEVALGN----------------EYGVQSEMYSYGLLLYELSEMEKPFK--DLSPQK-------IIDLV
. ... ... |||| |. || .. .||.|..|.|. ..|.. . .|.. .. .|
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV
IKGGRRPELT------------KKKPENLKNFIEKCWSENPHRRPSIEEAFKEF
.. |.||.. . |. .|. ...||...|. ||| .| |..
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | 92477.m00232.AA | Dicty4-Unclassified | 130-279 | 30 | 2.4e-34 | 115.04 | In-house | 113-263 (263) | Show / Hide |
Range on Protein: 130-279 Range on HMM: 113-263/263 Sequence Identity: 30% (46 aa) KIAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQFIDSLQSNTKKIDVTAYTAPEVALGNEYGVQSEMYSYGLLLYELSEMEKPFKDLS |.|. || |. | |.. .||||. |||.| .| || |||. || . | . ..||. . | | |||...|||| . |. . KYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQ -PQKIIDLVIKGGRRPELTKKKPENLKNFIEKCWSENPHRRPSIEEAFKEF . . .| . ||.. . ..| | ||.. | .||.... . SIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
|||||||||
| Kinase | 92477.m00232.AA | Dicty5 | 131-283 | 35 | 2.9e-34 | 115.35 | In-house | 109-260 (260) | Show / Hide |
Range on Protein: 131-283 Range on HMM: 109-260/260 Sequence Identity: 35% (55 aa) IAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQFIDSLQSNTKKIDVTAYTAPEVALGNEYGVQSEMYSYGLLLYELSEMEKPFKDLSP .||.|| .. |.||..|||||| .|.|. .. ||| ||. |.| | . .. |.|. |. | ||.| |.|. |.... MAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINN QKIIDLVIKGGRRPELTKKKPENLKNFIEKCWSENPHRRPSIEEAFKEFSSHK | .| ||. ||.. | | | |.||| . ||.||| | | | | WNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
|||||||||
| Kinase | 92477.m00232.AA | TKL-Unique | 130-279 | 25 | 1.3e-32 | 112.39 | In-house | 114-290 (290) | Show / Hide |
Range on Protein: 130-279 Range on HMM: 114-290/290 Sequence Identity: 25% (46 aa) KIAIGIAWGLMHIHSKG--IIHRDLCVNNILLDQD-----FVPKIIGFGIAQFIDSLQSNTKK----------IDVTAYTAPEVALG--NEYGVQSEMYS |.|| || |. ..|... |||||| |.|.|.. . ||..||.. | .. .|.. .. . . |||| . . | .|. || KMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYS YGLLLYELSEMEK------PFKDLSPQKIIDLVIK--GGRRPELTKKKPENLKNFIEKCWSENPHRRPSIEEAFKEF .| |.|. . . |.......... .| . . ||.. |..... |..|| .| ||| .| .. FGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
|||||||||
| Kinase | 92477.m00232.AA | LRRK | 130-281 | 28 | 1.5e-29 | 101.69 | In-house | 168-351 (351) | Show / Hide |
Range on Protein: 130-281 Range on HMM: 168-351/351 Sequence Identity: 28% (52 aa) KIAIGIAWGLMHIHSKG--IIHRDLCVNNILL---D---------QDFVPKIIGFGIAQ-FIDSLQS--NTKKIDVTAYTAPEVALGN---EYGVQSEMY |||. || |. . ||. |||||| |||| . .. . ||. ||| . | .... .. . . |||. .| || .. .| KIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCY SYGLLLYELSEME-KPFKDLS-P-----QKIIDLVIKGGRRPELTKK-KPE-----NLKNFIEKCWSENPHRRPSIEEAFKEFSS |.|..|.|| . || ... . . .| . |..|.|| . |. ... |..||...| .||. .. .| |. SFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Pkinase | 92477.m00232.AA | Pkinase | 25-279 | 22 | 6.2e-29 | 103.38 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 25-279 Range on HMM: 1-293/293 Sequence Identity: 22% (68 aa) FDIKAEMGPTNSGVLFFAVEKTTNRNVIIRKISKNKESEDKLRRFNL--EVRALARCNSICVNKLIGYTI-FQPYSIITEYQPNK----TVDTFIYSINP . |. | ..|. . ...| |.. | . .|.| .|...|... . |.. ..|.|. .. .|... . . ...|| .. ..| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--- CRKACII--GTYQTK-IAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVP----KIIGFGIAQFI-DSLQSNTKKIDVTA-YTAPEVAL-GNEYGVQSE .. . . . | .. |. || ..||.||||||| |||.|.. .. ||. ||.| .. .| .. . .| | |||| . |..|| . -WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD MYSYGLLLYELSEMEKPFKDL------SPQKIIDLVIKGGRRPELTKKKP-------------------ENLKNFIEKCWSENPHRRPSIEEAFKE--F |.|.|..|||. . ||.. .....|... .. . . .. . |..| ||..|. .|..||..|.... | MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 92477.m00232.AA | TK | 128-279 | 16 | 2e-28 | 91.75 | In-house | 237-486 (486) | Show / Hide |
Range on Protein: 128-279
Range on HMM: 237-486/486
Sequence Identity: 16% (41 aa)
QTKIAIGIAWGLMHIHSK------GIIHRDLCVNNILLDQDFV-----------PKIIGFGIA--------QFIDSLQSNTKKIDVTA------------
. .. || |. ..||| ...||||. |.|.... | || || . |.| . ..| . ..
LL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPW
---------------YTAPEVALGNE---------YGVQSEMYSYGLLLYELSEME-KPFKD-LSP---------QKIIDLVIKG-----------GRRP
..|||. .... . .| ..|.| |..|. .|. .| | ..... .| |.|
QDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRM
ELT--KKKP--------------ENLKNFIEKCWSENPHRRPSIEEAFKEF
.. . | | . .. .||...| .||. .. ...
RMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | 92477.m00232.AA | Ciliate-E2-Unclassified | 25-277 | 18 | 1.3e-27 | 92.84 | In-house | 1-348 (352) | Show / Hide |
Range on Protein: 25-277
Range on HMM: 1-348/352
Sequence Identity: 18% (64 aa)
FDIKAEMGPTNSGVLFFAVEKTTNRNVIIRKISKNKESEDKLRRFN---------LEVR--------------ALARCNSICVNKLIGY-TIFQPYSIIT
. | | . |. . ...| .. .. ..|... .|. ... .. . | ...... |.. . . | |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
EYQPNKTVDTFIYSINP-----------CRKACIIGTYQTK------IAIGIAWGLMHIHSKG-IIHRDLCVNNILLDQD---FVPKIIGFGIAQFIDSL
|| .... .| . . ... .|. .|.| .. | || ..|.|. |||||. .|||.|.. . .|||.|||. ....
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
---------------QSNTKKI---DVTA--YTAPEVALGNEYG----VQSEMYSYGLLLYELSEMEKPFKDLSPQK---------------IIDLVIKG
| ... . . |||||| |..|. .. ..| | .|||. . ||.| . . .. ||
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ
G---RRPELT----KKKPENLKNFIE----KCWSENPHRRPSIEEAFK
. ... |. ... |.||. |. || |...|....
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
|
|||||||||
| Kinase | 92477.m00232.AA | TKL-ciliate1 | 135-279 | 25 | 5.4e-25 | 82.49 | In-house | 112-279 (279) | Show / Hide |
Range on Protein: 135-279 Range on HMM: 112-279/279 Sequence Identity: 25% (42 aa) IAWGLMHIHSKG--IIHRDLCVNNILLDQDFVPKIIGFGIAQF----------IDSLQSNTKKIDVTAYTAPEVAL-----GNEYGVQSEMYSYGLLLYE || |. ..|.. .||||| . |||.| .. .|| |. ....| ... . |||. . . . |.|| ..|. IAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYI LSEMEKPF-KDLSPQKIIDLVIKGGRRPEL-----TKKKPENLKNFIEKCWSENPHRRPSIEEAFKEF | ..|| .| |. .. . || | .. |.|. |.. .||..|| ||. .| LCFRKTPFQQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL |
|||||||||
| Kinase | 92477.m00232.AA | STE | 25-280 | 16 | 2.4e-24 | 82.95 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 25-280
Range on HMM: 1-359/359
Sequence Identity: 16% (61 aa)
FDIKAEMGPTNSGVLFFAVEK------TTNRN---------VIIRKISKNKES---------------EDKLRRFNLEVRALARCN--SICVNKLIGYTI
... . | ..|. . |. . |... . | ........ .... .. |.. . .|| . . | .|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
FQP--------YSIITEYQPNKTVDTFIYSINPCRK---------ACIIGTYQTKIAIGIAWG-LMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQ
|. || .. ..| .| . | | .. . .|. | | | ..||..|||||. |||| |.. ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
FIDS---------------LQSNTKKIDV--TAYTAPEVALG------NEYGVQSEMYSYGLLLYELSEMEKPFKDLSPQKIIDLVIKG-----------
... .. . .| . |||| .. ..|.... ..| |... |. . . |. |..| . . . ...
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC
---GRRPELTK-------------------KKPENLKNFIEKCWSENPHRRPSIEEAFK---EFS
| | | | ...|.||.|| .|. ||. .. | .|
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
|
|||||||||
| Kinase | 92477.m00232.AA | TK-Unique | 131-279 | 26 | 3.3e-24 | 80.46 | In-house | 136-294 (294) | Show / Hide |
Range on Protein: 131-279 Range on HMM: 136-294/294 Sequence Identity: 26% (43 aa) IAIGIAWGLMHIHS--KGIIHRDLCVNNILLDQDFVPKIIGFGIAQFIDS---LQSN-TKKIDVTAYTAPEVAL--GNEY-GVQSEMYSYGLLLYEL-SE .|..|| |.....| |.|.||||| |.|| |.| || .||.| .. .... ... .. |||. . .. | .|. .|.| |..|. . FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTL MEKPFKDLSPQKIIDLVIKGGRRPELTKKK-PENLKNFIEKCWSENPHRRPSIEEAFKEF .. |. .... .|... |. | |... .. .. . |... ||...|. |||... ... GACPYPGMPWKDIMEC-IRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | 92477.m00232.AA | S_TKc | 25-280 | 23 | 1.2e-18 | 69.22 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-280 Range on HMM: 1-231/231 Sequence Identity: 23% (63 aa) FDIKAEMGPTNSGVLFFAVEKTTNRNVIIRKISKNKESEDKLRRFNLEVRALARCNSICVNKLIGYTIFQPYSIITEYQPN--KTVDTFIYSINP-CRKA ..| . | |. . ...| |.| | | .|. ... |.. | . . . ||... . . ...|| .. .. ..| . .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF CIIGTYQTKIAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQFIDSLQSNTKKIDVT-AYTAPEVALGNEYGV-QSEMYSYGLLLYELS . ... |. .| ..||.||||||| |||||. . ||. ||.| .. . . .| | |||| || . ..| | .|||. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML EMEKPFKDLSPQKIIDLVIKGGRRPELTKKKPENLKNFIEKCWSENPHRRPSIEEAFK--------EFS . || .|...... .. .|.||.||. .| .||.. ||.. .. CGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 92477.m00232.AA | Pkinase_Tyr | 130-279 | 24 | 8.9e-18 | 60.83 | Pfam | 115-270 (270) | Show / Hide |
Range on Protein: 130-279 Range on HMM: 115-270/270 Sequence Identity: 24% (39 aa) KIAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQFI---DSL-QSNTKKIDVTAYTAPEVALGNEYGVQSEMYSYGLLLYELSEME-KP .... ||.|. . .||..|||||. |.|.. ..| || || | | | .. .. .|||. ... ..| .|.| |..|. .| QMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP -FKDLSPQKIIDLV-IKGGRRPELTKKK--PENLKNFIEKCWSENPHRRPSIEEAFKEF ....|.. ..... .|.| . . . |. . . . .|| ..| .||. .| .. TYPGMSNEEVYEYIYEDGYR---MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | 92477.m00232.AA | TyrKc | 25-279 | 19 | 1.1e-14 | 15.04 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-279 Range on HMM: 1-280/280 Sequence Identity: 19% (58 aa) FDIKAEMGPTNSGVLFFAVEKTTNRNVIIRKISKNKESEDKLRRFNLEVRALARC--NSICVNKLIGYTIF--------QPYSIITEYQPNKTVDTFI-Y . . | . |. . .. | ..| . .. ... .. | | | . . . .. .|.|. . .|. |..|| |. . .. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK SINPCRKACIIGTYQTKIAIGIAWGLMHIHSKGIIHRDLCVNNILLDQDFVPKIIGFGIAQFIDSL-------QSNTKK--IDVT-----AYTAPEVALG . . . .... || | ..|||..||||| |.|.. ... || || . .|.. . .|| . .|||. HRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY NEYGVQSEMYSYGLLLYELSEM-EKPFKD-----LSPQKIIDLVIKGGRRPELTK-------KKPENLKNFIEKCWSENPHRRPSIEEAFKEF ... .| .|.| ...|. ..| . .|.| .| .| .|.|.| |. . . ...|| |.|. ||. .| ..| GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | 92477.m00232.AA | TKL-Unique | 53-102 | 21 | 0.031264 | 3.89 | In-house | 25-81 (290) | Show / Hide |
Range on Protein: 53-102 Range on HMM: 25-81/290 Sequence Identity: 21% (12 aa) IRKISKNKESEDKLRR-FNLEVRALARCN-SICVNKLIGYTI----FQP-YSIITEY | ....| .|. .... |. ||. . . . .. . ...||.. .| ..|..|| IKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEY |
|||||||||