Gene 89154.m00264 (T.vaginalis)

89154.m00264

Species: T.vaginalis
Alias: TvagK0400, 89154.m00264
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
89154.m00264.AA Protein None 435 None Fasta, JSON
89154.m00264.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of 89154.m00264.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 89154.m00264.AA PH 7-101 35 2.6e-23 86.73 Pfam 1-92 (92) Show / Hide 
Range on Protein: 7-101
Range on HMM: 1-92/92
Sequence Identity: 35% (34 aa)

PCHVGWATKCGGFIKTWHRRWFVLTPKYINYYKKPGGRQKGKIPLSNVTEVAPHPECSRKYAFRVVVPNVRTYQVSCDSDEEMKEWVREINKLIS
. . || .| | ..|.|..|||||..... |||... | ||.||||.. .| ..|.  |.. |...  . ||| ....|.|||..|.. |.....
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 89154.m00264.AA PH 7-103 34 1.8e-22 81.87 SMART 1-82 (82) Show / Hide 
Range on Protein: 7-103
Range on HMM: 1-82/82
Sequence Identity: 34% (33 aa)

PCHVGWATKCGGFIKTWHRRWFVLTPKYINYYKKPGGRQKGKIPLSNVTEVAPHPECSRKYAFRVVVPNVRTYQVSCDSDEEMKEWVREINKLISGA
. . || .|..    .|..|||||..... |||..  . ||.||||.. .| . |      .|...  .  || ..|.|.|||.||.. |.|.|. .
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDC-TVRE-P------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
PDK1_PH 89154.m00264.AA PDK1_PH 44-102 26 2.9e-05 16.2 In-house 54-112 (112) Show / Hide 
Range on Protein: 44-102
Range on HMM: 54-112/112
Sequence Identity: 26% (17 aa)

RQKGKIPLS-NVTEVAPHPECS-----RKYAFRVVVPNVRTYQVSCDSDEEMKEWVREINKLISG
..||.||.| . ..|    |        . .|....|| |||.  .|.. . ..|...|.|..  
VIKGEIPWSSKDLYV----EYKPDRKNNFKHFFIHTPN-RTYYF-EDPKGCANKWCEAIEKVCKR
Kinase 89154.m00264.AA AGC 112-369 36 3e-180 470.93 In-house 1-395 (395) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-395/395
Sequence Identity: 36% (144 aa)

FDILKVLGKGTYGKVQLVKNK------KTSQIYAMKSISKRL-LAEYD--LVERTLTE------------RDVLLKAN----------HPFIVS-AKYCF
|..|||.|||..||| ||. |       | ..|||| ..|.    . .   ||.|.||            |..| |.|          |||||.  .|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTETK--IFLVLDYVA---------GG-ELFARLR---EEHKFTIDRARYYIAE-------LVLAIGYLHS-IGVVHRD-LKPENILFDKDGYIKLTDFG
|....  ...|..|.          || ||| .|.    | .|. .|||.|.||       .|||. ||||  |..||| |||||||.|.||.|||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LVKEKMT--------------------------------------------------KQSKTSTFCG--TPEYLAPEIIEGNEYGMAVDWWA--LGTLAY
| || |.                                                  |. .|.||||  ||||.||||.    || |.|||.  || | |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGYPPFYDTN----------TNQMYRYIL------RDDVTFP----------DDATPDAIDLLSKLLDKNPDTRLGSGPSD-----MEEIKAHPFF
|||.||||||. |           ..|.  |.       ..|.||          .  .|.| ||..||| |.|. |||.|..|      ||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 89154.m00264.AA Akt 112-369 54 7.6e-156 501.72 In-house 1-264 (264) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-264/264
Sequence Identity: 54% (144 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIY-AMKSISKRLLAEYDLVERTLTERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHKFTID
||.|||||||..||| ||| |.| ..| |||...|. . . . || |.||| .| . ||||||. .| |||..|...|.||. |||||  |. . .|. |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RARYYIAELVLAIGYLHSIGVVHRD-LKPENILFDKDGYIKLTDFGLVKEK-MTKQSKTSTFCGTPEYLAPEIIEGNEYGMAVDWWA-LGTLAYEMLYGY
|||.|.||..|||..||| ... || ||||||| ||||.|.|||||| ||  .. . || |||||||||||||..|| ...|||||. || . |||..| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYDTNTNQMYRYILRDDVTFP--DDATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
||||. .  ||.  |.  .| ||  |   |.. ||.|.|| |.|. |||.||.| .|||.||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 89154.m00264.AA SGK 112-369 45 1.4e-143 446.58 In-house 1-283 (283) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-283/283
Sequence Identity: 45% (128 aa)

FDILKVLGKGTYGKVQLVKNKKT------------------SQIYAMKSISKRLLA-------EYDLVERTLTER-DVLLKANHPFIVSAKYCFQTETKI
||.|||.||| .||| .|| |..                   ..|||| ..|              ..  ...|| ..| . .|||||. .| |||..| 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FLVLDYVAGGELFARLREEHKFTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEKMTKQSKTSTFCGTPEYLAPEIIEGN
..|.||| |||.|  |. | .|  |||| | ||.|.|..||||. ...||||||||| | .|...|||||| ||.. .. .|.||||||||||||.. . 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

EYGMAVDWWALGTLAYEMLYGYPPFYDTNTNQMYRYILRDDVTFPDDATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
... .|||| ||.. |||.|| ||||. |..|||  |.. .  .|   ..|| ||.  || |.|. |||.   | .||| ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF
Kinase 89154.m00264.AA AktR 112-369 46 2.5e-128 432.62 In-house 1-268 (268) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-268/268
Sequence Identity: 46% (125 aa)

FDILKVLGKGTYGKVQLVKNK-KTSQIYAMKSISKRLLAEYDLVERTLTERDVLL-KANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHKFTI
|...|.||||..||| ||. | .. ..||||.|.|  . |. . ..|.|||...  ..||||||  .|||||..|.|....|..|||||  |. ..||. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRARYYIAELVLAIGYLHSI-GVVHRDLKPENILFDKDGYIKLTDFGLVK-EKMT-KQSKTSTFCGTPEYLAPEIIEG-NEYGMAVDWWALGTLAYEMLY
..|| |.|. .||. |||.   .. ||||||||| |.||..|.||||| | ..|  .  |. .|||||||.|||.|     .. .|||||.|.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYPPFYDTNTNQMYRYILRDD-VTFPDDATP--DAIDLLS-KLLDKNPDTRLGSGPSDMEEIKAHPFF
|.||||. |.|||. .|.  . . ||. . .   . ||.  |||.|||  |||.. .. |||| ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 89154.m00264.AA RSK 115-369 44 1.7e-121 409.97 In-house 1-278 (278) Show / Hide 
Range on Protein: 115-369
Range on HMM: 1-278/278
Sequence Identity: 44% (124 aa)

LKVLGKGTYGKVQLVKNK---KTSQIYAMKSISKRLLAEYDL-VERTLTERDVLLKAN-HPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHK---
|||||.| |||| |.. .   .| |||||| ..|. ..  .  ...|.|||..|.  . |||||. .| ||||.|..|...|. ||||| .|..|     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDK---DGYIKLTDFGLVKE-KMTKQSKTSTFCGTPEYLAPEIIE----GNEYGMAVDWWALGT
|. |.|..|.||.|||. .||. |..||||||||||.|    .| |||||||. |. .  . ..| |||.| ||.|||..     .. .. |.||| || 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LAYEMLYGYPPFYD---TNTNQMYRYILRDD--VTFP--DDATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
| |||| |.|||.     | ..  . |.. .  .|.|  .  ...| ||..|.| ..|  |||.||.|.||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 89154.m00264.AA PKA 112-369 43 4.4e-117 395.28 In-house 1-263 (263) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-263/263
Sequence Identity: 43% (117 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTLTERDVLLKANHPFIV-SAKYCFQTETKIFLVLDYVAGGELFARLREEHKFTID
|.|...||.|..|.|.|...|.. ..|||| ..|.       ||....|. .|.  .||||| . .. ||.......|..||.|||.| .|| . .|. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RARYYIA-ELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEKMTKQSKTSTFCGTPEYLAPEIIEGN-EYGMAVDWWALGTLAYEMLYGYP
 |. |.| . |||. ||||   ..||||||||| ||.|.||.|||| .| |..    |.| |||||||||||| .   .| .||||||| | |||| |||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK-KVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYDT--NTNQMYRYILRDDVTFPDDATPDA---IDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
||||.  ...|.|. |.  .. ||   ..||    ||..||| ...  |.|.  .. . || |..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 89154.m00264.AA RSK-Unclassified 112-369 37 5.4e-112 353.19 In-house 1-283 (283) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-283/283
Sequence Identity: 37% (107 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTLTERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLR--EEHKFTI
|   . .|.|  ||| ||. |.| ||||||  .|  .    .. . .||....   ||||||   . |||. . .|...|  ||..|  |    | .|. 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

DRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEK---------------------MTKQSKTSTFCGTPEYLAPEIIEGNEYG
|..|.|..| ..|  |||  ... |||||.||. ...| ..||||.| ..                      .   ..|  |||| ||||||.| ..  .
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

MAVDWWALGTLAYEMLYGYPPFYDTNTNQMYRYILRDDVTFP--DDATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
 ||||| || . |||| | ||.|  |.| ..  |.. .| ||       .. ||. ||| .||  |||..  | ..||.||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 89154.m00264.AA PKC 112-369 42 1.5e-111 362.9 In-house 1-262 (262) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-262/262
Sequence Identity: 42% (112 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTLTERDVL-LKANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHKFTID
|. ||||||| .||| |.. |.| ..||.| . | .  . | || |.||. || | ..||| ..   ||||. ..| |. || || |     . ..|   
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEKMTKQSKTSTFCGTPEYLAPEIIEGNEYGMAVDWWALGTLAYEMLYGYPPF
.|| | || ..|  .||. |.. |||| .|.| |..| ||..|||. || |.. ..||||||||.|.||||... ||| .|||||.| | |||. | .||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YDTNTNQMYRYILRDDVTFPDDATPDAIDLLSKLLDKNPDTRLGSGPSD---MEEIKAHPFF
   .  .. . |. |.. .| . . .| ........||| .|||..|..    ..|..||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 89154.m00264.AA S_TKc 112-369 36 3.1e-110 373.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-231/231
Sequence Identity: 36% (97 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTLTERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAG--GELFARLREEHK---
..||...|||..||| ....||| .|.|.| |.          |... |...| | .||.||  ...||. .....|..|. |  |.|| ....  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEKMTKQSKTSTFCGTPEYLAPEIIEGNEYGM-AVDWWALGTLAYE
   |.  .||.|......|. |.|| |..||||||||||.|.   ||..|||| ..        .||||||.|.|||..    ||  ..|||..| . ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLYGYPPFYDTNTNQMYRYILRDDVTFPDDATPDAIDLLSKLLDKNPDTRLGSGPSDM--EEIKAHPFF
||.|||||.  . ..|.. |.          .|.|.|...|.|.|.|. |..        ..||.||.|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89154.m00264.AA RSK 112-369 38 4.1e-100 338.9 In-house 1-271 (271) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-271/271
Sequence Identity: 38% (105 aa)

FDILKVLGKGTYGKVQLVKNK---KTSQIYAMKSISKRLLAEYDLVERTLTERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHKFT
.......|.|...|| ..| .    | | |||| | |  ..  |   .. .||..|   .|||||  .| ||.|.|.....|  .||.|| ||  .  |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

IDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKD----GYIKLTDFGLVKEKMTKQSKTSTFCGTPEYLAPEIIEGNEYGMAVDWWALGTLAYEML
 . .. | ||. ||  |||| |.|||||||||||.| .    | ||..|||. |.   .  .. |||.| .|.|||..    ...|.||| .|.| ||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

YGYPPFYDTNTNQMYRYILRDDVTF-------PDDATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
 |..||. .. . .   |.| ..         .|  .. | |||...|. .|  |||.|| . |.|| ||.|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 89154.m00264.AA Pkinase 112-369 31 6.9e-96 329.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTL-TERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAGG----ELFARLR--EE
. |....|.|..|.| . ..|.|..|.|.| |.||   .  ...... .|  .... |||.||  ...|.....| .|..|. ||    .||....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HKF--TIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYI----KLTDFGLVKEK-MTKQSKTSTFCGTPEYLAPEIIE-GNEYGMAVDWWAL
 .|  . . .. |. ... .. |.|| |..||||||||||.|..|.|    |..|||| | .   ..| ..||||||.|.|||.|  |..|| .||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GTLAYEMLYGYPPFYDT------NTNQMYRYILRDDVTFPDDAT---------------------PDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
| . |||| |.|||..       . .||.. |.. .. |. . .                     ....|.....|.|.|  |..      |.|. ||.|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase 89154.m00264.AA p70 154-369 42 1.3e-91 310.61 In-house 72-299 (299) Show / Hide 
Range on Protein: 154-369
Range on HMM: 72-299/299
Sequence Identity: 42% (96 aa)

VERTLTERDVLLKANHPFIVSAKYCFQTETKIFLVLDYVAGGELFARLREEHKFTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTD
.|||. || .|   .||||.   | |||. | .|.|.|  |||||  | ..  .  | |..| .| ..|...||. |.. |||||||.. .. | ..|||
LERTFAERNILEEVKHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTD

FGLVKEKMTKQSK----------TSTFCGTPEYLAPEIIEGNEYGMAVDWWALGTLAYEMLYGYPPFYDTNTNQMYRYILRDD--VTFPDDATPDAIDLL
||| ||.. . ..          | |||||.|| ||||. .  .. |||||.|| | | || | |||   |  .    ||.    .. |   |... ||.
FGLCKESIHDGAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLI

SKLLDKNPDTRLGSGPSDMEEIKAHPFF
 ||| ..|..|.|.||.| ..|..||||
KKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 89154.m00264.AA TyrKc 112-369 19 1.3e-14 13.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 112-369
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FDILKVLGKGTYGKVQLVKNKKTSQIYAMKSISKRLLAEYDLVERTLTERDVLLKA--NHPFIVSAKYCFQTE-------TKIFLVLDYVAGGELFARLR
   .|.|| | .|.| . . |   .  | |.. .        .|  . |  .. |   .|| ||    .  ..         ...|. |...| |  .||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EEHK-FTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEKMTK-------QSKTSTF--CGTP----EYLAPEIIEGNEYG
. .. .. .   ..         |||| ...||||   |.| .... .| .|||| ..   .       . ....   .|        .||| |  ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

MAVDWWALGTLAYEML-YGYPPFYD-----TNTNQMYRYILRDDV-TFPDD--------ATPDAIDLLSKLLDKNPDTRLGSGPSDMEEIKAHPFF
 . | |. | . .|.. || .| ..      .  ....|. . .    |..        ....  .. ..  . .|. |       ..||  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase 89154.m00264.AA S_TK_X 370-433 35 2.7e-14 54.71 SMART 1-79 (79) Show / Hide 
Range on Protein: 370-433
Range on HMM: 1-79/79
Sequence Identity: 35% (28 aa)

GNLNWKSLFQ--KTIPMEWKPQIK----SVTDVSQFDRQFTCEAPKLTYEDPSLVGAGVQQQ---------LQGFTYIN
 ...|. |..  |.|.  .||.||    | ||.|.||  || |.|.||  || |...  |..           ||||..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 89154.m00264.AA Pkinase_C 389-435 44 3e-13 49.86 Pfam 1-46 (46) Show / Hide 
Range on Protein: 389-435
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

QIKSVTDVSQFDRQFTCEAPKLTYEDPSLVGAGVQQQLQGFTYINEG
|.|| ||.| || .||.|.|..|. |..   .| | . .|||| |. 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase 89154.m00264.AA p70 112-146 52 9.5e-13 42.62 In-house 1-38 (299) Show / Hide 
Range on Protein: 112-146
Range on HMM: 1-38/299
Sequence Identity: 52% (20 aa)

FDILKVLGKGTYGKVQLVKNKK---TSQIYAMKSISKR
|  ||||||| |||| .|.  .   |..||||| . |.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKA
Kinase 89154.m00264.AA Pkinase_Tyr 178-322 24 6e-06 20.83 Pfam 73-228 (270) Show / Hide 
Range on Protein: 178-322
Range on HMM: 73-228/270
Sequence Identity: 24% (39 aa)

CF-QTET-KIFLVLDYVAGGELFARLRE----EHKFTIDRARYYIAELVLAIGYLHSIGVVHRDLKPENILFDKDGYIKLTDFGLVKEK-----MTKQSK
|  | |  .|..|. |...| |   ||.    ....|. .   . ..   .  ||.|.. .||||   |.| .... .| .|||| .          ...
CTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKR

TSTFCGTPEYLAPEIIEGNEYGMAVDWWALGTLAYEMLY-GYPP-FYDTNTNQMYRYI
...       .||| |  ...  . | |. | | .|..  |  | ...   ...|.||
GGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase 89154.m00264.AA Pkinase_Tyr 112-126 40 0.562528 3.93 Pfam 1-15 (270) Show / Hide 
Range on Protein: 112-126
Range on HMM: 1-15/270
Sequence Identity: 40% (6 aa)

FDILKVLGKGTYGKV
  ..|.||.| .|.|
ITFGKKLGEGAFGEV