Gene 94179.m00345 (T.vaginalis)

94179.m00345

Species: T.vaginalis
Alias: 94179.m00345, TvagK0336
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
94179.m00345.AA Protein None 1108 None Fasta, JSON
94179.m00345.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of 94179.m00345.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94179.m00345.AA MLK 220-473 34 8.1e-89 301.37 In-house 1-291 (291) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-291/291
Sequence Identity: 34% (102 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRI-----VAVKKMKAAHFTQYSL-----EMFMREITIFSKMNHPA----ILPFVGVTITP-P-FYIVTEFMEG
......||.|.| .|.     . .. |..     ||||. .|  |   |      . | .|. ......||     | .|.|| . | . |.||.|..||
IQFHEWIGSGSFGKVW-----KGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEG

GCLYNRLHDNQP-------------LRDPTKLTIIAIGVAHAMKYLHSQG---IVHRDLKSLNVLLDA------NDFPKVCDFGMSRTLPENGELMSGSV
|.||| ||....               |.  .  .|  .|..| ||||.    |.|||||| |.|.|.      ..  |.|||| || . .... | .  
GSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA

GTVQWMAPEVL---KSERYTEKADVYSYGVLLWELLTGDSPFK-KMRDVQVTIAVLSSNARPMMPPN-PSRISKLIKICWDTDPDKRPDFETIAKIL
||. ||||||.   ..|.|.||.||.|.||.|||.||.  |.|  .   .. . |   . || .|.. | ...||.|.||..|| |||.|  | ..|
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 94179.m00345.AA TKL 226-473 26 7.4e-83 281.58 In-house 1-364 (364) Show / Hide 
Range on Protein: 226-473
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

IGHGAFADVYWSYQVSDNMNN----------RIVAVKKMKAAH-------------------------FTQYSLEMFMREITIFSKMNHPAILPFVGVTI
|| |.|. ||       . ..          . |||||.|  .                         ...   . . .|| . |. .|| |..|.|. .
IGSGGFGEVY-----KGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCC

TPP--------------FYIVTEFMEGGCLYNRLHDNQPLRDPTKLTIIAIGVAHAMKYLHSQG--------IVHRDLKSLNVLLDAN------------
 ||              ..||.|...||.|...||       . ..  .|...| .| ||||..        |.|||||| |.|.| |            
CPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

--DFPKVCDFGMSRTLPENGE-------------------LMSGSVGTVQWMAPEVLKSE----------------RYTEKADVYSYGVLLWELLTGDSP
  ...|.|||| ||.. ..|.                     .  .|| .|||||||. .                 |.||.||||.|..|||.||.  |
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

FKKMRDVQVT---------IAVLSSNARPMMPPNPSR-------------ISKLIKICWDTDPDKRPDFETIAKIL
....   ..          . | . . || .|| ...             ..||.. |||.||.||| |..| |.|
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 94179.m00345.AA TyrKc 220-473 30 1.7e-74 254.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-280/280
Sequence Identity: 30% (89 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKMKAAHFTQYSLEMFMREITIFSKM--NHPAILPFVGVTIT--------PPFYIVTEFMEGGCLYNR
  |.|..|.|||  ||           . ||||..|. .     .|.||||. | .|   .|| |. ..|| ..        .| .||.|.|..|.| ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LHDNQPLRDPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLDANDFPKVCDFGMSRTLPEN------GELMS-----GSV--GTVQWMAPEVLKSER
|....|   . .|  ... .|  | ||||....||||   |.|...|   |..|||.|| . .       ..  .     |.     . |||||...  .
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTEKADVYSYGVLLWELLT-GDSPFKKM----RDVQVTIAVLSSNARPMMPPN---------PSRISKLIKICWDTDPDKRPDFETIAKIL
.|.| ||.|.||..||..| |..|   |     . |  |. . .  |.. |||         |. . ...| ||. ||..|| |..| ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 94179.m00345.AA HH498 220-473 31 1.9e-72 228.9 In-house 1-284 (284) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-284/284
Sequence Identity: 31% (92 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKMKAAHFTQYSL------EMFMREITIFSKMNHPAILPFVGVTITPP--FYIVTEFMEGGCLYNRL-
.  .. || |.| .||  .       | |||||  .|  |   |        || ||. | .. |||    ||. ..  |  | |||.. ..| |. .| 
IEFHEKIGSGSFGKVYKGE-----WRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILN

-------------HDNQ---PLRDPTKLTIIAIGVAHAMKYLHS---QGIVHRDLKSLNVLLDANDFPKVCDFGMSRTLPENGELMSGS-VGTVQWMAPE
             | ..      |.    .|.. ||| | |||.   . |.|||| | |.|....   .| ||| || . . ..    .  |   |||||
TIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPE

VLK-SERYTEKADVYSYGVLLWELLTGDSPFKKMRDVQVTIAVLSSNARPMMPPN-----PSRISKLIKICWDTDPDKRPDFETIAKIL
| . . .|..|.||.||.  .||..|.  ||     .     .     || .|       | ..| || .||.  |. ||||  |  ||
VFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 94179.m00345.AA Pkinase_Tyr 220-473 32 5e-70 237.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-270/270
Sequence Identity: 32% (90 aa)

FDLKKVIGHGAFADVYWSYQV-SDNMNNRIVAVKKMKAAHFTQYS--LEMFMREITIFSKM-NHPAILPFVGVTI--TPP--FYIVTEFMEGGCLYNRLH
  . |..|.||| .||  .   ..  ..  ||||..|  . ..    .|.||||. | ... .|| |. ..|| .    |   |||.|.|..|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

D----NQPLRDPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLDANDFPKVCDFGMSRTLPENGEL---MSGSVGTVQWMAPEVLKSERYTEKADVY
.    .|||  .. |  ... .| .| ||.|....||||   |.|.. | . |.||||..|.. . ..     .|.   . |||||...  ..|.| ||.
KHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGVLLWELLT-GDSP-FKKMRDVQVTIAVL-SSNARPMMPPN-PSRISKLIKICWDTDPDKRPDFETIAKIL
|.|||.||..| |..| .. | . .  .. .  .. |  .|.| |  | .|.| ||. ||..|| |. |  .|
SFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 94179.m00345.AA Dicty4 220-475 36 2.9e-67 223.43 In-house 1-277 (277) Show / Hide 
Range on Protein: 220-475
Range on HMM: 1-277/277
Sequence Identity: 36% (103 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKM--KAAHFTQYSLEMFMREITIFSKMNHPAILPFVGVTI----TP-PFYIVTEFMEGGCLYNRLHD
 .  . || |.|. ||       .    .|||||.  .   | .. |. | .|..| .|  || |. | |  .    .|  . ||||.|  | ||. |||
INIEQRIGKGSFGEVYKG-----TWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

-----NQPLRDP-TKLTI---IAIGVAHAMKYLHS--QGIVHRDLKSLNVLLDANDFPKVCDFGMSR---TLPENGELMSGSVGTVQWMAPEVLKSERYT
      |    . .  .    .|. .|  | .||.    |.|||||| | | |.|   |||||| |.   .  ...  ... .||. ||||||. ...|.
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

EKADVYSYGVLLWELLTGDSPFK--KMRDVQVTIAVLSSNARPMMPPN-PSRISKLIKICWDTDPDKRPDFETIAKI--LES
|||||||.| .|||.||.. |.    |  .|. .|| .   || .|.. | ....||. |||.|| .|| || | ..  ||.
EKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 94179.m00345.AA TKL-Unique 248-473 32 4.2e-67 229.24 In-house 22-290 (290) Show / Hide 
Range on Protein: 248-473
Range on HMM: 22-290/290
Sequence Identity: 32% (87 aa)

IVAVKKMKA-AHFTQYSLEMFMREITIFSKMN-HPAILPFVGVTI----TPP-FYIVTEFMEGGCLYNRLH---------DNQPLRDPTKLTIIAIGVAH
.||.|. .  . .   ... | .|... .| . || |. ..|...    .|| ..||.|...|| ||. ||          |    .. .   .|| .| 
PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQ

AMKYLHSQG--IVHRDLKSLNVLLDAN-----DFPKVCDFGMSRTLP-ENGELMSGS--------VGTVQWMAPEVLKS--ERYTEKADVYSYGVLLWEL
.| |||. .  | ||||||.|.|.| |        |.|||| |...  .| .  ...        .|. .|||||||..  . |.||.||||.|. |||.
GMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEI

LTGDS------PFKKMRDVQVTIAVLS--SNARPMMPPN-PSRISKLIKICWDTDPDKRPDFETIAKIL
.|..       |...| . |.  .| .   | ||. |.. | ....||. ||. ||..|| |..| . |
ATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 94179.m00345.AA TK 220-473 17 3.5e-64 213.79 In-house 1-486 (486) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

FDLKKVIGHGAFA---DVYWSYQVSDN----------------------MNNRIVAVKKMK---AAHFTQYSLEM------------FMREITIFS--KM
  | |..|.|.|    .||     ..|                      ...  |||| .|   |.. ..  .|.            ...|. ...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPAILPFVG-VTIT------------PPFYIVTEFMEGGC----LYNRLHDNQPLRDPTKLTI------------------------------------
.|| |. ..| .|              .|..||.|.|..|.    | . |... | . .   ..                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IAIGVAHAMKYLHSQ------GIVHRDLKSLNVLLDANDF-----------PKVCDFGMS--
                                      ..  .| .| ||||.      ..|||||   |.|.. |.             |..|||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RTLPENGELMSGS-VGT-------------------------VQWMAPEVLKSE---------RYTEKADVYSYGVLLWELLT-GDSPFKKMRD
      | ......  . |  ||                         . |||||.|..          ..|.| ||.|.|||.||..| |. |.  . .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

V---------QVTIAVLSS---------------NARPMMPPNP--------------SRISKLIKICWDTDPDKRPDFETIAKIL
          |  .  | .               . .|  |  |                .  |.. ||. ||..||.|... . |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 94179.m00345.AA LRRK 220-475 28 6.4e-64 218.66 In-house 1-351 (351) Show / Hide 
Range on Protein: 220-475
Range on HMM: 1-351/351
Sequence Identity: 28% (100 aa)

FDLKKVIGHGAFA-DVY---WS------------------YQVSDNMNNRI--VAVKKMKA--------------------------------AHFTQYS
.   . || |.|.  ||   |                   ||   |  ..   ||.||..                                 . ..  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LEMFMREITIFSKMNHPAILPFVGVTITPPFYIVTEFMEGGCLYNRLHDNQ--PL-----R-DPTKLTIIAIGVAHAMKYLHSQG--IVHRDLKSLNVLL
.  | .|..| |..||| |.. .|..|  |. .|.|..  | || .||...  ..     . ... .  ||. .| .|.||||.   |.|||||| |.||
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DANDFP------------KVCDFGMSR--TLPENGELMSGSVGTVQWMAPEVLK---SERYTEKADVYSYGVLLWELLTGD-SPFKKMR--D----VQVT
   . .            |..||| ||  .   .| . .|.||. .|||||...    | ||||.|.||.|..||||||..  ||  .   |        
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG-VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQI

IAVLSSNARPMMP---PNPS----RISKLIKICWDTDPDKRPDFETIAKILES
    ..  ||  |    .|     . ..||. ||..||.||| |..| |.|..
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 94179.m00345.AA Dicty4-Unclassified 220-473 33 1.4e-63 216.64 In-house 1-263 (263) Show / Hide 
Range on Protein: 220-473
Range on HMM: 1-263/263
Sequence Identity: 33% (91 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKMKAAHFTQY--SLEMFMREITIFSKMNHPAILPFVGVTITP-----PFYIVTEFMEGGCLYNRLH-
    . || |.|. |.       |   . |||||.    |      .. | .|. |   . ||  .   |  | |      . ||.|||  | |    | 
IQIDQFIGKGHFSKVHKG-----NWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHS

----DNQPLR-DPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLDANDFPKVCDFGMSRTLPENGELMSGSVGTVQWMAPEVLKSERYTEKADVYSY
     .||.. | |    .|. .|  | .||.  ..|||.|| |.|.| .   |. |||.||   ..   |    ||. | .||.|. | |. |.|||||
KPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVI-DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GVLLWELLTGDSPFKKMR-DVQVTIAVLSSNARPMMPPN-PSRISKLIKICWDTDPDKRPDFETIAKIL
...|.||.||| |.      . . . | .   || .| | .  ..|||| ||  || ||| .. | . |
AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 94179.m00345.AA S_TKc 220-472 29 3.9e-62 213.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 220-472
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKMKAAHFTQYSLEMFMREITIFSKMNHPAILPFVGVTITPPFYIVTEFMEG--GCLYNRLHDNQPL-
... ..||.|||. ||  . ..    .||||.|..|         |...||| | .| .|| |  . .|  .  .|.|.|...|  | |. .......  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----RDPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLDANDFPKVCDFGMSRTLPENGELMSGSVGTVQWMAPEVLKSERYTE-KADVYSYGVLLW
     ..     ..  .. |..|.||.||.|||||  |.|||     |.||||..| |       .  .||  .||||||    |.  |.|..| |..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGDSPFKKMRDVQVTIAVLSSNARPMMPPNPSRISKLIKICWDTDPDKRPDFETIAK----------I
|.|.|  ||    ..|... ..           |. .. .|. |.. ||.|||    . .          .
EMLCGYPPFP---QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94179.m00345.AA DRK 248-475 37 8.1e-59 197.84 In-house 24-258 (258) Show / Hide 
Range on Protein: 248-475
Range on HMM: 24-258/258
Sequence Identity: 37% (90 aa)

IVAVKKMKAAHFT-QYSLEMFMREITIFSKMNHPAILPFVGV-TITPPFYIVTEFMEGGCLYNRLHDNQPLRDPTKLTIIAIGVAHAMKYLHSQG--IVH
.||||....        |  | |||.. ..  || |  | |  .. |   |..|.|  | ||| |||     |   .  ... .|  | |||.    |.|
QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIH

RDLKSLNVLLDANDFPKVCDFGMSRT----LPENGELMSGSVGTVQWMAPEVLKSERYTEKADVYSYGVLLWELLTGDSPFKKMRDVQVTIAVLSSNARP
||||| | | | .   || ||| | |      . .  |   .||  | ||||| ..||||||||||... |||..|   |.  |   || ..|     ||
RDLKSHNLLVDEHWQVKVADFGLS-TRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRP

MMPPN-PSRISKLIKICWDTDPDKRPDFETIAKILES
 ||.. |    .|.. ||..||  || .. . ..||.
PMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 94179.m00345.AA Dicty5 264-477 37 9.6e-58 197.33 In-house 40-260 (260) Show / Hide 
Range on Protein: 264-477
Range on HMM: 40-260/260
Sequence Identity: 37% (85 aa)

LEMFMREITIFSKMN--HPAILPFVGVTITPPFY--IVTEFMEGGCLYNRLHD--N---QPLRDPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLD
.. | ||.|| | .   || .  . |       |  .|||.   | | | | |  .   ||.  ...|  .||..| .|..||| .|.||||||.|.|. 
WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLH-MAIDIAQSMRHLHSMNIIHRDLKSMNFLIT

ANDFPKVCDFGMSRTLPENGELMSGSVGTVQWMAPEVLKSERYTEKADVYSYGVLLWELLTGDSPFKKMRDVQVTIAVLSSNARPMMPPN-PSRISKLIK
 |   |. ||| ||   .|   |   |||  |||.|. ..  |..|.||||.|. |||..| ..|.. .      . | .   || .|.  |. ||.|||
ENWKIKIIDFGTSRFV-DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIK

ICWDTDPDKRPDFETIAKILESGE
 ||   | .|| |  | |..||  
KCWQQKPHNRPSFKEICKYFESII
Kinase 94179.m00345.AA Pkinase 220-476 26 1.1e-55 196.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 220-476
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FDLKKVIGHGAFADVYWSYQVSDNMNNRIVAVKKMKAAHFTQYSLEMFMR--EITIFSKMNHPAILPFVGVTITPP-FYIVTEFMEGG----CLYNRLH-
. ....|| |.|. |   |.  .  ...|||||..|  |     ..   |  || |  ..||| |. . ..  ...  |.|.|..|||     |. ... 
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-DNQPL-RDPTKLTIIAIGVAHAMKYLHSQGIVHRDLKSLNVLLDANDFP----KVCDFGMSRTL-PENGELMSGSVGTVQWMAPEVLK-SERYTEKADV
 .. ..  ..  .  ..  .. ...|.||.||.|||||. |.|.| |. .    |.|||| .. .   |.. |.. .||  .|||||.. .. |. |.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGVLLWELLTGDSPFK------KMRDVQVTIAVLSSNARPMMPPNP---------------------SRISKLIKICWDTDPDKRPDFETIAKILES-
.|.|..|.|.|.|  ||.      . .| .. |.   .   .   |..                     .   ..|| |.. || |||    .. ||.. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

-G
  
WF