Gene 81841.m00095 (T.vaginalis)

81841.m00095

Species: T.vaginalis
Alias: TvagK0268, 81841.m00095
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
81841.m00095.AA Protein None 783 None Fasta, JSON
81841.m00095.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of 81841.m00095.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81841.m00095.AA TKL 229-468 26 2.5e-80 273.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 229-468
Range on HMM: 1-364/364
Sequence Identity: 26% (98 aa)

IGSGTFGSVHIGQLTG--------TFKKVAIKVLNTKVLGGRQL-------------------------ETFKREVWTMATLNHPNILRLIGVTLTPP--
||||.|| |. |.. |        | | ||.|.....    . .                         .....|.  |  |.||||....|. . ||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIITELL-KCSLFDRLKLLSATKRSLIALKVSQAMENLHAAR--------IIHRDLKSANILLDDEDM--------------PRVCD
            .||..|.  . ||...|      .|  .|| ....|. ||. .        ||||||||.|||.|.                 . .||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

FGLVGFKTGA---------------------TRTGFVGTAQWMAPEILRSSPF---------------YDEKVDVYSFGVMLWEMLTLKEPYAGMSQDQM
|||  |...                      |.   .|| .|||||.|| ...               |.||.||||||..|||.|| ..||...  ..|
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM

V---------MAIIEDGLRPSV----------VGC--GPPRVVELIQRCWAEVPSDRPTFAQVSQAL
.         | ....|||| .          . |   ||.. .|.|.||.. |..||.| .. . |
IFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 81841.m00095.AA Dicty4 223-470 37 2.6e-70 233.72 In-house 1-277 (277) Show / Hide 
Range on Protein: 223-470
Range on HMM: 1-277/277
Sequence Identity: 37% (104 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVL-NTKV-LGGRQLETFKREVWTMATLNHPNILRLIGVTL----TP-PFCIITELL-KCSLFDRLKL---
  |.| ||.| ||.|. |   |  |.||.|.| |... .    |. |..||  |. . ||||. . |  .    .|  .|| ||.. | .|.  |     
INIEQRIGKGSFGEVYKGTWRG--KEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

-------LS--ATKR-SLIALKVSQAMENLHA--ARIIHRDLKSANILLDDEDMPRVCDFGLVG-FKTGA--TR--TGFVGTAQWMAPEILRSSPFYDEK
       |.    ||  ..|. . . |  ||.   .||||||||.|.| |.     ||||||   .|..   .   .. .||. |||||.... | |.||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YNEK

VDVYSFGVMLWEMLTLKEPYA--GMSQDQMVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQA--LAQ
.|||||| .|||.|| .|||.  .|. .| | |. . .|||..   .||.  .|||.|| . |. ||.|....|.  |  
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 81841.m00095.AA LRRK 223-470 29 8.7e-69 234.84 In-house 1-351 (351) Show / Hide 
Range on Protein: 223-470
Range on HMM: 1-351/351
Sequence Identity: 29% (104 aa)

FEIGQVIGSGTFG-SVHIGQLTG--------------------------TFKKVAIKVLNTK---------VLGG-----------------------RQ
..|.. ||.|.|| .|. . . |                           ...||||..|.             .                       | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LETFKREVWTMATLNHPNILRLIGVTLTPPFCIITELLKC-SLFDRLK------L------LSATKRSLIALKVSQAMENLHAAR--IIHRDLKSANILL
. .| .||| | .||||||. |.|...  |.|...|.. . .| ..|.      .      .| . .  ||| .. .|| || ..  |||||||| ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

DDEDMP------------RVCDFGLVG--FKTGAT-RTGFVGTAQWMAPEILRSS--PFYDEKVDVYSFGVMLWEMLTLK-EPYAGMS-QDQM-VMAIIE
   ...             ..|||. .  . .. . . |.||. .||||||.|      |.||||.||||. ||| ||..  |. ...  |.|  | .||
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

D----GLRPSVV-G-CGP----PRVVELIQRCWAEVPSDRPTFAQVSQALAQ
|    ||||..    |.|    ... .||| ||.. | .||.| |. . | |
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 81841.m00095.AA Pkinase 223-468 28 2.7e-67 234.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLGGRQLETFKR--EVWTMATLNHPNILRLIGVTLTPP-FCIITELLKC-----SLFDRLK----
..||..||||.||.| ...  || |.||.|... .     ...|  |  |.  |. ||||||.||...  ...  ....|.. .     .|||...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

-LL--SATKRSLIALKVSQAMENLHAARIIHRDLKSANILLDDEDMP----RVCDFGLVG---FKTGATRTGFVGTAQWMAPEILRSSPFYDEKVDVYSF
  .  |      ... . ...| .|. .|||||||..|||.|... .    ..|||||        .   |.|.||  .||||..|... |. |||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVMLWEMLTLKEPYAGM------SQDQMVMAIIEDGLRPSVVGCGP-------------------PRVVELIQRCWAEVPSDRPTFAQVSQA--L
|..|.|||. . |. |       .|.||.  | .  |. .     .                   .   ..| .|..  |..|||..|. |   .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 81841.m00095.AA MLK 223-468 31 4.7e-67 229.09 In-house 1-291 (291) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-291/291
Sequence Identity: 31% (93 aa)

FEIGQVIGSGTFGSVHIGQLTGTF---KKVAIKVLN----TKVLGGRQLETFKREVWTMATLNHPN----ILRLIGVTLTP-P-FCIITELLKC-SLFDR
... ..||||.||.|. |.  ..    | ||.|  .     |.  . . . |..|.   . |.|||    | .. || | | . |||..| . . ||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKL-----------------LSATKRSLIALKVSQAMENLHA-AR--IIHRDLKSANILLDD------EDMPRVCDFGLVGFKTGA-T-RTGFVGTAQWM
|.                   .      .|| ....|. ||. |.  |||||||| |||.|.      ..  ..||||.. ...   | .... ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEIL---RSSPFYDEKVDVYSFGVMLWEMLTLKEPYA-GMSQDQMVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
|||..   |... |.||.||.|.||.|||||| ..||. .... .  . ... |||| .    |..  .|...|| . |..||.|.|. | |
APEVIQQFRCEK-YSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 81841.m00095.AA S_TKc 223-473 29 1e-66 228.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 223-473
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLGGRQLETFKREVWTMATLNHPNILRLIGVTLTPPFCIITELLKC---SLFDRLKL--------
.||...||.|.||.|. .. ..| ..||||...         |...||.  .   .|||| .|..|  .  .....|..     .|||..|         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSATKRSLIALKVSQAMENLHAARIIHRDLKSANILLDDEDMPRVCDFGLVGFKTGATRTGFVGTAQWMAPEILRSSPFYDE-KVDVYSFGVMLWEMLT
 ..      ..  . .|.| .|  .||||||| .|||||.     .|||||  .      | |.||  .||||.|     |.  |.|..|.|..|.|||.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC

LKEPYAGMSQDQMVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQ----ALAQPEF
 . |.    |.||.. .|            .| . ..|..|.   |..|||  .. |    . . | |
GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81841.m00095.AA TKL-Unique 225-468 32 5.8e-66 225.45 In-house 1-290 (290) Show / Hide 
Range on Protein: 225-468
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

IGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNT-KVLGGRQLETFKREVWTMATLN-HPNILRLIGVTL----TPP-FCIITE-LLKCSLFDRLK------
.. .||.|..|.|  |  .. ...||||...    .  . ...|..|| .| .|. ||||....|..     .|| .||..| .   || | |       
FWNKIGEGGYGQVYKG--KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-------LLSATKRSLIALKVSQAMENLHAAR--IIHRDLKSANILLDDE-----DMPRVCDFGLVGFKTGATRTGFV-----------GTAQWMAPEIL
        |.  .|  .|....|.|..||     |||||||| |.|.| .        ..|||||. |..  ... .            |...|||||.|
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RSS-PFYDEKVDVYSFGVMLWEMLTLKE------PYAGMSQDQMVMAIIE--DGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
|..   |.||.||||||..|||..| |       || ||.|.|   .. .  ...|| .    |..  .|||.||.  ||.||.| ..   |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 81841.m00095.AA TK 223-468 17 3.9e-59 196.54 In-house 1-486 (486) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

FEIGQVIGSGTFG---SVHIGQLTGTFK-------------------------KVAIKVLN--TKVLGGRQLETFKR----------EVWTMATLN----
 ..|...|.| ||    |. |.. |  .                         .||.|.|   .     .... . .          |.  |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILRLIG-VTLT------------PPFCIITELLKC-----SLFDRLKLLSATKRSL----------------------------------------
 ||||.||.| .|              .|..|..|. ..     || | |.  . ...                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------IALKVSQAMENLHAA------RIIHRDLKSANILLDDEDM-----------PRVCDFG----
                                      ... ....|| ||.       ...||||   |.|.....             ...|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

-------LVGFKTGATRTGFVGTAQ-------------------------WMAPEILRSSPF--------YDEKVDVYSFGVMLWEMLTLK-EPYAG-MS
        .. ..  .|..  ||.                          ||||| |..  |        . .| ||.||||..||..|.  |||.| ||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

Q--------DQMVMAIIEDG--------------LRPSV-VGCGP-------------PRVVELIQRCWAEVPSDRPTFAQVSQAL
         .| ||  ...|              .|.   ..| .             . . .|.|.||.. |.|||||.|. ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 81841.m00095.AA TyrKc 223-468 26 1.5e-52 181.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-280/280
Sequence Identity: 26% (77 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLGGRQLETFKREVWTMATL--NHPNILRLIGVTLT--------PPFCIITELLKCSLFDRLKLL
 . |...|.| || |. |...    .||.|.|.        .| | ||   |  |  .||||.||.|| ..        .| .|..|.  ... | .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY--MPHGDLKDYL

SATKR-------SLIALKVSQAMENLHAARIIHRDLKSANILLDDEDMPRVCDFGLVGFKTGA------TRTGFVGT---AQ------WMAPEILRSSPF
 ....         ... ... || ||  ..|||||   |.|....   ...||||  . .        . .  . .   .       ||||| .     
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK

YDEKVDVYSFGVMLWEMLTL-KEPYAG-----MSQDQMVMAIIEDGLRPSVVG-------CGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
. .| ||.||||..||..|. ..|| |     || ....  . . . .|           | |. . .....||.| |.|||||... . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 81841.m00095.AA Dicty4-Unclassified 223-468 31 2.2e-50 170.78 In-house 1-263 (263) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-263/263
Sequence Identity: 31% (85 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLGGR--QLETFKREVWTMATLNHPNILRLIGVTLTP-----PFCIITELL-KCSLFDRLK----
  | | || | |  || |   |  | ||.| .|      |   .. ||.||  .  . ||| ... |  . |      .||..|.. |  ||        
IQIDQFIGKGHFSKVHKGNWKG--KDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

------LLSATKRSLIALKVSQAMENLHAARIIHRDLKSANILLDDEDMPRVCDFGLV-GFKTGATRTGFVGTAQWMAPEILRSSPFYDEKVDVYSFGVM
       |  |    .|. . | |  ||   .||||.||.|||.|     .. |||.        . |   ||  | .||.|.    |  | ||||...|
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYAMM

LWEMLTLKEPYAGMS-QDQMVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
|.|..|  ||| .      .   . . .||| .    .. .  ||  || . |  |||. |. | |
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 81841.m00095.AA TK-Unique 223-468 28 2.5e-46 157.79 In-house 1-294 (294) Show / Hide 
Range on Protein: 223-468
Range on HMM: 1-294/294
Sequence Identity: 28% (84 aa)

FEIGQVIGSGTFGSVHIGQLT------GTFKKVAIKVLNTKVLGGRQLETFKREVWTMATLN-HPNILRLIGVTLTP--PFCIITELLKCS-LFDRLK--
.|.|.|||.| || |. |...      . .|.||.| |. . . . .   |..|   |  |  ||||....|.. ..  |..|| | . |. | . |.  
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDN-ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

------------------------LLS-ATKRSLI--ALKVSQAMENLHA--ARIIHRDLKSANILLDDEDMPRVCDFGLV-----GFKTGATRTGFVGT
                        ...  . ..|.  |  . ..|| |.    .|.|||| . |.|| .  .  .||||.      . ..  ... .   
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

AQWMAPEILR--SSPFYDEKVDVYSFGVMLWEMLTL-KEPYAGMSQDQMVMAIIEDGLRPSV-VGCGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
  |||||.|.    ... .| ||.|||| .||..|| . || ||.... .|  |.|| |. .  .| .... .|...|| ..|..||.|.|. . |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase 81841.m00095.AA DRK 336-470 41 5.9e-42 139.89 In-house 121-258 (258) Show / Hide 
Range on Protein: 336-470
Range on HMM: 121-258/258
Sequence Identity: 41% (58 aa)

IIHRDLKSANILLDDEDMPRVCDFGLVG-FKT----GATRTGFVGTAQWMAPEILRSSPFYDEKVDVYSFGVMLWEMLTLKEPYAGMSQDQMVMAIIEDG
|||||||| | | |.     | ||||   ||     ....|  .||  | |||.||. . | || |||||.. |||..| . ||.||   | |...  .|
IIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQR-YTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHG

LRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQALAQ
.|| .   .||  . |...|| | |. ||.. .. . |  
MRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 81841.m00095.AA Shk 331-468 40 2e-37 130.64 In-house 117-264 (269) Show / Hide 
Range on Protein: 331-468
Range on HMM: 117-264/269
Sequence Identity: 40% (61 aa)

LHA--ARIIHRDLKSANILLDDEDMPRVCDFGLVG-FKTGA----TRTGFVGTAQWMAPEILRSSPFYDEKVDVYSFGVMLWEMLTLKEPYA--GMSQDQ
||.   .|||||||.|| | |      |||||.    |..        |  ||. |||||..   |. .||.||||||  |||.|| .|||     . |.
LHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPY-NEKADVYSFGIILWEILTCQEPYPKHHSEYDK

MVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQA--L
 . || .  .||.     |..  .|||.||   |. || |. ..|.  |
FYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRIL
Kinase 81841.m00095.AA Pkinase_Tyr 223-361 31 1.5e-28 97.32 Pfam 1-157 (270) Show / Hide 
Range on Protein: 223-361
Range on HMM: 1-157/270
Sequence Identity: 31% (49 aa)

FEIGQVIGSGTFGSVHIGQLT----GTFKKVAIKVLNTKVLGGRQ--LETFKREVWTMATL-NHPNILRLIGVTL--TPP--FCIITELLKC-SLFDRLK
 ..|...|.| ||.|. | ..    .|  .||.|.|       .|  .| | ||. .| .| .||||.||.|| .    |   .|..|. .. .| | |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

L-------LSATKRSLIALKVSQAMENLHAARIIHRDLKSANILLDDEDMPRVCDFGL
        |.      ... ....|| |.. ..|||||   |.|....   ..|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL
Kinase 81841.m00095.AA Pkinase_Tyr 379-468 39 8.9e-22 74.38 Pfam 180-270 (270) Show / Hide 
Range on Protein: 379-468
Range on HMM: 180-270/270
Sequence Identity: 39% (36 aa)

WMAPEILRSSPFYDEKVDVYSFGVMLWEMLTL-KEP-YAGMSQDQMVMAIIEDGLRPSVVGCGPPRVVELIQRCWAEVPSDRPTFAQVSQAL
||||| .. .  . .| ||.|||| .||..|. ..| |.|||  ... .| ||| |       |. . .|...||.. |.|||||... . |
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 81841.m00095.AA Shk 223-283 32 2.6e-08 26.21 In-house 1-59 (269) Show / Hide 
Range on Protein: 223-283
Range on HMM: 1-59/269
Sequence Identity: 32% (20 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLGGRQLETFKREVWTMATLNHPNIL
      .|.| ||.|  |   |  |.||.||.   ..    .  |. ||  |. . ||||.
INREDFLGQGSFGKVYKGRCRG--KEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNIC
Kinase 81841.m00095.AA DRK 223-299 37 4e-07 20.21 In-house 1-77 (258) Show / Hide 
Range on Protein: 223-299
Range on HMM: 1-77/258
Sequence Identity: 37% (30 aa)

FEIGQVIGSGTFGSVHIGQLTGTFKKVAIKVLNTKVLG-GRQLETFKREVWTMATLNHPNILRLIGVTLTPP-FCIITE
  ||  || | .| |  |   ||  .||.| |          |  |.||.  |  | ||||   .|  . ||  ||..|
IKIGNRIGRGNYGEVFRGTWRGT--QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICME