Gene 92349.m00207 (T.vaginalis)
92349.m00207
Species: T.vaginalis
Alias: TvagK0871, 92349.m00207
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92349.m00207.AA | Protein | None | 834 | None | Fasta, JSON |
| 92349.m00207.kin_dom | Protein Kinase Domain | None | 248 | None | Fasta, JSON |
Protein domains of 92349.m00207.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 92349.m00207.AA | TKL | 116-264 | 17 | 2.3e-25 | 88.29 | In-house | 137-364 (364) | Show / Hide |
Range on Protein: 116-264 Range on HMM: 137-364/364 Sequence Identity: 17% (41 aa) LLFSAAVGLKYLHDNN--------IVHGDFKTKSIYVSHDMY--------------IKVADYAPFQII--------------------VRNARKDASLKS . ..| |. ||| .| |.| | |.| | | .. .|..|. . . ... .. . WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT SVYIAPELYQGS----------------PPTKESDIYAFGTLLFSFYT--LKFS---MGRKILN----GPFSELAVSGERVNIP------------DIIP . |||. .|. . .. .|.|.|| .|. .| . .. . |.. |. .. |.| || . .| PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCP IKIQSLIERCWKQNPQERPTMEEIVFQL . .|...||...|..||...||. .| PSMKKLMQDCWDHDPEKRPSFQEILKRL |
|||||||||
| Kinase | 92349.m00207.AA | Dicty5 | 120-268 | 28 | 1.7e-17 | 56.77 | In-house | 113-260 (260) | Show / Hide |
Range on Protein: 120-268 Range on HMM: 113-260/260 Sequence Identity: 28% (44 aa) AAVGLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADYAPFQIIVR--NARKDASL--KSSVYIAPELYQGSPPTKESDIYAFGTLLFSFYTLKFSMGRKIL .| ....|| ||.| | | . . . ||. |. . | .|. . . . |.||..| | . |.|.|| |. | | . | IAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFG----TSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRK-EPYDNIN NGPFSELAVSGERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQLYTLW | . .||| || .| | ||. || | |. ||. ||. . . NWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
|||||||||
| Kinase | 92349.m00207.AA | Dicty4 | 226-266 | 39 | 6e-14 | 43.08 | In-house | 235-277 (277) | Show / Hide |
Range on Protein: 226-266 Range on HMM: 235-277/277 Sequence Identity: 39% (17 aa) GERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQ--LYT ..| ||| | .. .||..|| .|| ||..|||... | . KLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | 92349.m00207.AA | PLK1 | 123-266 | 24 | 5.4e-13 | 38.78 | In-house | 111-253 (253) | Show / Hide |
Range on Protein: 123-266 Range on HMM: 111-253/253 Sequence Identity: 24% (35 aa) GLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADYAPFQIIVRN-ARKDASLKSSVYIAPELYQGSPPTKESDIYAFGTLLFSFYTLKFSMGRKILNGPFSE | .|||.|.|.| |.| ... .. .|. |. . . || |||||. . . | ||.. | ... . | |. .| GCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKETYSR LAVSGERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQLYT . ||..| ..||.. ...|..|||.|... . . IKKN--EYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
|||||||||
| Kinase | 92349.m00207.AA | MLK | 223-264 | 38 | 1e-12 | 40.54 | In-house | 250-291 (291) | Show / Hide |
Range on Protein: 223-264 Range on HMM: 250-291/291 Sequence Identity: 38% (16 aa) AVSGERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQL |. |.|. || .| . .|...||.|.| .||.. .|| .| AYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| S_TKc | 92349.m00207.AA | S_TKc | 15-266 | 17 | 4.5e-11 | -14.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-266 Range on HMM: 1-231/231 Sequence Identity: 17% (48 aa) FEKKSNVRDGKFIRVDRVIHKVTKKKYTLTTIKIPNPKFKNEENWLPRIKYLASLHHPAIKTIVGYIDNGNLPILVDDDEEN--MPAFLELTKFK----- .|. . | | .| ...|| |.... . || |. . |. | . ||| | .. ..... . .| . .. | . | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --INSTNKICLLFSAAVGLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADY---APFQIIVRNARKDASLKSSVYIAPELYQGSPPTK-ESDIYAFGTLLF .. ... . .|.|.|...|.| | | | ... ||..| . . . . |.|||. . .| ..|....| .|. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY SFYT------LKFSMGRKILNGPFSELAVSGERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVF-------QLYT ... . | .||. . ..|..|.. .|..||| |. . EMLCGYPPFPQMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 92349.m00207.AA | RAF | 121-201 | 24 | 1.1e-10 | 30.51 | In-house | 113-212 (282) | Show / Hide |
Range on Protein: 121-201 Range on HMM: 113-212/282 Sequence Identity: 24% (24 aa) AVGLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADYAPFQIIVRNA--RKDASLKSS---VYIAPELYQ--------------GSPPTKESDIYAFGTLLF . |. ||| ||.| | |.. |. || .|. |.. . | .. . . ..||| | . .||.|.||. .. CQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMY |
|||||||||
| Kinase | 92349.m00207.AA | RAF | 123-201 | 27 | 1.2e-10 | 32.74 | In-house | 112-208 (275) | Show / Hide |
Range on Protein: 123-201 Range on HMM: 112-208/275 Sequence Identity: 27% (27 aa) GLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADYAPFQII-VRNA--RKDASLKSS---VYIAPELYQGS------------PPTKESDIYAFGTLLF | ||| ||.|.| |.| |. .. ... | . | . .|.. ||. . .. ..|||. | ...|| ||||| .. GMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVWY |
|||||||||
| Kinase | 92349.m00207.AA | TKL-Unique | 228-264 | 37 | 5.6e-10 | 31.57 | In-house | 254-290 (290) | Show / Hide |
Range on Protein: 228-264 Range on HMM: 254-290/290 Sequence Identity: 37% (14 aa) RVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQL |. ||. .| .. ||..||...|..||. .||. | RPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
|||||||||
| Kinase | 92349.m00207.AA | Fer | 223-265 | 31 | 1.8e-09 | 28.56 | In-house | 240-283 (283) | Show / Hide |
Range on Protein: 223-265 Range on HMM: 240-283/283 Sequence Identity: 31% (14 aa) AVSGERVNIPDIIPIKIQSLIE-RCWKQNPQERPTMEEIVFQLY ...| . .|. | | .... .||...| .|||| ||. .|. IKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
|||||||||
| Kinase | 92349.m00207.AA | Dicty4-Unclassified | 231-264 | 41 | 2.4e-09 | 28.1 | In-house | 230-263 (263) | Show / Hide |
Range on Protein: 231-264 Range on HMM: 230-263/263 Sequence Identity: 41% (14 aa) IPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQL ||| .. ...|| || |. ||||..|. | IPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
|||||||||
| Kinase | 92349.m00207.AA | Pkinase_Tyr | 225-264 | 40 | 5.6e-09 | 31.03 | Pfam | 231-270 (270) | Show / Hide |
Range on Protein: 225-264 Range on HMM: 231-270/270 Sequence Identity: 40% (16 aa) SGERVNIPDIIPIKIQSLIERCWKQNPQERPTMEEIVFQL .|.| .|. | .| .|. .||...|..|||..||. || DGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| TyrKc | 92349.m00207.AA | TyrKc | 13-264 | 17 | 7.8e-09 | -79.86 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-264 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) DDFEKK------SNVRDGKFIRVDRVIHKVTKKKYTLTTIKIPNPKFKNEENWLPRIKYLASL--HHPAIKTIVGYIDNG-------NLPILVDD--DEE ..|| |. |. . | |. |. .| . .. . .| ||| | ..|.. . . .| . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG NMPAFLELTKFKINSTNKICLLFSAAVGLKYLHDNNIVHGDFKTKSIYVSHDMYIKVADYAPFQIIVRN-------ARKDA----SLK--SSV-YIAPEL . .| .. |.. .. . .| | |||..|..| | . . |... .|..| | ... . | . ||| DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC YQGSPPTKESDIYAFGTLLFSFYTLKFSMGRK-----ILNGPFSELAVSGERVNIPDI--------IPIKIQSLIERCWKQNPQERPTMEEIVFQL . . | .||...|| ... .|. . . | |. .|.| .|. | .. .....||. .| .|||..||. .. INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | 92349.m00207.AA | TKL-Unique | 120-200 | 23 | 9.5e-09 | 27.17 | In-house | 119-218 (290) | Show / Hide |
Range on Protein: 120-200 Range on HMM: 119-218/290 Sequence Identity: 23% (23 aa) AAVGLKYLHDNN--IVHGDFKTKSIYVSHD-----MYIKVADYAPFQIIVRNARKDAS----------LKSSVYIAPELYQG--SPPTKESDIYAFGTLL .| |. ||| .. | |.| |.....|. . . ||..| . .. .. .. ..| ..|||. . . .. ||.|.||. | IAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL |
|||||||||
| Kinase | 92349.m00207.AA | Pkinase | 173-264 | 15 | 2e-08 | 30.9 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 173-264 Range on HMM: 174-293/293 Sequence Identity: 15% (19 aa) SSVYIAPELYQ-GSPPTKESDIYAFGTLLFSFYT--LKFSMGR----KILNGPFSELAVSGERVNIPDIIP---------------------IKIQSLIE .. |.|||. . |.. ....|....| .|. ... . |. |. . .. . . | .. . . ...|. TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK RCWKQNPQERPTMEEIVFQ--L .|....|..||| |.|. . WCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 92349.m00207.AA | RAF | 235-264 | 30 | 4.3e-07 | 20.34 | In-house | 246-275 (275) | Show / Hide |
Range on Protein: 235-264 Range on HMM: 246-275/275 Sequence Identity: 30% (9 aa) IPIKIQSLIERCWKQNPQERPTMEEIVFQL .| .. |.. ||...|.|||. .|. . CPKEMKELLMECWSYQPEERPSFQQIMKMI |
|||||||||
| Kinase | 92349.m00207.AA | Dicty4-Unclassified | 118-154 | 37 | 2.5e-05 | 14.17 | In-house | 116-152 (263) | Show / Hide |
Range on Protein: 118-154 Range on HMM: 116-152/263 Sequence Identity: 37% (14 aa) FSAAVGLKYLHDNNIVHGDFKTKSIYVSHDMYIKVAD |. | |. .|| |..| | | | . . ||.|| FDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIAD |
|||||||||
| Kinase | 92349.m00207.AA | RAF | 235-266 | 31 | 2.9e-05 | 12.68 | In-house | 251-282 (282) | Show / Hide |
Range on Protein: 235-266 Range on HMM: 251-282/282 Sequence Identity: 31% (10 aa) IPIKIQSLIERCWKQNPQERPTMEEIVFQLYT .| ... |.| ||| ...||| ..|. .. CPKAMHRLMEDCWKFQREERPLFQQILKRITV |
|||||||||
| Kinase | 92349.m00207.AA | Dicty4 | 118-154 | 38 | 5.7e-05 | 12.71 | In-house | 119-157 (277) | Show / Hide |
Range on Protein: 118-154 Range on HMM: 119-157/277 Sequence Identity: 38% (15 aa) FSAAVGLKYLHD-N-NIVHGDFKTKSIYVSHDMYIKVAD |.|| |. .|| | .|.| | |. . |. .. .||.| FDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCD |
|||||||||
| Kinase | 92349.m00207.AA | Fer | 113-136 | 45 | 8.6e-05 | 12.37 | In-house | 113-136 (283) | Show / Hide |
Range on Protein: 113-136 Range on HMM: 113-136/283 Sequence Identity: 45% (11 aa) KICLLFSAAVGLKYLHDNNIVHGD || .. || |..||| .|..| | KIRMCYQAACGMEYLHSKNCIHRD |
|||||||||
| Kinase | 92349.m00207.AA | Pkinase | 123-154 | 33 | 0.220767 | 5.97 | Pfam | 120-155 (293) | Show / Hide |
Range on Protein: 123-154 Range on HMM: 120-155/293 Sequence Identity: 33% (12 aa) GLKYLHDNNIVHGDFKTKSIYVSHDMYI----KVAD ||.|.|...|.| | | | ......| |..| GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD |
|||||||||
| Kinase | 92349.m00207.AA | Fer | 188-201 | 21 | 0.301986 | 0.13 | In-house | 196-209 (283) | Show / Hide |
Range on Protein: 188-201 Range on HMM: 196-209/283 Sequence Identity: 21% (3 aa) TKESDIYAFGTLLF ....|...|| ... SPKTDVWSFGVMCW |
|||||||||
| Kinase | 92349.m00207.AA | Pkinase_Tyr | 123-136 | 42 | 1.196407 | 2.82 | Pfam | 123-136 (270) | Show / Hide |
Range on Protein: 123-136 Range on HMM: 123-136/270 Sequence Identity: 42% (6 aa) GLKYLHDNNIVHGD |. ||...|..| | GMEYLESKNCIHRD |
|||||||||
| Ank | 92349.m00207.AA | Ank | 705-738 | 35 | 3e-06 | 26.57 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 705-738 Range on HMM: 1-33/33 Sequence Identity: 35% (12 aa) FGWTPLHWAAFKSKVSILSILNGAEGVDPNIADD |.||||.|... ..... | . | |.|. || DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
|||||||||
| Ank | 92349.m00207.AA | Ank | 739-772 | 35 | 6.8e-05 | 21.92 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 739-772 Range on HMM: 1-33/33 Sequence Identity: 35% (12 aa) WGITPLHLAAEYGSDKGLQELMRYKNLNVNICDK | ||||||...|. . ...|. .. .||. |. DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
|||||||||
| Ank | 92349.m00207.AA | Ank | 773-806 | 32 | 0.029823 | 12.38 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 773-806 Range on HMM: 1-33/33 Sequence Identity: 32% (11 aa) RGQSPLHKAVESGEITNVKIILSDKRVDTQICDK |..||| |...| . || |. . | . |. DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
|||||||||
| Ank | 92349.m00207.AA | Ank | 672-704 | 21 | 0.707561 | 7.42 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 672-704 Range on HMM: 1-33/33 Sequence Identity: 21% (7 aa) LGYLLINAAVISGNVDILLYCLSNGVDVMQREN |. |...|..... . |..| || . . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
|||||||||