Gene 84950.m00105 (T.vaginalis)

84950.m00105

Species: T.vaginalis
Alias: TvagK0286, 84950.m00105
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
84950.m00105.AA Protein None 797 None Fasta, JSON
84950.m00105.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of 84950.m00105.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84950.m00105.AA TKL 212-456 26 1.1e-80 274.4 In-house 1-364 (364) Show / Hide 
Range on Protein: 212-456
Range on HMM: 1-364/364
Sequence Identity: 26% (97 aa)

IGAGVSSHVFYGKYKKTD--------QEVAIKRLKFKKLSGLKL-------------------------ASFQREVSVLATCCHPCLIGFVG-ATDTPP-
|| | .. |. ||.. ..        ..||.|..| .  .   .                           . .|. ..  ..|| .. |.| ... |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIVTEWMPNDTLYHDLHKHHKLDTTMRTIA-AFDIARGMQELHSKH--------IIHRDLKSLNVLLDKDYH--------------V
            .|||.|..|. .|.|.||         ...  | ||||||. |||..        |||||||| |.|.|....              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

HICDFGFSR-----GAGEEQLYTQN---------------VGTPHWMAPELLD----SSH-----------SYNYKVDVYAYGIVLWEIMTCQLPYSGLE
 |||||.||     |  . . .|..               .||| |||||.|.     ..           .|. |.|||..|||||||.|...||... 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

STQII---------AQVMMNDLRPSIP------------ESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
. ..|         ..|  . ||| ||            ...  ....| . ||| .|. ||.|.||. |.
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 84950.m00105.AA TKL-Unique 208-456 34 9.9e-78 264.55 In-house 1-290 (290) Show / Hide 
Range on Protein: 208-456
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

VIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKF-KKLSGLKLASFQREVSVLATCC-HPCLIGFVGATD----TPP-FCIVTEWMPNDTLYHDLH------
... ||.|... |. ||....  .||||....  ..|  ..  | .||... .   || .  ..|..     .|| .|||.| .|  .||  ||      
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

----KHHKLDTTMRTIAAFDIARGMQELHSKH--IIHRDLKSLNVLLDKD-----YHVHICDFGFSRGAGEEQLYTQN----------VGTPHWMAPELL
    ...||.  .|   | |||.||  ||..   ||||||||.|.|.| .     . . |||||.|. .  .   | |          .|.. |||||.|
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

DSS-HSYNYKVDVYAYGIVLWEIMTCQL------PYSGLESTQIIAQVMM--NDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
 ..   |. |.|||..||||||| | ..      ||.|....|... |      .|| ||.. .  .||| . ||...|. ||.||||| | 
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 84950.m00105.AA MLK 206-456 31 2.1e-68 233.59 In-house 1-291 (291) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-291/291
Sequence Identity: 31% (91 aa)

FEVIKEIGAGVSSHVFYGKYKKTD---QEVAIKRLKFKK----LSGLKLASFQREVSVLATCCHPC----LIGFVGA-TDTPP-FCIVTEWMPNDTLYHD
... . ||.| .  |. |.....|    .||.|| .. .     ..     |..|.  |.  .||      | |.|. ...|. ||||.|....  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHKHHK--------------LDTTMRTIAAFDIARGMQELHSKH---IIHRDLKSLNVLLD------KDYHVHICDFGFSRGAGEE-QLYTQNVGTPHWM
||   .               |       |...||||. |||.    |||||||| |.|.|      .. .. ||||| ||   .  .  . | ||. ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APELLD--SSHSYNYKVDVYAYGIVLWEIMTCQLPYS-GLESTQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
||| .    .  |. |.||. .|.||||..|...||. .... .|...| .| ||| || . . ..  | . ||. .| .||.|..|.  .
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 84950.m00105.AA Dicty4 206-458 37 7.9e-68 225.34 In-house 1-277 (277) Show / Hide 
Range on Protein: 206-458
Range on HMM: 1-277/277
Sequence Identity: 37% (106 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRL--KFKKLSGLKLASFQREVSVLATCCHPCLIGFVGATD----TP-PFCIVTEWMPNDTLYHDLHK---
  . ..|| |  . |. |. .   .|||.| |  .  ...   | .| .||. ..   || .. | ||      .|  .||||| ||  .||  ||.   
INIEQRIGKGSFGEVYKGTWRG--KEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

----HHKLD-TTMRT---IAAFDIARGMQELHS--KHIIHRDLKSLNVLLDKDYHVHICDFGFSR----GAGEEQ-LYTQNVGTPHWMAPELLDSSHSYN
      ||| ....    . |||.||||. ||.    |||||||| | | ||.. | .||||.|.    .    . . |. .||| ||||| .  ...||
EQQQSIKLDWPLIKRAMRM-AFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVM-MHQPYN

YKVDVYAYGIVLWEIMTCQLPYS--GLESTQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRR--FQT
 |.||| .||||||| |.| ||.  . .  |... |    |||.|| ..  ....| . ||| .| .||.| ||| |    .
EKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 84950.m00105.AA LRRK 206-458 24 1.2e-67 231.09 In-house 1-351 (351) Show / Hide 
Range on Protein: 206-458
Range on HMM: 1-351/351
Sequence Identity: 24% (87 aa)

FEVIKEIGAGVSS-HVFYGKYKK--------------------------TDQEVAIKRLKF--------------------------------KKLSGLK
..  ..|| |..   |. .|...                           .|.|||| ...                                   .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LASFQREVSVLATCCHPCLIGFVGATDTPPFCIVTEWMPNDTLYHDLHKHH---------KLDTTMRTIAAFDIARGMQELHSKH--IIHRDLKSLNVLL
. .|..||... .  ||...  .| .   |.|.|.| .|. .||| ||...         ... ...   | .||.||. |||..  |||||||| |.||
FREFRHEVWIMSHLNHPNIVSLKGFC-IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

---D---------KDYHVHICDFGFSR--GAGEEQLYTQNVGTPHWMAPELLDSS--HSYNYKVDVYAYGIVLWEIMTCQ-LPYSGLE----S--TQIIA
   .          .....|.||| ||   .  . .    ||.| ||||| .      .|. |||.|..|..|||..| | .|. ...    .  . .| 
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

QVMMNDLRPSIPES-TNG-----PLRDLTTSCWDRNPDRRPTFDEIIRRFQT
. ... |||.||..  ..      . || ..||. .|..||.| .|. |  .
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 84950.m00105.AA S_TKc 206-458 24 3.2e-62 213.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 206-458
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKKLSGLKLASFQREVSVLATCCHPCLIGFVGATDTPPFCIVTEWMPN--DTLYHDLHKHHK-----
.|....|| |  . |. .. |||...||||..|          ...||...|    || .. . .. ..  ...|.| ...   .|.. ..|. .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHVHICDFGFSRGAGEEQLYTQNVGTPHWMAPELLDSSHSYNY-KVDVYAYGIVLWEIM
 ..  .    .  |..... .||..|||||||  |.|||.  |. |||||..|        |  .|||..||||.|    .|.. |.|... |..|.| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TCQLPYSGLESTQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIR-------RFQT
. . |..     | . ....             ...|.   |....|..|||  |. .           
CGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84950.m00105.AA Pkinase 206-456 24 8.2e-62 216.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-293/293
Sequence Identity: 24% (71 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKKLSGLKLASFQR--EVSVLATCCHPCLIGFVGAT-DTPPFCIVTEWMPND----TLYHDLH--KH
..... ||.| .. |. .. |.| ..||.|..| .. .  |. .  |  |..... ..||. . . ..  | .  ..|.|.....     |.. ..  .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HKL--DTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHV----HICDFGFSRG--AGEEQLYTQNVGTPHWMAPELLDSSHSYNYKVDVYAY
 ..  .       .  |.||.. .||. |||||||. |.|.|...|.    .|||||...       . .|  .|||..||||.. ..  | .|||....
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIVLWEIMTCQLPYSGL------ESTQIIAQVMMNDLRPSIPESTN-------------------GPLRDLTTSCWDRNPDRRPTFDEIIRR--F
|..|.| .. ..|..|       .  |.|...|. .|. ..|.. .                    ...|. ..|....| .|||...|     |
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84950.m00105.AA Pkinase_Tyr 206-456 30 3e-61 208.05 Pfam 1-270 (270) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-270/270
Sequence Identity: 30% (83 aa)

FEVIKEIGAGVSSHVFYGKYK----KTDQEVAIKRLKFKKLSGLK---LASFQREVSVLATC-CHPCLIGFVGA-T-DTPP--FCIVTEWMPNDTLYHDL
 . .|..|.|   .|. |..|    .|...||.| |  |  .  .   ...| ||.... .   || .. ..|. | .  |   .||.| ||.  |.. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

HKH----HKLDTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHVHICDFGFSRGAGEEQLY-TQNVGTP---HWMAPELLDSSHSYNYKVDV
.||    ..|.. .    ...||.||. |.||..|||||   |.|.... .| ||||| .|   ..  | ..  |..    ||||| .  .  .. | ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDV

YAYGIVLWEIMT-CQLP-YSGLESTQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
...|...|||.| .. | | |.  .......  .  |  .|| .  .. || ..||. .|..|||| ||....
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 84950.m00105.AA Dicty4-Unclassified 206-456 34 1.4e-59 202.67 In-house 1-263 (263) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-263/263
Sequence Identity: 34% (93 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKKLSGL--KLASFQREVSVLATCCHPCLIGFVGATDTP-----PFCIVTEWMPNDTLYHDLH----
  . ..|| |  | |  |  |    .||.| .   | .     .  | .|| .|    || |.   |.   |      .|||.| |.  .|    |    
IQIDQFIGKGHFSKVHKGNWK--GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

---KHHKLDTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHVHICDFGFSRGAGEEQLYTQNVGTPHWMAPELLDSSHSYNYKVDVYAYGIV
   .  ||| |.    |||||.||| ||.. .||||.|| |.|.||.. . | ||| ||     .  |   ||| | .|| |    ||| | ||| |...
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECL-MHESYNQKSDVYSYAMM

LWEIMTCQLPYSGLE-STQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
|.| .|   || .      .   |    ||| ||..    .. |   ||   | .|||...|| . 
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase 84950.m00105.AA TK 206-456 16 5.5e-59 196.05 In-house 1-486 (486) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

FEVIKEIGAGVSS---HVFYGKYKKTD-------------------------QEVAIKRLKFK-KLSGL-KLASFQR----------EVSVLATCC----
 ...|..|.|       |. |...  .                         ..||.| || .   |   ... . .          |.....  |    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPCLIGFVG-ATDT------------PPFCIVTEWMPNDT----LYHDLHKHHK---------------------------------------------
 || .. ..|  |.             .|..||.|.||.      | . |.|...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDTTMRTIAAFDIARGMQELHSK------HIIHRDLKSLNVLLDKDYH-----------VHICDFG---
                               |..  .   ...||.||. ||||      ...||||   |.|......           . |.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FSRGAGE-EQLYTQN-VGTPH-------------------------WMAPELLDSSH--------SYNYKVDVYAYGIVLWEIMT-CQLPYSGLE
      .|  .. .  |...  ||.                          ||||| |.. .         .  | ||...|...|||.| .| || |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

S----------TQIIAQVMMN-------------DLRPSIPESTN--------------GPLRDLTTSCWDRNPDRRPTFDEIIRRF
|          .... .. .               .|.  |.                   . || ..||...|..||||... ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 84950.m00105.AA Dicty5 207-460 34 1.8e-55 189.36 In-house 2-260 (260) Show / Hide 
Range on Protein: 207-460
Range on HMM: 2-260/260
Sequence Identity: 34% (92 aa)

EVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKKLSGLKLASFQREVSVLATCC--HPCLIGFVGA--TDTPPFCIVTEWMPNDTLYHDLHKHHK----
 . . | .| |  |. | ||  |  |||| .      .  . .|.||| ..      || .| . ||   ..    .|||   | .|   |    |    
SFHDWIASGASGRVYNGIYKGMD--VAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQ

-LDTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHVHICDFGFSRGAGEEQLYTQNVGTPHWMAPELLDSSHSYNYKVDVYAYGIVLWEIMT
 .    .   | |||..|. |||. ||||||||.|.|. ... . | ||| ||       .| .|||. |||.||   .  |  |.|||..||||||..|
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFN-GQPYHQKCDVYSFGIVLWEMFT

CQLPYSGLESTQIIAQVMMNDLRPSIPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRFQTNE
   ||  . .  |   ||  . || ||         |  .||   | .||.| ||.  |.   
RKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 84950.m00105.AA HH498 206-456 29 4.2e-54 169.73 In-house 1-284 (284) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-284/284
Sequence Identity: 29% (84 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKK-LSGLK-----LASFQREVSVLATCCHPCLIGFVGAT--DTPPFCIVTEWMPNDTLYHDL----
.|  . ||.|    |. |..      ||.|| . .. ..  .        | ||||..    ||| . ||.|.  |   | |||..  |  |.  |    
IEFHEKIGSGSFGKVYKGEWR--NKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

----------HKHH----KLDTTMRTIAAFDIARGMQELHS---KHIIHRDLKSLNVLLDKDYHVHICDFGFSR---GAGEEQLYTQNVGTPHWMAPELL
          |        .|   . . . |.|.||. ||.   . |||||| | |.|...| |  . ||| ||     ... . |   | . |||||  
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNM-TKQPGNLRWMAPEVF

DSSHSYNYKVDVYAYGIVLWEIMTCQLPYSGLESTQIIAQVMMNDLRPSIPES----TNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
  .  |  ||||. |....||. |  .|.. ..     | .     || || .       .   |   ||. .|. ||.||.|..  
SQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 84950.m00105.AA TyrKc 206-456 28 3e-53 184.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 206-456
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

FEVIKEIGAGVSSHVFYGKYKKTDQEVAIKRLKFKKLSGLKLASFQREVSVLATC--CHPCLIGFVGATDT--------PPFCIVTEWMPNDTLYHDLHK
 . .|..| |    |. |..|   ..||.| ||  .     .. | || ...      ||... ..|.  .        .| .||.| ||.  | . |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HHK-LDTTMRTIAAFDIARGMQELHSKHIIHRDLKSLNVLLDKDYHVHICDFGFSRGAGEE-------QLYTQNV--GTP-----HWMAPELLDSSHSYN
|.. | .      ...||.||. ||||..|||||   |.|......| |.||| ||  ...       . |..    |.       ||||| .   . ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

YKVDVYAYGIVLWEIMT-CQLPYSG-----LESTQIIAQVMMNDLRPSIPE-------STNGPLRDLTTSCWDRNPDRRPTFDEIIRRF
 | ||...|...|||.| .| ||.|     .. ...|..|.  . .|  |.            . .. ..||...|. |||| ||...|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 84950.m00105.AA DRK 231-458 34 1e-52 176.88 In-house 24-258 (258) Show / Hide 
Range on Protein: 231-458
Range on HMM: 24-258/258
Sequence Identity: 34% (82 aa)

EVAIKRLKFKKLSGLKLAS-FQREVSVLATCCHPCLIGFVGATDTPP-FCIVTEWMPNDTLYHDLHKHH-KLDTTMRTIAAFDIARGMQELHSKH--IIH
.||.|.|.      ... . |.||. ..    ||  . | |.   ||  ||..| ||   ||  ||    ..|   .   .||.|.||  ||.    |||
QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIH

RDLKSLNVLLDKDYHVHICDFGFSR--GAGEEQLYTQ-NVGTPHWMAPELLDSSHSYNYKVDVYAYGIVLWEIMTCQLPYSGLESTQIIAQVMMNDLRPS
||||| | | |  . | . ||| |      ...  .   .||| | ||| |  .  |  | ||| ..|||||..| | || |    |..  |    .|| 
RDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVL-RNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPP

IPESTNGPLRDLTTSCWDRNPDRRPTFDEIIRRFQT
.|.    .   | . ||. .|  ||...|.. |   
MPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA